Mitochondrial bioenergetics and dynamics in Huntington's disease: tripartite synapses and selective striatal degeneration

scientific article published on June 2010

Mitochondrial bioenergetics and dynamics in Huntington's disease: tripartite synapses and selective striatal degeneration is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/S10863-010-9287-6
P698PubMed publication ID20454921
P5875ResearchGate publication ID44584923

P2093author name stringJorge M A Oliveira
P2860cites workTripartite synapses: astrocytes process and control synaptic informationQ22337308
Glial cells as intrinsic components of non-cell-autonomous neurodegenerative diseaseQ24621854
Increased susceptibility of striatal mitochondria to calcium-induced permeability transitionQ28183063
Mitochondrial dysfunction and oxidative stress in neurodegenerative diseasesQ28269333
Age-dependent changes in the calcium sensitivity of striatal mitochondria in mouse models of Huntington's DiseaseQ28512442
Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitroQ28584697
Tripartite synapses: glia, the unacknowledged partnerQ29615224
Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseasesQ29615646
N-terminal mutant huntingtin associates with mitochondria and impairs mitochondrial traffickingQ30486372
Effects of overexpression of huntingtin proteins on mitochondrial integrityQ30489322
Expression of mutant huntingtin in mouse brain astrocytes causes age-dependent neurological symptomsQ30492587
Mutant huntingtin aggregates impair mitochondrial movement and trafficking in cortical neuronsQ45300079
Mitochondrial-dependent Ca2+ handling in Huntington's disease striatal cells: effect of histone deacetylase inhibitors.Q45302980
Mitochondrial dysfunction in Huntington's disease: the bioenergetics of isolated and in situ mitochondria from transgenic miceQ45304684
Astrocytes in Huntington's chorea: accomplice or guilty of the neuronal death?Q45306684
Weight loss in early stage of Huntington's diseaseQ45307146
Synaptic mitochondria are more susceptible to Ca2+overload than nonsynaptic mitochondriaQ46975941
Cyclosporin A protects striatal neurons in vitro and in vivo from 3-nitropropionic acid toxicity.Q52540884
Mutant huntingtin in glial cells exacerbates neurological symptoms of Huntington disease miceQ33796172
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Huntington's disease: the challenge for cell biologistsQ34106564
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Astrocyte mitochondrial mechanisms of ischemic brain injury and neuroprotectionQ35707254
Early resistance to cell death and to onset of the mitochondrial permeability transition during hepatocarcinogenesis with 2-acetylaminofluoreneQ35811320
Mitochondrial trafficking in neurons: a key variable in neurodegeneration?Q35891832
Astrocytic contributions to bioenergetics of cerebral ischemiaQ36104665
Juvenile Huntington's disease: does a dosage-effect pathogenic mechanism differ from the classical adult disease?Q36308082
3-Nitropropionic acid: a mitochondrial toxin to uncover physiopathological mechanisms underlying striatal degeneration in Huntington's disease.Q36318579
Expression of mutant huntingtin in glial cells contributes to neuronal excitotoxicityQ36320596
Mitochondria and neuronal activity.Q36648486
Mitochondrial trafficking and morphology in healthy and injured neuronsQ36692390
Astrocyte metabolism and signaling during brain ischemiaQ36983687
Mitochondria modulate Ca2+-dependent glutamate release from rat cortical astrocytesQ37039965
Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic viewQ37179623
Therapeutic application of histone deacetylase inhibitors for central nervous system disordersQ37283454
Mitochondria and Huntington's disease pathogenesis: insight from genetic and chemical modelsQ37348586
Multiple roles of HDAC inhibition in neurodegenerative conditions.Q37407855
The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's diseaseQ37459062
Non-cell autonomous toxicity in neurodegenerative disorders: ALS and beyondQ37642283
Targeting glial cells to elucidate the pathogenesis of Huntington's disease.Q37682680
Nature and cause of mitochondrial dysfunction in Huntington's disease: focusing on huntingtin and the striatum.Q37733750
Techniques to investigate neuronal mitochondrial function and its pharmacological modulation.Q37833113
Mitochondria exert a negative feedback on the propagation of intracellular Ca2+ waves in rat cortical astrocytesQ39508107
Juvenile Huntington chorea: Clinical, ultrastructural, and biochemical studiesQ39838932
Toxicity of beta-amyloid in HEK293 cells expressing NR1/NR2A or NR1/NR2B N-methyl-D-aspartate receptor subunitsQ40150876
Mutant huntingtin directly increases susceptibility of mitochondria to the calcium-induced permeability transition and cytochrome c releaseQ40551652
Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines.Q40721588
Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway.Q41969689
In situ respiration and bioenergetic status of mitochondria in primary cerebellar granule neuronal cultures exposed continuously to glutamateQ42462301
Cyclosporin A increases mitochondrial calcium uptake capacity in cortical astrocytes but not cerebellar granule neuronsQ43247423
The relationship between free and total calcium concentrations in the matrix of liver and brain mitochondria.Q44378787
Glutamate decreases mitochondrial size and movement in primary forebrain neurons.Q44566043
Enhanced Akt signaling is an early pro-survival response that reflects N-methyl-D-aspartate receptor activation in Huntington's disease knock-in striatal cellsQ44605170
Mitochondrial defect in Huntington's disease caudate nucleusQ45291734
In situ mitochondrial Ca2+ buffering differences of intact neurons and astrocytes from cortex and striatum.Q45292096
P433issue3
P921main subjectmitochondrionQ39572
Huntington's diseaseQ190564
striatumQ1319792
P304page(s)227-234
P577publication date2010-06-01
P1433published inJournal of Bioenergetics and BiomembranesQ5044470
P1476titleMitochondrial bioenergetics and dynamics in Huntington's disease: tripartite synapses and selective striatal degeneration
P478volume42

Reverse relations

cites work (P2860)
Q88701768A stocked toolbox for understanding the role of astrocytes in disease
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Q90140618Cell-Autonomous and Non-cell-Autonomous Pathogenic Mechanisms in Huntington's Disease: Insights from In Vitro and In Vivo Models
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Q38021396Mitochondrial dynamics: the intersection of form and function
Q39014966Mitochondrial membrane fluidity is consistently increased in different models of Huntington disease: restorative effects of olesoxime
Q38818474Modulation of Molecular Chaperones in Huntington's Disease and Other Polyglutamine Disorders.
Q36411728ROCK-phosphorylated vimentin modifies mutant huntingtin aggregation via sequestration of IRBIT.
Q90236449Sodium selenite protects from 3-nitropropionic acid-induced oxidative stress in cultured primary cortical neurons
Q36863901Targeting sirtuin-1 in Huntington's disease: rationale and current status
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Q53716390Therapy development in Huntington disease: From current strategies to emerging opportunities.

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