High chromosome number in hematological cancer cell lines is a negative predictor of response to the inhibition of Aurora B and C by GSK1070916.

scientific article published on 15 July 2011

High chromosome number in hematological cancer cell lines is a negative predictor of response to the inhibition of Aurora B and C by GSK1070916. is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1045473420
P356DOI10.1186/1479-5876-9-110
P932PMC publication ID3146841
P698PubMed publication ID21762492
P5875ResearchGate publication ID51495788

P50authorKurt BachmanQ56884608
Christopher M MoyQ57417181
Junping JingQ114779503
Joel GreshockQ114779505
Yan Y DegenhardtQ114779509
Mary Ann HardwickeQ114779510
Richard WoosterQ37061916
P2093author name stringRamona Plant
Catherine A Oleykowski
P2860cites workCell line-based platforms to evaluate the therapeutic efficacy of candidate anticancer agentsQ37714306
Notch activation is associated with tetraploidy and enhanced chromosomal instability in meningiomasQ38526539
Discovery of N-phenyl-4-(thiazol-5-yl)pyrimidin-2-amine aurora kinase inhibitorsQ39704729
Discovery of GSK1070916, a potent and selective inhibitor of Aurora B/C kinaseQ39710753
Aurora-A gene is frequently amplified in basal-like breast cancer.Q39757054
Analysis of Aurora B kinase in non-Hodgkin lymphomaQ39788234
PHA-680626 exhibits anti-proliferative and pro-apoptotic activity on Imatinib-resistant chronic myeloid leukemia cell lines and primary CD34+ cells by inhibition of both Bcr-Abl tyrosine kinase and Aurora kinasesQ39976723
Simultaneous targeting of Aurora kinases and Bcr-Abl kinase by the small molecule inhibitor PHA-739358 is effective against imatinib-resistant BCR-ABL mutations including T315I.Q40014063
PHA-739358, a potent inhibitor of Aurora kinases with a selective target inhibition profile relevant to cancer.Q40033870
Activity of the Aurora kinase inhibitor VX-680 against Bcr/Abl-positive acute lymphoblastic leukemiasQ40491709
AT9283, a potent inhibitor of the Aurora kinases and Jak2, has therapeutic potential in myeloproliferative disordersQ43052731
GSK1070916, a potent Aurora B/C kinase inhibitor with broad antitumor activity in tissue culture cells and human tumor xenograft models.Q45945470
Biochemical characterization of GSK1070916, a potent and selective inhibitor of Aurora B and Aurora C kinases with an extremely long residence time1.Q46089532
Inhibitors of ABL and the ABL-T315I mutationQ46450465
Effects of the aurora kinase inhibitors AZD1152-HQPA and ZM447439 on growth arrest and polyploidy in acute myeloid leukemia cell lines and primary blastsQ46681619
Scaling properties of the two-dimensional randomly stirred Navier-Stokes equationQ51903971
Dynamic localization and functional implications of Aurora-C kinase during male mouse meiosisQ52029921
A novel treatment strategy targeting Aurora kinases in acute myelogenous leukemiaQ53332866
Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer.Q53381806
Tetraploidy and tumor developmentQ53649343
Array comparative genomic hybridization reveals distinct DNA copy number differences between gastrointestinal stromal tumors and leiomyosarcomasQ80283497
AZD1152, a novel and selective aurora B kinase inhibitor, induces growth arrest, apoptosis, and sensitization for tubulin depolymerizing agent or topoisomerase II inhibitor in human acute leukemia cells in vitro and in vivoQ80313902
[Chromosomal translocation t(8,21) in acute myeloid leukemia of children: prognostic value of additional karyotype abnormalities]Q84318119
INCENP is required for proper targeting of Survivin to the centromeres and the anaphase spindle during mitosisQ24291596
The COSMIC (Catalogue of Somatic Mutations in Cancer) database and websiteQ24645514
Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeuticsQ27851412
Notch signalling regulates stem cell numbers in vitro and in vivoQ28248390
A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancersQ28272347
The interactive online SKY/M-FISH & CGH database and the Entrez cancer chromosomes search database: linkage of chromosomal aberrations with the genome sequenceQ34016358
VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivoQ34300737
Targeting Aurora kinases for the treatment of prostate cancerQ34567584
Aurora kinases as anticancer drug targetsQ34762466
Molecular diagnostics in acute leukemiasQ35007333
G1 tetraploidy checkpoint and the suppression of tumorigenesisQ35063578
G2 and spindle assembly checkpoint adaptation, and tetraploidy arrest: implications for intrinsic and chemically induced genomic instabilityQ35595545
Overexpression of aurora B kinase (AURKB) in primary non-small cell lung carcinoma is frequent, generally driven from one allele, and correlates with the level of genetic instabilityQ36615322
Aurora kinase inhibitors: a new class of targeted drugs in cancerQ36616719
Clinically useful prognostic factors in acute myeloid leukemiaQ36998146
Molecular diagnostics in chronic lymphocytic leukemia - pathogenetic and clinical implicationsQ37152757
Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detectionQ37288945
Lymphomas with concurrent BCL2 and MYC translocations: the critical factors associated with survivalQ37351043
Adult Burkitt lymphoma: advances in diagnosis and treatment.Q37365569
Danusertib (formerly PHA-739358)--a novel combined pan-Aurora kinases and third generation Bcr-Abl tyrosine kinase inhibitorQ37674234
P275copyright licenseCreative Commons Attribution 2.0 GenericQ19125117
P6216copyright statuscopyrightedQ50423863
P921main subjectchromosome numberQ54031484
P304page(s)110
P577publication date2011-07-15
P1433published inJournal of Translational MedicineQ15716664
P1476titleHigh chromosome number in hematological cancer cell lines is a negative predictor of response to the inhibition of Aurora B and C by GSK1070916.
P478volume9

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cites work (P2860)
Q38223271Aurora kinase inhibitor patents and agents in clinical testing: an update (2011 - 2013).
Q38030445Mitotic failures in cancer: Aurora B kinase and its potential role in the development of aneuploidy
Q38756932The Aurora kinase inhibitors in cancer research and therapy

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