Gains ofREL in primary mediastinal B-cell lymphoma coincide with nuclear accumulation of REL protein

scientific article published on 01 April 2007

Gains ofREL in primary mediastinal B-cell lymphoma coincide with nuclear accumulation of REL protein is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/GCC.20420
P698PubMed publication ID17243160

P50authorMartin DyerQ53138021
José I Martín-SuberoQ39062643
P2093author name stringReiner Siebert
Peter Möller
Stefan Gesk
Marc A Weniger
Thomas F E Barth
Steve Ehrlich
P2860cites workCharacterization of target genes at the 2p15-16 amplicon in diffuse large B-cell lymphoma.Q53620559
The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma.Q53931762
Gains of the proto-oncogene BCL11A and nuclear accumulation of BCL11A(XL) protein are frequent in primary mediastinal B-cell lymphoma.Q55042257
Similar patterns of genomic alterations characterize primary mediastinal large-B-cell lymphoma and diffuse large-B-cell lymphomaQ56915483
The BCL11AXL transcription factor: its distribution in normal and malignant tissues and use as a marker for plasmacytoid dendritic cellsQ57447372
Lack of IKBA coding region mutations in primary mediastinal large B-cell lymphoma and the host response subtype of diffuse large B-cell lymphomaQ58051632
The use of real-time quantitative polymerase chain reaction and comparative genomic hybridization to identify amplification of the REL gene in follicular lymphomaQ73309612
I kappa B epsilon, a novel member of the I kappa B family, controls RelA and cRel NF-kappa B activityQ24318573
Molecular diagnosis of primary mediastinal B cell lymphoma identifies a clinically favorable subgroup of diffuse large B cell lymphoma related to Hodgkin lymphomaQ24672476
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT MethodQ25938999
The c-Rel transcription factor and B-cell proliferation: a deal with the devilQ28241767
Shaping the nuclear action of NF-kappaBQ29614600
Mutations of the tumor suppressor gene SOCS-1 in classical Hodgkin lymphoma are frequent and associated with nuclear phospho-STAT5 accumulationQ33236181
The BCL11 gene family: involvement of BCL11A in lymphoid malignanciesQ34102839
Recurrent involvement of the REL and BCL11A loci in classical Hodgkin lymphoma.Q34112913
Development of a sensitive multi-well colorimetric assay for active NFkappaBQ34233830
Mediastinal (thymic) large B-cell lymphoma: where do we stand?Q34688561
Gene expression profiling of diffuse large B-cell lymphomaQ35808389
Diffuse large B-cell lymphoma subgroups have distinct genetic profiles that influence tumor biology and improve gene-expression-based survival predictionQ35848430
Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2.Q38486378
Constitutive nuclear factor-kappaB-RelA activation is required for proliferation and survival of Hodgkin's disease tumor cellsQ39795545
Genetic analysis of NF- B/Rel transcription factors defines functional specificitiesQ39962410
NF-kappaB-inducing kinase is involved in the activation of the CD28 responsive element through phosphorylation of c-Rel and regulation of its transactivating activityQ40296221
NFkappaB activity, function, and target-gene signatures in primary mediastinal large B-cell lymphoma and diffuse large B-cell lymphoma subtypesQ40427138
Biallelic mutation of SOCS-1 impairs JAK2 degradation and sustains phospho-JAK2 action in the MedB-1 mediastinal lymphoma lineQ40486172
Stimulation of c-Rel transcriptional activity by PKA catalytic subunit betaQ40545229
Gains of 2p involving the REL locus correlate with nuclear c-Rel protein accumulation in neoplastic cells of classical Hodgkin lymphomaQ40679662
Genomic organization and expression of the rearranged REL proto-oncogene in the human B-cell lymphoma cell line RC-K8.Q40741599
PU.1/Spi-B regulation of c-rel is essential for mature B cell survivalQ40773247
MedB-1, a human tumor cell line derived from a primary mediastinal large B-cell lymphomaQ40814255
Gain of chromosome arm 9p is characteristic of primary mediastinal B-cell lymphoma (MBL): comprehensive molecular cytogenetic analysis and presentation of a novel MBL cell lineQ40821711
The precursor of NF-kappa B p50 has I kappa B-like functionsQ41598400
Regulation of nuclear factor kappa B transactivation. Implication of phosphatidylinositol 3-kinase and protein kinase C zeta in c-Rel activation by tumor necrosis factor alphaQ42502005
Degradation of proto-oncoprotein c-Rel by the ubiquitin-proteasome pathwayQ42823633
Deletion of either C-terminal transactivation subdomain enhances the in vitro transforming activity of human transcription factor REL in chicken spleen cellsQ44611183
Relationship between REL amplification, REL function, and clinical and biologic features in diffuse large B-cell lymphomasQ47387310
A biophysical characterisation of factors controlling dimerisation and selectivity in the NF-kappaB and NFAT familiesQ47393670
RELevant gene amplification in B-cell lymphomas?Q47800510
P433issue4
P921main subjectB-cell lymphomaQ4833719
primary mediastinal B-cell lymphomaQ53660452
P304page(s)406-415
P577publication date2007-04-01
P1433published inGenes, Chromosomes and CancerQ5532697
P1476titleGains of REL in primary mediastinal B-cell lymphoma coincide with nuclear accumulation of REL protein
P478volume46

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cites work (P2860)
Q36949574CAPERalpha is a novel Rel-TAD-interacting factor that inhibits lymphocyte transformation by the potent Rel/NF-kappaB oncoprotein v-Rel
Q34543027Clinical, pathological and genetic features of primary mediastinal large B-cell lymphomas and mediastinal gray zone lymphomas in children
Q57279383Frequent occurrence of deletions in primary mediastinal B-cell lymphoma
Q40087598Further delineation of chromosomal consensus regions in primary mediastinal B-cell lymphomas: an analysis of 37 tumor samples using high-resolution genomic profiling (array-CGH).
Q35850206Genomic Landscape of Primary Mediastinal B-Cell Lymphoma Cell Lines
Q30873773High resolution genome-wide analysis of chromosomal alterations in Burkitt's lymphoma
Q38651957High-depth, high-accuracy microsatellite genotyping enables precision lung cancer risk classification
Q38182355Mechanisms and consequences of constitutive NF-κB activation in B-cell lymphoid malignancies
Q35909668Molecular distinctions between pediatric and adult mature B-cell non-Hodgkin lymphomas identified through genomic profiling
Q38996724PD-1-PD-L1 immune-checkpoint blockade in B-cell lymphomas
Q33889168Pathogenetic importance and therapeutic implications of NF-κB in lymphoid malignancies
Q37341168Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family
Q37905667Primary mediastinal DLBCL: evolving biologic understanding and therapeutic strategies
Q34266819Primary mediastinal large B-cell lymphoma
Q37725413Primary mediastinal large B-cell lymphoma: transcriptional regulation by miR-92a through FOXP1 targeting
Q37327973Racial patterns of patients with primary mediastinal large B-cell lymphoma: SEER analysis
Q90041758Regulation of B-cell function by NF-kappaB c-Rel in health and disease
Q36495569Repression of B-cell linker (BLNK) and B-cell adaptor for phosphoinositide 3-kinase (BCAP) is important for lymphocyte transformation by rel proteins
Q52668197Ruxolitinib significantly enhances in vitro apoptosis in Hodgkin lymphoma and primary mediastinal B-cell lymphoma and survival in a lymphoma xenograft murine model.
Q37781972The Basis and Rational Use of Molecular Genetic Testing in Mature B-cell Lymphomas
Q91658641The Unsolved Puzzle of c-Rel in B Cell Lymphoma
Q35556506The c-Rel Transcription Factor in Development and Disease
Q39135290XPO1 in B cell hematological malignancies: from recurrent somatic mutations to targeted therapy.
Q85896419[Lymph node pathology - an update]
Q26772234c-Rel and its many roles in cancer: an old story with new twists
Q90458228c-Rel gain in B cells drives germinal center reactions and autoantibody production

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