The thrombopoietin/MPL pathway in hematopoiesis and leukemogenesis

scientific article published on June 2011

The thrombopoietin/MPL pathway in hematopoiesis and leukemogenesis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1002/JCB.23089
P8608Fatcat IDrelease_txdnsszahrfjbc22n6bw7a3q2y
P698PubMed publication ID21360575
P5875ResearchGate publication ID50229536

P2093author name stringFu-Sheng Chou
James C Mulloy
P2860cites workPromotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietinQ24316187
Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamilyQ24564819
c-mpl mutations are the cause of congenital amegakaryocytic thrombocytopeniaQ28141146
A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitorsQ28243227
Mpl receptor defect leads to earlier appearance of hematopoietic cells/hematopoietic stem cells in the Aorta-Gonad-Mesonephros region, with increased apoptosisQ28504451
Circulating thrombopoietin as an in vivo growth factor for blast cells in acute myeloid leukemiaQ33369381
Posttransplant thrombopoiesis predicts survival in patients undergoing autologous hematopoietic progenitor cell transplantationQ33375947
Congenital amegakaryocytic thrombocytopenia-3 novel c-MPL mutations and their phenotypic correlationsQ33377857
Thrombocytopenia in c-mpl-deficient miceQ33491977
Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylationQ34207417
AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesisQ34299077
MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasiaQ34770384
Thrombopoietin induces HOXA9 nuclear transport in immature hematopoietic cells: potential mechanism by which the hormone favorably affects hematopoietic stem cellsQ35663894
Hematopoietic stem cell deficiencies in mice lacking c-Mpl, the receptor for thrombopoietin.Q35800066
Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype.Q35847967
The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potentialQ36375771
Sustained ex vivo expansion of hematopoietic stem cells mediated by thrombopoietinQ36417126
AML1/RUNX1 works as a negative regulator of c-Mpl in hematopoietic stem cellsQ37142554
Runx1 is required for the endothelial to haematopoietic cell transition but not thereafterQ37347018
Combined administration of recombinant human megakaryocyte growth and development factor and granulocyte colony-stimulating factor enhances multilineage hematopoietic reconstitution in nonhuman primates after radiation-induced marrow aplasiaQ37354699
Balancing dormant and self-renewing hematopoietic stem cellsQ37610592
Thrombopoietin expands hematopoietic stem cells after transplantationQ39738286
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche.Q39997716
Continuous expression of Bcl-xL protein during megakaryopoiesis is post-translationally regulated by thrombopoietin-mediated Akt activation, which prevents the cleavage of Bcl-xL.Q40153818
Antiapoptotic protein Bcl-x(L) is up-regulated during megakaryocytic differentiation of CD34(+) progenitors but is absent from senescent megakaryocytes.Q40802790
cMpl ligand is a humoral regulator of megakaryocytopoiesisQ41460906
Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivoQ41460916
The human stem cell hierarchy is defined by a functional dependence on Mcl-1 for self-renewal capacityQ43043792
MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patientsQ44008600
Thrombopoietin stimulates Hoxb4 expression: an explanation for the favorable effects of TPO on hematopoietic stem cells.Q46003161
The role of apoptosis in the development of AGM hematopoietic stem cells revealed by Bcl-2 overexpression.Q47205774
Dual role of Mpl receptor during the establishment of definitive hematopoiesis.Q50894334
MPLW515L mutation in acute megakaryoblastic leukaemia.Q53313140
A prototype nonpeptidyl, hydrazone class, thrombopoietin receptor agonist, SB-559457, is toxic to primary human myeloid leukemia cells.Q53362508
Obligate role of anti-apoptotic MCL-1 in the survival of hematopoietic stem cells.Q54679983
Critical Role of Thrombopoietin in Maintaining Adult Quiescent Hematopoietic Stem CellsQ57362319
P433issue6
P921main subjecthemopoiesisQ919283
P304page(s)1491-1498
P577publication date2011-06-01
P1433published inJournal of Cellular BiochemistryQ6294917
P1476titleThe thrombopoietin/MPL pathway in hematopoiesis and leukemogenesis
P478volume112

Reverse relations

cites work (P2860)
Q35952453Blockade of Thrombopoietin Reduces Organ Damage in Experimental Endotoxemia and Polymicrobial Sepsis
Q44026903CD34 Antigen and the MPL Receptor Expression Defines a Novel Class of Human Cord Blood-Derived Primitive Hematopoietic Stem Cells
Q37599843DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells
Q33414087Eltrombopag can overcome the anti-megakaryopoietic effects of lenalidomide without increasing proliferation of the malignant myelodysplastic syndrome/acute myelogenous leukemia clone
Q33401421Eltrombopag inhibits the proliferation of leukemia cells via reduction of intracellular iron and induction of differentiation
Q24626423Exome sequencing identifies MPL as a causative gene in familial aplastic anemia
Q21296679Hematopoietic stem cell development, niches, and signaling pathways
Q39016705Identification of a new Mpl-interacting protein, Atp5d
Q26779936Inflammation as a Driver of Clonal Evolution in Myeloproliferative Neoplasm
Q36413813Inhibition of poly(ADP-ribose) polymerase 1 protects against acute myeloid leukemia by suppressing the myeloproliferative leukemia virus oncogene
Q42244901Interleukin-2-regulatory T cell axis critically regulates maintenance of hematopoietic stem cells.
Q42315227Kras is Required for Adult Hematopoiesis
Q38266904Signal, transduction, and the hematopoietic stem cell
Q36356216TWIST-1 promotes cell growth, drug resistance and progenitor clonogenic capacities in myeloid leukemia and is a novel poor prognostic factor in acute myeloid leukemia
Q34737531The thrombopoietin receptor, MPL, is critical for development of a JAK2V617F-induced myeloproliferative neoplasm
Q21296645Thrombopoietin as biomarker and mediator of cardiovascular damage in critical diseases
Q41090525Transcriptome Analysis of Minimal Residual Disease in Subtypes of Pediatric B Cell Acute Lymphoblastic Leukemia
Q37194990VEGF controls lung Th2 inflammation via the miR-1-Mpl (myeloproliferative leukemia virus oncogene)-P-selectin axis.
Q41672333Whole genome gene expression changes and hematological effects of rikkunshito in patients with advanced non-small cell lung cancer receiving first line chemotherapy.

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