Mitochondria as Crucial Players in Demyelinated Axons: Lessons from Neuropathology and Experimental Demyelination

scientific article published on 08 February 2011

Mitochondria as Crucial Players in Demyelinated Axons: Lessons from Neuropathology and Experimental Demyelination is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.4061/2011/262847
P953full work available online athttp://downloads.hindawi.com/journals/ad/2011/262847.pdf
http://downloads.hindawi.com/journals/ad/2011/262847.xml
https://downloads.hindawi.com/journals/ad/2011/262847.pdf
https://europepmc.org/articles/PMC3038418
https://europepmc.org/articles/PMC3038418?pdf=render
P932PMC publication ID3038418
P698PubMed publication ID21331147
P5875ResearchGate publication ID49845498

P50authorGraham R CampbellQ57017440
P2093author name stringDon J. Mahad
P2860cites workBrain PathologyQ4955776
Dynamin-related protein Drp1 is required for mitochondrial division in mammalian cellsQ24291591
Suppression of mitochondrial oxidative stress provides long-term neuroprotection in experimental optic neuritisQ24294447
Loss of OPA1 perturbates the mitochondrial inner membrane structure and integrity, leading to cytochrome c release and apoptosisQ24338169
The pathophysiology of multiple sclerosis: the mechanisms underlying the production of symptoms and the natural history of the diseaseQ24676476
Mitochondrial DNA mutations in human diseaseQ24676881
Lamotrigine for neuroprotection in secondary progressive multiple sclerosis: a randomised, double-blind, placebo-controlled, parallel-group trial.Q39858360
A splice site mutation in the murine Opa1 gene features pathology of autosomal dominant optic atrophy.Q40240586
Biotechnological agents for the immunotherapy of multiple sclerosis. Principles, problems and perspectivesQ40895456
Retrograde but not anterograde bead movement in intact axons requires dyneinQ41666684
Axonal transport of mitochondria along microtubules and F-actin in living vertebrate neuronsQ41903637
Differential control of clustering of the sodium channels Na(v)1.2 and Na(v)1.6 at developing CNS nodes of RanvierQ43601410
Regulation of gene expression in experimental autoimmune encephalomyelitis indicates early neuronal dysfunctionQ44285188
Blockers of sodium and calcium entry protect axons from nitric oxide-mediated degenerationQ44296099
Phenytoin protects spinal cord axons and preserves axonal conduction and neurological function in a model of neuroinflammation in vivoQ44540512
Enhanced number and activity of mitochondria in multiple sclerosis lesionsQ44595788
Axonal protection using flecainide in experimental autoimmune encephalomyelitis.Q44880213
Axonal mitochondrial transport and potential are correlatedQ44901240
Sodium channels contribute to microglia/macrophage activation and function in EAE and MS.Q45076768
Gene expression analysis of normal appearing brain tissue in an animal model for multiple sclerosis revealed grey matter alterations, but only minor white matter changesQ45203854
Heterogeneous distribution of axonal cytoskeleton proteins in the human optic nerveQ46147673
Mitochondrial dysfunction as a cause of axonal degeneration in multiple sclerosis patientsQ47660422
Co-localization of sodium channel Nav1.6 and the sodium-calcium exchanger at sites of axonal injury in the spinal cord in EAE.Q48122449
Proteomic analysis of demyelinated and remyelinating brain tissue following dietary cuprizone administrationQ48232676
Sodium channel Na(v)1.6 is expressed along nonmyelinated axons and it contributes to conductionQ48460269
Galactocerebroside antiserum causes demyelination of cat optic nerveQ48506416
The distribution of mitochondrial activity in relation to optic nerve structureQ48587524
Na(+)-Ca2+ exchanger mediates Ca2+ influx during anoxia in mammalian central nervous system white matterQ48658234
Amyloid precursor protein accumulates in white matter at the margin of a focal ischaemic lesionQ48682199
Cortical demyelination and diffuse white matter injury in multiple sclerosis.Q48726181
Axonal damage in acute multiple sclerosis lesionsQ48776354
Ionic mechanisms of anoxic injury in mammalian CNS white matter: role of Na+ channels and Na(+)-Ca2+ exchangerQ51697656
Sodium channels in single demyelinated mammalian axonsQ51755545
Mitochondrial Protein Nitration Primes Neurodegeneration in Experimental Autoimmune EncephalomyelitisQ58119404
Effect of Demyelination on Conduction in the Central Nervous SystemQ59065519
Axonal injury in multiple sclerosisQ61709639
Local modulation of neurofilament phosphorylation, axonal caliber, and slow axonal transport by myelinating Schwann cellsQ67531806
Nanomolar concentrations of nitric oxide reversibly inhibit synaptosomal respiration by competing with oxygen at cytochrome oxidaseQ72370715
Beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injuryQ72624827
The regulation of bidirectional mitochondrial transport is coordinated with axonal outgrowthQ72789184
Oxidative damage to mitochondrial DNA and activity of mitochondrial enzymes in chronic active lesions of multiple sclerosisQ74297187
Focal accumulation of intra-axonal mitochondria in demyelination of the cat optic nerveQ77094754
Axonal protection achieved in a model of multiple sclerosis using lamotrigineQ79547534
Opa1 deficiency in a mouse model of autosomal dominant optic atrophy impairs mitochondrial morphology, optic nerve structure and visual functionQ80146686
Exacerbation of experimental autoimmune encephalomyelitis after withdrawal of phenytoin and carbamazepineQ80678677
Axonal dysfunction in chronic multiple sclerosis: meltdown in the membraneQ80897644
Distribution of mitochondria along small-diameter myelinated central nervous system axonsQ80995993
Increase in mitochondrial density within axons and supporting cells in response to demyelination in the Plp1 mouse modelQ82002626
Increased axonal mitochondrial activity as an adaptation to myelin deficiency in the Shiverer mouseQ82920303
Nuclear gene OPA1, encoding a mitochondrial dynamin-related protein, is mutated in dominant optic atrophyQ28140286
Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1BbetaQ28199148
Multiple sclerosisQ28299151
Distribution of a calcium channel subunit in dystrophic axons in multiple sclerosis and experimental autoimmune encephalomyelitisQ28574796
Mitofusins Mfn1 and Mfn2 coordinately regulate mitochondrial fusion and are essential for embryonic developmentQ28594513
Mitochondrial respiratory-chain diseasesQ29614474
Axonal Transection in the Lesions of Multiple SclerosisQ29615585
Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axonsQ30477062
Low density of sodium channels supports action potential conduction in axons of neonatal rat optic nerveQ33838989
Sodium channel expression within chronic multiple sclerosis plaquesQ34680249
Cytotoxic T lymphocytes in autoimmune and degenerative CNS diseases.Q34710256
Imaging correlates of decreased axonal Na+/K+ ATPase in chronic multiple sclerosis lesions.Q34774294
Axonal loss in the pathology of MS: consequences for understanding the progressive phase of the diseaseQ35057231
The role of nitric oxide in multiple sclerosisQ35172450
Traumatically induced axonal injury: pathogenesis and pathobiological implicationsQ35243746
The distributions of mitochondria and sodium channels reflect the specific energy requirements and conduction properties of the human optic nerve headQ35591713
The diagnosis of mitochondrial muscle disease.Q35690669
Quantitative ultrastructural analysis of a single spinal cord demyelinated lesion predicts total lesion load, axonal loss, and neurological dysfunction in a murine model of multiple sclerosisQ35745786
Familial amyotrophic lateral sclerosis-linked SOD1 mutants perturb fast axonal transport to reduce axonal mitochondria contentQ35894389
Evolution of a neuroprotective function of central nervous system myelinQ36117106
In situ localization of mitochondrial DNA replication in intact mammalian cellsQ36256880
Axon degeneration mechanisms: commonality amid diversityQ36285969
Docking of axonal mitochondria by syntaphilin controls their mobility and affects short-term facilitationQ36484737
Persistent inhibition of cell respiration by nitric oxide: crucial role of S-nitrosylation of mitochondrial complex I and protective action of glutathione.Q36501983
Axonal conduction and injury in multiple sclerosis: the role of sodium channelsQ36657811
Mitochondrial changes within axons in multiple sclerosisQ36709397
Mitochondrial biogenesis in the axons of vertebrate peripheral neuronsQ36883274
Matrix metalloproteinase expression in an experimentally-induced DTH model of multiple sclerosis in the rat CNSQ36897642
Mechanisms of disease: sodium channels and neuroprotection in multiple sclerosis-current statusQ37070221
Virtual hypoxia and chronic necrosis of demyelinated axons in multiple sclerosisQ37398059
Overexpression of mitochondrial Hsp70/Hsp75 protects astrocytes against ischemic injury in vitro.Q38786382
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
P304page(s)262847
P577publication date2011-02-08
P13046publication type of scholarly workreview articleQ7318358
P1433published inAutoimmune DiseasesQ26842451
P1476titleMitochondria as crucial players in demyelinated axons: lessons from neuropathology and experimental demyelination
Mitochondria as Crucial Players in Demyelinated Axons: Lessons from Neuropathology and Experimental Demyelination
P478volume2011

Reverse relations

cites work (P2860)
Q33689103Aging-related changes of optic nerve of Wistar albino rats
Q91642009Brain atrophy in multiple sclerosis: mechanisms, clinical relevance and treatment options
Q35856138Cell type-specific Nrf2 expression in multiple sclerosis lesions.
Q36570149Cerebrospinal fluid lactate is associated with multiple sclerosis disease progression
Q53410201Combined effects of rat Schwann cells and 17β-estradiol in a spinal cord injury model.
Q92369012Distinctive functional deficiencies in axonal conduction associated with two forms of cerebral white matter injury
Q34831961Is a hypothetical melanoma-like neuromelanin the underlying factor essential for the aetiopathogenesis and clinical manifestations of multiple sclerosis?
Q49161838Newly lesioned tissue in multiple sclerosis--a role for oxidative damage?
Q35910495Nuclear export inhibitors avert progression in preclinical models of inflammatory demyelination
Q41886918Paradigms in multiple sclerosis: time for a change, time for a unifying concept
Q46290321Protective effects of melatonin against mitochondrial injury in a mouse model of multiple sclerosis

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