ABC transporters involved in drug resistance in human parasites.

scientific article published on September 2011

ABC transporters involved in drug resistance in human parasites. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1042/BSE0500121
P698PubMed publication ID21967055
P5875ResearchGate publication ID51688841

P50authorMarc OuelletteQ38546122
P2093author name stringPhilippe Leprohon
Danielle Légaré
P2860cites workDeclining artesunate-mefloquine efficacy against falciparum malaria on the Cambodia-Thailand borderQ21032539
Artemisinin Resistance in Plasmodium falciparum MalariaQ22061852
The genome of the kinetoplastid parasite, Leishmania majorQ22065797
The Genome of the African Trypanosome Trypanosoma bruceiQ22065798
The Genome Sequence of Trypanosoma cruzi, Etiologic Agent of Chagas DiseaseQ22065799
Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalisQ22065878
The genome of the blood fluke Schistosoma mansoniQ22122228
The Schistosoma japonicum genome reveals features of host-parasite interplayQ22122229
Genome sequence of the human malaria parasite Plasmodium falciparumQ22122524
Disruption of a Plasmodium falciparum Multidrug Resistance-associated Protein (PfMRP) Alters Its Fitness and Transport of Antimalarial Drugs and GlutathioneQ27861935
Plasmodium falciparum: the pfmdr2 protein is not overexpressed in chloroquine-resistant isolates of the malaria parasiteQ27974631
pfmdr2 confers heavy metal resistance to Plasmodium falciparumQ27974633
Genetic selection of low fertile Onchocerca volvulus by ivermectin treatmentQ28469339
Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy numberQ29615128
Drug resistance in leishmaniasisQ29616242
Localization of the ATP-binding cassette (ABC) transport proteins PfMRP1, PfMRP2, and PfMDR5 at the Plasmodium falciparum plasma membraneQ30041396
Analysis of a single-domain P-glycoprotein-like gene in the early-diverging protist Trichomonas vaginalisQ46688741
A novel ATP-binding cassette transporter, ABCG6 is involved in chemoresistance of LeishmaniaQ46776164
Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin.Q47618838
Entamoeba histolytica: physiology of multidrug resistanceQ47885898
Modulation in aquaglyceroporin AQP1 gene transcript levels in drug-resistant Leishmania.Q48123401
The overexpression of a new ABC transporter in Leishmania is related to phospholipid trafficking and reduced infectivity.Q48243238
The Cryptosporidium parvum ABC protein familyQ48318040
A novel ATP-binding cassette transporter from Leishmania is involved in transport of phosphatidylcholine analogues and resistance to alkyl-phospholipids.Q50680649
Effects of the multidrug-resistance-reversing agents verapamil and CL 347,099 on the efficacy of ivermectin or moxidectin against unselected and drug-selected strains of Haemonchus contortus in jirds (Meriones unguiculatus).Q52575083
Genomic organization and effects of ivermectin selection on Onchocerca volvulus P-glycoprotein.Q52658591
Novel Intracellular SbV reducing activity correlates with antimony susceptibility in Leishmania donovani.Q54027189
Role of ABC transporter MRPA, gamma-glutamylcysteine synthetase and ornithine decarboxylase in natural antimony-resistant isolates of Leishmania donovani.Q54563374
Evidence that the High Incidence of Treatment Failures in Indian Kala‐Azar Is Due to the Emergence of Antimony‐Resistant Strains ofLeishmania donovaniQ56781882
Chloroquine transport via the malaria parasite's chloroquine resistance transporterQ30041673
Cellular location and function of the P-glycoproteins (EhPgps) in Entamoeba histolytica multidrug-resistant trophozoitesQ30880883
Modulation of a Schistosoma mansoni multidrug transporter by the antischistosomal drug praziquantelQ33552868
Are transporter genes other than the chloroquine resistance locus (pfcrt) and multidrug resistance gene (pfmdr) associated with antimalarial drug resistance?Q33836765
Metabolism and functions of trypanothione in the KinetoplastidaQ33972467
Resistance to pentamidine in Leishmania mexicana involves exclusion of the drug from the mitochondrion.Q34253333
Genetic variability following selection of Haemonchus contortus with anthelminticsQ34351503
Surveillance of the efficacy of artesunate and mefloquine combination for the treatment of uncomplicated falciparum malaria in CambodiaQ34560158
Lack of association between putative transporter gene polymorphisms in Plasmodium falciparum and chloroquine resistance in imported malaria isolates from AfricaQ34567489
Prevalence and intensity of Onchocerca volvulus infection and efficacy of ivermectin in endemic communities in Ghana: a two-phase epidemiological studyQ34638307
Injectable paromomycin for Visceral leishmaniasis in IndiaQ34639916
Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemicQ34648820
Cryptosporidiosis and the challenges of chemotherapyQ34750382
Modulation of Leishmania ABC protein gene expression through life stages and among drug-resistant parasites.Q35075211
Molecular and pharmacological determinants of the therapeutic response to artemether-lumefantrine in multidrug-resistant Plasmodium falciparum malariaQ35112348
Amodiaquine and artemether-lumefantrine select distinct alleles of the Plasmodium falciparum mdr1 gene in Tanzanian children treated for uncomplicated malaria.Q35647706
Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugsQ35669039
Leishmaniasis: drugs in the clinic, resistance and new developments.Q35943371
Substrate recognition and transport by multidrug resistance protein 1 (ABCC1).Q36357541
CpABC, a Cryptosporidium parvum ATP-binding cassette protein at the host-parasite boundary in intracellular stagesQ36367680
Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma bruceiQ36369970
Antimalarial drugs: recent advances in molecular determinants of resistance and their clinical significanceQ36478273
Mechanisms of experimental resistance of Leishmania to miltefosine: Implications for clinical use.Q36524693
Polymorphism in PfMRP1 (Plasmodium falciparum multidrug resistance protein 1) amino acid 1466 associated with resistance to sulfadoxine-pyrimethamine treatment.Q37204143
Schistosoma mansoni P-glycoprotein levels increase in response to praziquantel exposure and correlate with reduced praziquantel susceptibilityQ37223703
Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasisQ37315241
The role of ATP-binding cassette (ABC) proteins in protozoan parasitesQ37493118
An ATP-dependent As(III)-glutathione transport system in membrane vesicles of Leishmania tarentolaeQ37713114
Transporters as mediators of drug resistance in Plasmodium falciparumQ37732867
The overexpression of an intracellular ABCA-like transporter alters phospholipid trafficking in LeishmaniaQ38329011
EhPgp5 mRNA stability is a regulatory event in the Entamoeba histolytica multidrug resistance phenotypeQ38358206
Identification of variant ABC-transporter genes among Onchocerca volvulus collected from ivermectin-treated and untreated patients in Ghana, West AfricaQ38878937
The phenomenon of treatment failures in Human African TrypanosomiasisQ38884830
Two Schistosoma mansoni cDNAs encoding ATP-binding cassette (ABC) family proteinsQ38915677
Characterization of Leishmania (Leishmania) amazonensis promastigotes resistant to pentamidineQ38949587
Role of the ABC transporter PRP1 (ABCC7) in pentamidine resistance in Leishmania amastigotes.Q38949592
Functional genetic identification of PRP1, an ABC transporter superfamily member conferring pentamidine resistance in Leishmania majorQ38949602
Gene expression analysis of the mechanism of natural Sb(V) resistance in Leishmania donovani isolates from NepalQ38968281
Increase in mRNA of multiple Eh pgp genes encoding P-glycoprotein homologues in emetine-resistant Entamoeba histolytica parasites.Q38970928
Increased sensitivity to the antimalarials mefloquine and artemisinin is conferred by mutations in the pfmdr1 gene of Plasmodium falciparumQ38980049
The tyrosine-86 allele of the pfmdr1 gene of Plasmodium falciparum is associated with increased sensitivity to the anti-malarials mefloquine and artemisininQ38980054
Transcripts of the multidrug resistance genes in chloroquine-sensitive and chloroquine-resistant Plasmodium falciparumQ38983864
Overexpression of P-glycoprotein gene 1 by transfected Entamoeba histolytica confers emetine-resistanceQ39022591
Role of pfmdr1 mutations on chloroquine resistance in Plasmodium falciparum isolates with pfcrt K76T from Papua New GuineaQ39254724
Susceptibility of an emetine-resistant mutant of Entamoeba histolytica to multiple drugs and to channel blockersQ39427240
Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum.Q39596634
Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1.Q39792488
Functional characterization of the nucleotide binding domain of the Cryptosporidium parvum CpABC4 transporter: an iron-sulfur cluster transporter homologQ39854056
Modulation of gene expression of three Cryptosporidium parvum ATP-binding cassette transporters in response to drug treatmentQ40092489
The role of Trypanosoma brucei MRPA in melarsoprol susceptibilityQ40341001
Localization and activity of multidrug resistance protein 1 in the secretory pathway of Leishmania parasitesQ40580596
pfmdr1 mutations contribute to quinine resistance and enhance mefloquine and artemisinin sensitivity in Plasmodium falciparumQ41911870
Efflux of chloroquine from Plasmodium falciparum: mechanism of chloroquine resistance.Q41913045
In vitro monitoring of Plasmodium falciparum susceptibility to artesunate, mefloquine, quinine and chloroquine in Cambodia: 2001-2002.Q41913057
Reversal of chloroquine resistance in Plasmodium falciparum by verapamilQ41914126
Multiple transporters associated with malaria parasite responses to chloroquine and quinineQ41915501
High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1.Q41919827
Early transcriptional response to chloroquine of the Plasmodium falciparum antioxidant defence in sensitive and resistant clonesQ41936651
In vitro activities of piperaquine, lumefantrine, and dihydroartemisinin in Kenyan Plasmodium falciparum isolates and polymorphisms in pfcrt and pfmdr1.Q41937598
Characterization of an ABCG-like transporter from the protozoan parasite Leishmania with a role in drug resistance and transbilayer lipid movementQ41940537
Selection of Plasmodium falciparum multidrug resistance gene 1 alleles in asexual stages and gametocytes by artemether-lumefantrine in Nigerian children with uncomplicated falciparum malariaQ41940547
Several alleles of the multidrug-resistance gene are closely linked to chloroquine resistance in Plasmodium falciparumQ41943905
Chloroquine resistance not linked to mdr-like genes in a Plasmodium falciparum crossQ41943911
The potential inhibitory effect of antiparasitic drugs and natural products on P-glycoprotein mediated effluxQ41944927
Decreasing pfmdr1 copy number in plasmodium falciparum malaria heightens susceptibility to mefloquine, lumefantrine, halofantrine, quinine, and artemisininQ41944932
Flavonoid dimers as bivalent modulators for pentamidine and sodium stiboglucanate resistance in leishmania.Q42112263
Evaluation of diamidine compound (pentamidine isethionate) in the treatment resistant cases of kala-azar occurring in North Bihar, IndiaQ42260163
Overexpression of histone H2A modulates drug susceptibility in Leishmania parasitesQ43081906
Intracellular localization of the ABCC proteins of Leishmania and their role in resistance to antimonialsQ43121812
The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase.Q43578165
Overexpression of the putative thiol conjugate transporter TbMRPA causes melarsoprol resistance in Trypanosoma bruceiQ43936767
Overexpression of LaMDR2, a novel multidrug resistance ATP-binding cassette transporter, causes 5-fluorouracil resistance in Leishmania amazonensisQ44795160
Cryptosporidium parvum: effect of multi-drug reversing agents on the expression and function of ATP-binding cassette transporters.Q44917424
In vivo selection of Plasmodium falciparum pfmdr1 86N coding alleles by artemether-lumefantrine (Coartem).Q45270651
Genetic analysis of decreased praziquantel sensitivity in a laboratory strain of Schistosoma mansoni.Q46019928
Quinacrine and a novel apigenin dimer can synergistically increase the pentamidine susceptibility of the protozoan parasite Leishmania.Q46045590
Characterization of a half-size ATP-binding cassette transporter gene which may be a useful marker for ivermectin selection in Onchocerca volvulusQ46157527
Increased expression of ABC transport proteins is associated with ivermectin resistance in the model nematode Caenorhabditis elegansQ46426011
Comparison of the efficacy of mebendazole, albendazole and pyrantel in treatment of human hookworm infections in the southern region of Mali, West AfricaQ46519155
P-glycoprotein-like protein, a possible genetic marker for ivermectin resistance selection in Onchocerca volvulusQ46685880
P433issue1
P304page(s)121-144
P577publication date2011-09-01
P1433published inEssays in BiochemistryQ15754041
P1476titleABC transporters involved in drug resistance in human parasites
P478volume50

Reverse relations

cites work (P2860)
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