Role of Ca2(+)-ATPases in regulation of cellular Ca2+ signalling, as studied with the selective microsomal Ca2(+)-ATPase inhibitor, thapsigargin

scientific article published on January 1990

Role of Ca2(+)-ATPases in regulation of cellular Ca2+ signalling, as studied with the selective microsomal Ca2(+)-ATPase inhibitor, thapsigargin is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1007/BF01964706
P698PubMed publication ID2139301

P2093author name stringO Thastrup
P2860cites workMolecular cloning of cDNAs from human kidney coding for two alternatively spliced products of the cardiac Ca2+-ATPase geneQ24293009
Complete primary structure of a human plasma membrane Ca2+ pumpQ28281426
Two Ca2+ ATPase genes: homologies and mechanistic implications of deduced amino acid sequencesQ28285061
A model for receptor-regulated calcium entryQ29620427
Analysis of the stimulative effect of thapsigargin, a non-TPA-type tumour promoter, on arachidonic acid metabolism in rat peritoneal macrophagesQ35755607
Electrophoretic separation of different phophosproteins associated with Ca-ATPase and Na, K-ATPase in human red cell ghostsQ36388698
Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPaseQ37726811
Inositol phosphates: proliferation, metabolism and functionQ39472079
Thapsigargine and thapsigargicine, two new histamine liberators from Thapsia garganica L.Q39499707
Intracellular calcium homeostasisQ39664946
Effects of adenosine 3':5'-monophosphate-dependent protein kinase on sarcoplasmic reticulum isolated from cardiac and slow and fast contracting skeletal musclesQ39974338
Phosphodiesterase protein activator mimics red blood cell cytoplasmic activator of (Ca2+-Mg2+)ATPaseQ40096871
Partial purification of the Ca2+-Mg2+ ATPase activator from human erythrocytes: Its similarity to the activator of 3′:5′ — cyclic nucleotide phosphodiesteraseQ40096880
Phosphorylation of the Sarcoplasmic Reticulum and SarcolemmaQ40129114
Control of calcium channels by membrane receptors in the rat parotid glandQ40160626
The calcium mobilizing tumor promoting agent, thapsigargin elevates the platelet cytoplasmic free calcium concentration to a higher steady state level. A possible mechanism of action for the tumor promotionQ41354984
Effects of affinity-purified antibodies on the Ca2+ pumping ATPase of erythrocyte membranesQ41537450
A novel tumour promoter, thapsigargin, transiently increases cytoplasmic free Ca2+ without generation of inositol phosphates in NG115-401L neuronal cellsQ41989793
Cyclic GMP regulation of the plasma membrane (Ca2+-Mg2+)ATPase in vascular smooth muscleQ42099473
Topology of the erythrocyte Ca2+ pump. A monoclonal antibody against the almost inaccessible extracellular faceQ42115883
Inhibition by glucagon of the calcium pump in liver plasma membranes.Q42447324
Thapsigargin, a new calcium-dependent epithelial anion secretagogueQ42491884
Ca2+-transport ATPases of vascular smooth muscleQ42506236
Identification of a novel inflammatory stimulant of chondrocytes. Early events in cell activation by bradykinin receptors on pig articular chondrocytesQ42835801
Micro-injection of inositol 1,3,4,5-tetrakisphosphate activates sea urchin eggs by a mechanism dependent on external Ca2+.Q42855151
Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentrationQ43500706
Purification and properties of an adenosine triphosphatase from sarcoplasmic reticulum.Q43558757
Kinetics of Calcium Transport by Fragmented Sarcoplasmic ReticulumQ44477274
Thrombin-induced calcium movements in platelet activationQ45332682
Structure of the rabbit fast-twitch skeletal muscle Ca2+-ATPase geneQ48325905
Amino-acid sequence of a Ca2+ + Mg2+-dependent ATPase from rabbit muscle sarcoplasmic reticulum, deduced from its complementary DNA sequenceQ48376136
The phosphorylation of the membranal protein of the sarcoplasmic vesicles during active calcium transport.Q54317459
Regulation of Ca2+-pumping ATPase of heart sarcolemma by a phosphorylation-dephosphorylation ProcessQ54530616
Thapsigargin, a histamine secretagogue, is a non-12-O-tetradecanolphorbol-13-acetate (TPA) type tumor promoter in two-stage mouse skin carcinogenesisQ60307112
Phosphorylation of the Ca2+-pumping ATPase of heart sarcolemma and erythrocyte plasma membrane by the cAMP-dependent protein kinaseQ67299240
Evidence for the presence of phospholamban in the endoplasmic reticulum of smooth muscleQ68876665
Agonists stimulate divalent cation channels in the plasma membrane of human plateletsQ68934091
Ca2+ transients and Mn2+ entry in human neutrophils induced by thapsigarginQ69266225
Activation of calcium entry by the tumor promoter thapsigargin in parotid acinar cells. Evidence that an intracellular calcium pool and not an inositol phosphate regulates calcium fluxes at the plasma membraneQ69517251
Thapsigargin, a novel molecular probe for studying intracellular calcium release and storageQ69741696
Inositol trisphosphate and the contraction of vascular smooth muscle cellsQ69994649
Carbachol partially inhibits the plasma-membrane Ca2+-pump in microsomes from pig stomach smooth muscleQ70046506
Guanine nucleotide-, and inositol triphosphate-induced inhibition of the CA2+ pump in rat heart sarcolemmal vesiclesQ70055555
ATP-dependent calcium transport in rat parotid basolateral membrane vesicles is modulated by membrane potentialQ70058445
Effects of cAMP- and cGMP-dependent protein kinases, and calmodulin on Ca2+ uptake by highly purified sarcolemmal vesicles of vascular smooth muscleQ70217199
The inflammatory and tumor-promoting sesquiterpene lactone, thapsigargin, activates platelets by selective mobilization of calcium as shown by protein phosphorylationsQ70315193
Effect of thapsigargin on cytoplasmic Ca2+ and proliferation of human lymphocytes in relation to AIDSQ70412772
The Ca2+-pumping ATPase of heart sarcolemma. Characterization, calmodulin dependence, and partial purificationQ70541563
Acidic phospholipids, unsaturated fatty acids, and limited proteolysis mimic the effect of calmodulin on the purified erythrocyte Ca2+ - ATPaseQ70551986
Vasopressin-, angiotensin II-, and alpha 1-adrenergic-induced inhibition of Ca2+ transport by rat liver plasma membrane vesiclesQ71260765
Studies on the mechanism of thyroid hormone stimulation of human red cell Ca2+-ATPase activityQ72927382
P433issue1-2
P304page(s)8-15
P577publication date1990-01-01
P1433published inAgents and ActionsQ23928727
P1476titleRole of Ca2(+)-ATPases in regulation of cellular Ca2+ signalling, as studied with the selective microsomal Ca2(+)-ATPase inhibitor, thapsigargin
P478volume29

Reverse relations

cites work (P2860)
Q42706522A novel P2-purinoceptor expressed by a subpopulation of astrocytes from the dorsal spinal cord of the rat.
Q51681198A patch-clamp study of the Ca2+ mobilization from internal stores in bovine aortic endothelial cells. II. Effects of thapsigargin on the cellular Ca2+ homeostasis
Q51746429ARTC1-mediated ADP-ribosylation of GRP78/BiP: a new player in endoplasmic-reticulum stress responses.
Q34468601Ability of various bombesin receptor agonists and antagonists to alter intracellular signaling of the human orphan receptor BRS-3.
Q36888627Actions of 4-chloro-3-ethyl phenol on internal Ca2+ stores in vascular smooth muscle and endothelial cells
Q36329586Activation by calcium alone of chloride secretion in T84 epithelial cells
Q36707078Activation of P2-purinoreceptors triggered Ca2+ release from InsP3-sensitive internal stores in mammalian oligodendrocytes.
Q39249023Activation of calcium oscillations by thapsigargin in parotid acinar cells
Q24791208Activation of tumor necrosis factor receptor 1 in airway smooth muscle: a potential pathway that modulates bronchial hyper-responsiveness in asthma?
Q90431820Age attenuates the T-type CaV 3.2-RyR axis in vascular smooth muscle
Q36361292Alpha 2-adrenergic inhibition of Cl- transport by opercular epithelium is mediated by intracellular Ca2+.
Q54183390Altered prostacyclin synthesis by aortae from hepatic portal vein-constricted rats: evidence for effects on protein kinase C and calcium.
Q72136348Biphasic increase in cytosolic free calcium induced by bradykinin and histamine in cultured tracheal smooth muscle cells: is the sustained phase artifactual?
Q35874675Blockade of the inward rectifier potassium current by the Ca(2+)-ATPase inhibitor 2',5'-di(tert-butyl)-1,4-benzohydroquinone (BHQ)
Q46583093Buffering of calcium influx by sarcoplasmic reticulum during the action potential in guinea-pig ventricular myocytes.
Q42015156Ca2+ increase and Ca(2+)-influx in human tracheal smooth muscle cells: role of Ca2+ pools controlled by sarco-endoplasmic reticulum Ca(2+)-ATPase 2 isoform.
Q41882090Ca2+ release from platelet intracellular stores by thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone: relationship to Ca2+ pools and relevance in platelet activation
Q35880695Cadmium Induces Apoptosis in Freshwater Crab Sinopotamon henanense through Activating Calcium Signal Transduction Pathway
Q41254445Caffeine-induced oscillations of cytosolic Ca2+ in GH3 pituitary cells are not due to Ca2+ release from intracellular stores but to enhanced Ca2+ influx through voltage-gated Ca2+ channels
Q37299501Calcineurin-mediated dephosphorylation of eNOS at serine 116 affects eNOS enzymatic activity indirectly by facilitating c-Src binding and tyrosine 83 phosphorylation
Q50707896Calcium movements during pigment aggregation in freshwater shrimp chromatophores.
Q33758134Calcium signaling in lacrimal glands
Q36736005Calcium waves and dynamics visualized by confocal microscopy in Xenopus oocytes expressing cloned TRH receptors
Q35764275Calcium- and CaMKII-dependent chloride secretion induced by the microsomal Ca(2+)-ATPase inhibitor 2,5-di-(tert-butyl)-1,4-hydroquinone in cystic fibrosis pancreatic epithelial cells
Q77789555Calcium-induced calcium release contributes to action potential-evoked calcium transients in hippocampal CA1 pyramidal neurons
Q41286003Capacitative Ca2+ entry contributes to the Ca2+ influx induced by thyrotropin-releasing hormone (TRH) in GH3 pituitary cells
Q42832658Capacitative Ca2+ entry regulates Ca(2+)-sensitive adenylyl cyclases
Q46658408Changes in guinea pig gallbladder smooth muscle Ca2+ homeostasis by acute acalculous cholecystitis
Q36714973Confocal fluorescence microscopy for studying thapsigargin-induced bivalent-cation entry into B cells
Q41153142Coupling between intracellular Ca2+ stores and the Ca2+ permeability of the plasma membrane. Comparison of the effects of thapsigargin, 2,5-di-(tert-butyl)-1,4-hydroquinone, and cyclopiazonic acid in rat thymic lymphocytes
Q35532621Cytokines induce airway smooth muscle cell hyperresponsiveness to contractile agonists
Q72641136Cytosolic calcium homeostasis in bovine parathyroid cells and its modulation by protein kinase C
Q67901375Demonstration of two forms of calcium pumps by thapsigargin inhibition and radioimmunoblotting in platelet membrane vesicles
Q36293994Dense core secretory vesicles revealed as a dynamic Ca(2+) store in neuroendocrine cells with a vesicle-associated membrane protein aequorin chimaera.
Q42158948Dephosphorylation of the catenins p120 and p100 in endothelial cells in response to inflammatory stimuli
Q42859231Design, Synthesis, and Development of Novel Guaianolide-Endoperoxides as Potential Antimalarial Agents
Q42714168Differential changes of adrenoceptor- and muscarinic receptor-linked prostacyclin synthesis by the aorta and urinary bladder of the diabetic rat
Q42466369Dissociation of intracellular Ca2+ release and Ca2+ entry response to 5-hydroxytryptamine in cultured canine tracheal smooth muscle cells
Q73271710Distinct calcium signaling within neuronal growth cones and filopodia
Q42815562Econazole inhibits thapsigargin-induced platelet calcium influx by mechanisms other than cytochrome P-450 inhibition
Q31032792Effect of dialkyl phthalates on the degranulation and Ca2+ response of RBL-2H3 mast cells
Q67463861Effect of thapsigargin and caffeine on Ca2+ homeostasis in HeLa cells: implications for histamine-induced Ca2+ oscillations
Q70951160Effects of 2,5-di(tert-butyl)-1,4-hydroquinone on intracellular free Ca2+ levels and histamine secretion in RBL-2H3 cells
Q42459718Effects of intracellular stores and extracellular Ca(2+) on Ca(2+)-activated K(+) currents in mature mouse inner hair cells
Q40871436Effects of low concentrations of paraoxon on Ca(2+) mobilization in a human parotid salivary cell-line HSY.
Q42439104Effects of salbutamol on intracellular calcium oscillations in porcine airway smooth muscle.
Q71956370Effects of three different Ca(2+)-ATPase inhibitors on Ca2+ response and leukotriene release in RBL-2H3 cells
Q46703385Endothelin-1 increases intracellular Ca(2+) in rabbit pulmonary artery smooth muscle cells through phospholipase C.
Q28653191G-protein-coupled receptor controls steroid hormone signaling in cell membrane
Q34992302Gene targeting and Calcium handling efficiencies in mouse embryonic stem cell lines.
Q73744732Germacranolides from seeds of the endangered Umbelliferae species Rouya polygama
Q105125286Guaiane esters from Thapsia villosa
Q71616708Histamine-evoked Ca2+ oscillations in HeLa cells are sensitive to methylxanthines but insensitive to ryanodine
Q40794013Hypotonic swelling-induced Ca(2+) release by an IP(3)-insensitive Ca(2+) store
Q40931948Imaging Ca2+ concentration changes at the secretory vesicle surface with a recombinant targeted cameleon
Q35874247Importance of inositol (1,4,5)-trisphosphate, intracellular Ca2+ release and myofilament Ca2+ sensitization in 5-hydroxytryptamine-evoked contraction of rabbit mesenteric artery
Q42485248Increase in [Ca2+]i by CCh in adult rat sympathetic neurons are not dependent on intracellular Ca2+ pools
Q41927811Inhibition by SK&F96365 of NO-mediated relaxation induced by Ca2(+) -ATPase inhibitors in rat thoracic aorta
Q52583141Inhibition by diallyl trisulfide, a garlic component, of intracellular Ca(2+) mobilization without affecting inositol-1,4, 5-trisphosphate (IP(3)) formation in activated platelets.
Q42862501Inhibition of adenylate cyclase by Ca(2+)--a counterpart to stimulation by Ca2+/calmodulin
Q41817246Inhibition of calcium release from the sarcoplasmic reticulum of rabbit aorta by hydralazine
Q73375412Inhibition of interleukin-8-activated human neutrophil chemotaxis by thapsigargin in a calcium- and cyclic AMP-dependent way
Q42796428Inhibition of protein synthesis and early protein processing by thapsigargin in cultured cells
Q35437144Intracellular Ca(2+) release from endoplasmic reticulum regulates slow wave currents and pacemaker activity of interstitial cells of Cajal
Q52509408Intracellular mechanisms of cytoplasmic Ca2+ oscillation in rat megakaryocyte
Q42810038Intraluminal calcium of the liver endoplasmic reticulum stimulates the glucuronidation of p-nitrophenol
Q42442713Involvement of both calcium influx and calcium mobilization in growth hormone-induced [Ca2+]i increases in Chinese hamster ovary cells
Q42076086Ionomycin activates electrogenic Ca2+ influx in rat thymic lymphocytes
Q33817828Linkages between the life-history evolution of tropical and temperate birds and the resistance of cultured skin fibroblasts to oxidative and non-oxidative chemical injury.
Q41615535Manipulation of intracellular calcium in NCB-20 cells
Q28578393Maturation and secretion of rat hepatic lipase is inhibited by alpha1B-adrenergic stimulation through changes in Ca2+ homoeostasis: thapsigargin and EGTA both mimic the effect of adrenaline
Q48657675Mechanisms for stimulation of rat anterior pituitary cells by arginine and other amino acids.
Q42439161Mechanisms involved in ATP-evoked Ca2+ oscillations in isolated human granulosa-luteal cells.
Q41006785Mechanisms of spontaneous cytosolic Ca2+ transients in differentiated human neuronal cells
Q48381613Migration and Phagocytic Ability of Activated Microglia During Post-natal Development is Mediated by Calcium-Dependent Purinergic Signalling
Q42104901Mobilization of Ca2+ by thapsigargin and 2,5-di-(t-butyl)-1,4-benzohydroquinone in permeabilized insulin-secreting RINm5F cells: evidence for separate uptake and release compartments in inositol 1,4,5-trisphosphate-sensitive Ca2+ pool
Q54045147Modulation of K+ and Ca2+ channels by histamine H1-receptor stimulation in rabbit coronary artery cells.
Q40339148Multiple G-protein-dependent pathways mediate the antisecretory effects of somatostatin and clonidine in the HT29-19A colonic cell line
Q31841611Müller cell Ca2+ waves evoked by purinergic receptor agonists in slices of rat retina
Q77998315N-acetyl-sphingenine-1-phosphate is a potent calcium mobilizing agent
Q42115637Noradrenaline release from rat sympathetic neurones triggered by activation of B2 bradykinin receptors
Q44237492Norepinephrine induces slow calcium signalling in murine brown preadipocytes through the beta-adrenoceptor/cAMP/protein kinase A pathway.
Q42843308Nucleotides control the excitability of sensory neurons via two P2Y receptors and a bifurcated signaling cascade.
Q28362742PKC- and ERK-dependent activation of I kappa B kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor-mediated CaMK activation
Q42069272Phospholipase D activation by P2Z-purinoceptor agonists in human lymphocytes is dependent on bivalent cation influx
Q41947092Propofol regulation of calcium entry pathways in cultured A10 and rat aortic smooth muscle cells
Q46720202Prostaglandin production by guinea-pig endometrial cells: effects of caffeine and other modulators of intracellular calcium
Q41671501Reciprocal photolabile O2 consumption and chemoreceptor excitation by carbon monoxide in the cat carotid body: evidence for cytochrome a3 as the primary O2 sensor
Q30577176Reduced IRE1α mediates apoptotic cell death by disrupting calcium homeostasis via the InsP3 receptor.
Q31919919Regulation of slow wave frequency by IP(3)-sensitive calcium release in the murine small intestine
Q36697553Role of Inositol Phosphates in the Actions of Substance P on NK1Receptors in Exocrine Gl and Cells
Q53929863Role of different Ca2+ sources in the superoxide production of human neutrophil granulocytes.
Q46683752Role of intracellular Ca2+ stores in smooth muscle contractions of the guinea pig vas deferens
Q71871655Role of intracellular calcium stores in contrast medium-induced renal vasoconstriction
Q33608788Role of the Bcl-2 gene family in prostate cancer progression and its implications for therapeutic intervention
Q36548599Rotaviruses induce an early membrane permeabilization of MA104 cells and do not require a low intracellular Ca2+ concentration to initiate their replication cycle.
Q39870438Selective depletion of stored calcium by thapsigargin blocks rotavirus maturation but not the cytopathic effect.
Q36809348Selective inhibition of oxalate-stimulated Ca2+ transport by cyclopiazonic acid and thapsigargin in smooth muscle microsomes
Q40719850Stretch-induced Ca(2+) release via an IP(3)-insensitive Ca(2+) channel
Q46734598Studies on the mechanism of spasmolytic activity of (O-methyl-)-N-(2,6-dihydroxybenzoyl)tyramine, a constituent of Aniba riparia (Nees) Mez. (Lauraceae), in rat uterus, rabbit aorta and guinea-pig alveolar leucocytes
Q42160237Thapsigargin activates univalent- and bivalent-cation entry in human neutrophils by a SK&F I3 96365- and Gd3+-sensitive pathway and is a partial secretagogue: involvement of pertussis-toxin-sensitive G-proteins and protein phosphatases 1/2A and 2B i
Q67852231Thapsigargin inhibits contraction and Ca2+ transient in cardiac cells by specific inhibition of the sarcoplasmic reticulum Ca2+ pump
Q41665432Thapsigargin inhibits the sarcoplasmic or endoplasmic reticulum Ca-ATPase family of calcium pumps
Q42708089Thapsigargin- and cyclopiazonic acid-induced endothelium-dependent hyperpolarization in rat mesenteric artery
Q36730684Thapsigargin-induced nuclear calcium signals in rat basophilic leukaemia cells
Q71823786The Brefeldin A-induced Retrograde Transport from the Golgi Apparatus to the Endoplasmic Reticulum Depends on Calcium Sequestered to Intracellular Stores
Q36441999The Capacitative Model for Receptor-Activated Calcium Entry
Q93216435The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections
Q38092648The antibody-drug conjugate: an enabling modality for natural product-based cancer therapeutics
Q37361151The antifungal antibiotic, clotrimazole, inhibits Cl- secretion by polarized monolayers of human colonic epithelial cells
Q41485717The isoquinoline derivative LOE 908 selectively blocks vasopressin-activated nonselective cation currents in A7r5 aortic smooth muscle cells
Q67899761The role of intracellular Ca2+ in the regulation of the plasma membrane Ca2+ permeability of unstimulated rat lymphocytes
Q35870580The rotavirus nonstructural glycoprotein NSP4 possesses membrane destabilization activity.
Q41656954The thapsigargin-sensitive intracellular Ca2+ pool is more important in plasma membrane Ca2+ entry than the IP3-sensitive intracellular Ca2+ pool in neuronal cell lines
Q33735095Unlike the synchronous Plasmodium falciparum and P. chabaudi infection, the P. berghei and P. yoelii asynchronous infections are not affected by melatonin
Q72192495Veratridine-induced oscillations of cytosolic calcium and membrane potential in bovine chromaffin cells
Q87422754Zip14 expression induced by lipopolysaccharides in macrophages attenuates inflammatory response
Q54046400[Calcium and liver]