Pairing phosphoinositides with calcium ions in endolysosomal dynamics: phosphoinositides control the direction and specificity of membrane trafficking by regulating the activity of calcium channels in the endolysosomes

scientific article published on 28 April 2011

Pairing phosphoinositides with calcium ions in endolysosomal dynamics: phosphoinositides control the direction and specificity of membrane trafficking by regulating the activity of calcium channels in the endolysosomes is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1002/BIES.201000152
P932PMC publication ID3107950
P698PubMed publication ID21538413
P5875ResearchGate publication ID51094368

P2093author name stringXiang Wang
Haoxing Xu
Dongbiao Shen
P2860cites workPIP2 increases the speed of response of synaptotagmin and steers its membrane-penetration activity toward the plasma membrane.Q55038004
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VAC14 nucleates a protein complex essential for the acute interconversion of PI3P and PI(3,5)P(2) in yeast and mouseQ24318746
EEA1 links PI(3)K function to Rab5 regulation of endosome fusionQ24322668
Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter releaseQ24611697
The phosphoinositide kinase PIKfyve is vital in early embryonic development: preimplantation lethality of PIKfyve-/- embryos but normality of PIKfyve+/- miceQ24618677
Assembly of a Fab1 phosphoinositide kinase signaling complex requires the Fig4 phosphoinositide phosphataseQ24643186
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Fusion of lysosomes with late endosomes produces a hybrid organelle of intermediate density and is NSF dependentQ24678109
Loss of Vac14, a regulator of the signaling lipid phosphatidylinositol 3,5-bisphosphate, results in neurodegeneration in mice.Q24678783
The Vac14p-Fig4p complex acts independently of Vac7p and couples PI3,5P2 synthesis and turnoverQ24683845
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Ca2+/calmodulin signals the completion of docking and triggers a late step of vacuole fusion.Q27935567
Svp1p defines a family of phosphatidylinositol 3,5-bisphosphate effectorsQ27936381
Internal Ca(2+) release in yeast is triggered by hypertonic shock and mediated by a TRP channel homologueQ27938797
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Endocytic delivery to lysosomes mediated by concurrent fusion and kissing events in living cells.Q50777337
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Plasma membrane repair is mediated by Ca(2+)-regulated exocytosis of lysosomesQ28572060
PI(3,5)P2 controls membrane trafficking by direct activation of mucolipin Ca2+ release channels in the endolysosomeQ29543488
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Endocytic recyclingQ29547737
Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulumQ29614500
Retrograde transport from endosomes to the trans-Golgi networkQ29617826
The emerging shape of the ESCRT machineryQ29620787
Compartmental signal modulation: Endosomal phosphatidylinositol 3-phosphate controls endosome morphology and selective cargo sorting.Q30478189
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TPCs: Endolysosomal channels for Ca2+ mobilization from acidic organelles triggered by NAADPQ33840138
Lysosome-endosome fusion and lysosome biogenesis.Q33883540
HOPS initiates vacuole docking by tethering membranes before trans-SNARE complex assemblyQ33948566
TRP channels of intracellular membranesQ34001734
Phosphoinositides function asymmetrically for membrane fusion, promoting tethering and 3Q-SNARE subcomplex assemblyQ34386086
Phosphatidylinositol 3,5-bisphosphate defines a novel PI 3-kinase pathway in resting mouse fibroblastsQ34427650
Osmotic stress activates phosphatidylinositol-3,5-bisphosphate synthesisQ34446025
The lysosome turns fiftyQ34447595
Two di-leucine motifs regulate trafficking of mucolipin-1 to lysosomesQ34478343
Phosphoinositide 5-phosphatase Fig 4p is required for both acute rise and subsequent fall in stress-induced phosphatidylinositol 3,5-bisphosphate levelsQ34512579
Mucolipin-2 localizes to the Arf6-associated pathway and regulates recycling of GPI-APsQ34657408
Phagosome maturation: aging gracefullyQ34682299
Mechanisms of membrane fusion: disparate players and common principles.Q34780589
Niemann-Pick disease type C1 is a sphingosine storage disease that causes deregulation of lysosomal calciumQ34866369
Deleterious variants of FIG4, a phosphoinositide phosphatase, in patients with ALS.Q34913669
Phosphatidylinositol 3,5-bisphosphate and Fab1p/PIKfyve underPPIn endo-lysosome functionQ34959368
Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytesQ34990714
Defective autophagy in neurons and astrocytes from mice deficient in PI(3,5)P2.Q35005794
Regulation of presynaptic calcium channels by synaptic proteinsQ35165594
Calcium and calmodulin in membrane fusionQ35197974
Calcium: a fundamental regulator of intracellular membrane fusion?Q35658408
Phosphoinositides in constitutive membrane traffic.Q35842974
Cell biology of mycobacterium tuberculosis phagosome.Q35912811
An enzymatic cascade of Rab5 effectors regulates phosphoinositide turnover in the endocytic pathwayQ36320962
Trans-SNARE interactions elicit Ca2+ efflux from the yeast vacuole lumenQ36322360
Role of phosphatidylinositol 3-kinase and Rab5 effectors in phagosomal biogenesis and mycobacterial phagosome maturation arrestQ36377580
Mutations in phosphoinositide metabolizing enzymes and human diseaseQ36402106
Regulation of epithelial ion channels by Rab GTPasesQ36644799
Phosphatidylinositol 4,5-bisphosphate regulates SNARE-dependent membrane fusionQ36790508
Autophagic dysfunction in mucolipidosis type IV patientsQ36835710
Lysosomes: fusion and functionQ36885390
PIP2 is a necessary cofactor for ion channel function: how and why?Q37197976
Deficiency of MIP/MTMR14 phosphatase induces a muscle disorder by disrupting Ca(2+) homeostasisQ37219948
Function and dysfunction of the PI system in membrane trafficking.Q37266145
Caenorhabditis elegans functional orthologue of human protein h-mucolipin-1 is required for lysosome biogenesisQ37357908
Phosphatidylinositol metabolism and membrane fusionQ37386315
Identification of the penta-EF-hand protein ALG-2 as a Ca2+-dependent interactor of mucolipin-1.Q37479337
Tethering factors as organizers of intracellular vesicular trafficQ37540143
Cholesterol involvement in the pathogenesis of neurodegenerative diseases.Q37574307
Coordination of membrane events during autophagy by multiple class III PI3-kinase complexesQ37606853
Acquisition of Hrs, an essential component of phagosomal maturation, is impaired by mycobacteriaQ37732047
Lysosomal storage disease: revealing lysosomal function and physiology.Q37739706
Membrane fusion: five lipids, four SNAREs, three chaperones, two nucleotides, and a Rab, all dancing in a ring on yeast vacuolesQ37762546
Endolysosomal calcium regulation and diseaseQ37813734
TRPM2 functions as a lysosomal Ca2+-release channel in beta cellsQ39849413
Mucolipin-1 is a lysosomal membrane protein required for intracellular lactosylceramide trafficQ40231477
Membrane perforations inhibit lysosome fusion by altering pH and calcium in Listeria monocytogenes vacuolesQ40293294
Salmonella modulates vesicular traffic by altering phosphoinositide metabolismQ40531614
Class III phosphoinositide 3-kinase--Beclin1 complex mediates the amino acid-dependent regulation of autophagy in C2C12 myotubes.Q40635710
Multivesicular body morphogenesis requires phosphatidyl-inositol 3-kinase activityQ40980700
Motor deficit in a Drosophila model of mucolipidosis type IV due to defective clearance of apoptotic cells.Q42254064
Protein kinase B phosphorylation of PIKfyve regulates the trafficking of GLUT4 vesicles.Q42823479
Calcium uptake via endocytosis with rapid release from acidifying endosomes.Q42823932
The role of intraorganellar Ca(2+) in late endosome-lysosome heterotypic fusion and in the reformation of lysosomes from hybrid organellesQ42919564
Regulation of PIKfyve phosphorylation by insulin and osmotic stressQ43049902
P433issue6
P407language of work or nameEnglishQ1860
P304page(s)448-457
P577publication date2011-04-28
P1433published inBioEssaysQ4914614
P1476titlePairing phosphoinositides with calcium ions in endolysosomal dynamics: phosphoinositides control the direction and specificity of membrane trafficking by regulating the activity of calcium channels in the endolysosomes
P478volume33

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cites work (P2860)
Q38359528A New Perspective of Lysosomal Cation Channel-Dependent Homeostasis in Alzheimer's Disease
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Q37557563Autophagy maturation associated with CD38-mediated regulation of lysosome function in mouse glomerular podocytes
Q38202209Ca(2+) signals, NAADP and two-pore channels: role in cellular differentiation
Q35771431Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion
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Q33653667Lysosomal exocytosis and lipid storage disorders
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Q59354303NAADP-dependent Ca signaling regulates Middle East respiratory syndrome-coronavirus pseudovirus translocation through the endolysosomal system
Q36595827PIPing on lysosome tubes
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Q37409739Regulation of mTORC1 by lysosomal calcium and calmodulin.
Q38123475Regulation of membrane trafficking by signalling on endosomal and lysosomal membranes
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