Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics

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Genetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1035561820
P356DOI10.1038/NRC2230
P3181OpenCitations bibliographic resource ID60596
P698PubMed publication ID17891190

P50authorElías CampoQ5830202
Dolors ColomerQ43096016
Pedro JaresQ58035979
P2860cites workThe Bcl-2 apoptotic switch in cancer development and therapyQ24620437
The DNA damage response: putting checkpoints in perspectiveQ28131713
Phosphorylation-dependent regulation of cyclin D1 nuclear export and cyclin D1-dependent cellular transformationQ28140810
Antitumor activity of rituximab plus thalidomide in patients with relapsed/refractory mantle cell lymphomaQ28263800
Minireview: Cyclin D1: normal and abnormal functionsQ28279069
Dimethyl sulfoxide to vorinostat: development of this histone deacetylase inhibitor as an anticancer drugQ28282479
Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localizationQ28290083
HDACs, histone deacetylation and gene transcription: from molecular biology to cancer therapeuticsQ28290352
ATM and related protein kinases: safeguarding genome integrityQ29547735
Cyclins and cancer. II: Cyclin D and CDK inhibitors come of ageQ29618409
Functional interactions of the retinoblastoma protein with mammalian D-type cyclinsQ29618856
The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locusQ29619815
Mantle cell lymphoma. A proposal for unification of morphologic, immunologic, and molecular dataQ30951567
In situ localization of follicular lymphoma: description and analysis by laser capture microdissectionQ31049018
Relevance of cyclin D1b expression and CCND1 polymorphism in the pathogenesis of multiple myeloma and mantle cell lymphomaQ33259459
Indolent mantle cell lymphoma with nodal involvement and mutated immunoglobulin heavy chain genesQ33357506
Phase II study of proteasome inhibitor bortezomib in relapsed or refractory B-cell non-Hodgkin's lymphomaQ33364240
Phase II clinical experience with the novel proteasome inhibitor bortezomib in patients with indolent non-Hodgkin's lymphoma and mantle cell lymphomaQ33364244
Partial uniparental disomy: a recurrent genetic mechanism alternative to chromosomal deletion in malignant lymphomaQ61312250
Molecular diagnosis of t(11;14) in mantle cell lymphoma using two-colour interphase fluorescence in situ hybridizationQ71127548
A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal diseaseQ73062440
t(11;14)-positive mantle cell lymphomas exhibit complex karyotypes and share similarities with B-cell chronic lymphocytic leukemiaQ73459806
Spatial proximity of translocation-prone gene loci in human lymphomasQ73531485
Visualization of mono-allelic chromosomal aberrations 3′ and 5′ of the cyclin D1 gene in mantle cell lymphoma using DNA fiber fluorescence in situ hybridizationQ73903411
Blastic mantle cell lymphoma associated with Burkitt‐type translocation and hypodiploidyQ77231041
Cyclin D1/PRAD1/BCL-1 alternative transcript [B] protein product in B-lymphoid malignancies with t(11;14)(q13;q32) translocationQ77392061
Mutations of Chk2 in primary hematopoietic neoplasmsQ77929239
Expression of Mcl-1 in mantle cell lymphoma is associated with high-grade morphology, a high proliferative state, and p53 overexpressionQ78634781
Mantle cell lymphomas with clonal immunoglobulin V(H)3-21 gene rearrangements exhibit fewer genomic imbalances than mantle cell lymphomas utilizing other immunoglobulin V(H) genesQ80347650
Novel chromosomal imbalances in mantle cell lymphoma detected by genome-wide array-based comparative genomic hybridizationQ80894677
Association between acquired uniparental disomy and homozygous gene mutation in acute myeloid leukemiasQ81362541
TRAIL receptor-selective mutants signal to apoptosis via TRAIL-R1 in primary lymphoid malignanciesQ81631545
Comparison of chemical inhibitors of antiapoptotic Bcl-2-family proteinsQ83215997
Cyclin D1 splice variants. Differential effects on localization, RB phosphorylation, and cellular transformationQ42801826
ATM gene inactivation in mantle cell lymphoma mainly occurs by truncating mutations and missense mutations involving the phosphatidylinositol-3 kinase domain and is associated with increasing numbers of chromosomal imbalancesQ43833429
Seventy-two hour continuous infusion flavopiridol in relapsed and refractory mantle cell lymphomaQ44086086
Histopathology, cell proliferation indices and clinical outcome in 304 patients with mantle cell lymphoma (MCL): a clinicopathological study from the European MCL NetworkQ44135718
CHK2-decreased protein expression and infrequent genetic alterations mainly occur in aggressive types of non-Hodgkin lymphomasQ44189799
Phase II study of oral vinorelbine in first-line advanced breast cancer chemotherapyQ44265652
Inhibition of constitutive NF-kappa B activation in mantle cell lymphoma B cells leads to induction of cell cycle arrest and apoptosisQ44484550
Thalidomide therapy induces response in relapsed mantle cell lymphomaQ44582819
Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcomeQ44730863
Checkpoint kinase 1 (CHK1) protein and mRNA expression is downregulated in aggressive variants of human lymphoid neoplasmsQ45138887
Immunohistochemical analysis of ZAP-70 expression in B-cell lymphoid neoplasmsQ45247281
The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 statusQ46706369
Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regionsQ51597461
Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations.Q52947124
Mantle cell lymphoma: presenting features, response to therapy, and prognostic factorsQ53356360
The heat shock protein 90 inhibitor 17-AAG induces cell cycle arrest and apoptosis in mantle cell lymphoma cell lines by depleting cyclin D1, Akt, Bid and activating caspase 9.Q53603846
Mantle cell lymphoma-derived cell lines: unique research toolsQ53630718
Differential effect of epigenetic alterations and genomic deletions of CDK inhibitors [p16(INK4a), p15(INK4b), p14(ARF)] in mantle cell lymphomaQ53651184
Clonal proliferation of cyclin D1-positive mantle lymphocytes in an asymptomatic patient: an early-stage event in the development or an indolent form of a mantle cell lymphoma?Q54633278
Mantle cell lymphomas with low levels of cyclin D1 long mRNA transcripts are highly proliferative and can be discriminated by elevated cyclin A2 and cyclin B1.Q54663102
Low prevalence of circulating t(11;14)(q13;q32)-positive cells in the peripheral blood of healthy individuals as detected by real-time quantitative PCR.Q54709200
VH mutation status and VDJ rearrangement structure in mantle cell lymphoma: correlation with genomic aberrations, clinical characteristics, and outcome.Q54765675
ZAP-70 expression as a surrogate for immunoglobulin-variable-region mutations in chronic lymphocytic leukemia.Q55036524
The BH3-mimetic GX15-070 synergizes with bortezomib in mantle cell lymphoma by enhancing Noxa-mediated activation of BakQ57279398
Increased MDM2 expression is associated with inferior survival in mantle cell lymphoma, but not related to the MDM2 SNP309Q57279405
Selective Inhibition of I B Kinase Sensitizes Mantle Cell Lymphoma B Cells to TRAIL by Decreasing Cellular FLIP LevelQ57279413
Unbalanced expression of licensing DNA replication factors occurs in a subset of mantle cell lymphomas with genomic instabilityQ57279418
CDK4andMDM2Gene Alterations Mainly Occur in Highly Proliferative and Aggressive Mantle Cell Lymphomas with Wild-typeINK4a/ARFLocusQ57279470
Sequestration of p27Kip1 protein by cyclin D1 in typical and blastic variants of mantle cell lymphoma (MCL): implications for pathogenesisQ57279567
The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphomaQ57279573
A chromosomal translocation in cyclin D1-negative/cyclin D2-positive mantle cell lymphoma fuses the CCND2 gene to the IGK locusQ61312211
Clinical experience with intravenous and oral formulations of the novel histone deacetylase inhibitor suberoylanilide hydroxamic acid in patients with advanced hematologic malignanciesQ33369463
Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphomaQ33372761
Expression of constitutively nuclear cyclin D1 in murine lymphocytes induces B-cell lymphomaQ33706095
Mechanisms of chromosomal translocations in B cell lymphomasQ34405423
Apoptosis-based therapies for hematologic malignanciesQ34556301
Monoclonal antibodies in the treatment of non-Hodgkin's lymphomaQ34576803
Oligonucleotide microarrays demonstrate the highest frequency of ATM mutations in the mantle cell subtype of lymphomaQ34983013
Function of a human cyclin gene as an oncogeneQ34994859
Linking cyclins to transcriptional control.Q35012861
Mantle cell lymphoma is characterized by inactivation of the ATM geneQ35081325
Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survivalQ35828800
Targeting death receptors in cancer with Apo2L/TRAIL.Q35834889
Cyclin D1-negative mantle cell lymphoma: a clinicopathologic study based on gene expression profilingQ35848185
Constitutive activation of Akt contributes to the pathogenesis and survival of mantle cell lymphomaQ35848973
The CD5+ B-cellQ35864122
Mechanisms of B-cell lymphoma pathogenesisQ36085626
Pathogenesis of mantle-cell lymphoma: all oncogenic roads lead to dysregulation of cell cycle and DNA damage response pathwaysQ36254627
Current treatment approaches for mantle-cell lymphomaQ36254655
Targeting histones and proteasomes: new strategies for the treatment of lymphomaQ36254672
Treatment of mantle cell lymphoma: current approach and future directionsQ36496414
Specific secondary genetic alterations in mantle cell lymphoma provide prognostic information independent of the gene expression-based proliferation signatureQ36629194
The impact of translocations and gene fusions on cancer causationQ36760027
Immunochemotherapy with rituximab and overall survival in patients with indolent or mantle cell lymphoma: a systematic review and meta-analysisQ36807184
ATM mutations are associated with inactivation of the ARF-TP53 tumor suppressor pathway in diffuse large B-cell lymphomaQ38363906
Phase I pharmacokinetic and biologic correlative study of mapatumumab, a fully human monoclonal antibody with agonist activity to tumor necrosis factor-related apoptosis-inducing ligand receptor-1.Q38433102
Identification of novel regions of amplification and deletion within mantle cell lymphoma DNA by comparative genomic hybridizationQ38457830
Nuclear survivin expression in mantle cell lymphoma is associated with cell proliferation and survivalQ38584605
Evaluation of novel cell cycle inhibitors in mantle cell lymphomaQ40157194
Inactivation of RB1 in mantle-cell lymphoma detected by nonsense-mediated mRNA decay pathway inhibition and microarray analysis.Q40164612
Antiproliferative activity of RAD001 (everolimus) as a single agent and combined with other agents in mantle cell lymphomaQ40202733
Mantle cell lymphoma cells express predominantly cyclin D1a isoform and are highly sensitive to selective inhibition of CDK4 kinase activity.Q40280853
Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell linesQ40322845
Genomic and expression profiling identifies the B-cell associated tyrosine kinase Syk as a possible therapeutic target in mantle cell lymphomaQ40330626
Expression of the cyclin-dependent kinase inhibitor p27 and its deregulation in mouse B cell lymphomasQ40381482
Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphomaQ40397270
In vitro activity of cyclin-dependent kinase inhibitor CYC202 (Seliciclib, R-roscovitine) in mantle cell lymphomas.Q40430809
Histone deacetylase inhibitors profoundly decrease proliferation of human lymphoid cancer cell lines.Q40468483
Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM.Q40479135
Molecular cytogenetic characterization of the mantle cell lymphoma cell line GRANTA-519.Q40518890
MCL-1 expression in B-cell non-Hodgkin's lymphomasQ40519635
Cyclin D1/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice.Q40792693
Alkaline Phosphatase-positive Malignant Lymphoma: A Subtype of B-cell LymphomasQ40825424
Variations in ATM protein expression during normal lymphoid differentiation and among B-cell-derived neoplasiasQ41893936
P433issue10
P407language of work or nameEnglishQ1860
P921main subjectmantle cell lymphomaQ268713
pathogenesisQ372016
P304page(s)750-62
P577publication date2007-10-01
P13046publication type of scholarly workreview articleQ7318358
P1433published inNature Reviews CancerQ641657
P1476titleGenetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeutics
P478volume7

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Q47111277Smoldering mantle cell lymphoma.
Q81752872Specific lentiviral shRNA-mediated knockdown of cyclin D1 in mantle cell lymphoma has minimal effects on cell survival and reveals a regulatory circuit with cyclin D2
Q33959993Superior Efficacy of a Combined Epigenetic Therapy against Human Mantle Cell Lymphoma Cells
Q44418379TP53 mutation is not an independent prognostic factor in patients with mantle cell lymphoma at advanced stage
Q42558443Targeting Wnt pathway in mantle cell lymphoma-initiating cells.
Q37132788Targeting the Mammalian Target of Rapamycin (mTOR) in Cancer Therapy: Lessons from Past and Future Perspectives
Q41241688Temsirolimus in the treatment of relapsed and/or refractory mantle cell lymphoma
Q57279328The Classification of Lymphoma: Updating the WHO Classification
Q37809817The IgH 3' regulatory region and its implication in lymphomagenesis.
Q39570078The alpha-fetoprotein (AFP) third domain: a search for AFP interaction sites of cell cycle proteins
Q38017789The emerging role of lenalidomide in the management of mantle cell lymphoma (MCL)
Q55007581The molecular pathogenesis of mantle cell lymphoma.
Q42040698The potential of copy number gains and losses, detected by array-based comparative genomic hybridization, for computational differential diagnosis of B-cell lymphomas and genetic regions involved in lymphomagenesis
Q38891634The synergistic effect of BCR signaling inhibitors combined with an HDAC inhibitor on cell death in a mantle cell lymphoma cell line
Q49831534Therapeutic effects of β-elemene via attenuation of the Wnt/β-catenin signaling pathway in cervical cancer cells
Q84586504Therapy of Mantle Cell Lymphoma: New Treatment Options in an Old Disease or Vice Versa?
Q35146262Treatment-induced oxidative stress and cellular antioxidant capacity determine response to bortezomib in mantle cell lymphoma
Q42744045Tumour-promoting role of EMT-inducing transcription factor ZEB1 in mantle cell lymphoma
Q37143660Uniparental disomies, homozygous deletions, amplifications, and target genes in mantle cell lymphoma revealed by integrative high-resolution whole-genome profiling.
Q37938600Unlocking the secrets of immunoglobulin receptors in mantle cell lymphoma: Implications for the origin and selection of the malignant cells
Q37772500Update on the molecular pathogenesis and clinical treatment of Mantle Cell Lymphoma (MCL): minutes of the 9th European MCL Network conference.
Q38199196Use of mTOR inhibitors in the treatment of malignancies
Q85653321Variability in morphology and cell proliferation in sequential biopsies of mantle cell lymphoma at diagnosis and relapse: clinical correlation and insights into disease progression
Q35572084WIN55,212-2 induces cytoplasmic vacuolation in apoptosis-resistant MCL cells
Q88515440[Anti-tumor effects of 13-cis-retinoic acid combined with interferon α-2b in animal model of mantle cell lymphoma]
Q52716876miRNA‑222 promotes liver cancer cell proliferation, migration and invasion and inhibits apoptosis by targeting BBC3.
Q36952171microRNA expression profiles identify subtypes of mantle cell lymphoma with different clinicobiological characteristics
Q53312593t(11;14)-positive clones can persist over a long period of time in the peripheral blood of healthy individuals

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