| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2014PNAS..111E1648M |
| P356 | DOI | 10.1073/PNAS.1315542111 |
| P932 | PMC publication ID | 4000785 |
| P698 | PubMed publication ID | 24706819 |
| P5875 | ResearchGate publication ID | 261409561 |
| P50 | author | Stephanie L. Borgland | Q41654211 |
| Theodore M Kamenecka | Q88039489 | ||
| P2093 | author name string | William A Carlezon | |
| Jennifer L Thompson | |||
| Paul J Kenny | |||
| John W Muschamp | |||
| Linda C Hassinger | |||
| Sara Onvani | |||
| George Voren | |||
| Jonathan A Hollander | |||
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| Orexin A in the VTA is critical for the induction of synaptic plasticity and behavioral sensitization to cocaine. | Q34494218 | ||
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| The kappa-opioid agonist U69,593 blocks cocaine-induced enhancement of brain stimulation reward | Q36992810 | ||
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| kappa-Opioid receptor signaling and brain reward function | Q37455456 | ||
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| Interactions between VTA orexin and glutamate in cue-induced reinstatement of cocaine seeking in rats. | Q40557626 | ||
| The social defeat animal model of depression shows diminished levels of orexin in mesocortical regions of the dopamine system, and of dynorphin and orexin in the hypothalamus | Q42506937 | ||
| 1,3-Biarylureas as selective non-peptide antagonists of the orexin-1 receptor | Q43679857 | ||
| Anatomical substrates of orexin-dopamine interactions: lateral hypothalamic projections to the ventral tegmental area | Q43975918 | ||
| Excitation of ventral tegmental area dopaminergic and nondopaminergic neurons by orexins/hypocretins. | Q44270164 | ||
| κ-Opioid Agonists Directly Inhibit Midbrain Dopaminergic Neurons | Q44343360 | ||
| Effect of the endogenous kappa opioid agonist dynorphin A(1-17) on cocaine-evoked increases in striatal dopamine levels and cocaine-induced place preference in C57BL/6J mice | Q44344098 | ||
| Effects of kappa-opioid receptor ligands on intracranial self-stimulation in rats | Q44344204 | ||
| Dynorphin Is a Specific Endogenous Ligand of the κ Opioid Receptor | Q44352111 | ||
| Heterosynaptic dopamine neurotransmission selects sets of corticostriatal terminals | Q44905912 | ||
| A role for lateral hypothalamic orexin neurons in reward seeking | Q46650606 | ||
| A role for hypocretin (orexin) in male sexual behavior. | Q48241796 | ||
| Differential target-dependent actions of coexpressed inhibitory dynorphin and excitatory hypocretin/orexin neuropeptides. | Q48338808 | ||
| Neuroanatomical sites mediating the motivational effects of opioids as mapped by the conditioned place preference paradigm in rats. | Q48387652 | ||
| Differential expression of orexin receptors 1 and 2 in the rat brain | Q48693654 | ||
| Orexin (hypocretin) neurons contain dynorphin. | Q48785521 | ||
| A novel procedure for pre-embedding double immunogold-silver labeling at the ultrastructural level | Q49023458 | ||
| The application of the 5-choice serial reaction time task for the assessment of visual attentional processes and impulse control in rats | Q64218040 | ||
| A review on electron microscopy and neurotransmitter systems | Q81078577 | ||
| P4510 | describes a project that uses | ImageJ | Q1659584 |
| P433 | issue | 16 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | dynorphin | Q324076 |
| P304 | page(s) | E1648-55 | |
| P577 | publication date | 2014-03-24 | |
| P1433 | published in | Proceedings of the National Academy of Sciences of the United States of America | Q1146531 |
| P1476 | title | Hypocretin (orexin) facilitates reward by attenuating the antireward effects of its cotransmitter dynorphin in ventral tegmental area | |
| P478 | volume | 111 |
| Q46514264 | A Decade of Orexin/Hypocretin and Addiction: Where Are We Now? |
| Q36001330 | Acetylcholine Acts through Nicotinic Receptors to Enhance the Firing Rate of a Subset of Hypocretin Neurons in the Mouse Hypothalamus through Distinct Presynaptic and Postsynaptic Mechanisms(.) |
| Q35295721 | Binge-like consumption of ethanol and other salient reinforcers is blocked by orexin-1 receptor inhibition and leads to a reduction of hypothalamic orexin immunoreactivity |
| Q57184128 | Cell type- and pathway-specific synaptic regulation of orexin neurocircuitry |
| Q92649112 | Chemogenetic Modulation of Orexin Neurons Reverses Changes in Anxiety and Locomotor Activity in the A53T Mouse Model of Parkinson's Disease |
| Q44345663 | Chronic nicotine-induced changes in gene expression of delta and kappa-opioid receptors and their endogenous ligands in the mesocorticolimbic system of the rat. |
| Q38698951 | Computational implications of biophysical diversity and multiple timescales in neurons and synapses for circuit performance |
| Q33558914 | Constitutive activation of kappa opioid receptors at ventral tegmental area inhibitory synapses following acute stress |
| Q52662325 | Contribution of Dynorphin and Orexin Neuropeptide Systems to the Motivational Effects of Alcohol. |
| Q53687526 | DARK Classics in Chemical Neuroscience: Cathinone-Derived Psychostimulants. |
| Q49646040 | Differences in trait impulsivity do not bias the response to pharmacological drug challenge in the rat five-choice serial reaction time task. |
| Q61796757 | Distinct Subsets of Lateral Hypothalamic Neurotensin Neurons are Activated by Leptin or Dehydration |
| Q58698159 | Drug Seeking and Relapse: New Evidence of a Role for Orexin and Dynorphin Co-transmission in the Paraventricular Nucleus of the Thalamus |
| Q26997989 | Drug withdrawal conceptualized as a stressor. |
| Q47312810 | Dynorphin Counteracts Orexin in the Paraventricular Nucleus of the Thalamus: Cellular and Behavioral Evidence |
| Q89956203 | Dynorphin and its role in alcohol use disorder |
| Q42485658 | Dynorphin inhibits basal forebrain cholinergic neurons by pre- and postsynaptic mechanisms |
| Q55023327 | Early-life adversity facilitates acquisition of cocaine self-administration and induces persistent anhedonia. |
| Q47329791 | Effects of Suvorexant, a Dual Orexin/Hypocretin Receptor Antagonist, on Impulsive Behavior Associated with Cocaine |
| Q58608771 | Enhanced food-related responses in the ventral medial prefrontal cortex in narcolepsy type 1 |
| Q39358557 | Functional consequences of neuropeptide and small-molecule co-transmission |
| Q47118659 | Global analysis of gene expression mediated by OX1 orexin receptor signaling in a hypothalamic cell line. |
| Q38950401 | How contexts promote and prevent relapse to drug seeking. |
| Q38865497 | Hubs and spokes of the lateral hypothalamus: cell types, circuits and behaviour. |
| Q55442317 | Hypocretin as a Hub for Arousal and Motivation. |
| Q47333843 | Hypocretin receptor 1 blockade produces bimodal modulation of cocaine-associated mesolimbic dopamine signaling |
| Q41925736 | Hypocretin receptor 1 knockdown in the ventral tegmental area attenuates mesolimbic dopamine signaling and reduces motivation for cocaine |
| Q39183160 | Hypocretin/Orexin and Plastic Adaptations Associated with Drug Abuse |
| Q35006072 | Hypocretin/Orexin regulation of dopamine signaling and cocaine self-administration is mediated predominantly by hypocretin receptor 1. |
| Q52310246 | Hypocretin/orexin knock-out mice display disrupted behavioral and dopamine responses to cocaine. |
| Q38687612 | Hypocretins, Neural Systems, Physiology, and Psychiatric Disorders |
| Q35956461 | Hypothalamic neuropeptide signaling in alcohol addiction |
| Q90307797 | Identification of discrete, intermingled hypocretin neuronal populations |
| Q89819781 | Increased Hypothalamic Projections to the Lateral Hypothalamus and Responses to Leptin in Rat Neonates From High Fat Fed Mothers |
| Q40284548 | Individual differences in orexin-I receptor modulation of motivation for the opioid remifentanil |
| Q38534913 | Interactions of the histamine and hypocretin systems in CNS disorders. |
| Q35736840 | Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment |
| Q53820719 | Knockdown of hypocretin attenuates extended access of cocaine self-administration in rats. |
| Q89713018 | Learned avoidance requires VTA KOR-mediated reductions in dopamine |
| Q47880888 | Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms. |
| Q89983521 | Modulation of feeding behavior and metabolism by dynorphin |
| Q35105241 | Motivational activation: a unifying hypothesis of orexin/hypocretin function |
| Q41664909 | Neurochemical Heterogeneity Among Lateral Hypothalamic Hypocretin/Orexin and Melanin-Concentrating Hormone Neurons Identified Through Single-Cell Gene Expression Analysis |
| Q38869219 | Neuroendocrine Regulation of Anxiety: Beyond the Hypothalamic-Pituitary-Adrenal Axis |
| Q52316238 | Neuropeptidomics of the Rat Habenular Nuclei. |
| Q48587669 | Nicotinic receptor blockade decreases fos immunoreactivity within orexin/hypocretin-expressing neurons of nicotine-exposed rats. |
| Q36672532 | Nigrostriatal Dopamine Acting on Globus Pallidus Regulates Sleep. |
| Q64120996 | On the Abilities of Unconscious Freudian Motivational Drives to Evoke Conscious Emotions |
| Q43061528 | Opioid and hypocretin neuromodulation of ventral tegmental area neuronal subpopulations |
| Q37725190 | Opposing roles of cotransmission of dynorphin and hypocretin on reward and motivation. |
| Q35307482 | Optogenetic evidence for inhibitory signaling from orexin to MCH neurons via local microcircuits |
| Q47357997 | Orexin and Central Modulation of Cardiovascular and Respiratory Function |
| Q91875136 | Orexin signaling in GABAergic lateral habenula neurons modulates aggressive behavior in male mice |
| Q39049017 | Orexin signaling in rostral lateral hypothalamus and nucleus accumbens shell in the control of spontaneous physical activity in high- and low-activity rats. |
| Q48217405 | Orexin-1 receptor signalling in the prelimbic cortex and ventral tegmental area regulates cue-induced reinstatement of ethanol-seeking in iP rats |
| Q47671028 | Orexin/Hypocretin System: Role in Food and Drug Overconsumption |
| Q47699370 | Orexin/Hypocretin and Organizing Principles for a Diversity of Wake-Promoting Neurons in the Brain |
| Q38849902 | Orexin/hypocretin neuron activation is correlated with alcohol seeking and preference in a topographically specific manner |
| Q58699595 | Orexinergic Modulation of Spinal Motor Activity in the Neonatal Mouse Spinal Cord |
| Q89187439 | Orexins and stress |
| Q58605289 | Parallel circuits from the bed nuclei of stria terminalis to the lateral hypothalamus drive opposing emotional states |
| Q92479425 | Presynaptic MAST kinase controls opposing postsynaptic responses to convey stimulus valence in Caenorhabditis elegans |
| Q44341733 | Prodynorphin and kappa opioid receptor mRNA expression in the brain relates to social status and behavior in male European starlings |
| Q36461023 | Progressive Loss of the Orexin Neurons Reveals Dual Effects on Wakefulness |
| Q57160068 | Recent advances in understanding the roles of hypocretin/orexin in arousal, affect, and motivation |
| Q47647841 | Regulation of lateral hypothalamic orexin activity by local GABAergic neurons. |
| Q47658139 | Restoring Serotonergic Homeostasis in the Lateral Hypothalamus Rescues Sleep Disturbances Induced by Early-Life Obesity. |
| Q50508409 | Role of hypocretin/orexin receptor blockade on drug-taking and ultrasonic vocalizations (USVs) associated with low-effort self-administration of cathinone-derived 3,4-methylenedioxypyrovalerone (MDPV) in rats. |
| Q26770785 | Sex Differences in Kappa Opioid Receptor Function and Their Potential Impact on Addiction |
| Q53481362 | Stay alert, don't get hurt. |
| Q38832061 | Suvorexant, an orexin/hypocretin receptor antagonist, attenuates motivational and hedonic properties of cocaine |
| Q47878237 | The C-2 derivatives of salvinorin A, ethoxymethyl ether Sal B and β-tetrahydropyran Sal B, have anti-cocaine properties with minimal side effects. |
| Q30362407 | The Dual Hypocretin Receptor Antagonist Almorexant is Permissive for Activation of Wake-Promoting Systems. |
| Q64104867 | The Network Mechanism of the Central Circadian Pacemaker of the SCN: Do AVP Neurons Play a More Critical Role Than Expected? |
| Q47788221 | The Role of Orexins/Hypocretins in Alcohol Use and Abuse. |
| Q64054609 | The Treatment of Narcolepsy With Amphetamine-Based Stimulant Medications: A Call for Better Understanding |
| Q36309147 | The dual orexin receptor antagonist TCS1102 does not affect reinstatement of nicotine-seeking |
| Q52316130 | The hypocretin/orexin system as a target for excessive motivation in alcohol use disorders. |
| Q37072638 | The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation. |
| Q34650892 | The kappa opioid receptor: from addiction to depression, and back. |
| Q90463916 | The neurobiological basis of narcolepsy |
| Q38444486 | The orexin 1 receptor modulates kappa opioid receptor function via a JNK-dependent mechanism |
| Q90015566 | The orexin-1 receptor antagonist SB-334867 reduces motivation, but not inhibitory control, in a rat stop signal task |
| Q58097452 | The role of co-neurotransmitters in sleep and wake regulation |
| Q34668388 | To ingest or rest? Specialized roles of lateral hypothalamic area neurons in coordinating energy balance |
| Q40273091 | Upregulation of orexin/hypocretin expression in aged rats: Effects on feeding latency and neurotransmission in the insular cortex |
| Q33364025 | VTA dopamine neuron plasticity - the unusual suspects |
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| Q41811426 | What optogenetic stimulation is telling us (and failing to tell us) about fast neurotransmitters and neuromodulators in brain circuits for wake-sleep regulation |
| Q36990567 | mTOR signalling in the nucleus accumbens shell is critical for augmented effect of TFF3 on behavioural response to cocaine |
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