Functional analysis of human BRCA2 variants using a mouse embryonic stem cell-based assay.

scientific article published on January 2010

Functional analysis of human BRCA2 variants using a mouse embryonic stem cell-based assay. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/978-1-60761-759-4_16
P932PMC publication ID6669890
P698PubMed publication ID20721749

P50authorSergey KuznetsovQ37372506
P2093author name stringShyam K Sharan
Suhwan Chang
P2860cites workA systematic genetic assessment of 1,433 sequence variants of unknown clinical significance in the BRCA1 and BRCA2 breast cancer-predisposition genesQ36492194
Mouse embryonic stem cell-based functional assay to evaluate mutations in BRCA2Q37092814
Karyotypic complexity of the NCI-60 drug-screening panel.Q40604171
Clonally derived human embryonic stem cell lines maintain pluripotency and proliferative potential for prolonged periods of cultureQ40843384
Insertional mutagenesis by retroviruses and promoter traps in embryonic stem cellsQ44140193
Mismatch amplification mutation assay (MAMA): application to the c-H-ras geneQ67997592
Gene targeting in embryonic stem cellsQ72583953
Rapid engineering of bacterial artificial chromosomes using oligonucleotidesQ73339514
Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cellsQ22003975
Simple and highly efficient BAC recombineering using galK selectionQ24794075
Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2Q28236543
Evaluation of a soluble tetrazolium/formazan assay for cell growth and drug sensitivity in culture using human and other tumor cell linesQ28297800
Recombineering: a homologous recombination-based method of genetic engineeringQ28307909
Rad51-deficient vertebrate cells accumulate chromosomal breaks prior to cell deathQ29614845
An efficient recombination system for chromosome engineering in Escherichia coliQ29615038
A full-likelihood method for the evaluation of causality of sequence variants from family dataQ30816468
Chromosome engineering in miceQ34290413
Recombineering: a powerful new tool for mouse functional genomicsQ34389493
Array-based DNA diagnostics: let the revolution beginQ34706763
A simple two-step, 'hit and fix' method to generate subtle mutations in BACs using short denatured PCR fragmentsQ35222962
Functional assays for BRCA1 and BRCA2.Q35775886
P407language of work or nameEnglishQ1860
P304page(s)259-280
P577publication date2010-01-01
P1433published inMethods in Molecular BiologyQ15752859
P1476titleFunctional analysis of human BRCA2 variants using a mouse embryonic stem cell-based assay
P478volume653

Reverse relations

cites work (P2860)
Q41084246Acquired cross-linker resistance associated with a novel spliced BRCA2 protein variant for molecular phenotyping of BRCA2 disruption.
Q50210067Assessment of the Clinical Relevance of BRCA2 Missense Variants by Functional and Computational Approaches
Q104466347Epidemiological and ES cell-based Functional Evaluation of BRCA2 Variants Identified in Families with Breast Cancer

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