Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective properties

scientific article published on 20 March 2014

Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective properties is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1002066739
P356DOI10.1186/1758-5996-6-42
P932PMC publication ID3998187
P698PubMed publication ID24650557
P5875ResearchGate publication ID260995477

P50authorFlávio ReisQ38545312
Helena ValaQ47352510
Rosa FernandesQ47503161
Paulo Rodrigues-SantosQ50880687
Jorge OliveiraQ59675095
Edite Teixeira De LemosQ64190488
P2093author name stringCristina Mega
Edite Teixeira de Lemos
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Sitagliptin prevents the development of metabolic and hormonal disturbances, increased β-cell apoptosis and liver steatosis induced by a fructose-rich diet in normal ratsQ84959531
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New therapeutic strategies for the treatment of type 2 diabetes mellitus based on incretinsQ42078124
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Glucagon-like peptide-1 promotes islet cell growth and inhibits apoptosis in Zucker diabetic rats.Q44193794
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Overexpression of TRB3 gene in adipose tissue of rats with high fructose-induced metabolic syndromeQ46581204
Efficacy and safety of sitagliptin when added to ongoing metformin therapy in patients with type 2 diabetesQ46804059
Variations in inflammatory biomarkers following the addition of sitagliptin in patients with type 2 diabetes not controlled with metforminQ51333357
A dipeptidyl peptidase-4 inhibitor, sitagliptin, exerts anti-inflammatory effects in type 2 diabetic patients.Q51350351
Both sitagliptin analogue & pioglitazone preserve the beta-cell proportion in the islets with different mechanism in non-obese and obese diabetic miceQ51364785
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Islet microvasculature in islet hyperplasia and failure in a model of type 2 diabetesQ52574567
Reduced Incretin Effect in Type 2 DiabetesQ58168459
Both Subcutaneously and Intravenously Administered Glucagon-Like Peptide I Are Rapidly Degraded From the NH2-Terminus in Type II Diabetic Patients and in Healthy SubjectsQ58449089
Protective effects of the dipeptidyl peptidase IV inhibitor sitagliptin in the blood-retinal barrier in a type 2 diabetes animal modelQ61952011
P433issue1
P304page(s)42
P577publication date2014-03-20
P1433published inDiabetology and Metabolic SyndromeQ15816649
P1476titleSitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective properties
P478volume6

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cites work (P2860)
Q64898328DPP-4 Inhibitor Sitagliptin Improves Cardiac Function and Glucose Homeostasis and Ameliorates β-Cell Dysfunction Together with Reducing S6K1 Activation and IRS-1 and IRS-2 Degradation in Obesity Female Mice.
Q36639293DPP-4 inhibition improves early mortality, β cell function, and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid
Q42319765Effect of dipeptidyl peptidase 4 inhibitors on acute and subacute models of inflammation in male Wistar rats: An experimental study
Q46254755Ephedrine as a lead compound for the development of new DPP-IV inhibitors.
Q34344972Immuno-modulator metallo-Peptide reduces inflammatory state in obese zucker fa/fa rats
Q42876331Renoprotective Effects of the Dipeptidyl Peptidase-4 Inhibitor Sitagliptin: A Review in Type 2 Diabetes
Q48270894Sitagliptin Attenuates Endothelial Dysfunction of Zucker Diabetic Fatty Rats: Implication of the Antiperoxynitrite and Autophagy
Q38941094Sitagliptin and pancreatic cancer risk in patients with type 2 diabetes
Q92282014The Biological Impacts of Sitagliptin on the Pancreas of a Rat Model of Type 2 Diabetes Mellitus: Drug Interactions with Metformin
Q38820260The incretin system ABCs in obesity and diabetes - novel therapeutic strategies for weight loss and beyond
Q61814333Therapeutic Options Targeting Oxidative Stress, Mitochondrial Dysfunction and Inflammation to Hinder the Progression of Vascular Complications of Diabetes

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