| review article | Q7318358 |
| scholarly article | Q13442814 |
| P2093 | author name string | Ajit P Yoganathan | |
| Kartik Balachandran | |||
| Philippe Sucosky | |||
| P2860 | cites work | A novel flex-stretch-flow bioreactor for the study of engineered heart valve tissue mechanobiology. | Q30452677 |
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| Differential immediate-early gene responses to elevated pressure in porcine aortic valve interstitial cells. | Q33434821 | ||
| The effects of combined cyclic stretch and pressure on the aortic valve interstitial cell phenotype | Q33787707 | ||
| Altered shear stress stimulates upregulation of endothelial VCAM-1 and ICAM-1 in a BMP-4- and TGF-beta1-dependent pathway | Q33787801 | ||
| Experimental measurement of dynamic fluid shear stress on the aortic surface of the aortic valve leaflet | Q33849850 | ||
| Experimental measurement of dynamic fluid shear stress on the ventricular surface of the aortic valve leaflet | Q33862860 | ||
| Elevated cyclic stretch induces aortic valve calcification in a bone morphogenic protein-dependent manner | Q33947156 | ||
| Clinical practice. Evaluation and management of chronic mitral regurgitation | Q34362727 | ||
| Clinical factors associated with calcific aortic valve disease. Cardiovascular Health Study | Q34418948 | ||
| Axial flow velocity patterns in a normal human pulmonary artery model: pulsatile in vitro studies | Q34513070 | ||
| Advances towards understanding heart valve response to injury. | Q34588824 | ||
| Differences in valvular and vascular cell responses to strain in osteogenic media | Q34590497 | ||
| Spatial heterogeneity of endothelial phenotypes correlates with side-specific vulnerability to calcification in normal porcine aortic valves. | Q34670503 | ||
| Deficiency of cathepsin S reduces atherosclerosis in LDL receptor-deficient mice | Q34967612 | ||
| The cardiac valve interstitial cell | Q35024662 | ||
| Functional structure and composition of the extracellular matrix | Q35170426 | ||
| An ex vivo study of the biological properties of porcine aortic valves in response to circumferential cyclic stretch | Q35230128 | ||
| Design and validation of a novel splashing bioreactor system for use in mitral valve organ culture. | Q35547713 | ||
| Novel approaches to cardiac valve repair: from structure to function: Part I. | Q35679284 | ||
| Cardiac valve calcification: characteristics of patients with calcification of the mitral annulus or aortic valve | Q35843017 | ||
| Endothelin-1 and the aortic valve | Q81401477 | ||
| Extracellular matrix remodelling in human aortic valve disease: the role of matrix metalloproteinases and their tissue inhibitors | Q81644115 | ||
| Neuronal regulation of aortic valve cusps | Q83197693 | ||
| Cyclic strain inhibits acute pro-inflammatory gene expression in aortic valve interstitial cells | Q84302609 | ||
| Fluid mechanics of aortic stenosis | Q36421627 | ||
| Pathogenesis of calcific aortic valve disease: a disease process comes of age (and a good deal more). | Q36482441 | ||
| Correlation of endothelial cell shape and wall shear stress in a stenosed dog aorta | Q36492778 | ||
| Valvulogenesis: the moving target | Q36849680 | ||
| The emerging role of valve interstitial cell phenotypes in regulating heart valve pathobiology | Q36933045 | ||
| Mechanobiology of the aortic heart valve | Q37118688 | ||
| Mitral leaflet adaptation to ventricular remodeling: occurrence and adequacy in patients with functional mitral regurgitation | Q37143009 | ||
| Active adaptation of the tethered mitral valve: insights into a compensatory mechanism for functional mitral regurgitation. | Q37362986 | ||
| Expression of the elastolytic cathepsins S and K in human atheroma and regulation of their production in smooth muscle cells | Q37384330 | ||
| The next frontier in cardiovascular developmental biology--an integrated approach to adult disease? | Q40249222 | ||
| Multimodality molecular imaging identifies proteolytic and osteogenic activities in early aortic valve disease. | Q40251686 | ||
| Matrix metalloproteinases and cardiovascular disease | Q40410789 | ||
| Connective tissue and repair in the heart. Potential regulatory mechanisms | Q40528455 | ||
| Synergistic effects of cyclic tension and transforming growth factor-beta1 on the aortic valve myofibroblast | Q40640217 | ||
| Interstitial cells from the atrial and ventricular sides of the bovine mitral valve respond differently to denuding endocardial injury | Q40725072 | ||
| The mechanism of opening of the aortic valve | Q41579295 | ||
| Regional analysis of dynamic deformation characteristics of native aortic valve leaflets | Q41847890 | ||
| Human Aortic Valve Calcification Is Associated With an Osteoblast Phenotype | Q41950206 | ||
| Biosynthetic activity in heart valve leaflets in response to in vitro flow environments | Q42511408 | ||
| Organ culture as a tool to identify early mechanisms of serotonergic valve disease | Q42835724 | ||
| Vasoactive agents alter the biomechanical properties of aortic heart valve leaflets in a time-dependent manner. | Q43121219 | ||
| Aortic valve sclerosis and aortic atherosclerosis: different manifestations of the same disease? Insights from a population-based study | Q43723164 | ||
| Endothelium-dependent regulation of the mechanical properties of aortic valve cusps | Q43813007 | ||
| Influence of 5-hydroxytryptamine on aortic valve competence in vitro | Q43839813 | ||
| Progression of aortic valve stenosis: TGF-beta1 is present in calcified aortic valve cusps and promotes aortic valve interstitial cell calcification via apoptosis | Q44329666 | ||
| Unique morphology and focal adhesion development of valvular endothelial cells in static and fluid flow environments. | Q44875056 | ||
| Calcific aortic stenosis--time to look more closely at the valve | Q46348662 | ||
| Aortic valve sclerosis is associated with preclinical cardiovascular disease in hypertensive adults: the Hypertension Genetic Epidemiology Network study | Q46388296 | ||
| Effects of constant static pressure on the biological properties of porcine aortic valve leaflets | Q47675713 | ||
| Dynamic deformation characteristics of porcine aortic valve leaflet under normal and hypertensive conditions | Q48831205 | ||
| Cyclic pressure and shear stress regulate matrix metalloproteinases and cathepsin activity in porcine aortic valves. | Q51118260 | ||
| Collagen synthesis by mesenchymal stem cells and aortic valve interstitial cells in response to mechanical stretch. | Q51188903 | ||
| Valvular endothelial cells regulate the phenotype of interstitial cells in co-culture: effects of steady shear stress. | Q51211040 | ||
| A collagen-glycosaminoglycan co-culture model for heart valve tissue engineering applications. | Q51313795 | ||
| Design of a sterile organ culture system for the ex vivo study of aortic heart valves. | Q51330667 | ||
| Normal physiological conditions maintain the biological characteristics of porcine aortic heart valves: an ex vivo organ culture study. | Q51362579 | ||
| Cyclic pressure affects the biological properties of porcine aortic valve leaflets in a magnitude and frequency dependent manner. | Q51557689 | ||
| Microfabricated arrays for high-throughput screening of cellular response to cyclic substrate deformation. | Q51560966 | ||
| Calcification by valve interstitial cells is regulated by the stiffness of the extracellular matrix. | Q51756063 | ||
| Neonatal and adult cardiovascular pathophysiological remodeling and repair: developmental role of periostin. | Q51960827 | ||
| In vitro determination of the curvatures and bending strains acting on the leaflets of polyurethane trileaflet heart valves during leaflet motion. | Q52870870 | ||
| Transforming growth factor-beta1 mechanisms in aortic valve calcification: increased alkaline phosphatase and related events. | Q53570521 | ||
| Valvular calcification and its relationship to atherosclerosis in chronic kidney disease | Q57914668 | ||
| Elevated cyclic stretch alters matrix remodeling in aortic valve cusps: implications for degenerative aortic valve disease | Q64355515 | ||
| Bone Morphogenic Protein-4 Induces Hypertension in Mice | Q64355523 | ||
| Bone Morphogenic Protein 4 Produced in Endothelial Cells by Oscillatory Shear Stress Stimulates an Inflammatory Response | Q64355527 | ||
| Cathepsin L deficiency reduces diet-induced atherosclerosis in low-density lipoprotein receptor-knockout mice. | Q64885339 | ||
| Primary tissue failure in pericardial heart valves | Q69235338 | ||
| Mechanical effects on endothelial cell morphology: in vitro assessment | Q69620316 | ||
| Stress sharing between the sinus and leaflets of canine aortic valve | Q69635630 | ||
| Tissue and cell renewal in the natural aortic valve of rats: an autoradiographic study | Q70902856 | ||
| The cyclic changes and structure of the base of the aortic valve | Q71130862 | ||
| Actin filament stress fibers in vascular endothelial cells in vivo | Q71227976 | ||
| Characterization of the early lesion of 'degenerative' valvular aortic stenosis. Histological and immunohistochemical studies | Q71636568 | ||
| Age-dependent changes in the radial stretch of human aortic valve leaflets determined by biaxial testing | Q71986535 | ||
| Biaxial strain analysis of the porcine aortic valve | Q71986667 | ||
| Structural alterations in heart valves during left ventricular pressure overload in the rat | Q72083683 | ||
| Helical and retrograde secondary flow patterns in the aortic arch studied by three-directional magnetic resonance velocity mapping | Q72560623 | ||
| Collagen synthesis is upregulated in mitral valves subjected to altered stress | Q73342017 | ||
| Bone formation and inflammation in cardiac valves | Q73635711 | ||
| Receptor-mediated contraction of aortic valve leaflets | Q73691268 | ||
| Activated interstitial myofibroblasts express catabolic enzymes and mediate matrix remodeling in myxomatous heart valves | Q77198147 | ||
| Correlation between heart valve interstitial cell stiffness and transvalvular pressure: implications for collagen biosynthesis | Q81125654 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P921 | main subject | hemodynamics | Q1642137 |
| inflammation | Q101991 | ||
| aorta | Q101004 | ||
| P304 | page(s) | 263870 | |
| P577 | publication date | 2011-07-06 | |
| P1433 | published in | International Journal of Inflammation | Q26854008 |
| P1476 | title | Hemodynamics and mechanobiology of aortic valve inflammation and calcification | |
| P478 | volume | 2011 |
| Q37717699 | 4D flow imaging with MRI |
| Q89859244 | A multilayered valve leaflet promotes cell-laden collagen type I production and aortic valve hemodynamics |
| Q51034936 | A survey of membrane receptor regulation in valvular interstitial cells cultured under mechanical stresses. |
| Q64268885 | Adaptation of a Mice Doppler Echocardiography Platform to Measure Cardiac Flow Velocities for Embryonic Chicken and Adult Zebrafish |
| Q33767188 | Aortic valve: mechanical environment and mechanobiology |
| Q35190489 | Architectural trends in the human normal and bicuspid aortic valve leaflet and its relevance to valve disease. |
| Q38086380 | Biomechanical factors in the biology of aortic wall and aortic valve diseases |
| Q51182113 | Biomedical modeling: the role of transport and mechanics. |
| Q38259727 | Cardiac valve cells and their microenvironment--insights from in vitro studies |
| Q51347743 | Computational comparison of regional stress and deformation characteristics in tricuspid and bicuspid aortic valve leaflets. |
| Q27318417 | Coronary Flow Impacts Aortic Leaflet Mechanics and Aortic Sinus Hemodynamics |
| Q37240362 | Critical Role of Coaptive Strain in Aortic Valve Leaflet Homeostasis: Use of a Novel Flow Culture Bioreactor to Explore Heart Valve Mechanobiology |
| Q55317084 | Cross Talk between NOTCH Signaling and Biomechanics in Human Aortic Valve Disease Pathogenesis. |
| Q42664882 | Culturing Mouse Cardiac Valves in the Miniature Tissue Culture System |
| Q36943806 | Current progress in tissue engineering of heart valves: multiscale problems, multiscale solutions |
| Q35078393 | Defining the role of fluid shear stress in the expression of early signaling markers for calcific aortic valve disease |
| Q90573880 | Deletion of calponin 2 attenuates the development of calcific aortic valve disease in ApoE-/- mice |
| Q47317443 | Developing a Clinically Relevant Tissue Engineered Heart Valve-A Review of Current Approaches. |
| Q42290144 | Evaluation of Whole Blood Viscosity in Patients with Aortic Sclerosis |
| Q31106131 | Ex vivo evidence for the contribution of hemodynamic shear stress abnormalities to the early pathogenesis of calcific bicuspid aortic valve disease |
| Q45344936 | Fully coupled fluid-structure interaction model of congenital bicuspid aortic valves: effect of asymmetry on hemodynamics |
| Q102075292 | Geometry influences inflammatory host cell response and remodeling in tissue-engineered heart valves in-vivo |
| Q90347771 | Impact of Aortoseptal Angle Abnormalities and Discrete Subaortic Stenosis on Left-Ventricular Outflow Tract Hemodynamics: Preliminary Computational Assessment |
| Q50852526 | Is Transcatheter Aortic Valve Implantation of Living Tissue-Engineered Valves Feasible? An In Vitro Evaluation Utilizing a Decellularized and Reseeded Biohybrid Valve. |
| Q90644868 | Materials and manufacturing perspectives in engineering heart valves: a review |
| Q37323329 | Mechanobiology in Cardiovascular Disease Management: Potential Strategies and Current Needs |
| Q36851326 | Noggin attenuates the osteogenic activation of human valve interstitial cells in aortic valve sclerosis |
| Q47234951 | Off-the-shelf tissue engineered heart valves for in situ regeneration: current state, challenges and future directions |
| Q99408896 | Oscillatory fluid-induced mechanobiology in heart valves with parallels to the vasculature |
| Q48013383 | Phenotype Transformation of Aortic Valve Interstitial Cells Due to Applied Shear Stresses Within a Microfluidic Chip. |
| Q61798847 | Quest for cardiovascular interventions: precise modeling and 3D printing of heart valves |
| Q48124901 | RNA expression profile of calcified bicuspid, tricuspid, and normal human aortic valves by RNA sequencing |
| Q35137484 | Reciprocal interactions between mitral valve endothelial and interstitial cells reduce endothelial-to-mesenchymal transition and myofibroblastic activation. |
| Q52771993 | Reversal of myofibroblastic activation by polyunsaturated fatty acids in valvular interstitial cells from aortic valves. Role of RhoA/G-actin/MRTF signalling. |
| Q57818857 | Role of TGF-β1 Signaling in Heart Valve Calcification Induced by Abnormal Mechanical Stimulation in a Tissue Engineering Model |
| Q36110798 | Spatial expression of components of a calcitonin receptor-like receptor (CRL) signalling system (CRL, calcitonin gene-related peptide, adrenomedullin, adrenomedullin-2/intermedin) in mouse and human heart valves |
| Q49215602 | Systolic hypertension and progression of aortic valve calcification in patients with aortic stenosis: results from the PROGRESSA study |
| Q50110073 | The Contribution of Whole Blood Viscosity to the Process of Aortic Valve Sclerosis |
| Q59136506 | The Genetic Regulation of Aortic Valve Development and Calcific Disease |
| Q58566343 | The effect of heparin hydrogel embedding on glutaraldehyde fixed bovine pericardial tissues: Mechanical behavior and anticalcification potential |
| Q37082556 | The pathology and pathobiology of bicuspid aortic valve: State of the art and novel research perspectives |
| Q46536538 | The presence of fructosamine in human aortic valves is associated with valve stiffness |
| Q64894259 | The roles of inflammatory mediators and immunocytes in tendinopathy. |
| Q40757486 | Three-dimensional macro-scale assessment of regional and temporal wall shear stress characteristics on aortic valve leaflets. |
| Q42373907 | Valve interstitial cell contractile strength and metabolic state are dependent on its shape |
| Q64355502 | miR-214 is Stretch-Sensitive in Aortic Valve and Inhibits Aortic Valve Calcification |
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