The kidney as a new target for antidiabetic drugs: SGLT2 inhibitors

scientific article published on 12 June 2013

The kidney as a new target for antidiabetic drugs: SGLT2 inhibitors is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1111/JCPT.12077
P698PubMed publication ID23909868
P5875ResearchGate publication ID255174713

P2093author name stringP J Lee
S Singh
P J Shim
R B Raffa
Y-Y Chang
M E Joseph
R Judge
C Ruchalski
I C Madhani
J S John
K Kudratov
L M Huynh
R C Guduru
R Kimmey
S Cangoz
S J Chempakaseril
S T John
P2860cites workA clinical trial to maintain glycemic control in youth with type 2 diabetesQ36340078
Management of hyperglycemia in type 2 diabetes: A consensus algorithm for the initiation and adjustment of therapy: a consensus statement from the American Diabetes Association and the European Association for the Study of DiabetesQ36549321
Regulatory mechanisms of Na(+)/glucose cotransporters in renal proximal tubule cells.Q36891945
Sodium-glucose cotransport inhibition with dapagliflozin in type 2 diabetesQ37139427
Banting Lecture. From the triumvirate to the ominous octet: a new paradigm for the treatment of type 2 diabetes mellitusQ37141727
Sodium glucose co-transporter 2 inhibitors: blocking renal tubular reabsorption of glucose to improve glycaemic control in patients with diabetesQ37244353
Glucose control by the kidney: an emerging target in diabetesQ37424426
Renal sodium-glucose transport: role in diabetes mellitus and potential clinical implicationsQ37439364
Dapagliflozin: where does it fit in the treatment of type 2 diabetes?Q37593086
Renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for new anti-diabetic agentQ37697842
Sodium-glucose co-transport inhibitors: progress and therapeutic potential in type 2 diabetes mellitusQ37703184
Sodium-glucose transport: role in diabetes mellitus and potential clinical implications.Q37764285
Dapagliflozin: more than just another oral glucose-lowering agent?Q37812136
Sodium-glucose co-transporter 2 inhibitors: from apple tree to 'Sweet Pee'.Q37815524
SGLT inhibitors as new therapeutic tools in the treatment of diabetesQ37864206
Diabetes mellitus: new drugs for a new epidemicQ37879307
SGLT2 inhibition in diabetes mellitus: rationale and clinical prospects.Q37981884
TS-071 is a novel, potent and selective renal sodium-glucose cotransporter 2 (SGLT2) inhibitor with anti-hyperglycaemic activityQ38387199
Overexpression of SGLT1 is correlated with tumor development and poor prognosis of ovarian carcinomaQ38406543
Evaluation of the effect of dapagliflozin on cardiac repolarization: a thorough QT/QTc studyQ38435071
Expression of SGLT-1 in preneoplastic and neoplastic lesions of the head and neckQ40609497
Glycemic response and attainment of A1C goals following newly initiated insulin therapy for type 2 diabetesQ42021894
Antigenicity of insulin: diabetes induced by specific antibodiesQ42267512
Discovery of canagliflozin, a novel C-glucoside with thiophene ring, as sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes mellitus.Q42944430
Dapagliflozin, an SGLT2 inhibitor, for diabetesQ42977474
The stunned beta cell: a brief historyQ43073326
(1S)-1,5-anhydro-1-[5-(4-ethoxybenzyl)-2-methoxy-4-methylphenyl]-1-thio-D-glucitol (TS-071) is a potent, selective sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for type 2 diabetes treatmentQ43123822
Multiple-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy overweight and obese subjects: a randomized double-blind studyQ43143768
Single-dose pharmacokinetics and pharmacodynamics of sergliflozin etabonate, a novel inhibitor of glucose reabsorption, in healthy volunteers and patients with type 2 diabetes mellitusQ43199877
Troglitazone ameliorates high glucose-induced EMT and dysfunction of SGLTs through PI3K/Akt, GSK-3β, Snail1, and β-catenin in renal proximal tubule cellsQ43218265
In vitro characterization and pharmacokinetics of dapagliflozin (BMS-512148), a potent sodium-glucose cotransporter type II inhibitor, in animals and humansQ43227334
SGLT gene expression in primary lung cancers and their metastatic lesionsQ43709713
Normalization of cytoplasmic calcium response in pancreatic beta-cells of spontaneously diabetic GK rat by the treatment with T-1095, a specific inhibitor of renal Na+-glucose co-transporters.Q43978130
Beneficial effect of T-1095, a selective inhibitor of renal Na+-glucose cotransporters, on metabolic index and insulin secretion in spontaneously diabetic GK rats.Q43993113
Active- and placebo-controlled dose-finding study to assess the efficacy, safety, and tolerability of multiple doses of ipragliflozin in patients with type 2 diabetes mellitusQ44007780
Regulatory mechanisms of intracellular distribution of Na+-dependent glucose transporter and the role in recovery from cellular injuryQ45172046
Dapagliflozin, a novel, selective SGLT2 inhibitor, improved glycemic control over 2 weeks in patients with type 2 diabetes mellitusQ46171591
Long-term treatment with the Na+-glucose cotransporter inhibitor T-1095 causes sustained improvement in hyperglycemia and prevents diabetic neuropathy in Goto-Kakizaki RatsQ46406143
Remogliflozin etabonate, in a novel category of selective low-affinity sodium glucose cotransporter (SGLT2) inhibitors, exhibits antidiabetic efficacy in rodent modelsQ46516165
Discovery of dapagliflozin: a potent, selective renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetesQ46764321
SGLT-1-mediated glucose uptake protects intestinal epithelial cells against LPS-induced apoptosis and barrier defects: a novel cellular rescue mechanism?Q46783993
Glucose transporters in human renal proximal tubular cells isolated from the urine of patients with non-insulin-dependent diabetesQ46818617
Survival of cancer cells is maintained by EGFR independent of its kinase activityQ24309274
Standards of medical care in diabetes--2012Q24632533
Global prevalence of diabetes: estimates for the year 2000 and projections for 2030Q27860575
The sodium/glucose cotransport family SLC5Q28204259
The SLC2 family of facilitated hexose and polyol transportersQ28204545
Islet-cell antibodies in diabetes mellitus with autoimmune polyendocrine deficienciesQ28237011
Expression cloning and cDNA sequencing of the Na+/glucose co-transporterQ28306556
Improved diabetic syndrome in C57BL/KsJ-db/db mice by oral administration of the Na(+)-glucose cotransporter inhibitor T-1095Q28346436
10-year follow-up of intensive glucose control in type 2 diabetesQ29615973
Remogliflozin etabonate, a selective inhibitor of the sodium-dependent transporter 2 reduces serum glucose in type 2 diabetes mellitus patientsQ33451134
Molecular mechanism of insulin resistance in obesity and type 2 diabetesQ33893897
Genotyping analysis of Helicobacter pylori using multiple-locus variable-number tandem-repeats analysis in five regions of China and Japan.Q34010205
Phloridzin: biosynthesis, distribution and physiological relevance in plantsQ34107672
SGLT2 inhibition--a novel strategy for diabetes treatmentQ34117872
The human kidney low affinity Na+/glucose cotransporter SGLT2. Delineation of the major renal reabsorptive mechanism for D-glucoseQ34121476
Islet cell antibodies predict insulin-dependent diabetes in United States school age children as powerfully as in unaffected relativesQ34150475
Dapagliflozin monotherapy in type 2 diabetic patients with inadequate glycemic control by diet and exercise: a randomized, double-blind, placebo-controlled, phase 3 trialQ34153496
Empagliflozin, a novel selective sodium glucose cotransporter-2 (SGLT-2) inhibitor: characterisation and comparison with other SGLT-2 inhibitorsQ34222752
Dose-ranging effects of canagliflozin, a sodium-glucose cotransporter 2 inhibitor, as add-on to metformin in subjects with type 2 diabetesQ34227891
Oral antihyperglycemic therapy for type 2 diabetes: scientific reviewQ34492673
Sergliflozin, a novel selective inhibitor of low-affinity sodium glucose cotransporter (SGLT2), validates the critical role of SGLT2 in renal glucose reabsorption and modulates plasma glucose levelQ34575066
Efficacy and safety of canagliflozin monotherapy in subjects with type 2 diabetes mellitus inadequately controlled with diet and exerciseQ34646948
Expression of SGLT1, Bcl-2 and p53 in primary pancreatic cancer related to survival.Q34657372
Inhibition of renal glucose reabsorption: a novel strategy for achieving glucose control in type 2 diabetes mellitusQ34876148
Community-based lifestyle interventions to prevent type 2 diabetesQ35207016
Diminished glucagon suppression after β-cell reduction is due to impaired α-cell function rather than an expansion of α-cell massQ35756418
Minireview: Epigenetics of obesity and diabetes in humansQ35762714
Glucose transporter and Na+/glucose cotransporter as molecular targets of anti-diabetic drugsQ35950011
Phlorizin: a reviewQ35995949
A Phase IIb, randomized, placebo-controlled study of the SGLT2 inhibitor empagliflozin in patients with type 2 diabetesQ47916425
United Kingdom Prospective Diabetes Study 17: a 9-year update of a randomized, controlled trial on the effect of improved metabolic control on complications in non-insulin-dependent diabetes mellitus.Q50109154
Long-term treatment with empagliflozin, a novel, potent and selective SGLT-2 inhibitor, improves glycaemic control and features of metabolic syndrome in diabetic rats.Q51366978
Safety, pharmacokinetic, and pharmacodynamic profiles of ipragliflozin (ASP1941), a novel and selective inhibitor of sodium-dependent glucose co-transporter 2, in patients with type 2 diabetes mellitus.Q51369293
Effect of dapagliflozin in patients with type 2 diabetes who have inadequate glycaemic control with glimepiride: a randomized, 24-week, double-blind, placebo-controlled trial.Q51372081
Influence of hepatic impairment on the pharmacokinetics and safety profile of dapagliflozin: an open-label, parallel-group, single-dose study.Q51396403
Autoantibodies in type 1 diabetes.Q51456535
Discovery of Ipragliflozin (ASP1941): a novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus.Q51759708
Pharmacological profile of ipragliflozin (ASP1941), a novel selective SGLT2 inhibitor, in vitro and in vivo.Q51763308
Correction of hyperglycemia and insulin sensitivity by T-1095, an inhibitor of renal Na+-glucose cotransporters, in streptozotocin-induced diabetic rats.Q54024831
P433issue5
P304page(s)350-359
P577publication date2013-06-12
P1433published inJournal of Clinical Pharmacy and TherapeuticsQ15753553
P1476titleThe kidney as a new target for antidiabetic drugs: SGLT2 inhibitors
P478volume38

Reverse relations

cites work (P2860)
Q34181385A Review on the Relationship between SGLT2 Inhibitors and Cancer.
Q38537119A comprehensive review of the pharmacodynamics of the SGLT2 inhibitor empagliflozin in animals and humans
Q89627944Dysplastic urothelial changes accompany empagliflozin administration in urinary bladder of experimental diabetes
Q49617047Emerging roles of SGLT2 inhibitors in obesity and insulin resistance: Focus on fat browning and macrophage polarization
Q88871989Insulin dependent and independent normalization of blood glucose levels reduces the enhanced rewarding effects of nicotine in a rodent model of diabetes
Q34412028Ipragliflozin: first global approval
Q40236660Management of Type 2 Diabetes in the Setting of Morbid Obesity: How Can Weight Gain Be Prevented or Reversed?
Q53482444Personalizing Type 2 Diabetes Management: Use of a Patient-Centered Approach to Individualizing A1C Goals and Pharmacological Regimens.
Q38654762SGLT2 inhibitors and risk of cancer in type 2 diabetes: a systematic review and meta-analysis of randomised controlled trials
Q47642298SGLT2 inhibitors: are they safe?
Q35359647Xenobiotic transporter expression along the male genital tract

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