Molecular mechanisms of general anesthesia

scientific article published on 21 July 2010

Molecular mechanisms of general anesthesia is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.4097/KJAE.2010.59.1.3
P932PMC publication ID2908224
P698PubMed publication ID20651990
P5875ResearchGate publication ID45282954

P2093author name stringYong Son
P2860cites workBenzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.Q51434685
Propofol modulates activation and desensitization of GABAA receptors in cultured murine hippocampal neurons.Q51617593
α5GABAA Receptors Regulate the Intrinsic Excitability of Mouse Hippocampal Pyramidal NeuronsQ60706586
Expression of GABA(A) receptor alpha5 subunit-like immunoreactivity in human hippocampusQ73093479
Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptorsQ24530653
Molecular targets underlying general anaesthesiaQ24670260
Inhalational anesthetics activate two-pore-domain background K+ channelsQ28143765
Tonically activated GABAA receptors in hippocampal neurons are high-affinity, low-conductance sensors for extracellular GABAQ28218182
International Union of Pharmacology. XV. Subtypes of gamma-aminobutyric acidA receptors: classification on the basis of subunit structure and receptor functionQ28275171
Trace fear conditioning involves hippocampal alpha5 GABA(A) receptorsQ28594296
Volatile anesthetic inhibition of neuronal Ca channel currents expressed in Xenopus oocytesQ30304143
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Autoradiographic localization of alpha5 subunit-containing GABAA receptors in rat brainQ33855433
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Inhaled anesthetics and immobility: mechanisms, mysteries, and minimum alveolar anesthetic concentrationQ35204661
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The TREK K2P channels and their role in general anaesthesia and neuroprotectionQ35921675
Emerging molecular mechanisms of general anesthetic action.Q36242467
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Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cellsQ40644380
Molecular determinants for the action of general anesthetics at recombinant alpha(2)beta(3)gamma(2)gamma-aminobutyric acid(A) receptors.Q40756567
Which GABAA-receptor subtypes really occur in the brain?Q41003268
The general anesthetic propofol slows deactivation and desensitization of GABA(A) receptors.Q42615282
Distinct functional and pharmacological properties of tonic and quantal inhibitory postsynaptic currents mediated by gamma-aminobutyric acid(A) receptors in hippocampal neurons.Q43548389
Receptors with different affinities mediate phasic and tonic GABA(A) conductances in hippocampal neurons.Q43990181
Effect of a nonsedative dose of propofol on memory for aversively loaded information in ratsQ44085503
The sedative component of anesthesia is mediated by GABA(A) receptors in an endogenous sleep pathwayQ44114040
General anesthetic actions in vivo strongly attenuated by a point mutation in the GABA(A) receptor beta3 subunit.Q44244818
GABA(A) agonists and partial agonists: THIP (Gaboxadol) as a non-opioid analgesic and a novel type of hypnoticQ44346867
Isoflurane and propofol inhibit voltage-gated sodium channels in isolated rat neurohypophysial nerve terminalsQ44517622
Sedation and anesthesia mediated by distinct GABA(A) receptor isoforms.Q44588647
Major role for tonic GABAA conductances in anesthetic suppression of intrinsic neuronal excitabilityQ44894460
Depression by isoflurane of the action potential and underlying voltage-gated ion currents in isolated rat neurohypophysial nerve terminalsQ45064207
Selective enhancement of tonic GABAergic inhibition in murine hippocampal neurons by low concentrations of the volatile anesthetic isoflurane.Q45084926
Volatile anesthetics depress glutamate transmission via presynaptic actions.Q46006598
The main source of ambient GABA responsible for tonic inhibition in the mouse hippocampus.Q46039131
Extrasynaptic GABAA receptors of thalamocortical neurons: a molecular target for hypnotics.Q46851461
How quickly can GABAA receptors open?Q48196098
Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the alpha 5 subunit of the GABAA receptor.Q48560999
Alpha5GABAA receptors mediate the amnestic but not sedative-hypnotic effects of the general anesthetic etomidate.Q48592383
Alpha 4 beta 2 neuronal nicotinic acetylcholine receptors in the central nervous system are inhibited by isoflurane and propofol, but alpha 7-type nicotinic acetylcholine receptors are unaffectedQ48748312
Localizing 3H-GABA in Nerve Terminals of Rat Cerebral Cortex by Electron Microscopic AutoradiographyQ48846486
P275copyright licenseCreative Commons Attribution-NonCommercial 3.0 UnportedQ18810331
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectgeneral anaesthesiaQ166543
P304page(s)3-8
P577publication date2010-07-21
P1433published inKorean Journal of AnesthesiologyQ17088651
P1476titleMolecular mechanisms of general anesthesia
P478volume59