Primary mediastinal DLBCL: evolving biologic understanding and therapeutic strategies

scientific article published on October 2011

Primary mediastinal DLBCL: evolving biologic understanding and therapeutic strategies is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1007/S11912-011-0189-5
P698PubMed publication ID21789543

P50authorPier Luigi ZinzaniQ56098967
P2093author name stringPier Paolo Piccaluga
P2860cites workMolecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphomaQ24672476
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Primary mediastinal B-cell lymphoma: high frequency of BCL-6 mutations and consistent expression of the transcription factors OCT-2, BOB.1, and PU.1 in the absence of immunoglobulinsQ35036705
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Discordant expression of immunoglobulin and its associated molecule mb-1/CD79a is frequently found in mediastinal large B cell lymphomas.Q35794900
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Further delineation of chromosomal consensus regions in primary mediastinal B-cell lymphomas: an analysis of 37 tumor samples using high-resolution genomic profiling (array-CGH).Q40087598
NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypesQ40427138
Downregulation of internal enhancer activity contributes to abnormally low immunoglobulin expression in the MedB-1 mediastinal B-cell lymphoma cell line.Q40463591
Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma lineQ40486172
Constitutive STAT6 activation in primary mediastinal large B-cell lymphoma.Q40573622
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Primary mediastinal large cell lymphomaQ40655994
Isotype-switched immunoglobulin genes with a high load of somatic hypermutation and lack of ongoing mutational activity are prevalent in mediastinal B-cell lymphomaQ40772895
Gain of chromosome arm 9p is characteristic of primary mediastinal B-cell lymphoma (MBL): comprehensive molecular cytogenetic analysis and presentation of a novel MBL cell lineQ40821711
MAL, a novel integral membrane protein of human T lymphocytes, associates with glycosylphosphatidylinositol-anchored proteins and Src-like tyrosine kinasesQ40990037
Rituximab combined with MACOP-B or VACOP-B and radiation therapy in primary mediastinal large B-cell lymphoma: a retrospective studyQ43254582
The human thymus contains a novel population of B lymphocytesQ43410995
Lipid rafts mediate biosynthetic transport to the T lymphocyte uropod subdomain and are necessary for uropod integrity and functionQ43863946
Mediastinal lymphoma of clear cell type is a tumor corresponding to terminal steps of B cell differentiationQ43901216
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AID expression identifies interfollicular large B cells as putative precursors of mature B-cell malignancies.Q46790535
Primary mediastinal large B-cell lymphoma: a clinicopathologic study of 43 patients from the Nebraska Lymphoma Study Group.Q53347810
Magnetic resonance imaging and 67gallium scan in mediastinal malignant lymphoma: a prospective pilot study.Q53805583
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.Q53931762
Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma.Q55042257
Induction chemotherapy strategies for primary mediastinal large B-cell lymphoma with sclerosis: a retrospective multinational study on 426 previously untreated patientsQ57004874
Treatment and clinical management of primary mediastinal large B-cell lymphoma with sclerosis: MACOP-B regimen and mediastinal radiotherapy monitored by (67)Gallium scan in 50 patientsQ57011679
Molecular features of primary mediastinal B-cell lymphoma: involvement of p16INK4A, p53 and c-mycQ57426191
Mediastinal B-cell lymphoma: A study of its histomorphologic spectrum based on 109 casesQ57786661
Treatment outcome and prognostic factors for primary mediastinal (thymic) B-cell lymphoma: a multicenter study of 106 patientsQ57786732
Gains ofREL in primary mediastinal B-cell lymphoma coincide with nuclear accumulation of REL proteinQ61312181
Expression of bcl-6 and CD10 in Primary Mediastinal Large B-Cell LymphomaQ61596469
Mediastinal large-B-cell lymphoma with sclerosis: a clinical study of 21 patientsQ67657715
Stage II large B-cell lymphoma with sclerosis treated with MACOP-BQ67711476
Mediastinal large cell lymphoma. An uncommon subset of adult lymphoma curable with combined modality therapyQ67927289
Thymic medullary cells expressing B lymphocyte antigensQ68098972
Defective expression of MHC class I antigens is frequent in B-cell lymphomas of high-grade malignancyQ68162123
Sequential combination chemotherapy of high-grade non-Hodgkin's lymphoma with 5-fluorouracil, methotrexate, cytosine-arabinoside, cyclophosphamide, doxorubicin, vincristine, and prednisone (F-MACHOP)Q69394796
Mediastinal diffuse large-cell lymphoma with sclerosis: a condition with a poor prognosisQ69768342
Mediastinal diffuse large-cell lymphoma with sclerosis. A clinicopathologic study of 60 casesQ70025005
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Primary mediastinal (thymic) B-cell lymphoma is characterized by gains of chromosomal material including 9p and amplification of the REL geneQ71017596
Primary Mediastinal B-cell lymphoma with sclerosis: clinical and therapeutic evaluation of 22 patientsQ71310217
Mediastinal large B-cell lymphoma: clinical and immunohistological findings in 18 patients treated with different third-generation regimensQ71695942
Primary mediastinal lymphoma in adultsQ71848069
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Large-cell and immunoblastic lymphoma of the mediastinum: prognostic features and treatment outcome in 57 patientsQ72790352
The MAL gene is expressed in primary mediastinal large B-cell lymphomaQ73160449
Distribution and pattern of BCL-6 mutations throughout the spectrum of B-cell neoplasiaQ73337958
MACOP-B and involved field radiation therapy is an effective therapy for primary mediastinal large B-cell lymphoma with sclerosisQ77565347
Whole-body positron emission tomography using 18F-fluorodeoxyglucose for posttreatment evaluation in Hodgkin's disease and non-Hodgkin's lymphoma has higher diagnostic and prognostic value than classical computed tomography scan imagingQ77974747
CD30 expression is common in mediastinal large B-cell lymphomaQ78105218
Expression of TRAF1 and nuclear c-Rel distinguishes primary mediastinal large cell lymphoma from other types of diffuse large B-cell lymphomaQ79467568
Primary mediastinal large B-cell lymphoma: results of intensive chemotherapy regimens (MACOP-B/VACOP-B) plus involved field radiotherapy on 53 patients. A single institution experienceQ80017604
CD23 expression in mediastinal large B-cell lymphomasQ81070836
Primary mediastinal large cell lymphoma (PMBL): frontline treatment with autologous stem cell transplantation (ASCT). The GEL-TAMO experienceQ81141429
Mediastinal gray zone lymphoma: the missing link between classic Hodgkin's lymphoma and mediastinal large B-cell lymphomaQ81349866
Primary mediastinal B-cell lymphoma treated with CHOP-like chemotherapy with or without rituximab: results of the Mabthera International Trial Group studyQ84774064
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)407-415
P577publication date2011-10-01
P1433published inCurrent Oncology ReportsQ2264969
P1476titlePrimary mediastinal DLBCL: evolving biologic understanding and therapeutic strategies
P478volume13

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cites work (P2860)
Q91326189High frequency of CD74 expression in lymphomas: implications for targeted therapy using a novel anti-CD74-drug conjugate
Q34137948Medical history, lifestyle, family history, and occupational risk factors for diffuse large B-cell lymphoma: the InterLymph Non-Hodgkin Lymphoma Subtypes Project
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Q38203924The utility and limitations of (18)F-fluorodeoxyglucose positron emission tomography with computed tomography in patients with primary mediastinal B-cell lymphoma: single institution experience and literature review.
Q55430662[A case report of anterior-mediastinal bulky lesion].