Ephedrine as a lead compound for the development of new DPP-IV inhibitors.

scientific article

Ephedrine as a lead compound for the development of new DPP-IV inhibitors. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4155/FMC-2017-0080
P698PubMed publication ID29172693

P50authorRaúl Beltrán-DebónQ42175504
Santiago Garcia-VallvéQ43371030
Miquel MuleroQ80031984
P2093author name stringCristina Valls
Gerard Pujadas
Adrià Cereto-Massagué
Aleix Gimeno
María José Ojeda-Montes
Andrea Ardid-Ruiz
Sarah Tomás-Hernández
P2860cites work1,3-disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitorsQ27644379
Involvement of DPP-IV catalytic residues in enzyme-saxagliptin complex formationQ27649728
Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: A new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554Q27670819
Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to StructureQ27720944
A Review of Natural Stimulant and Non-stimulant Thermogenic AgentsQ28076560
Ephedra in perspective--a current reviewQ28201511
Structural requirements for catalysis, expression, and dimerization in the CD26/DPIV gene familyQ28203913
Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (part I): virtual screening and activity assaysQ28483681
Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (Part II): in silico prediction in antidiabetic extractsQ28483936
The Principles of Ligand Specificity on beta-2-adrenergic receptorQ28822521
Natural Products As Sources of New Drugs over the 30 Years from 1981 to 2010Q29616640
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9.Q33368655
An overview on antidiabetic medicinal plants having insulin mimetic propertyQ34338134
Multi-ingredient, caffeine-containing dietary supplements: history, safety, and efficacyQ35281767
Sitagliptin prevents aggravation of endocrine and exocrine pancreatic damage in the Zucker Diabetic Fatty rat - focus on amelioration of metabolic profile and tissue cytoprotective propertiesQ37720797
Recent Advances in Non-Peptidomimetic Dipeptidyl Peptidase 4 Inhibitors: Medicinal Chemistry and Preclinical AspectsQ38019603
Physiology of incretins and loss of incretin effect in type 2 diabetes and obesity.Q38122004
DPP-IV inhibitors: Beyond glycaemic control?Q38168002
Recent approaches to medicinal chemistry and therapeutic potential of dipeptidyl peptidase-4 (DPP-4) inhibitors.Q38188386
DPP-4 inhibitors: a patent review (2012 - 2014).Q38284522
An overview of recent dipeptidyl peptidase-IV inhibitors: linking their structure and physico-chemical properties with sar, pharmacokinetics and toxicityQ38531506
Chemical composition of various Ephedra speciesQ41292416
The good, the bad and the dubious: VHELIBS, a validation helper for ligands and binding sitesQ42538022
Protective effects of dipeptidyl peptidase-4 (DPP-4) inhibitor against increased β cell apoptosis induced by dietary sucrose and linoleic acid in mice with diabetesQ42821880
Hydrophilic residues surrounding the S1 and S2 pockets contribute to dimerisation and catalysis in human dipeptidyl peptidase 8 (DP8).Q43035089
Pancreatic Islet Regeneration by Ephedrine in Mice with Streptozotocin-induced DiabetesQ43853447
1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic propertiesQ44474559
Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV.Q44919467
(2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetesQ45212807
The history of Ephedra (ma-huang)Q47317316
Structure-based virtual screening for low molecular weight chemical starting points for dipeptidyl peptidase IV inhibitors.Q47363647
Soma of the Rigveda and an attempt to identify it.Q47371589
Design, Synthesis and Biological Evaluation of Imidazo[1,2-a]pyridine Derivatives as Novel DPP-4 InhibitorsQ50997819
P433issue18
P921main subject(−)-ephedrineQ219626
P304page(s)2129-2146
P577publication date2017-11-27
P1433published inFuture Medicinal ChemistryQ19280078
P1476titleEphedrine as a lead compound for the development of new DPP-IV inhibitors
P478volume9

Reverse relations

Q90291678The perceptions of natural compounds against dipeptidyl peptidase 4 in diabetes: from in silico to in vivocites workP2860

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