A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-κB signaling and improves survival in mouse models of sepsis

scientific article published on 11 June 2012

A novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-κB signaling and improves survival in mouse models of sepsis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/APS.2012.56
P932PMC publication ID4003113
P698PubMed publication ID22684031
P5875ResearchGate publication ID225290602

P2093author name stringYang Liu
Jie Li
Kan Ding
Wen-Feng Liao
Jian-Ping Fang
You-Hong Hu
P2860cites workNF-kappaB-inducing kinase activates IKK-alpha by phosphorylation of Ser-176Q24319941
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HMG-1 as a late mediator of endotoxin lethality in miceQ28139166
Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylationQ28140878
Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4Q28283196
Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expressionQ28609338
Shared principles in NF-kappaB signalingQ29547234
Signaling to NF-kappaBQ29547844
Activators and target genes of Rel/NF-kappaB transcription factorsQ29547882
Regulation and function of NF-kappaB transcription factors in the immune systemQ29616427
Histone H3 phosphorylation by IKK-alpha is critical for cytokine-induced gene expressionQ33289443
Novel therapies for septic shock over the past 4 decadesQ33396219
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Constitutively active NF-kappaB triggers systemic TNFalpha-dependent inflammation and localized TNFalpha-independent inflammatory disease.Q33659872
Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinaseQ33886831
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Eritoran tetrasodium (E5564) treatment for sepsis: review of preclinical and clinical studiesQ34726541
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Unravelling the complexities of the NF-kappaB signalling pathway using mouse knockout and transgenic models.Q36637897
Inhibitors of NF-kappaB signaling: 785 and countingQ36637918
NF-kappaB inhibitors for the treatment of inflammatory diseases and cancer.Q36737905
Severe sepsis and septic shock: the role of gram-negative bacteremiaQ37014803
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HMGB1, a potent proinflammatory cytokine in sepsisQ37720063
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Eriocalyxin B inhibits nuclear factor-kappaB activation by interfering with the binding of both p65 and p50 to the response element in a noncompetitive mannerQ38310225
Caffeic acid phenethyl ester-mediated Nrf2 activation and IkappaB kinase inhibition are involved in NFkappaB inhibitory effect: structural analysis for NFkappaB inhibitionQ39685010
Crucial role of TNF receptors 1 and 2 in the control of polymicrobial sepsisQ39973887
Differential regulation of IKK alpha-mediated activation of IRF3/7 by NIK.Q40037557
Proinflammatory stimuli induce IKKalpha-mediated phosphorylation of PIAS1 to restrict inflammation and immunity.Q40125826
Novel mechanism of inhibition of nuclear factor-kappa B DNA-binding activity by diterpenoids isolated from Isodon rubescensQ40426582
IKK beta plays an essential role in the phosphorylation of RelA/p65 on serine 536 induced by lipopolysaccharideQ40646108
Tumor necrosis factor, other cytokines and diseaseQ40800572
Sepsis: a new hypothesis for pathogenesis of the disease processQ41535777
A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expressionQ44467329
Nuclear factor-kappaB and its role in sepsis-associated organ failureQ44638744
Essential function for the kinase TAK1 in innate and adaptive immune responsesQ50335551
IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammationQ59054264
Comprehensive gene expression profile of LPS-stimulated human monocytes by SAGEQ72992381
P433issue9
P921main subjectlipopolysaccharideQ421804
sepsisQ183134
NF-κBQ411114
P304page(s)1204-1216
P577publication date2012-06-11
P1433published inActa Pharmacologica SinicaQ15749885
P1476titleA novel small molecule, HK-156, inhibits lipopolysaccharide-induced activation of NF-κB signaling and improves survival in mouse models of sepsis
P478volume33

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cites work (P2860)
Q42543208Celebrating the 80th anniversary of the Shanghai Institute of Materia Medica, Chinese Academy of Sciences (SIMM).
Q87301082Effects of honokiol on sepsis-induced acute kidney injury in an experimental model of sepsis in rats
Q46897628Oligosaccharide G19 inhibits U-87 MG human glioma cells growth in vitro and in vivo by targeting epidermal growth factor (EGF) and activating p53/p21 signaling

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