Sodium-glucose transport: role in diabetes mellitus and potential clinical implications.

scientific article published on September 2010

Sodium-glucose transport: role in diabetes mellitus and potential clinical implications. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1097/MNH.0B013E32833BEC06
P932PMC publication ID5886710
P698PubMed publication ID20539226

P50authorVolker VallonQ61090162
P2093author name stringKumar Sharma
P2860cites workRenal Na(+)-glucose cotransportersQ28141135
The sodium/glucose cotransport family SLC5Q28204259
Autosomal recessive renal glucosuria attributable to a mutation in the sodium glucose cotransporter (SGLT2)Q28215167
Effects of AVE2268, a substituted glycopyranoside, on urinary glucose excretion and blood glucose in mice and ratsQ46166885
Dapagliflozin, a novel SGLT2 inhibitor, induces dose-dependent glucosuria in healthy subjectsQ46171594
Long-term treatment with the Na+-glucose cotransporter inhibitor T-1095 causes sustained improvement in hyperglycemia and prevents diabetic neuropathy in Goto-Kakizaki RatsQ46406143
Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent modelsQ46516165
Oxidative stress pathway genes and chronic renal insufficiency in Asian Indians with Type 2 diabetesQ46644155
Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetesQ46764321
Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetesQ46818617
Na(+) -glucose transporter-2 messenger ribonucleic acid expression in kidney of diabetic rats correlates with glycemic levels: involvement of hepatocyte nuclear factor-1alpha expression and activity.Q46930511
Adenosine A(1) receptors determine glomerular hyperfiltration and the salt paradox in early streptozotocin diabetes mellitusQ63384113
Early glomerular hyperfiltration in insulin-dependent diabetics and late nephropathyQ69530391
Predicting diabetic nephropathy in insulin-dependent patientsQ71401816
Glomerular hyperfiltration in experimental diabetes mellitus: potential role of tubular reabsorptionQ73253331
T-1095, a renal Na+-glucose transporter inhibitor, improves hyperglycemia in streptozotocin-induced diabetic ratsQ74210650
T-1095, an inhibitor of renal Na+-glucose cotransporters, may provide a novel approach to treating diabetesQ78238839
Expression and activity of SGLT2 in diabetes induced by streptozotocin: relationship with the lipid environmentQ83717092
A novel missense mutation in SLC5A2 encoding SGLT2 underlies autosomal-recessive renal glucosuria and aminoaciduriaQ28299174
Improved diabetic syndrome in C57BL/KsJ-db/db mice by oral administration of the Na(+)-glucose cotransporter inhibitor T-1095Q28346436
Ornithine decarboxylase, kidney size, and the tubular hypothesis of glomerular hyperfiltration in experimental diabetesQ28346536
Molecular characteristics of Na(+)-coupled glucose transporters in adult and embryonic rat kidneyQ28580452
SLC2A2 gene expression in kidney of diabetic rats is regulated by HNF-1alpha and HNF-3betaQ28583067
Effects of intensive glucose lowering in type 2 diabetesQ29547736
Chronic renal insufficiency among Asian Indians with type 2 diabetes: I. Role of RAAS gene polymorphisms.Q33242098
Association of TGFbeta1, TNFalpha, CCR2 and CCR5 gene polymorphisms in type-2 diabetes and renal insufficiency among Asian IndiansQ33281836
Association analysis of ADPRT1, AKR1B1, RAGE, GFPT2 and PAI-1 gene polymorphisms with chronic renal insufficiency among Asian Indians with type-2 diabetesQ33547739
Glycemic control with diet, sulfonylurea, metformin, or insulin in patients with type 2 diabetes mellitus: progressive requirement for multiple therapies (UKPDS 49). UK Prospective Diabetes Study (UKPDS) Group.Q33864120
Anatomical and developmental patterns of facilitative glucose transporter gene expression in the rat kidneyQ33897182
The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucoseQ34121476
Diabetic kidney disease in thedb/dbmouseQ34195384
Human cardiomyocytes express high level of Na+/glucose cotransporter 1 (SGLT1)Q34264473
Oral antihyperglycemic therapy for type 2 diabetes: scientific reviewQ34492673
Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose levelQ34575066
Glomerular hyperfiltration and the salt paradox in early [corrected] type 1 diabetes mellitus: a tubulo-centric view.Q35049884
Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins.Q35060202
Phlorizin: a reviewQ35995949
Regulation of transforming growth factor beta in diabetic nephropathy: implications for treatmentQ36785571
Diabetes and chronic kidney disease: lessons from the Pima IndiansQ37102238
Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetesQ37139427
A study of dapagliflozin in patients with type 2 diabetes receiving high doses of insulin plus insulin sensitizers: applicability of a novel insulin-independent treatmentQ37319128
Familial renal glucosuria and SGLT2: from a mendelian trait to a therapeutic target.Q37645623
Dapagliflozin, a selective SGLT2 inhibitor, improves glucose homeostasis in normal and diabetic ratsQ39999985
Sodium-coupled glucose cotransporters contribute to hypothalamic glucose sensingQ41990239
(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatmentQ43123822
Multiple-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy overweight and obese subjects: a randomized double-blind studyQ43143768
Single-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy volunteers and patients with type 2 diabetes mellitusQ43199877
In vitro characterization and pharmacokinetics of dapagliflozin (BMS-512148), a potent sodium-glucose cotransporter type II inhibitor, in animals and humansQ43227334
Effect of treatment with losartan on salt sensitivity and SGLT2 expression in hypertensive diabetic ratsQ43267686
Changes in sodium or glucose filtration rate modulate expression of glucose transporters in renal proximal tubular cells of rat.Q43669733
Systemic and local effects of angiotensin II blockade in experimental diabetic nephropathy.Q43814835
Long-term outcome of renal glucosuria type 0: the original patient and his natural historyQ45010378
A novel SGLT2 mutation in a patient with autosomal recessive renal glucosuriaQ45117069
High glucose-induced oxidative stress inhibits Na+/glucose cotransporter activity in renal proximal tubule cellsQ45187170
TGF-beta impairs renal autoregulation via generation of ROS.Q45220024
Sergliflozin etabonate, a selective SGLT2 inhibitor, improves glycemic control in streptozotocin-induced diabetic rats and Zucker fatty ratsQ45763147
Long-term treatment with sergliflozin etabonate improves disturbed glucose metabolism in KK-A(y) mice.Q45926087
P433issue5
P921main subjectglucoseQ37525
glycobiologyQ899224
P304page(s)425-431
P577publication date2010-09-01
P1433published inCurrent Opinion in Nephrology and HypertensionQ15756282
P1476titleSodium-glucose transport: role in diabetes mellitus and potential clinical implications
P478volume19

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cites work (P2860)
Q38537119A comprehensive review of the pharmacodynamics of the SGLT2 inhibitor empagliflozin in animals and humans
Q37887401Antifibrotic treatment and other new strategies for improving renal outcomes
Q36836209Aquaporin 11 insufficiency modulates kidney susceptibility to oxidative stress.
Q27021632Early diabetic nephropathy in type 1 diabetes: new insights
Q34579919Effects of SGLT2 inhibition in human kidney proximal tubular cells--renoprotection in diabetic nephropathy?
Q38735470Effects of sodium-glucose cotransporter 2 inhibitors on urinary excretion of intact and total angiotensinogen in patients with type 2 diabetes.
Q37575461Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia.
Q35392355Inhibition of kidney proximal tubular glucose reabsorption does not prevent against diabetic nephropathy in type 1 diabetic eNOS knockout mice
Q36527897Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus
Q42575158Molecular determinants of renal glucose reabsorption. Focus on “Glucose transport by human renal Na+/d-glucose cotransporters SGLT1 and SGLT2”
Q35612377Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion
Q38111707Pathophysiology of the diabetic kidney.
Q37729725Patient considerations in the management of type 2 diabetes - critical appraisal of dapagliflozin
Q41295481Proximal tubule cell hypothesis for cardiorenal syndrome in diabetes
Q37253944Renal function in diabetic disease models: the tubular system in the pathophysiology of the diabetic kidney
Q37575455SGLT2 inhibitor empagliflozin reduces renal growth and albuminuria in proportion to hyperglycemia and prevents glomerular hyperfiltration in diabetic Akita mice.
Q34400029SGLT2 inhibitors act from the extracellular surface of the cell membrane
Q38783130Sodium glucose cotransporter SGLT1 as a therapeutic target in diabetes mellitus.
Q90514635Sodium-glucose Co-transporters: Functional Properties and Pharmaceutical Potential
Q38164537Sodium-glucose linked transporter-2 inhibitors: potential for renoprotection beyond blood glucose lowering?
Q27015001Sodium-retaining effect of insulin in diabetes
Q45189238Targeting of sodium-glucose cotransporters with phlorizin inhibits polycystic kidney disease progression in Han:SPRD rats.
Q38126109The kidney as a new target for antidiabetic drugs: SGLT2 inhibitors
Q37712484The prelude on novel receptor and ligand targets involved in the treatment of diabetes mellitus.
Q34979592The proximal tubule in the pathophysiology of the diabetic kidney
Q30663494The role of kidney in glucose homeostasis--SGLT2 inhibitors, a new approach in diabetes treatment
Q37838893The role of metabolic and haemodynamic factors in podocyte injury in diabetes

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