Too old to fight? Aging and its toll on innate immunity

scientific article published on February 2010

Too old to fight? Aging and its toll on innate immunity is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1111/J.2041-1014.2009.00562.X
P932PMC publication ID2839454
P698PubMed publication ID20305805
P5875ResearchGate publication ID42372761

P2093author name stringGeorge Hajishengallis
P2860cites workEffect of age on respiratory defense mechanisms: pulmonary bacterial clearance in Fischer 344 rats after intratracheal instillation of Listeria monocytogenesQ23914313
Immunosenescence and macrophage functional plasticity: dysregulation of macrophage function by age-associated microenvironmental changesQ24532069
Porphyromonas gingivalis-host interactions: open war or intelligent guerilla tactics?Q24655246
Inflamm-aging. An evolutionary perspective on immunosenescenceQ28141817
Resolution of inflammation: a new paradigm for the pathogenesis of periodontal diseasesQ28206660
Recognition of microorganisms and activation of the immune responseQ29617903
Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophagesQ33358865
Innate immunity and pulmonary host defenseQ33864369
Periodontal inflammation and bone loss in aged mice.Q33949702
Review article: ageing and the neutrophil: no appetite for killing?Q33992839
Periodontal diseases.Q34468885
Age-associated inflammation and toll-like receptor dysfunction prime the lungs for pneumococcal pneumoniaQ35007893
Host innate defenses in the lung: the role of cytokinesQ35160604
Inflammatory mediators in the elderlyQ35766426
Innate immunity in aging: impact on macrophage functionQ35842727
Signal transduction and functional changes in neutrophils with aging.Q35842752
MacrophAging: a cellular and molecular review.Q36257851
Interleukin 1 genetics, inflammatory mechanisms, and nutrigenetic opportunities to modulate diseases of agingQ36392635
Oral biofilms, periodontitis, and pulmonary infectionsQ36481768
The roles of cyclooxygenase-2 and prostaglandin E2 in periodontal diseaseQ36703953
Effects of age and oral disease on systemic inflammatory and immune parameters in nonhuman primatesQ36746942
Innate immunity and agingQ36929586
The use of rodent models to investigate host-bacteria interactions related to periodontal diseasesQ37058550
Importance of TLR2 in early innate immune response to acute pulmonary infection with Porphyromonas gingivalis in miceQ37059185
Regulation of immunological homeostasis in the respiratory tractQ37060276
A new inflammatory cytokine on the block: re-thinking periodontal disease and the Th1/Th2 paradigm in the context of Th17 cells and IL-17.Q37249268
Age-related alterations in innate immune receptor expression and ability of macrophages to respond to pathogen challenge in vitro.Q37280387
The onset age of periodontal destructionQ37297402
CD14-Mac-1 interactions in Bacillus anthracis spore internalization by macrophagesQ37310685
Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors.Q37525662
Effects of human aging on periodontal tissues.Q37538945
The aging immune system: primer and prospectusQ41003059
Evaluation of phagocytosis and arachidonate metabolism by alveolar macrophages and recruited neutrophils from F344xBN rats of different ages.Q43737691
A defective protein kinase C anchoring system underlying age-associated impairment in TNF-alpha production in rat macrophagesQ43921737
Oral health and mortality risk from pneumonia in the elderlyQ44468713
Age-dependent change in reactive oxygen species and nitric oxide generation by rat alveolar macrophages.Q44526576
Age-associated alterations in the recruitment of signal-transduction proteins to lipid rafts in human T lymphocytesQ44681165
Increased carrageenan-induced acute lung inflammation in old ratsQ44985186
Integrin activation by bacterial fimbriae through a pathway involving CD14, Toll-like receptor 2, and phosphatidylinositol-3-kinaseQ45288377
Impaired phagosomal maturation in neutrophils leads to periodontitis in lysosomal-associated membrane protein-2 knockout miceQ48014489
Nonopsonic and opsonic association of Mycobacterium tuberculosis with resident alveolar macrophages is inefficientQ48032255
Infection-mediated early-onset periodontal disease in P/E-selectin-deficient mice.Q52062804
Seeking wisdom in innate immunity.Q52553666
Aging and Innate ImmunityQ56986827
Effects of aging on triggering receptor expressed on myeloid cells (TREM)-1-induced PMN functionsQ57360825
Cutting edge: impaired Toll-like receptor expression and function in agingQ64127747
Aspiration pneumoniaQ68021123
Immune dysregulation in the aging human lungQ71078727
The effect of age on the development of gingivitis. Clinical, microbiological and histological findingsQ71343473
Age-related decline in murine macrophage production of nitric oxideQ73188487
Age-related decrease in accessory cell function of human alveolar macrophagesQ74593858
Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expressionQ79317442
Age-associated defect in human TLR-1/2 functionQ79485170
Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathwayQ81194599
AgingQ81562926
P433issue1
P304page(s)25-37
P577publication date2010-02-01
P1433published inOral Microbiology and ImmunologyQ15724666
P1476titleToo old to fight? Aging and its toll on innate immunity
P478volume25

Reverse relations

cites work (P2860)
Q90573363Age and Periodontal Health - Immunological View
Q42243773Age-related alterations in gene expression of gingival fibroblasts stimulated with Porphyromonas gingivalis.
Q39165175Age-related changes in immune function (immune senescence) in caries and periodontal diseases: a systematic review
Q38749853Ageing, dental caries and periodontal diseases.
Q51151389Aging Effects on Humoral Immune Responses in Chronic Periodontitis.
Q37681980Aging and its Impact on Innate Immunity and Inflammation: Implications for Periodontitis.
Q38921842Aging, inflammation, immunity and periodontal disease
Q38103939Bacterial behaviors associated with the quorum-sensing peptide pheromone ('alarmone') in streptococci
Q37929859Beyond the oral microbiome
Q33361553Can oral infection be a risk factor for Alzheimer's disease?
Q42102414Caveolin-1 serves as a negative effector in senescent human gingival fibroblasts during Fusobacterium nucleatum infection
Q64233770Characterization of oral microbiota in marmosets: Feasibility of using the marmoset as a human oral disease model
Q36331927Clinical profile of orofacial infections: an experience from two primary care dental practices
Q40963982Clinical profile of patients with advanced age and inflammatoric dilated cardiomyopathy on endomyocardial biopsy.
Q37632781Comparative analysis of gingival tissue antigen presentation pathways in ageing and periodontitis
Q50078106Comparative analysis of microbial sensing molecules in mucosal tissues with aging
Q37769810Complement and periodontitis.
Q39165186Dental caries and periodontal diseases in the ageing population: call to action to protect and enhance oral health and well-being as an essential component of healthy ageing - Consensus report of group 4 of the joint EFP/ORCA workshop on the boundar
Q38827309Dental geriatrics and periodontitis
Q36674783Differential Gene Expression Profiles Reflecting Macrophage Polarization in Aging and Periodontitis Gingival Tissues
Q36714894Effect of Aging on Periodontal Inflammation, Microbial Colonization, and Disease Susceptibility
Q36460098Effects of aging in the expression of NOD-like receptors and inflammasome-related genes in oral mucosa
Q42060985Experimental mucositis and experimental gingivitis in persons aged 70 or over. Clinical and biological responses
Q50026303Hypoxia Inducible Transcription Factors, HIF1A and HIF2A, Increase in Aging Mucosal Tissues
Q36378438Immune system transcriptome in gingival tissues of young nonhuman primates
Q28658053Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response
Q38253911Immunosenescence in monocytes, macrophages, and dendritic cells: lessons learned from the lung and heart
Q28084018Immunosenescence in renal transplantation: a changing balance of innate and adaptive immunity
Q36107991Impact of aging on TREM-1 responses in the periodontium: a cross-sectional study in an elderly population
Q39424405Increased nucleic Acid receptor expression in chronic periodontitis
Q36388104Inhibition of Porphyromonas gingivalis-induced periodontal bone loss by CXCR4 antagonist treatment.
Q58209776Innate Immunity to : Evolving Paradigms in Soft Tissue and Invasive Infections
Q36417215Local complement-targeted intervention in periodontitis: proof-of-concept using a C5a receptor (CD88) antagonist
Q90406756Microneedle-Mediated Vaccine Delivery to the Oral Mucosa
Q36443611Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity
Q37594566Neutrophil homeostasis and periodontal health in children and adults
Q35909279Neutrophils in periodontal inflammation
Q52325444Overexpression of antimicrobial peptides contributes to aging through cytotoxic effects in Drosophila tissues.
Q37964882Paradigm shift in the pharmacological management of periodontal diseases
Q36467461Perinatal epigenetic determinants of cognitive and metabolic disorders
Q92462298Periodontitis is associated with disease severity and anti-double stranded DNA antibody and interferon-gamma levels in patients with systemic lupus erythematosus
Q61145116Prostate Cancer: Is It a Battle Lost to Age?
Q35799715RNA regulators of host immunity and pathogen adaptive responses in the oral cavity
Q34886921Respiratory disease and the role of oral bacteria.
Q34727808Role of complement in host-microbe homeostasis of the periodontium
Q38765058Role of nitro-oxidative stress in the pathogenesis of experimental rat periodontitis.
Q24618908The C5a receptor impairs IL-12-dependent clearance of Porphyromonas gingivalis and is required for induction of periodontal bone loss
Q30513501The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss
Q46250979Transcriptome profiling analysis of senescent gingival fibroblasts in response to Fusobacterium nucleatum infection
Q48191223Triggering receptor expressed on myeloid cells in the pathogenesis of periodontitis: potential novel treatment strategies
Q46269475Vitamin C and Immune Function

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