TWISTing an embryonic transcription factor into an oncoprotein

scientific article published on 12 April 2010

TWISTing an embryonic transcription factor into an oncoprotein is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1038/ONC.2010.92
P698PubMed publication ID20383196
P5875ResearchGate publication ID43100158

P2093author name stringA Puisieux
A-P Morel
G Hinkal
J Bastid
S Ansieau
P2860cites workTwist and epithelial-mesenchymal transition are induced by the EBV oncoprotein latent membrane protein 1 and are associated with metastatic nasopharyngeal carcinomaQ24298635
Twist transcriptionally up-regulates AKT2 in breast cancer cells leading to increased migration, invasion, and resistance to paclitaxelQ24298654
Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescenceQ24309539
Mutations in TWIST, a basic helix-loop-helix transcription factor, in Saethre-Chotzen syndromeQ24311679
Mutations of the TWIST gene in the Saethre-Chotzen syndromeQ24311736
HOXA5-twist interaction alters p53 homeostasis in breast cancer cellsQ24315091
Twist and p53 reciprocally regulate target genes via direct interactionQ24316412
Direct regulation of TWIST by HIF-1alpha promotes metastasisQ24316939
Twist is a potential oncogene that inhibits apoptosisQ24599468
The basic domain of myogenic basic helix-loop-helix (bHLH) proteins is the novel target for direct inhibition by another bHLH protein, TwistQ24644315
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalitiesQ24651500
Twist-1 regulates the miR-199a/214 cluster during developmentQ24652478
A twist for survival and cancer progressionQ24652500
The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2αQ63987371
Expression profiling reveals novel pathways in the transformation of melanocytes to melanomasQ80408118
Markers of epithelial-mesenchymal transition and epithelial differentiation in sarcomatoid carcinoma: utility in the differential diagnosis with sarcomaQ80776135
Frequent genomic abnormalities at TWIST in human pediatric osteosarcomasQ81757983
High Twist expression is involved in infiltrative endometrial cancer and affects patient survivalQ82971580
Changes in the expression of E-cadherin repressors, Snail, Slug, SIP1, and Twist, in the development and progression of ovarian carcinoma: the important role of Snail in ovarian tumorigenesis and progressionQ84082530
Expression of Twist in different subtype of ameloblastomasQ84448413
Twist, an independent prognostic marker for predicting distant metastasis and survival rates of esophageal squamous cell carcinoma patientsQ84684425
Arabidopsis thaliana ECP63 encoding a LEA protein is located in chromosome 4Q95793606
Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformationQ24658400
The tumor suppressor microRNA let-7 represses the HMGA2 oncogeneQ24681392
Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesisQ24681977
Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasisQ28131703
Tumour invasion and metastasis initiated by microRNA-10b in breast cancerQ28131829
Regulation of histone acetyltransferases p300 and PCAF by the bHLH protein twist and adenoviral oncoprotein E1AQ28137624
TWIST, a basic helix-loop-helix transcription factor, can regulate the human osteogenic lineageQ28138553
Plk3 functionally links DNA damage to cell cycle arrest and apoptosis at least in part via the p53 pathwayQ28215975
Dermo-1, a multifunctional basic helix-loop-helix protein, represses MyoD transactivation via the HLH domain, MEF2 interaction, and chromatin deacetylationQ28216516
The snail superfamily of zinc-finger transcription factorsQ28216843
Transitions between epithelial and mesenchymal states: acquisition of malignant and stem cell traitsQ28237197
Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancerQ28247926
Let-7 prevents early cancer progression by suppressing expression of the embryonic gene HMGA2Q28254493
Identification of selective inhibitors of cancer stem cells by high-throughput screeningQ28255115
Cancer stem cells: mirage or reality?Q28257690
Short interfering RNA directed against TWIST, a novel zinc finger transcription factor, increases A549 cell sensitivity to cisplatin via MAPK/mitochondrial pathwayQ28272170
The transcriptional repressor Snail promotes mammary tumor recurrenceQ28272823
The M-twist gene of Mus is expressed in subsets of mesodermal cells and is closely related to the Xenopus X-twi and the Drosophila twist genesQ28276195
Dermo-1: A Novel Twist-Related bHLH Protein Expressed in the Developing DermisQ28291520
MicroRNA-10b and breast cancer metastasisQ28298453
Twist-2 controls myeloid lineage development and functionQ28507168
Zeb1 links epithelial-mesenchymal transition and cellular senescenceQ28508357
Twist mediates suppression of inflammation by type I IFNs and AxlQ28509359
A twist code determines the onset of osteoblast differentiationQ28510533
Twist1 dimer selection regulates cranial suture patterning and fusionQ28511874
TWIST-1 is overexpressed in neoplastic choroid plexus epithelial cells and promotes proliferation and invasionQ28580403
Twist-1 is a PPARdelta-inducible, negative-feedback regulator of PGC-1alpha in brown fat metabolismQ28589713
twist is required in head mesenchyme for cranial neural tube morphogenesisQ28590860
M-twist is an inhibitor of muscle differentiationQ28594505
Activation of the DNA damage checkpoint and genomic instability in human precancerous lesionsQ29614216
DNA damage response as a candidate anti-cancer barrier in early human tumorigenesisQ29614217
Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathwaysQ29615855
Systemic spread is an early step in breast cancerQ29617041
Endogenous human microRNAs that suppress breast cancer metastasisQ29617352
Association of reactive oxygen species levels and radioresistance in cancer stem cellsQ29617812
Twist expression predicts poor clinical outcome of patients with clear cell carcinoma of the ovaryQ40095651
Upregulation of Twist-1 by NF-kappaB blocks cytotoxicity induced by chemotherapeutic drugsQ40150799
Twist overexpression correlates with hepatocellular carcinoma metastasis through induction of epithelial-mesenchymal transition.Q40227825
Chronic oxaliplatin resistance induces epithelial-to-mesenchymal transition in colorectal cancer cell linesQ40252973
The clinical significance of twist expression in nasopharyngeal carcinomaQ40329896
Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancerQ40345084
Twist is substrate for caspase cleavage and proteasome-mediated degradation.Q40386078
Up-regulation of TWIST in prostate cancer and its implication as a therapeutic targetQ40409031
Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells.Q40479295
Identification of a novel function of TWIST, a bHLH protein, in the development of acquired taxol resistance in human cancer cellsQ40599191
Inhibition of myogenic bHLH and MEF2 transcription factors by the bHLH protein TwistQ41192770
Tumour biology: senescence in premalignant tumoursQ42802962
Comparative roles of Twist-1 and Id1 in transcriptional regulation by BMP signalingQ42829993
Differential expression of the epithelial-mesenchymal transition regulators snail, SIP1, and twist in gastric cancerQ42855720
The expression of Twist has an impact on survival in human bladder cancer and is influenced by the smoking status.Q43614338
Twist expression in patients with cervical cancer is associated with poor disease outcomeQ43624019
A Xenopus mRNA related to Drosophila twist is expressed in response to induction in the mesoderm and the neural crestQ44762736
Oncogene-induced senescence as an initial barrier in lymphoma developmentQ46634165
Tamoxifen resistance in MCF7 cells promotes EMT-like behaviour and involves modulation of beta-catenin phosphorylation.Q46634459
Expression profiles of osteosarcoma that can predict response to chemotherapy.Q46706109
Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activityQ47614351
Expression of the transcription factor snail and its target gene twist are associated with malignancy in pheochromocytomasQ47890673
Transcription factors Snail, Slug, Twist, and SIP1 in spindle cell carcinoma of the head and neckQ47973701
Control of cell behavior during vertebrate development by Slug, a zinc finger geneQ48082697
TWIST family of basic helix-loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment.Q50737248
Tissue deformation modulates twist expression to determine anterior midgut differentiation in Drosophila embryos.Q51948974
Transforming growth factor-beta and Wnt signals regulate chondrocyte differentiation through Twist1 in a stage-specific manner.Q51978877
Twist is required for muscle template splitting during adult Drosophila myogenesis.Q52182517
Twist-mediated Activation of the NK-4 Homeobox Gene in the Visceral Mesoderm of Drosophila Requires Two Distinct Clusters of E-box Regulatory ElementsQ52193458
twist: a myogenic switch in Drosophila.Q52201086
Unique expression pattern of the EMT markers Snail, Twist and E-cadherin in benign and malignant parathyroid neoplasia.Q53313402
TWIST1 overexpression is associated with nodal invasion and male sex in primary colorectal cancer.Q53316057
Deregulating EMT and senescence: double impact by a single twist.Q53468443
Expression of twist gene in primary liver cancer.Q54331843
Methylation of the TWIST1 promoter, TWIST1 mRNA levels, and immunohistochemical expression of TWIST1 in breast cancer.Q54504122
Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of Twist expression in pancreatic juice.Q54561467
Epithelial to mesenchymal transition: expression of the regulators snail, slug, and twist in pancreatic cancer.Q55044320
The variable expressivity and incomplete penetrance of the twist-null heterozygous mouse phenotype resemble those of human Saethre-Chotzen syndromeQ56380189
Genomic analysis of single cytokeratin-positive cells from bone marrow reveals early mutational events in breast cancerQ57270634
Direct Evidence for Epithelial-Mesenchymal Transitions in Breast CancerQ57590972
Significance of TWIST expression and its association with E-cadherin in bladder cancerQ58321598
Generation of breast cancer stem cells through epithelial-mesenchymal transitionQ29619717
Daughterless dictates Twist activity in a context-dependent manner during somatic myogenesisQ30368811
Mechanical induction of Twist in the Drosophila foregut/stomodeal primordiumQ31154597
Twist expression promotes migration and invasion in hepatocellular carcinomaQ33483712
Mutations in the human TWIST geneQ33825444
Epithelial to mesenchymal transition during gastrulation: an embryological viewQ34014907
DNA methylation of RASSF1A, HIN‐1, RAR‐β, Cyclin D2 and Twist in in situ and invasive lobular breast carcinomaQ34274795
E-cadherin transcriptional downregulation by promoter methylation but not mutation is related to epithelial-to-mesenchymal transition in breast cancer cell lines.Q34497064
Transitions between epithelial and mesenchymal states in development and diseaseQ34761972
TWIST is expressed in human gliomas and promotes invasionQ34769731
Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondriumQ35106164
Is mechano-sensitive expression of twist involved In mesoderm formation?Q35893690
Upregulation of Twist in oesophageal squamous cell carcinoma is associated with neoplastic transformation and distant metastasisQ36014361
Transforming growth factor-beta employs HMGA2 to elicit epithelial-mesenchymal transition.Q36118227
The twist gene: isolation of a Drosophila zygotic gene necessary for the establishment of dorsoventral patternQ36124335
Up-regulation of MSX2 enhances the malignant phenotype and is associated with twist 1 expression in human pancreatic cancer cellsQ36512280
Expression of Twist increases the risk for recurrence and for poor survival in epithelial ovarian carcinoma patientsQ36609779
Thrombin induces tumor growth, metastasis, and angiogenesis: Evidence for a thrombin-regulated dormant tumor phenotypeQ36650343
Twist is transcriptionally induced by activation of STAT3 and mediates STAT3 oncogenic functionQ36662693
Autoregulation of Th1-mediated inflammation by twist1.Q36851881
Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancersQ36937053
Twist1 homodimers enhance FGF responsiveness of the cranial sutures and promote suture closureQ37021513
Mechanical factors activate beta-catenin-dependent oncogene expression in APC mouse colonQ37091919
A tense situation: forcing tumour progressionQ37112264
A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasisQ37233401
Phosphoregulation of Twist1 provides a mechanism of cell fate controlQ37294321
Early origin of cancer metastases: dissemination and evolution of premalignant cells.Q37333521
A Myc-Slug (Snail2)/Twist regulatory circuit directs vascular developmentQ37341313
Expression and significance of TWIST basic helix-loop-helix protein over-expression in gastric cancerQ38430258
Comprehensive analysis of the independent effect of twist and snail in promoting metastasis of hepatocellular carcinoma.Q39788635
Interleukin 17 acts in synergy with B cell-activating factor to influence B cell biology and the pathophysiology of systemic lupus erythematosus.Q39844668
Translational activation of snail1 and other developmentally regulated transcription factors by YB-1 promotes an epithelial-mesenchymal transitionQ39857546
Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cellsQ39878879
Epithelial to mesenchymal transition derived from repeated exposure to gefitinib determines the sensitivity to EGFR inhibitors in A549, a non-small cell lung cancer cell lineQ39965559
Twist is required for thrombin-induced tumor angiogenesis and growthQ39976250
Expression of Twist gene in human hepatocellular carcinoma cell strains of different metastatic potentialQ39982276
Twist is a transcriptional repressor of E-cadherin gene expression in breast cancerQ40038777
P433issue22
P407language of work or nameEnglishQ1860
P304page(s)3173-3184
P577publication date2010-04-12
P1433published inOncogeneQ1568657
P1476titleTWISTing an embryonic transcription factor into an oncoprotein
P478volume29

Reverse relations

cites work (P2860)
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Q38713230AKR1B1 promotes basal-like breast cancer progression by a positive feedback loop that activates the EMT program.
Q89295005AMP-activated protein kinase promotes epithelial-mesenchymal transition in cancer cells through Twist1 upregulation
Q35889585ARTEMIN synergizes with TWIST1 to promote metastasis and poor survival outcome in patients with ER negative mammary carcinoma
Q64270466Activation of Epithelial-Mesenchymal Transition and Altered β-Catenin Signaling in a Novel Indian Colorectal Carcinoma Cell Line
Q35931354Adipocytes Promote B16BL6 Melanoma Cell Invasion and the Epithelial-to-Mesenchymal Transition
Q39446297An indirect role for ASPP1 in limiting p53-dependent p21 expression and cellular senescence
Q57115565Androgen deprivation and immunotherapy for the treatment of prostate cancer
Q36827512Androgen regulation of epithelial-mesenchymal transition in prostate tumorigenesis
Q36466583Artemin stimulates radio- and chemo-resistance by promoting TWIST1-BCL-2-dependent cancer stem cell-like behavior in mammary carcinoma cells
Q26740619Cancer of the Pancreas: Molecular Pathways and Current Advancement in Treatment
Q94476206Cellular plasticity and metastasis in breast cancer: a pre- and post-malignant problem
Q38285674Circulating tumor cells and epithelial, mesenchymal and stemness markers: characterization of cell subpopulations.
Q52629163Clinicopathological and prognostic significance of Twist overexpression in NSCLC.
Q52903652Contribution of EVX1 in Aggressiveness of Esophageal Squamous Cell Carcinoma.
Q61800330Correlations of Twist Expression with Pathological and Computed Tomography (CT) Characteristics and Prognosis of Non-Small Cell Lung Cancer (NSCLC)
Q35958293Cytoplasmic p27 promotes epithelial-mesenchymal transition and tumor metastasis via STAT3-mediated Twist1 upregulation
Q36544114Down-regulation of miR-129-5p via the Twist1-Snail feedback loop stimulates the epithelial-mesenchymal transition and is associated with poor prognosis in breast cancer
Q34288822EMT inducers catalyze malignant transformation of mammary epithelial cells and drive tumorigenesis towards claudin-low tumors in transgenic mice.
Q26995188EMT or EMT-Promoting Transcription Factors, Where to Focus the Light?
Q47152626Ectopic expression of TWIST1 upregulates the stemness marker OCT4 in the esophageal squamous cell carcinoma cell line KYSE30.
Q26773015Endothelial Transdifferentiation of Tumor Cells Triggered by the Twist1-Jagged1-KLF4 Axis: Relationship between Cancer Stemness and Angiogenesis
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Q54343559Expression analysis elucidates the roles of MAML1 and Twist1 in esophageal squamous cell carcinoma aggressiveness and metastasis.
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Q42708851Functional cooperation between Snail1 and twist in the regulation of ZEB1 expression during epithelial to mesenchymal transition
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Q34308984Genome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds, and peripheral nerve sheath tumor cells
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