Regulation of glucagon secretion by zinc: lessons from the β cell-specific Znt8 knockout mouse model.

scientific article published on October 2011

Regulation of glucagon secretion by zinc: lessons from the β cell-specific Znt8 knockout mouse model. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1111/J.1463-1326.2011.01451.X
P698PubMed publication ID21824264
P5875ResearchGate publication ID51554672

P50authorMichael B. WheelerQ40030429
Fabrice ChimientiQ57023843
P2093author name stringA B Hardy
N Wijesekara
A S Serino
P2860cites workIn vivo expression and functional characterization of the zinc transporter ZnT8 in glucose-induced insulin secretionQ24303979
The unique cytoarchitecture of human pancreatic islets has implications for islet cell functionQ24541464
Insulin storage and glucose homeostasis in mice null for the granule zinc transporter ZnT8 and studies of the type 2 diabetes-associated variantsQ28249275
Subtype-selective expression of the five somatostatin receptors (hSSTR1-5) in human pancreatic islet cells: a quantitative double-label immunohistochemical analysisQ28294253
Somatostatin inhibits exocytosis in rat pancreatic alpha-cells by G(i2)-dependent activation of calcineurin and depriming of secretory granulesQ28348790
Deletion of the mouse Slc30a8 gene encoding zinc transporter-8 results in impaired insulin secretionQ28506358
The role of assembly in insulin's biosynthesisQ28609745
Assessment of human pancreatic islet architecture and composition by laser scanning confocal microscopyQ30853783
Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cellsQ33265073
A K ATP channel-dependent pathway within alpha cells regulates glucagon release from both rodent and human islets of Langerhans.Q33284703
ATP-sensitive K+ channel mediates the zinc switch-off signal for glucagon response during glucose deprivationQ33556463
Unique arrangement of alpha- and beta-cells in human islets of LangerhansQ33803474
Glucose suppression of glucagon secretion: metabolic and calcium responses from alpha-cells in intact mouse pancreatic isletsQ33825190
Autonomic regulation of islet hormone secretion--implications for health and diseaseQ33923510
Insulin reciprocally regulates glucagon secretion in humansQ34135501
Paracrinology of islets and the paracrinopathy of diabetesQ34136529
Glucose-inhibition of glucagon secretion involves activation of GABAA-receptor chloride channelsQ34453916
GABA: an excitatory transmitter in early postnatal lifeQ34607633
GABA in the endocrine pancreas: its putative role as an islet cell paracrine-signalling moleculeQ35652707
Alpha-cells of the endocrine pancreas: 35 years of research but the enigma remainsQ36721554
Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet functionQ37066901
Insulin signaling in alpha cells modulates glucagon secretion in vivoQ37223046
Physiology of the pancreatic alpha-cell and glucagon secretion: role in glucose homeostasis and diabetes.Q37231345
Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice.Q37329685
Glucose sensing and the pathogenesis of obesity and type 2 diabetesQ37349825
Zinc, a regulator of islet function and glucose homeostasisQ37611963
The essential role of glucagon in the pathogenesis of diabetes mellitusQ39314896
Glucagon secretion from the perfused rat pancreas following acute and chronic streptozotocinQ39789724
Glucagon physiology and pathophysiology in the light of new advancesQ39832294
Investigation of transport mechanisms and regulation of intracellular Zn2+ in pancreatic alpha-cells.Q40016539
Insulin regulates islet alpha-cell function by reducing KATP channel sensitivity to adenosine 5'-triphosphate inhibitionQ40321285
Glucose-regulated glucagon secretion requires insulin receptor expression in pancreatic alpha-cellsQ40396199
Glucose or insulin, but not zinc ions, inhibit glucagon secretion from mouse pancreatic alpha-cells.Q40416559
Autometallography allows ultrastructural monitoring of zinc in the endocrine pancreasQ40698164
The Influence of γ-Aminobutyric Acid on Hormone Release by the Mouse and Rat Endocrine Pancreas*Q41135367
Measurement of zinc in hepatocytes by using a fluorescent probe, zinquin: relationship to metallothionein and intracellular zincQ41885735
Adrenaline stimulates glucagon secretion in pancreatic A-cells by increasing the Ca2+ current and the number of granules close to the L-type Ca2+ channelsQ41937980
Characterization of Erg K+ channels in alpha- and beta-cells of mouse and human isletsQ42060620
Membrane potential-dependent inactivation of voltage-gated ion channels in alpha-cells inhibits glucagon secretion from human isletsQ42138516
Immunoneutralization of somatostatin, insulin, and glucagon causes alterations in islet cell secretion in the isolated perfused human pancreasQ42511056
Zinc-induced changes in ionic currents of clonal rat pancreatic -cells: activation of ATP-sensitive K+ channelsQ42639139
Selective stimulation of glucagon secretion by beta 2-adrenoceptors in isolated islets of Langerhans of the rat.Q42716188
Zinc, zinc transporters and diabetesQ43057681
Beta cell-specific Znt8 deletion in mice causes marked defects in insulin processing, crystallisation and secretion.Q43083300
Ca2+-dependent exocytosis of L-glutamate by alphaTC6, clonal mouse pancreatic alpha-cellsQ43596002
Detection and imaging of zinc secretion from pancreatic beta-cells using a new fluorescent zinc indicatorQ43870970
Secretory granule-mediated co-secretion of L-glutamate and glucagon triggers glutamatergic signal transmission in islets of LangerhansQ44203924
Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.Q44364388
Involvement of alpha1 and beta-adrenoceptors in adrenaline stimulation of the glucagon-secreting mouse alpha-cellQ44731005
Regulation of alpha-cell function by the beta-cell during hypoglycemia in Wistar rats: the "switch-off" hypothesisQ44909441
ATP-sensitive K+ channel-dependent regulation of glucagon release and electrical activity by glucose in wild-type and SUR1-/- mouse alpha-cellsQ45161245
Beta-cell secretory products activate alpha-cell ATP-dependent potassium channels to inhibit glucagon releaseQ46513286
Glucose stimulates glucagon release in single rat alpha-cells by mechanisms that mirror the stimulus-secretion coupling in beta-cellsQ46635811
Autonomic mediation of glucagon secretion during hypoglycemia: implications for impaired alpha-cell responses in type 1 diabetes.Q53762233
P407language of work or nameEnglishQ1860
P921main subjectknockout mouseQ1364740
glucagonQ28163629
P304page(s)112-117
P577publication date2011-10-01
P1433published inDiabetes, Obesity and MetabolismQ5270109
P1476titleRegulation of glucagon secretion by zinc: lessons from the β cell-specific Znt8 knockout mouse model
P478volume13 Suppl 1

Reverse relations

cites work (P2860)
Q64088923Crosstalk between zinc and free fatty acids in plasma
Q36524094Effects of maternal mild zinc deficiency and different ways of zinc supplementation for offspring on learning and memory
Q38109738Fluorescent probes for monitoring regulated secretion
Q91715009Glucagon Receptor Signaling and Glucagon Resistance
Q52917339Intracellular zinc in insulin secretion and action: a determinant of diabetes risk?
Q38138370K(ATP) channels and islet hormone secretion: new insights and controversies
Q34131175Molecular pathogenesis of spondylocheirodysplastic Ehlers-Danlos syndrome caused by mutant ZIP13 proteins
Q51257457Postnatal development of the endocrine pancreas in mice lacking functional GABAB receptors.
Q39089307Probes for monitoring regulated exocytosis
Q34442232Protective antioxidant and antiapoptotic effects of ZnCl2 in rat pancreatic islets cultured in low and high glucose concentrations
Q58614412The Diabetes Susceptibility Gene SLC30A8 that Encodes the Zinc Transporter ZnT8 is a Pseudogene in Guinea Pigs Potentially Contributing to Low Guinea Pig Islet Zinc Content
Q34403988The molecular and metabolic influence of long term agmatine consumption
Q36796117Tolbutamide controls glucagon release from mouse islets differently than glucose: involvement of K(ATP) channels from both α-cells and δ-cells
Q36796078UCP2 regulates the glucagon response to fasting and starvation
Q26829276Zinc transporter 8 (ZnT8) and β cell function
Q33585706Zinc transporters and their role in the pancreatic β-cell
Q38071351Zinc, pancreatic islet cell function and diabetes: new insights into an old story

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