Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2.

scientific article published on May 2011

Regulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2. is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1042/BJ20101996
P698PubMed publication ID21486225

P2093author name stringShazib Pervaiz
Shefali Krishna
Ivan Cherh Chiet Low
P2860cites workbcl-2-immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferationQ41964290
Production of reactive oxygen species by mitochondria: central role of complex III.Q42163292
Intracellular acidification triggered by mitochondrial-derived hydrogen peroxide is an effector mechanism for drug-induced apoptosis in tumor cellsQ43507848
The cyclin-dependent kinase inhibitor flavopiridol induces apoptosis in human leukemia cells (U937) through the mitochondrial rather than the receptor-mediated pathwayQ43682235
Decrease in intracellular superoxide sensitizes Bcl-2-overexpressing tumor cells to receptor and drug-induced apoptosis independent of the mitochondriaQ44534499
Resveratrol inhibits drug-induced apoptosis in human leukemia cells by creating an intracellular milieu nonpermissive for death executionQ44769951
LY303511 enhances TRAIL sensitivity of SHEP-1 neuroblastoma cells via hydrogen peroxide-mediated mitogen-activated protein kinase activation and up-regulation of death receptorsQ45866584
ABT-737, a BH3 mimetic, induces glutathione depletion and oxidative stress.Q46031094
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joiningQ48375088
Connected to death: the (unexpurgated) mitochondrial pathway of apoptosis.Q50751772
Hydrogen peroxide-mediated cytosolic acidification is a signal for mitochondrial translocation of Bax during drug-induced apoptosis of tumor cells.Q53880972
Mechanisms of mitochondrial membrane permeabilizationQ57082831
Cell Death in DevelopmentQ67531415
Vaccinia virus anti-apoptotic F1L is a novel Bcl-2-like domain-swapped dimer that binds a highly selective subset of BH3-containing death ligandsQ24321449
The Bcl-2 apoptotic switch in cancer development and therapyQ24620437
Autocrine gastrins in colon cancer cells Up-regulate cytochrome c oxidase Vb and down-regulate efflux of cytochrome c and activation of caspase-3Q28142107
p53 regulates mitochondrial respirationQ28242400
Involvement of cytochrome c oxidase subunits Va and Vb in the regulation of cancer cell metabolism by Bcl-2Q28261611
Assembly of cytochrome-c oxidase in cultured human cellsQ28276105
Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cellsQ28294137
Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and deathQ28363890
Two CD95 (APO-1/Fas) signaling pathwaysQ29619631
Bcl-2 functions in an antioxidant pathway to prevent apoptosisQ29620401
Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeuticsQ29620467
Mitochondrial proteome: altered cytochrome c oxidase subunit levels in prostate cancerQ30981892
Ras, superoxide and signal transductionQ33541041
Mitochondrial outer membrane permeabilization during apoptosis: the innocent bystander scenarioQ33995987
Phagocyte recognition of cells undergoing apoptosisQ34355692
A permissive apoptotic environment: function of a decrease in intracellular superoxide anion and cytosolic acidificationQ34506501
Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cellsQ35153635
The BCL-2 family reunionQ35568029
Cancer metabolism: facts, fantasy, and fictionQ35617179
Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptideQ35931968
Redox mechanisms of cytoprotection by Bcl-2.Q36038217
Generation of superoxide by the mitochondrial Complex I.Q36469867
Bcl-2-family proteins and hematologic malignancies: history and future prospectsQ36508817
p53: new roles in metabolismQ36811794
Tumor-targeted induction of oxystress for cancer therapyQ36900213
Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak.Q37191994
BCL-2: pro-or anti-oxidant?Q37501953
Adenine nucleotide translocase: a component of the phylogenetically conserved cell death machineryQ37583572
Bcl-2 modulates resveratrol-induced ROS production by regulating mitochondrial respiration in tumor cellsQ39718930
Bcr-Abl-mediated redox regulation of the PI3K/AKT pathwayQ39871422
Bcl-2 induces pro-oxidant state by engaging mitochondrial respiration in tumor cellsQ40131176
Superoxide and hydrogen peroxide in relation to mammalian cell proliferationQ40525865
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectmitochondrionQ39572
P304page(s)545-551
P577publication date2011-05-01
P1433published inBiochemical JournalQ864221
P1476titleRegulation of mitochondrial metabolism: yet another facet in the biology of the oncoprotein Bcl-2.
P478volume435

Reverse relations

cites work (P2860)
Q36299600A novel SAHA-bendamustine hybrid induces apoptosis of leukemia cells
Q33422819Adipose-Derived Mesenchymal Stem Cells (ADSCs) With the Potential to Ameliorate Platelet Recovery, Enhance Megakaryopoiesis, and Inhibit Apoptosis of Bone Marrow Cells in a Mouse Model of Radiation-Induced Thrombocytopenia
Q36028480Amino-Nogo-A antagonizes reactive oxygen species generation and protects immature primary cortical neurons from oxidative toxicity
Q34964332Apoptotic and autophagic effects of Sesbania grandiflora flowers in human leukemic cells
Q38025197BCL-2 family of proteins and mammary cellular fate
Q26775888Bcl-2 family proteins as regulators of cancer cell invasion and metastasis: a review focusing on mitochondrial respiration and reactive oxygen species
Q28392561Bcl-xL-mediated remodeling of rod and cone synaptic mitochondria after postnatal lead exposure: electron microscopy, tomography and oxygen consumption
Q35009440Beyond cell death - antiapoptotic Bcl-2 proteins regulate migration and invasion of colorectal cancer cells in vitro
Q39395916CS055 (Chidamide/HBI-8000), a novel histone deacetylase inhibitor, induces G1 arrest, ROS-dependent apoptosis and differentiation in human leukaemia cells
Q38132083Cadmium and cellular signaling cascades: interactions between cell death and survival pathways
Q36100952Celecoxib and Bcl-2: emerging possibilities for anticancer drug design
Q38032497Central roles of apoptotic proteins in mitochondrial function.
Q26822419Ceramide-induced apoptosis in renal tubular cells: a role of mitochondria and sphingosine-1-phoshate
Q92254268Chromatin restriction by the nucleosome remodeler Mi-2β and functional interplay with lineage-specific transcription regulators control B-cell differentiation
Q37301710Cinobufagin inhibits tumor growth by inducing intrinsic apoptosis through AKT signaling pathway in human nonsmall cell lung cancer cells
Q39195722Combination of a novel HDAC inhibitor OBP-801/YM753 and a PI3K inhibitor LY294002 synergistically induces apoptosis in human endometrial carcinoma cells due to increase of Bim with accumulation of ROS.
Q36121785D(-)lentiginosine-induced apoptosis involves the intrinsic pathway and is p53-independent
Q58776042Effects of chidamide and its combination with decitabine on proliferation and apoptosis of leukemia cell lines
Q39352649Genetic damage, but limited evidence of oxidative stress markers in diethyl maleate-induced glutathione depleted mouse lymphoma L5178Y (TK(+/-)) cell cultures
Q34693392High concentrations of L-ascorbic acid specifically inhibit the growth of human leukemic cells via downregulation of HIF-1α transcription.
Q28483005Implications of altered glutathione metabolism in aspirin-induced oxidative stress and mitochondrial dysfunction in HepG2 cells
Q35750142Lipoic acid decreases Mcl-1, Bcl-xL and up regulates Bim on ovarian carcinoma cells leading to cell death
Q55517384Marine bisindole alkaloid: A potential apoptotic inducer in human cancer cells.
Q36602853MicroRNAs and Glucocorticoid-Induced Apoptosis in Lymphoid Malignancies
Q38638197Mitochondrial Retrograde Signaling: Triggers, Pathways, and Outcomes
Q42501190Multiplicity-dependent activation of a serine protease-dependent cytomegalovirus-associated programmed cell death pathway
Q36896218Natural compounds as regulators of the cancer cell metabolism
Q38172397Noxa in rheumatic diseases: present understanding and future impact
Q26998478Oxygen in human health from life to death--An approach to teaching redox biology and signaling to graduate and medical students
Q38746890Protein phosphatase 2A Cα regulates proliferation, migration, and metastasis of osteosarcoma cells
Q41612674Puerarin increases the chemosensitivity of hepatocellular carcinoma cells
Q40071681Quercetin-mediated synthesis of graphene oxide-silver nanoparticle nanocomposites: a suitable alternative nanotherapy for neuroblastoma
Q36646486Redox control of leukemia: from molecular mechanisms to therapeutic opportunities
Q61800083Role of FOXO3 Activated by HIV-1 Tat in HIV-Associated Neurocognitive Disorder Neuronal Apoptosis
Q48255378Salvianolic acid A, a novel PI3K/Akt inhibitor, induces cell apoptosis and suppresses tumor growth in acute myeloid leukemia.
Q33612421The Bcl-2/xL inhibitor ABT-263 increases the stability of Mcl-1 mRNA and protein in hepatocellular carcinoma cells
Q28389285The copper chelator ATN-224 induces caspase-independent cell death in diffuse large B cell lymphoma
Q28382968The copper chelator ATN-224 induces peroxynitrite-dependent cell death in hematological malignancies
Q38164707Viruses as modulators of mitochondrial functions
Q55441110Vitamin C in Cancer: A Metabolomics Perspective.
Q38180818Xenobiotic effects in the ovary: temporary versus permanent infertility

Search more.