NFAT, immunity and cancer: a transcription factor comes of age

scientific article published on August 20, 2010

NFAT, immunity and cancer: a transcription factor comes of age is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/NRI2818
P953full work available at URLhttp://www.nature.com/articles/nri2818
http://www.nature.com/articles/nri2818.pdf
P698PubMed publication ID20725108
P5875ResearchGate publication ID45721450

P50authorAnjana RaoQ85941651
P2093author name stringMartin R. Müller
P2860cites workEpigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?Q83125659
Deltex1 is a target of the transcription factor NFAT that promotes T cell anergyQ84207047
Tonicity-responsive enhancer binding protein, a rel-like protein that stimulates transcription in response to hypertonicityQ22008847
NFAT5, a constitutively nuclear NFAT protein that does not cooperate with Fos and JunQ22010152
Bridging the NFAT and NF-kappaB families: NFAT5 dimerization regulates cytokine gene transcription in response to osmotic stressQ24291525
FOXP3 controls regulatory T cell function through cooperation with NFATQ24298179
A genome-wide Drosophila RNAi screen identifies DYRK-family kinases as regulators of NFATQ24306261
Nuclear export of NF-ATc enhanced by glycogen synthase kinase-3Q24309262
Calcineurin imposes T cell unresponsiveness through targeted proteolysis of signaling proteinsQ24310048
Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteinsQ24317724
Loss of NFAT5 results in renal atrophy and lack of tonicity-responsive gene expressionQ24622498
FOXC2 controls formation and maturation of lymphatic collecting vessels through cooperation with NFATc1Q24641842
The epithelial-mesenchymal transition generates cells with properties of stem cellsQ24650786
Down's syndrome suppression of tumour growth and the role of the calcineurin inhibitor DSCR1Q24654657
The costimulatory molecule ICOS regulates the expression of c-Maf and IL-21 in the development of follicular T helper cells and TH-17 cellsQ24655751
NFAT Binding and Regulation of T Cell Activation by the Cytoplasmic Scaffolding Homer ProteinsQ27649708
NF-AT components define a family of transcription factors targeted in T-cell activationQ28114991
Requirement for RORgamma in thymocyte survival and lymphoid organ developmentQ28139666
Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculatureQ28204868
The role of NFAT transcription factors in integrin-mediated carcinoma invasionQ28206477
NFAT proteins: key regulators of T-cell development and functionQ28253919
The T-cell transcription factor NFATp is a substrate for calcineurin and interacts with Fos and JunQ28263918
A strategy for probing the function of noncoding RNAs finds a repressor of NFATQ28270512
Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathwayQ28274746
The biology of NKT cellsQ28277482
Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexesQ28277749
Akt blocks breast cancer cell motility and invasion through the transcription factor NFATQ28283545
The calcineurin phosphatase complex modulates immunogenic B cell responsesQ28296946
NFATc2-mediated repression of cyclin-dependent kinase 4 expressionQ28505899
Normal B-1a cell development requires B cell-intrinsic NFATc1 activityQ28509932
NFATc1 balances quiescence and proliferation of skin stem cellsQ28511548
Isolation of the cyclosporin-sensitive T cell transcription factor NFATpQ28511815
Regulation of the NFAT pathway discriminates CD4+CD25+ regulatory T cells from CD4+CD25- helper T cells.Q42521715
Constitutive NF-kappaB and NFAT activation leads to stimulation of the BLyS survival pathway in aggressive B-cell lymphomasQ42741779
Autoregulation of NFATc1/A expression facilitates effector T cells to escape from rapid apoptosisQ44066637
NF-ATc2 induces apoptosis in Burkitt's lymphoma cells through signaling via the B cell antigen receptorQ44321045
A new cell-permeable peptide allows successful allogeneic islet transplantation in miceQ44760624
Dectin-1 stimulation by Candida albicans yeast or zymosan triggers NFAT activation in macrophages and dendritic cellsQ45345622
Calcineurin/NFAT signaling in osteoblasts regulates bone massQ46675973
Regulation of NFAT by poly(ADP-ribose) polymerase activity in T cells.Q46851148
Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin AQ46979889
Role of NFAT proteins in IL13 gene transcription in mast cellsQ47260082
The NFAT1 transcription factor is a repressor of cyclin A2 gene expression.Q51796031
Inhibitory function of two NFAT family members in lymphoid homeostasis and Th2 development.Q54113549
Nuclear factor of activated T cells contains Fos and Jun.Q54271859
CD14 regulates the dendritic cell life cycle after LPS exposure through NFAT activationQ58883568
Linking calcineurin activity to leukemogenesisQ80442223
Expression analysis of nuclear factor of activated T cells (NFAT) during myeloid differentiation of CD34+ cells: regulation of Fas ligand gene expression in megakaryocytesQ80497569
Transcriptional partners in regulatory T cells: Foxp3, Runx and NFATQ80586216
The NFATc1 transcription factor is widely expressed in white cells and translocates from the cytoplasm to the nucleus in a subset of human lymphomasQ81311937
Calcium signalling in lymphocyte activation and diseaseQ36912139
Selective role of calcineurin in haematopoiesis and lymphopoiesisQ36969291
Dual roles for NFAT transcription factor genes as oncogenes and tumor suppressors.Q36994797
Suppressed NFAT-dependent VEGFR1 expression and constitutive VEGFR2 signaling in infantile hemangiomaQ36995485
Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylationQ37065897
Targeted cleavage of signaling proteins by caspase 3 inhibits T cell receptor signaling in anergic T cellsQ37072458
Akt/protein kinase b and glycogen synthase kinase-3beta signaling pathway regulates cell migration through the NFAT1 transcription factor.Q37155812
Requirement for balanced Ca/NFAT signaling in hematopoietic and embryonic developmentQ37182722
The gene encoding early growth response 2, a target of the transcription factor NFAT, is required for the development and maturation of natural killer T cellsQ37310026
Differential expression of interleukin-17A and -17F is coupled to T cell receptor signaling via inducible T cell kinaseQ37399188
Regulation of T-cell tolerance by calcium/NFAT signalingQ37597631
Ca2+-NFATc1 signaling is an essential axis of osteoclast differentiationQ37597633
Interaction of calcineurin with substrates and targeting proteinsQ37813260
Integrin alpha6beta4 promotes expression of autotaxin/ENPP2 autocrine motility factor in breast carcinoma cellsQ38326221
NFAT-induced histone acetylation relay switch promotes c-Myc-dependent growth in pancreatic cancer cellsQ39777198
NFAT signalling is a novel target of oncogenic BRAF in metastatic melanoma.Q39805013
MHC class II molecules activate NFAT and the ERK group of MAPK through distinct signaling pathways in B cellsQ39835067
HIF-1alpha is up-regulated in activated mast cells by a process that involves calcineurin and NFAT.Q39959183
TRPV6 channel controls prostate cancer cell proliferation via Ca(2+)/NFAT-dependent pathways.Q40126939
Targeting calcineurin activation as a therapeutic strategy for T-cell acute lymphoblastic leukemiaQ40130034
The B cell antigen receptor controls AP-1 and NFAT activity through Ras-mediated activation of Ral.Q40181180
Specific and redundant roles for NFAT transcription factors in the expression of mast cell-derived cytokines.Q40212619
Overexpression of c-myc in pancreatic cancer caused by ectopic activation of NFATc1 and the Ca2+/calcineurin signaling pathwayQ40250435
Identification of common transcriptional regulatory elements in interleukin-17 target genesQ40263019
NFAT induces breast cancer cell invasion by promoting the induction of cyclooxygenase-2.Q40310709
Proteolytic regulation of nuclear factor of activated T (NFAT) c2 cells and NFAT activity by caspase-3.Q40321353
Constitutive NF-kappaB and NFAT activation in aggressive B-cell lymphomas synergistically activates the CD154 gene and maintains lymphoma cell survivalQ40385482
Dual role of sumoylation in the nuclear localization and transcriptional activation of NFAT1.Q40561279
A constitutively active NFATc1 mutant induces a transformed phenotype in 3T3-L1 fibroblastsQ40669040
A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1.Q40815624
Epigenetic changes and suppression of the nuclear factor of activated T cell 1 (NFATC1) promoter in human lymphomas with defects in immunoreceptor signalingQ41825111
Requirement for IL-13 independently of IL-4 in experimental asthmaQ41881960
NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cellsQ41938630
SnapShot: Ca2+-calcineurin-NFAT signalingQ42163961
Regulation of the murine Nfatc1 gene by NFATc2.Q42515564
NFATc1 regulates lymphatic endothelial developmentQ28593523
Transcriptional regulation by calcium, calcineurin, and NFATQ29620410
Tyrosine phosphorylation of 3BP2 regulates B cell receptor-mediated activation of NFATQ30157087
Sumoylation of the transcription factor NFATc1 leads to its subnuclear relocalization and interleukin-2 repression by histone deacetylaseQ30486988
Affinity-driven peptide selection of an NFAT inhibitor more selective than cyclosporin A.Q30778570
Interleukin-11 in endometrial adenocarcinoma is regulated by prostaglandin F2alpha-F-prostanoid receptor interaction via the calcium-calcineurin-nuclear factor of activated T cells pathway and negatively regulated by the regulator of calcineurin-1.Q33556402
Prostaglandin F(2alpha)-F-prostanoid receptor regulates CXCL8 expression in endometrial adenocarcinoma cells via the calcium-calcineurin-NFAT pathwayQ33590672
A CD8 T cell-intrinsic role for the calcineurin-NFAT pathway for tolerance induction in vivo.Q33677482
Molecular basis of calcium signaling in lymphocytes: STIM and ORAIQ33819323
NFAT proteins: emerging roles in cancer progressionQ33837647
Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fateQ33908130
Wnt/Ca2+/NFAT signaling maintains survival of Ph+ leukemia cells upon inhibition of Bcr-Abl.Q33996893
The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation.Q34041946
Hyperactivation of nuclear factor of activated T cells 1 (NFAT1) in T cells attenuates severity of murine autoimmune encephalomyelitisQ34093829
Transcriptional mechanisms underlying lymphocyte tolerance.Q34135663
Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastasesQ34148745
Identification of a putative regulator of early T cell activation genesQ34171263
Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic moleculesQ34335785
NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21.Q34504363
Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and functionQ34567627
Control of regulatory T cell lineage commitment and maintenanceQ34658594
VEGF-A and the induction of pathological angiogenesisQ34718259
Smad3 and NFAT cooperate to induce Foxp3 expression through its enhancerQ34729938
Transcriptional complexes formed by NFAT dimers regulate the induction of T cell toleranceQ34967371
A tumor-suppressor function for NFATc3 in T-cell lymphomagenesis by murine leukemia virusQ35847639
Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivoQ36246828
Selective inhibition of vascular endothelial growth factor-mediated angiogenesis by cyclosporin A: roles of the nuclear factor of activated T cells and cyclooxygenase 2Q36369190
Discovery of vascular permeability factor (VPF).Q36375479
NFAT but not NF-kappaB is critical for transcriptional induction of the prosurvival gene A1 after IgE receptor activation in mast cellsQ36491849
Nuclear factor of activated T cells (NFAT) mediates CD154 expression in megakaryocytesQ36508895
Regulation of transcription factor NFAT by ADP-ribosylationQ36540217
B-1 B cell developmentQ36571904
The proto-oncogene c-maf is responsible for tissue-specific expression of interleukin-4.Q36804149
Contribution of platelet-derived CD40 ligand to inflammation, thrombosis and neoangiogenesis.Q36907331
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)645-656
P577publication date2010-08-20
P1433published inNature Reviews ImmunologyQ43355
P1476titleNFAT, immunity and cancer: a transcription factor comes of age
P478volume10

Reverse relations

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Q38511575Signaling in lymphocyte activation
Q41995058Skin infections are eliminated by cooperation of the fibrinolytic and innate immune systems.
Q47165489Src-family kinases negatively regulate NFAT signaling in resting human T cells.
Q37029755Store-Operated Ca(2+) Entry in Follicular T Cells Controls Humoral Immune Responses and Autoimmunity
Q47655605Store-Operated Ca2+ Entry Controls Clonal Expansion of T Cells through Metabolic Reprogramming.
Q34355882Stromal interaction molecule 1 (STIM1) and Orai1 mediate histamine-evoked calcium entry and nuclear factor of activated T-cells (NFAT) signaling in human umbilical vein endothelial cells.
Q26781513Structural Basis of Targeting the Exportin CRM1 in Cancer
Q36483189Systematic study of constitutive cyclooxygenase-2 expression: Role of NF-κB and NFAT transcriptional pathways
Q36754365TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter
Q38780085TPL2 Kinase Is a Crucial Signaling Factor and Mediator of NKT Effector Cytokine Expression in Immune-Mediated Liver Injury
Q59136425Targeting Anion Exchange of Osteoclast, a New Strategy for Preventing Wear Particles Induced- Osteolysis
Q64253749Targeting Tyrosine kinases in Renal Cell Carcinoma: "New Bullets against Old Guys"
Q33804696Tespa1 regulates T cell receptor-induced calcium signals by recruiting inositol 1,4,5-trisphosphate receptors.
Q36956985The DNA methylation profile of activated human natural killer cells.
Q38839497The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells.
Q36436005The NAD+-dependent histone deacetylase SIRT6 promotes cytokine production and migration in pancreatic cancer cells by regulating Ca2+ responses
Q92327821The Puzzling Role of Neuron-Specific PMCA Isoforms in the Aging Process
Q36779438The calcineurin-NFAT pathway negatively regulates megakaryopoiesis
Q27330253The calcineurin/NFAT pathway is activated in diagnostic breast cancer cases and is essential to survival and metastasis of mammary cancer cells.
Q47122756The cargo protein MAP17 (PDZK1IP1) regulates the immune microenvironment
Q50636803The cooperation of CREB and NFAT is required for PTHrP-induced RANKL expression in mouse osteoblastic cells.
Q28256143The short-chain fatty acid receptor GPR43 is transcriptionally regulated by XBP1 in human monocytes
Q42218721The transcription factor NFAT exhibits signal memory during serial T cell interactions with antigen-presenting cells
Q28068998Therapeutic potential of targeting acinar cell reprogramming in pancreatic cancer
Q36216395Transcription factor NFAT1 activates the mdm2 oncogene independent of p53.
Q36500059Transcription factor NFAT1 controls allergic contact hypersensitivity through regulation of activation induced cell death program.
Q41592849Transcription factor c-Rel is indispensable for generation of thymic but not of peripheral Foxp3+ regulatory T cells
Q37662252Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy.
Q24338120USP22 is a positive regulator of NFATc2 on promoting IL2 expression
Q38212817Unconventional post-translational modifications in immunological signaling
Q92757526Unleashing the full potential of Hsp90 inhibitors as cancer therapeutics through simultaneous inactivation of Hsp90, Grp94, and TRAP1
Q38000118Unraveling STIM2 function
Q36884697Up-regulation of Store-operated Ca2+ Entry and Nuclear Factor of Activated T Cells Promote the Acinar Phenotype of the Primary Human Salivary Gland Cells
Q59336036Upregulation of Ets1 expression by NFATc2 and NFKB1/RELA promotes breast cancer cell invasiveness
Q42152602Using machine learning algorithms to identify genes essential for cell survival
Q26851822Vesicular trafficking and signaling for cytokine and chemokine secretion in mast cells
Q40623679Virion encapsidated HIV-1 Vpr induces NFAT to prime non-activated T cells for productive infection
Q33833563Vitamin D in inflammatory diseases
Q36639258Vitamin D interacts with Esr1 and Igf1 to regulate molecular pathways relevant to Alzheimer's disease
Q38035203Waking up the sleepers: shared transcriptional pathways in axonal regeneration and neurogenesis.
Q39445406Wnt signaling in cardiovascular disease: opportunities and challenges
Q52804976c-Maf controls immune responses by regulating disease-specific gene networks and repressing IL-2 in CD4+ T cells.
Q64068287miR-194 suppresses high glucose-induced non-small cell lung cancer cell progression by targeting NFAT5
Q41390605miR-9 enhances the transactivation of nuclear factor of activated T cells by targeting KPNB1 and DYRK1B.

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