The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review

scientific article published on 26 February 2011

The emerging role of P-glycoprotein inhibitors in drug delivery: a patent review is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1517/13543776.2011.561784
P698PubMed publication ID21413912

P50authorSushama TalegaonkarQ59185733
Abdul AhadQ38546475
Farhan J. AhmadQ42182005
Mohd AqilQ42413205
P2093author name stringNaseem Akhtar
Zeenat Iqbal
Manu Jaggi
Roop Kishan Khar
P2860cites workEffect of PSC 833 liposomes and Intralipid on the transport of epirubicin in Caco-2 cells and rat intestinesQ43725876
Effects of nonionic surfactants on membrane transporters in Caco-2 cell monolayersQ44123431
Toxicologic and pharmacokinetic study of low doses of verapamil combined with doxorubicin.Q44199622
Effect of P-glycoprotein modulator, cyclosporin A, on the gastrointestinal excretion of irinotecan and its metabolite SN-38 in ratsQ44485062
Comparison of cyclosporin A, verapamil, PSC-833 and cremophor EL as enhancing agents of VP-16 in murine lymphoid leukemiasQ44525292
Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivoQ44907372
In vivo evaluation of P-glycoprotein and breast cancer resistance protein modulation in the brain using [(11)C]gefitinibQ46073165
Effect of P-glycoprotein inhibitor, verapamil, on oral bioavailability and pharmacokinetics of irinotecan in ratsQ46168447
Inhibition of P-glycoprotein function and expression by kaempferol and quercetin.Q46436186
Enhanced oral paclitaxel absorption with vitamin E-TPGS: effect on solubility and permeability in vitro, in situ and in vivoQ46487609
The value of the MDR1 reversal agent PSC-833 in addition to daunorubicin and cytarabine in the treatment of elderly patients with previously untreated acute myeloid leukemia (AML), in relation to MDR1 status at diagnosisQ46580597
Glutathione and thiolated chitosan inhibit multidrug resistance P-glycoprotein activity in excised small intestineQ46867532
Influence of vitamin E TPGS poly(ethylene glycol) chain length on apical efflux transporters in Caco-2 cell monolayersQ46892593
Modulation of intestinal P-glycoprotein function by polyethylene glycols and their derivatives by in vitro transport and in situ absorption studies.Q46962350
Reversal of resistance by GF120918 in cell lines expressing the ABC half-transporter, MXR.Q52171281
Resistance modification by PSC-833, a novel non-immunosuppressive cyclosporin AQ54307469
Development and in vivo evaluation of an oral drug delivery system for paclitaxelQ57355646
The study of innate drug resistance of human hepatocellular carcinoma Bel7402 cell lineQ33177639
Pharmacological strategies for overcoming multidrug resistanceQ33997660
Distribution of gefitinib to the brain is limited by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2)-mediated active effluxQ34028148
Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugsQ34060806
P-glycoprotein inhibitors and their screening: a perspective from bioavailability enhancementQ35193762
Multidrug resistance reversal agentsQ35570886
Structural understanding of efflux-mediated drug resistance: potential routes to efflux inhibitionQ35879831
Does inhibition of P-glycoprotein lead to drug-drug interactions?Q36069281
The molecular basis of multidrug resistance in cancer: the early years of P-glycoprotein researchQ36365560
Mechanisms and strategies to overcome multiple drug resistance in cancerQ36404538
Multidrug resistance: retrospect and prospects in anti-cancer drug treatment.Q36536479
A primer on the mechanics of P-glycoprotein the multidrug transporter.Q36649234
How can we best use structural information on P-glycoprotein to design inhibitors?Q36701490
Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitorQ36788463
Availability and applications of ATP-binding cassette (ABC) transporter blockersQ36830826
Dose-response assessment of tariquidar and elacridar and regional quantification of P-glycoprotein inhibition at the rat blood-brain barrier using (R)-[(11)C]verapamil PET.Q36949815
Natural and synthetic polymers as inhibitors of drug efflux pumpsQ36951710
Development of inhibitors of ATP-binding cassette drug transporters: present status and challengesQ37076348
Structure-activity relationships of tariquidar analogs as multidrug resistance modulatorsQ37510736
Chemical penetration enhancers: a patent reviewQ37529814
Novel formulation approaches for optimising delivery of anticancer drugs based on P-glycoprotein modulation.Q37569156
Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological, and diagnostic potentialsQ37635094
Reversion of multidrug resistance by co-encapsulation of vincristine and verapamil in PLGA nanoparticlesQ39843746
Phase II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with chemotherapy-resistant, advanced breast carcinomaQ40409946
Synthesis and evaluation of dihydropyrroloquinolines that selectively antagonize P-glycoproteinQ40582869
A comparison of commonly used polyethoxylated pharmaceutical excipients on their ability to inhibit P-glycoprotein activity in vitroQ40706801
Effects of ketoconazole on digoxin absorption and disposition in rat.Q41027740
Design and in vitro evaluation of a novel polymeric P-glycoprotein (P-gp) inhibitorQ42984640
Cyclosporin A inhibits the extrusion pump function of p-glycoprotein in the inner ear of mice treated with vinblastine and doxorubicinQ43614799
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectdrug deliveryQ1392806
P304page(s)561-576
P577publication date2011-02-26
P1433published inExpert Opinion on Therapeutic PatentsQ5421213
P1476titleThe emerging role of P-glycoprotein inhibitors in drug delivery: a patent review
P478volume21