Treatment-induced oxidative stress and cellular antioxidant capacity determine response to bortezomib in mantle cell lymphoma

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Treatment-induced oxidative stress and cellular antioxidant capacity determine response to bortezomib in mantle cell lymphoma is …
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scholarly articleQ13442814

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P356DOI10.1158/1078-0432.CCR-10-3367
P8608Fatcat IDrelease_6oaoc4dxu5dafjexabu2x6ctma
P932PMC publication ID3149767
P698PubMed publication ID21712452

P50authorWyndham H. WilsonQ110350523
P2093author name stringDelong Liu
Nalini Raghavachari
Yihong Ye
Adrian Wiestner
Peter J Munson
Kieron Dunleavy
Marc A Weniger
Qiuyan Wang
Patricia Pérez-Galán
Edgar G Rizzatti
Megan M Tweito
Therese White
P2860cites workGenetic and molecular pathogenesis of mantle cell lymphoma: perspectives for new targeted therapeuticsQ27851412
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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elementsQ28244853
Bortezomib-mediated 26S proteasome inhibition causes cell-cycle arrest and induces apoptosis in CD-30+ anaplastic large cell lymphomaQ28286125
ERAD inhibitors integrate ER stress with an epigenetic mechanism to activate BH3-only protein NOXA in cancer cellsQ28307506
PERK-dependent activation of Nrf2 contributes to redox homeostasis and cell survival following endoplasmic reticulum stressQ28511471
CHOP induces death by promoting protein synthesis and oxidation in the stressed endoplasmic reticulumQ28512249
Cell survival responses to environmental stresses via the Keap1-Nrf2-ARE pathwayQ29547371
An integrated stress response regulates amino acid metabolism and resistance to oxidative stressQ29547441
Mediators of endoplasmic reticulum stress-induced apoptosisQ29615496
IRE1 signaling affects cell fate during the unfolded protein responseQ29615502
ER stress triggers apoptosis by activating BH3-only protein BimQ29617730
Multicenter phase II study of bortezomib in patients with relapsed or refractory mantle cell lymphomaQ33372761
Time to treatment response in patients with follicular lymphoma treated with bortezomib is longer compared with other histologic subtypesQ33387817
Role of oxidative stress and intracellular glutathione in the sensitivity to apoptosis induced by proteasome inhibitor in thyroid cancer cellsQ33409161
High levels of Nrf2 determine chemoresistance in type II endometrial cancerQ33959077
RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapyQ34759878
NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cellsQ35850681
The role of the unfolded protein response in tumour development: friend or foe?Q35968425
Bortezomib in patients with relapsed or refractory mantle cell lymphoma: updated time-to-event analyses of the multicenter phase 2 PINNACLE studyQ36117384
Coordination of ER and oxidative stress signaling: the PERK/Nrf2 signaling pathwayQ36313774
Proteasome inhibitors: antitumor effects and beyondQ36649676
Genetic or pharmacologic amplification of nrf2 signaling inhibits acute inflammatory liver injury in miceQ36732083
Antioxidants Enhance Mammalian Proteasome Expression through the Keap1-Nrf2 Signaling PathwayQ37062266
Building and operating an antibody factory: redox control during B to plasma cell terminal differentiation.Q37074340
Proteasome inhibitors in cancer therapy: lessons from the first decadeQ37112347
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Bortezomib induces canonical nuclear factor-kappaB activation in multiple myeloma cellsQ37291635
Therapy of mantle cell lymphoma: current standards and future strategiesQ37309647
Oxidative folding: cellular strategies for dealing with the resultant equimolar production of reactive oxygen speciesQ37401266
Noxa mediates bortezomib induced apoptosis in both sensitive and intrinsically resistant mantle cell lymphoma cells and this effect is independent of constitutive activity of the AKT and NF-kappaB pathwaysQ39993811
Proteasome inhibitors induce death but activate NF-kappaB on endometrial carcinoma cell lines and primary culture explantsQ40273672
Proteasome inhibitor PS-341 induces apoptosis through induction of endoplasmic reticulum stress-reactive oxygen species in head and neck squamous cell carcinoma cells.Q40291997
Proteasome inhibitors induce a terminal unfolded protein response in multiple myeloma cellsQ40310345
Induction of cell cycle arrest and apoptosis by the proteasome inhibitor PS-341 in Hodgkin disease cell lines is independent of inhibitor of nuclear factor-kappaB mutations or activation of the CD30, CD40, and RANK receptorsQ40558321
Sequential waves of functionally related proteins are expressed when B cells prepare for antibody secretionQ40669445
Genome-wide siRNA screen for modulators of cell death induced by proteasome inhibitor bortezomibQ42164172
Redox homeostasis modulates the sensitivity of myeloma cells to bortezomibQ43806000
Reactive oxygen species generation and mitochondrial dysfunction in the apoptotic response to Bortezomib, a novel proteasome inhibitor, in human H460 non-small cell lung cancer cellsQ44488098
Patients with chemotherapy-refractory mantle cell lymphoma experience high response rates and identical progression-free survivals compared with patients with relapsed disease following treatment with single agent bortezomib: results of a multicentrQ44712612
Dissecting tBHQ induced ARE-driven gene expression through long and short oligonucleotide arrays.Q45197543
The proteasome inhibitor bortezomib induces apoptosis in mantle-cell lymphoma through generation of ROS and Noxa activation independent of p53 statusQ46706369
The Nrf2-Keap1-ARE signaling pathway: The regulation and dual function of Nrf2 in cancer.Q51145746
Prevalence of bortezomib-resistant constitutive NF-kappaB activity in mantle cell lymphomaQ59218456
ER stress signaling by regulated splicing: IRE1/HAC1/XBP1Q81604032
P433issue15
P407language of work or nameEnglishQ1860
P304page(s)5101-5112
P577publication date2011-06-28
P1433published inClinical Cancer ResearchQ332253
P1476titleTreatment-induced oxidative stress and cellular antioxidant capacity determine response to bortezomib in mantle cell lymphoma
P478volume17