Integrative physiology of the aging bone: insights from animal and cellular models

scientific article published on November 1, 2010

Integrative physiology of the aging bone: insights from animal and cellular models is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/J.1749-6632.2010.05813.X
P953full work available online athttps://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1111%2Fj.1749-6632.2010.05813.x
https://nyaspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1749-6632.2010.05813.x
P698PubMed publication ID21062298

P2093author name stringFarhan A. Syed
Kelley A. Hoey
P2860cites workInvolvement of the klotho protein in dentin formation and mineralizationQ80214101
The role of IGF system in the rise and fall in bone density with ageQ80235690
Age-related changes in bone mineral density, cross-sectional area and the strength of long bones in the hind limbs and first lumbar vertebra in female Wistar ratsQ80423114
Aged mice require full transcription factor, Runx2/Cbfa1, gene dosage for cancellous bone regeneration after bone marrow ablationQ80454895
Age-related loss of muscle mass and bone strength in mice is associated with a decline in physical activity and serum leptinQ83915414
The novel zinc finger-containing transcription factor osterix is required for osteoblast differentiation and bone formationQ24292169
Mutation of the mouse klotho gene leads to a syndrome resembling ageingQ24328782
Klotho and agingQ24654902
Bone resorption by osteoclastsQ28145169
Regulation of human skeletal stem cells differentiation by Dlk1/Pref-1Q28255069
Cell shape, cytoskeletal tension, and RhoA regulate stem cell lineage commitmentQ28255124
Effect of lamin A/C knockdown on osteoblast differentiation and functionQ28296549
Age-related bone loss in the LOU/c rat model of healthy ageingQ28300241
Leptin inhibits bone formation through a hypothalamic relay: a central control of bone massQ28505908
Augmented Wnt signaling in a mammalian model of accelerated agingQ28506533
FSH directly regulates bone massQ28512745
Leptin regulation of bone resorption by the sympathetic nervous system and CARTQ28589974
Concise review: mesenchymal stem cells: their phenotype, differentiation capacity, immunological features, and potential for homing.Q30157916
Leptin deficiency produces contrasting phenotypes in bones of the limb and spineQ33198910
Independent impairment of osteoblast and osteoclast differentiation in klotho mouse exhibiting low-turnover osteopeniaQ33853506
Age-dependent changes in B lymphocyte development in man and mouseQ33892787
Sex steroids and the construction and conservation of the adult skeletonQ34131889
Lrp5-independent activation of Wnt signaling by lithium chloride increases bone formation and bone mass in miceQ34161042
Osteoporosis and the replacement of cell populations of the marrow by adipose tissue. A quantitative study of 84 iliac bone biopsies.Q34228948
Nonhuman primate models in skeletal researchQ34319515
Aging activates adipogenic and suppresses osteogenic programs in mesenchymal marrow stroma/stem cells: the role of PPAR-gamma2 transcription factor and TGF-beta/BMP signaling pathwaysQ34371949
Playing with bone and fat.Q34494766
Nonhuman primate models of skeletal and reproductive agingQ34545373
PPARgamma insufficiency enhances osteogenesis through osteoblast formation from bone marrow progenitorsQ34546901
Natural ligands of PPARgamma: are prostaglandin J(2) derivatives really playing the part?Q34602968
Effects of estrogen therapy on bone marrow adipocytes in postmenopausal osteoporotic womenQ34750140
Estrogen receptors in skeletal metabolism: lessons from genetically modified models of receptor functionQ34999041
Skeletal involution by age-associated oxidative stress and its acceleration by loss of sex steroidsQ35058081
Effects of chronic estrogen treatment on modulating age-related bone loss in female mice.Q35059311
A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cellsQ35095530
A Cbfa1-dependent genetic pathway controls bone formation beyond embryonic developmentQ35194624
Biglycan knockout mice: new models for musculoskeletal diseasesQ35219616
Impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis in noggin-overexpressing miceQ35919695
Mechanisms of sex steroid effects on bone.Q36032079
PPAR gamma, 10 years laterQ36055769
Mouse models of senile osteoporosisQ36089638
Commitment of C3H10T1/2 pluripotent stem cells to the adipocyte lineageQ36448097
The nuclear envelope, a key structure in cellular integrity and gene expressionQ36822664
Age-dependent Wnt gene expression in bone and during the course of osteoblast differentiationQ36979410
Changes in bone mineral density of the proximal femur and spine with aging. Differences between the postmenopausal and senile osteoporosis syndromesQ36986611
Klotho as a regulator of oxidative stress and senescenceQ37051351
Mice lacking beta-adrenergic receptors have increased bone mass but are not protected from deleterious skeletal effects of ovariectomy.Q37072802
Osteoblastic cells: differentiation and trans-differentiationQ37136099
Trabecular bone deterioration in col9a1+/- mice associated with enlarged osteoclasts adhered to collagen IX-deficient boneQ37179397
Age-related changes in the osteogenic differentiation potential of mouse bone marrow stromal cellsQ37185139
Bone microstructure and its associated genetic variability in 12 inbred mouse strains: microCT study and in silico genome scanQ37246221
Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly menQ37272054
Osteoporosis: an age-related and gender-specific disease--a mini-reviewQ37307341
PPARgamma2 nuclear receptor controls multiple regulatory pathways of osteoblast differentiation from marrow mesenchymal stem cellsQ37349947
Linkage of decreased bone mass with impaired osteoblastogenesis in a murine model of accelerated senescenceQ37353867
Biological basis of bone formation, remodeling, and repair-part II: extracellular matrix.Q37381734
Increased lipid oxidation causes oxidative stress, increased peroxisome proliferator-activated receptor-gamma expression, and diminished pro-osteogenic Wnt signaling in the skeletonQ37448064
Aging of marrow stromal (skeletal) stem cells and their contribution to age-related bone lossQ37472321
Role of the pituitary-bone axis in skeletal pathophysiologyQ37611475
Accumulation of Lipofuscin (Age Pigment) in Aging Skeletal Connective Tissues as Revealed by Electron MicroscopyQ39312121
Aging does not lessen the effectiveness of TGFbeta2-enhanced bone regenerationQ39646055
Secreted frizzled-related protein 4 is a negative regulator of peak BMD in SAMP6 mice.Q40227448
Inhibition of osteoblast differentiation but not adipocyte differentiation of mesenchymal stem cells by sera obtained from aged femalesQ40306429
Insulin-Dependent Adipogenesis in Stromal ST2 Cells Derived from Murine Bone MarrowQ40650477
Estrogen promotes early osteoblast differentiation and inhibits adipocyte differentiation in mouse bone marrow stromal cell lines that express estrogen receptor (ER) alpha or betaQ40731274
Evidence for an inverse relationship between the differentiation of adipocytic and osteogenic cells in rat marrow stromal cell culturesQ41621797
Are the spines of calf, pig and sheep suitable models for pre-clinical implant tests?Q41974920
Age-related changes in osteogenic stem cells in miceQ42438625
Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse boneQ42525601
Female estrogen receptor beta-/- mice are partially protected against age-related trabecular bone loss.Q43703732
Treatment of postmenopausal osteoporosis with transdermal estrogenQ44087639
Estrogens (E2) regulate expression and response of 1,25-dihydroxyvitamin D3 receptors in bone cells: changes with aging and hormone deprivationQ44225467
Impaired marrow osteogenesis is associated with reduced endocortical bone formation but does not impair periosteal bone formation in long bones of SAMP6 miceQ45300436
Expression of RANKL and OPG correlates with age-related bone loss in male C57BL/6 miceQ46092958
Histological and elemental analyses of impaired bone mineralization in klotho-deficient miceQ46278282
Changes in mechanical properties of bone within the mandibular condyle with age.Q46279075
The role of noggin in human mesenchymal stem cell differentiationQ46280717
Bone development and age-related bone loss in male C57BL/6J miceQ46286440
The aging of hematopoietic stem cellsQ46785776
Sandblasted titanium osteointegration in young, aged and ovariectomized sheepQ51041130
Age-dependent change in the 3D structure of cortical porosity at the human femoral midshaftQ51083950
Osteointegration of hydroxyapatite-titanium implants coated with nonglycosylated recombinant human bone morphogenetic protein-2 (BMP-2) in aged sheepQ51361160
Phenotypic changes of adult porcine mesenchymal stem cells induced by prolonged passaging in cultureQ51474214
A progeroid syndrome in mice is caused by defects in A-type laminsQ52105480
High-dose estrogen-induced osteogenesis is decreased in aged RUNX2(+/-) miceQ53555813
Histological evidence of the altered distribution of osteocytes and bone matrix synthesis in klotho-deficient mice.Q53634680
Histomorphometry and bone biomarkers in cynomolgus females: a study in young, mature, and old monkeysQ54107567
Marrow stromal stem cellsQ54130286
Accelerated Features of Age-Related Bone Loss in Zmpste24 Metalloproteinase-Deficient MiceQ57086323
Canonical WNT Signaling Promotes Osteogenesis by Directly StimulatingRunx2Gene ExpressionQ57129723
Chapter 6. The Composition of BoneQ61759837
Cannabinoid Receptor Type 1 Protects against Age- Related Osteoporosis by Regulating Osteoblast and Adipocyte Differentiation in Marrow Stromal CellsQ63444479
A new murine model of accelerated senescenceQ71011567
Femoral peak bone mass and osteoclast number in an animal model of age‐related spontaneous osteopeniaQ71857792
Quantitative histological studies on age changes in boneQ72331165
Decreased AP-1 activity and interleukin-11 expression by bone marrow stromal cells may be associated with impaired bone formation in aged miceQ73831131
Increased Adipogenesis and Myelopoiesis in the Bone Marrow of SAMP6, a Murine Model of Defective Osteoblastogenesis and Low Turnover OsteopeniaQ73909789
Age-related osteoporosis in biglycan-deficient mice is related to defects in bone marrow stromal cellsQ77547312
Age-related changes in bone mineral density, cross-sectional area and strength at different skeletal sites in male ratsQ77656433
Consistency of low bone density across bone sites in SAMP6 laboratory miceQ79987384
Osteopontin deficiency enhances anabolic action of EP4 agonist at a sub-optimal dose in boneQ80076318
Serum levels of receptor activator of nuclear factor kappaB ligand (RANKL) in healthy women and menQ80177690
P407language of work or nameEnglishQ1860
P921main subjectanimal modelQ264024
physiologyQ521
P304page(s)95-106
P577publication date2010-11-01
P1433published inAnnals of the New York Academy of SciencesQ2431664
P1476titleIntegrative physiology of the aging bone: insights from animal and cellular models
P478volume1211

Reverse relations

cites work (P2860)
Q95266451Age-related and sex-specific effects on architectural properties and biomechanical response of the C57BL/6N mouse femur, tibia and ulna
Q34197048Bone marrow fat has brown adipose tissue characteristics, which are attenuated with aging and diabetes
Q87327139Decreased activity of osteocyte autophagy with aging may contribute to the bone loss in senile population
Q24594632Low-abundance biofilm species orchestrates inflammatory periodontal disease through the commensal microbiota and complement
Q38696891Main differences in osteoporotic fracture models: which should I use?
Q37310688Necrostatin-1 treatment inhibits osteocyte necroptosis and trabecular deterioration in ovariectomized rats
Q38267261Osteoporotic fracture models
Q38050691Physiological Challenges of Bone Repair
Q37932432Rodent Models of Aging Bone: An Update
Q36253105Skeletal effects of long-term caloric restriction in rhesus monkeys
Q38784529Stress fractures: pathophysiology, clinical presentation, imaging features, and treatment options
Q36775702Temperatures rising: brown fat and bone.
Q39220479Total hip arthroplasty revision in elderly patients

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