Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis

scientific article published on December 2008

Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

External links are
P356DOI10.1097/QCO.0B013E328318978F
P698PubMed publication ID18978535
P5875ResearchGate publication ID23445973

P50authorJürg UtzingerQ28324256
Michael J. DoenhoffQ41456714
P2093author name stringDonato Cioli
P2860cites workIdentification of an antimalarial synthetic trioxolane drug development candidateQ22061876
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectschistosomiasisQ221159
praziquantelQ424145
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)659-667
P577publication date2008-12-01
P1433published inCurrent Opinion in Infectious DiseasesQ15724406
P1476titlePraziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis
P478volume21

Reverse relations

cites work (P2860)
Q9963589630 years of parasitology research analysed by text mining
Q52677297A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing.
Q89823709A Review of Nanotechnology for Targeted Anti-schistosomal Therapy
Q39161231A catecholamine transporter from the human parasite Schistosoma mansoni with low affinity for psychostimulants.
Q39091997A conventional polymerase chain reaction-based method for the diagnosis of human schistosomiasis in stool samples from individuals in a low-endemicity area
Q37697955A multidisciplinary, integrated approach for the elimination of schistosomiasis: a longitudinal study in a historically hyper-endemic region in the lower reaches of the Yangtze River, China from 2005 to 2014
Q28476171A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility
Q36247094A survey of schistosome protein domain types: insights into unique biological properties
Q33486179A wake up call for urinary schistosomiasis: reconciling research effort with public health importance
Q37053762ABC multidrug transporters in schistosomes and other parasitic flatworms
Q37941754ABC transporters involved in drug resistance in human parasites.
Q38123553Advocacy, policies and practicalities of preventive chemotherapy campaigns for African children with schistosomiasis
Q39467299Algorithmic Mapping and Characterization of the Drug-Induced Phenotypic-Response Space of Parasites Causing Schistosomiasis
Q91771868An Efficient Schistosoma japonicum Bivalent Membrane Protein Antigen DNA Vaccine Against Schistosomiasis in Mice
Q28544852An artemisinin derivative of praziquantel as an orally active antischistosomal agent
Q28545088Anthelmintic activity in vivo of epiisopiloturine against juvenile and adult worms of Schistosoma mansoni
Q56909277Antibody Responses to Schistosoma mansoni Schistosomula Antigens
Q36018841Antischistosomal activities of mefloquine-related arylmethanols
Q37674908Antischistosomal activity of a calcium channel antagonist on schistosomula and adult Schistosoma mansoni worms
Q40601229Antischistosomal activity of hederacochiside C against Schistosoma japonicum harbored in experimentally infected animals.
Q28547348Application of RNAi to Genomic Drug Target Validation in Schistosomes
Q60949181Artemether and Praziquantel: Origin, Mode of Action, Impact, and Suggested Application for Effective Control of Human Schistosomiasis
Q42015454Artemisinin: the gifts from traditional Chinese medicine not only for malaria control but also for schistosomiasis control
Q55228407Atypical pharmacology of schistosome TRPA1-like ion channels.
Q62486477Benefits of annual chemotherapeutic control of schistosomiasis on the development of protective immunity
Q83769924Bioavailability and in vivo efficacy of a praziquantel-polyvinylpyrrolidone solid dispersion in Schistosoma mansoni-infected mice
Q38004814Biogenic amines and the control of neuromuscular signaling in schistosomes
Q38035721Cerebral and spinal schistosomiasis
Q37651018Characterization of Schistosoma japonicum CP1412 protein as a novel member of the ribonuclease T2 molecule family with immune regulatory function
Q34052174Characterization of the Src/Abl hybrid kinase SmTK6 of Schistosoma mansoni
Q43701919Characterization of the cGMP-dependent protein kinase SmcGK1 of Schistosoma mansoni
Q36802409Characterization of the methionine sulfoxide reductases of Schistosoma mansoni
Q55604560Cheminformatics models for inhibitors of Schistosoma mansoni thioredoxin glutathione reductase.
Q38630566Clinical implications of recent findings in schistosome proteomics
Q36884691Cloning and functional characterization of two calmodulin genes during larval development in the parasitic flatworm Schistosoma mansoni
Q34675128Combined TLR7/8 and TLR9 ligands potentiate the activity of a Schistosoma japonicum DNA vaccine
Q37680707Community knowledge, attitudes and practices on schistosomiasis in western Kenya--the SCORE Project
Q41758770Comparative biochemical analysis of three members of the Schistosoma mansoni TAL family: Differences in ion and drug binding properties
Q34705499Comparative pharmacology of flatworm and roundworm glutamate-gated chloride channels: Implications for potential anthelmintics
Q34629346Comparing parasitological vs serological determination of Schistosoma haematobium infection prevalence in preschool and primary school-aged children: implications for control programmes
Q34705415Compound library screening identified Akt/PKB kinase pathway inhibitors as potential key molecules for the development of new chemotherapeutics against schistosomiasis.
Q55000698Compounds from African Medicinal Plants with Activities Against Selected Parasitic Diseases: Schistosomiasis, Trypanosomiasis and Leishmaniasis.
Q37463234Conquering 'snail fever': schistosomiasis and its control in China.
Q40173400Conservation of protein kinase a catalytic subunit sequences in the schistosome pathogens of humans
Q46964347Control of schistosomiasis in sub-Saharan Africa: progress made, new opportunities and remaining challenges.
Q37771992Controlling schistosomiasis in Southeast Asia: a tale of two countries
Q37726920Controlling schistosomiasis with praziquantel: How much longer without a viable alternative?
Q37565174CpG oligodeoxynucleotide ligand potentiates the activity of the pVAX1-Sj26GST.
Q89920010Current and Novel Therapies Against Helminthic Infections: The Potential of Antioxidants Combined with Drugs
Q38093067Current drug targets for helminthic diseases
Q37682900DNA vaccines: a rational design against parasitic diseases.
Q36679169De novo transcriptomic analysis of the female and male adults of the blood fluke Schistosoma turkestanicum
Q36346161Defining the Schistosoma haematobium kinome enables the prediction of essential kinases as anti-schistosome drug targets
Q57822205Design, Synthesis, and Characterization of Novel Small Molecules as Broad Range Antischistosomal Agents
Q39004176Design, synthesis and biological evaluation of praziquantel and endoperoxide conjugates as antischistosomal agents
Q46243865Detection of duo-schistosome infection from filtered urine samples from school children in Zambia after MDA.
Q28483732Determining treatment needs at different spatial scales using geostatistical model-based risk estimates of schistosomiasis
Q36219372Development of an in vitro drug screening assay using Schistosoma haematobium schistosomula
Q35590947Diagnosis and management of schistosomiasis
Q38152776Diagnosis and treatment of schistosomiasis in children in the era of intensified control
Q39175318Dihydroartemisinin: a new story of an old drug against Schistosoma mansoni infection
Q36275312Dihydrobenz[e][1,4]oxazepin-2(3H)-ones, a new anthelmintic chemotype immobilising whipworm and reducing infectivity in vivo
Q28553478Discovery and Characterization of Novel Anti-schistosomal Properties of the Anti-anginal Drug, Perhexiline and Its Impact on Schistosoma mansoni Male and Female Reproductive Systems
Q42680012Discovery by organism based high-throughput screening of new multi-stage compounds affecting Schistosoma mansoni viability, egg formation and production.
Q33781930Does granulocyte-colony stimulating factor administration induce damage or repair response in schistosomiasis?
Q52672813Dose-response relationship in Schistosoma mansoni juvenile and adult stages following limonin treatment in experimentally infected mice.
Q52699502Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules.
Q99719959Drug metabolism and pharmacokinetics of praziquantel: A review of variable drug exposure during schistosomiasis treatment in human hosts and experimental models
Q38495057Drugging the schistosome zinc-dependent HDACs: current progress and future perspectives
Q24201000Drugs for treating Schistosoma mansoni infection
Q24194447Drugs for treating urinary schistosomiasis
Q36572029Dynamics of Schistosoma haematobium egg output and associated infection parameters following treatment with praziquantel in school-aged children
Q50781056Effect of Mirazid in Schistosoma japonicum-infected mice: parasitological and pathological assessment.
Q39338872Effect of a novel benzimidazole derivative in experimental Schistosoma mansoni infection.
Q38974529Effect of gold nanoparticles on mice splenomegaly induced by schistosomiasis mansoni
Q47872179Effect of ozonide OZ418 against Schistosoma japonicum harbored in mice
Q33449456Effect of single-dose oral mefloquine on the morphology of adult Schistosoma japonicum in mice
Q47998506Effectiveness of synthetic trioxolane OZ78 against Schistosoma japonicum in mice and rabbits
Q51456665Effects of artemether, artesunate and dihydroartemisinin administered orally at multiple doses or combination in treatment of mice infected with Schistosoma japonicum.
Q57116125Effects of miconazole/clotrimazole and praziquantel combinations against the liver fluke Opisthorchis felineus in vivo and in vitro
Q92238880Effects of the Environment on Developmental Plasticity and Infection Success of Schistosoma Parasites - An Epigenetic Perspective
Q39439977Efficacious and safe dose of praziquantel for the successful treatment of feline reservoir hosts with opisthorchiasis
Q47094509Efficacy and safety of praziquantel against Schistosoma haematobium in the Ikata-Likoko area of southwest Cameroon
Q33800953Efficacy and safety of praziquantel in preschool-aged and school-aged children infected with Schistosoma mansoni: a randomised controlled, parallel-group, dose-ranging, phase 2 trial
Q28484235Efficacy and safety of praziquantel in preschool-aged children in an area co-endemic for Schistosoma mansoni and S. haematobium
Q57805340Efficacy comparison between long-term high-dose praziquantel and surgical therapy for cerebral sparganosis: A multicenter retrospective cohort study
Q34081597Efficacy of Essential Oils of Thymus vulgaris and Origanum vulgare on Echinococcus granulosus
Q92892485Efficacy of Ozoroa pulcherrima Schweinf methanolic extract against Schistosoma mansoni-induced liver injury in mice
Q39576151Efficacy of artemether and artesunate in mice infected with praziquantel non-susceptible isolate of Schistosoma japonicum
Q42939143Efficacy of artesunate with sulfalene plus pyrimethamine versus praziquantel for treatment of Schistosoma mansoni in Kenyan children: an open-label randomised controlled trial
Q21198915Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis
Q38867800Efficacy of praziquantel syrup versus crushed praziquantel tablets in the treatment of intestinal schistosomiasis in Ugandan preschool children, with observation on compliance and safety
Q90504787Efficacy of single versus four repeated doses of praziquantel against Schistosoma mansoni infection in school-aged children from Côte d'Ivoire based on Kato-Katz and POC-CCA: An open-label, randomised controlled trial (RePST)
Q33528954Electroporation facilitates introduction of reporter transgenes and virions into schistosome eggs.
Q90179467Elucidation of Cellular Responses in Non-human Primates With Chronic Schistosomiasis Followed by Praziquantel Treatment
Q24601973Epidemiology and control of human gastrointestinal parasites in children
Q34159188Epigenetic control of gene function in schistosomes: a source of therapeutic targets?
Q33891612Eukaryotic protein kinases (ePKs) of the helminth parasite Schistosoma mansoni
Q90700581Evaluation of Artesunate and Praziquantel Combination Therapy in Murine Schistosomiasis mansoni
Q38966422Evaluation of the in vitro activity of dermaseptin 01, a cationic antimicrobial peptide, against Schistosoma mansoni
Q27303844Evidence for Novel Pharmacological Sensitivities of Transient Receptor Potential (TRP) Channels in Schistosoma mansoni
Q39574584Exosome-like vesicles derived by Schistosoma japonicum adult worms mediates M1 type immune- activity of macrophage
Q89054345Experimental avian philophthalmosis: Evaluation of diagnosis and treatment of chickens infected with Philophthalmus gralli (Trematoda: Philophthalmidae)
Q37694858Expression at a 20L scale and purification of the extracellular domain of the Schistosoma mansoni TSP-2 recombinant protein: a vaccine candidate for human intestinal schistosomiasis
Q34281731Expression profile of the Schistosoma japonicum degradome reveals differential protease expression patterns and potential anti-schistosomal intervention targets
Q83131540FLOTAC: new multivalent techniques for qualitative and quantitative copromicroscopic diagnosis of parasites in animals and humans
Q28607183Fast evolutionary rates associated with functional loss in class I glucose transporters of Schistosoma mansoni
Q24650873Food-borne trematodiases
Q37787339From innovation to application: Social–ecological context, diagnostics, drugs and integrated control of schistosomiasis
Q47988412Further studies on mefloquine and praziquantel alone or interaction of both drugs against Schistosoma japonicum in vitro
Q27680669Genetic and Molecular Basis of Drug Resistance and Species-Specific Drug Action in Schistosome Parasites
Q28478288Genetic knockdown and pharmacological inhibition of parasite multidrug resistance transporters disrupts egg production in Schistosoma mansoni
Q37282903Genomic linkage map of the human blood fluke Schistosoma mansoni
Q28481592Germline transgenesis and insertional mutagenesis in Schistosoma mansoni mediated by murine leukemia virus
Q33730904Gonad RNA-specific qRT-PCR analyses identify genes with potential functions in schistosome reproduction such as SmFz1 and SmFGFRs.
Q38205649HIV and schistosomiasis co-infection in African children
Q43857691Haemin enhances the in vivo efficacy of artemether against juvenile and adult Schistosoma mansoni in mice
Q33745207Health seeking behaviour and utilization of health facilities for schistosomiasis-related symptoms in Ghana
Q28551698High Throughput Screening Identifies Novel Lead Compounds with Activity against Larval, Juvenile and Adult Schistosoma mansoni
Q46120029Histopathological changes in adult Schistosoma japonicum harbored in mice treated with a single dose of mefloquine
Q30245056History of schistosomiasis epidemiology, current status, and challenges in China: on the road to schistosomiasis elimination
Q34413522Human schistosomiasis
Q28476429IL-10 blocks the development of resistance to re-infection with Schistosoma mansoni
Q33908196Identification of G protein-coupled receptors in Schistosoma haematobium and S. mansoni by comparative genomics
Q60932082Identification of novel multi-stage histone deacetylase (HDAC) inhibitors that impair Schistosoma mansoni viability and egg production
Q37675128Imatinib activity on Schistosoma mansoni
Q28539623Imatinib treatment causes substantial transcriptional changes in adult Schistosoma mansoni in vitro exhibiting pleiotropic effects
Q47349053Immune modulation of Th1, Th2, and T-reg transcriptional factors differing from cytokine levels in Schistosoma japonicum infection
Q34782228Immunology of human schistosomiasis
Q28551003Impact of Annual Praziquantel Treatment on Urogenital Schistosomiasis in a Seasonal Transmission Focus in Central Senegal
Q26825064Impact of human schistosomiasis in sub-Saharan Africa
Q37292213In Vitro Schistosomicidal Activity of Phytol and Tegumental Alterations Induced in Juvenile and Adult Stages of Schistosoma haematobium
Q60924844In silico repositioning of approved drugs against Schistosoma mansoni energy metabolism targets
Q28542999In silico repositioning-chemogenomics strategy identifies new drugs with potential activity against multiple life stages of Schistosoma mansoni
Q38648427In vitro and in vivo activity of R- and S- praziquantel enantiomers and the main human metabolite trans-4-hydroxy-praziquantel against Schistosoma haematobium
Q27339703In vitro and in vivo anti-schistosomal activity of the alkylphospholipid analog edelfosine
Q51301728In vitro evaluation of schistosomicidal potential of curcumin against Schistosoma japonicum.
Q99728045In vivo assessment of the antischistosomal activity of curcumin loaded nanoparticles versus praziquantel in the treatment of Schistosoma mansoni
Q50893356In-silico analysis of Sirt2 from Schistosoma mansoni: structures, conformations, and interactions with inhibitors.
Q36660891In-silico screening of Schistosoma mansoni Sirtuin1 inhibitors for prioritization of drug candidates
Q36851347Inferences on the biochemical and environmental regulation of universal stress proteins from Schistosomiasis parasites
Q27304398Inhibition of Granulomatous Inflammation and Prophylactic Treatment of Schistosomiasis with a Combination of Edelfosine and Praziquantel
Q40777879Inhibition of Tapeworm Thioredoxin and Glutathione Pathways by an Oxadiazole N-Oxide Leads to Reduced Mesocestoides vogae Infection Burden in Mice
Q28543846Inhibition or knockdown of ABC transporters enhances susceptibility of adult and juvenile schistosomes to Praziquantel
Q37840565Inhibitory activities of the marine streptomycete-derived compound SF2446A2 against Chlamydia trachomatis and Schistosoma mansoni.
Q64094995Insects in anthelminthics research: Lady beetle-derived harmonine affects survival, reproduction and stem cell proliferation of Schistosoma mansoni
Q40812997Interactions between mefloquine and the anti-fibrotic drug silymarin on Schistosoma mansoni infections in mice.
Q39126577Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitro
Q36856181Investigations of the catalytic mechanism of thioredoxin glutathione reductase from Schistosoma mansoni
Q51741191Investigations on the interplays between Schistosoma mansoni, praziquantel and the gut microbiome.
Q34782668Ion channels and drug transporters as targets for anthelmintics
Q51191319Is there a reduced sensitivity of dihydroartemisinin against praziquantel-resistant Schistosoma japonicum?
Q35105862Lactate as a novel quantitative measure of viability in Schistosoma mansoni drug sensitivity assays
Q40651231Large-Scale Overproduction and Purification of Recombinant Histone Deacetylase 8 (HDAC8) from the Human-Pathogenic Flatworm Schistosoma mansoni
Q46312164Lessons from a tarantula: new insights into myosin interacting-heads motif evolution and its implications on disease
Q30855808Lessons from implementing mass drug administration for soil transmitted helminths among pre-school aged children during school based deworming program at the Kenyan coast
Q37017439MCR synthesis of praziquantel derivatives
Q27663601Mapping the Catalytic Cycle of Schistosoma mansoni Thioredoxin Glutathione Reductase by X-ray Crystallography
Q93198814Medical Devices for Low- and Middle-Income Countries: A Review and Directions for Development
Q34366867Mefloquine, a new type of compound against schistosomes and other helminthes in experimental studies
Q28474353Mefloquine--an aminoalcohol with promising antischistosomal properties in mice
Q92919048Modifications of histones in parasites as drug targets
Q33552868Modulation of a Schistosoma mansoni multidrug transporter by the antischistosomal drug praziquantel
Q51213476Molecular and structural characteristics of multidrug resistance-associated protein 7 in Chinese liver fluke Clonorchis sinensis.
Q46316485Molecular characterization of transport lectin vesicular integral membrane protein 36 kDa (VIP36) in the life cycle of Schistosoma mansoni
Q46760732Molecular characterization of voltage-gated calcium channel β-subunits of Clonorchis sinensis
Q36089897Molecular docking to explore the possible binding mode of potential inhibitors of thioredoxin glutathione reductase
Q36834713Morphological Characteristics of Schistosoma mansoni PZQ-Resistant and -Susceptible Strains Are Different in Presence of Praziquantel
Q39211542Morphological effects and tegumental alterations induced by mefloquine on schistosomula and adult flukes of Schistosoma mansoni
Q36656087Natural products as a source for treating neglected parasitic diseases
Q33745561Neuroschistosomiasis
Q53678341Neuroschistosomiasis
Q57482606Neuroschistosomiasis mimicking lower back pain: case report of a rare differential diagnosis in a pediatric patient
Q37177725New approaches for understanding mechanisms of drug resistance in schistosomes
Q35905176New approaches to measuring anthelminthic drug efficacy: parasitological responses of childhood schistosome infections to treatment with praziquantel
Q37943763New insight into praziquantel against various developmental stages of schistosomes
Q35813630New insights into the genetic diversity of Schistosoma mansoni and S. haematobiumin Yemen
Q38253124New uses for old drugs: the tale of artemisinin derivatives in the elimination of schistosomiasis japonica in China.
Q27008897Novel therapeutic and prevention approaches for schistosomiasis: review
Q89169513Octopamine signaling in the metazoan pathogen Schistosoma mansoni: localization, small-molecule screening and opportunities for drug development
Q38927082One hundred years of neglect in paediatric schistosomiasis
Q40223894Outbreak of Cleidodiscus in juvenile black crappies (Pomoxis nigromaculatus) and bath treatment with praziquantel.
Q39384158Ovicidal effect of Piperaceae species on Biomphalaria glabrata, Schistosoma mansoni host
Q40045772Paediatric and maternal schistosomiasis: shifting the paradigms.
Q34339707Partial regulatory T cell depletion prior to schistosomiasis vaccination does not enhance the protection
Q28484474Performance and safety of praziquantel for treatment of intestinal schistosomiasis in infants and preschool children
Q64076106Performance of an Ultra-Sensitive Assay Targeting the Circulating Anodic Antigen (CAA) for Detection of Infection in a Low Endemic Area in Brazil
Q46921243Pharmacodynamics of mefloquine and praziquantel combination therapy in mice harbouring juvenile and adult Schistosoma mansoni
Q49632990Pharmacological and immunological effects of praziquantel against Schistosoma japonicum: a scoping review of experimental studies
Q35159499Pharmacology and potential physiological significance of schistosome multidrug resistance transporters
Q39188232Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target
Q54646067Piggy-backing the concept of cancer drugs for schistosomiasis treatment: a tangible perspective?
Q36099895Population Pharmacokinetics and Pharmacodynamics of Praziquantel in Ugandan Children with Intestinal Schistosomiasis: Higher Dosages Are Required for Maximal Efficacy.
Q64443565Population level changes in schistosome-specific antibody levels following chemotherapy
Q39160696Praziquantel derivatives with antischistosomal activity: aromatic ring modification
Q39164325Praziquantel for Schistosomiasis: Single-Drug Metabolism Revisited, Mode of Action, and Resistance.
Q28537753Praziquantel treatment decreases Schistosoma mansoni genetic diversity in experimental infections
Q37192109Praziquantel treatment in trematode and cestode infections: an update
Q28540831Praziquantel, mefloquine-praziquantel, and mefloquine-artesunate-praziquantel against Schistosoma haematobium: a randomized, exploratory, open-label trial
Q37413446Praziquantel: its use in control of schistosomiasis in sub-Saharan Africa and current research needs.
Q50590401Preliminary characterization and expression of Vasa-like gene in Schistosoma japonicum.
Q64989771Prevalence and risk factors of schistosomiasis and soil-transmitted helminthiases among preschool aged children (1-5 years) in rural KwaZulu-Natal, South Africa: a cross-sectional study.
Q36256196Prevalence of Schistosomes and Soil-Transmitted Helminths among Schoolchildren in Lake Victoria Basin, Tanzania
Q34510660Prevention and control of schistosomiasis: a current perspective
Q41722700Propolis enhances the effectiveness of praziquantel in experimental schistosomiasis: biochemical and histopathological study
Q27304864Protein kinase C and extracellular signal-regulated kinase regulate movement, attachment, pairing and egg release in Schistosoma mansoni
Q34173302Quantification and clustering of phenotypic screening data using time-series analysis for chemotherapy of schistosomiasis.
Q24203747Rapid screening and diagnostic tests for human schistosomiasis in endemic areas
Q33917776Receptor tyrosine kinases and schistosome reproduction: new targets for chemotherapy
Q34125799Research and development of antischistosomal drugs in the People's Republic of China a 60-year review
Q21144507Resolution of praziquantel
Q53696514Risk factors for hematemesis in Hoima and Buliisa Districts, Western Uganda, September-October 2015.
Q42176100Role of berberine in ameliorating Schistosoma mansoni-induced hepatic injury in mice
Q84344062Schistosoma japonicum calcium-binding tegumental protein SjTP22.4 immunization confers praziquantel schistosomulumicide and antifecundity effect in mice
Q48670759Schistosoma mansoni Polo-like kinases and their function in control of mitosis and parasite reproduction
Q28533358Schistosoma mansoni Sirtuins: characterization and potential as chemotherapeutic targets
Q33960332Schistosoma mansoni express higher levels of multidrug resistance-associated protein 1 (SmMRP1) in juvenile worms and in response to praziquantel
Q85346391Schistosoma mansoni tetraspanning orphan receptor (SmTOR): a new vaccine candidate against schistosomiasis
Q39266759Schistosoma mansoni: In vitro schistosomicidal activity of piplartine
Q33531955Schistosoma mansoni: signal transduction processes during the development of the reproductive organs
Q34705514Schistosome ABC multidrug transporters: From pharmacology to physiology
Q91591248Schistosome TRP channels: An appraisal
Q64098812Schistosome infection and its effect on pulmonary circulation
Q38495049Schistosome sirtuins as drug targets
Q90859559Schistosomiasis
Q91816690Schistosomiasis
Q37133810Schistosomiasis causes remodeling of pulmonary vessels in the lung in a heterogeneous localized manner: Detailed study
Q39031600Schistosomiasis elimination: lessons from the past guide the future
Q42559175Schistosomiasis in Africa: an emerging tragedy in our new global health decade
Q37427116Schistosomiasis in African infants and preschool children: let them now be treated!
Q33825627Schistosomiasis in the People's Republic of China: the era of the Three Gorges Dam.
Q33630932Schistosomiasis japonica control and research needs
Q83232661Schistosomicidal activity of the essential oil of Ageratum conyzoides L. (Asteraceae) against adult Schistosoma mansoni worms
Q35709480Schistosomicidal, hepatoprotective and antioxidant activities of the methanolic fraction from Clerodendrum umbellatum Poir leaves aqueous extract in Schistosoma mansoni infection in mice
Q61818153Screening of a PDE-focused library identifies imidazoles with in vitro and in vivo antischistosomal activity
Q91899315Seldom Differential of Dysuria in Northern America
Q92657705Separation of praziquantel enantiomers using simulated moving bed chromatographic unit with performance designed for semipreparative applications
Q27331388Serotonin signaling in Schistosoma mansoni: a serotonin-activated G protein-coupled receptor controls parasite movement
Q34705820Serum albumin and α-1 acid glycoprotein impede the killing of Schistosoma mansoni by the tyrosine kinase inhibitor Imatinib
Q28547483Single Versus Double Dose Praziquantel Comparison on Efficacy and Schistosoma mansoni Re-Infection in Preschool-Age Children in Uganda: A Randomized Controlled Trial
Q36135568SjCa8, a calcium-binding protein from Schistosoma japonicum, inhibits cell migration and suppresses nitric oxide release of RAW264.7 macrophages
Q34328607SmSak, the second Polo-like kinase of the helminth parasite Schistosoma mansoni: conserved and unexpected roles in meiosis
Q36135715SmShb, the SH2-Containing Adaptor Protein B of Schistosoma mansoni Regulates Venus Kinase Receptor Signaling Pathways.
Q89272035Sorafenib and praziquantel synergistically attenuate Schistosoma japonicum-induced liver fibrosis in mice
Q44115782Stem cell therapy for the treatment of parasitic infections: is it far away?
Q27680126Structural basis for the inhibition of histone deacetylase 8 (HDAC8), a key epigenetic player in the blood fluke Schistosoma mansoni
Q37409571Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis
Q28552326Structure-Bioactivity Relationship for Benzimidazole Thiophene Inhibitors of Polo-Like Kinase 1 (PLK1), a Potential Drug Target in Schistosoma mansoni
Q90191997Sulfonamide Inhibition Studies of an α-Carbonic Anhydrase from Schistosoma mansoni, a Platyhelminth Parasite Responsible for Schistosomiasis
Q38050973Susceptibility or resistance of praziquantel in human schistosomiasis: a review
Q28548401Synergy of Omeprazole and Praziquantel In Vitro Treatment against Schistosoma mansoni Adult Worms
Q21560762Systematic review and meta-analysis of artemisinin based therapies for the treatment and prevention of schistosomiasis
Q90055083T Lymphocyte-Mediated Liver Immunopathology of Schistosomiasis
Q36692301THE SUSCEPTIBILITY OF RECENT ISOLATES OF Schistosoma mansoni TO PRAZIQUANTEL.
Q43924119The Efficacy of Single-Dose versus Double-Dose Praziquantel Treatments on Schistosoma mansoni Infections: Its Implication on Undernutrition and Anaemia among Primary Schoolchildren in Two On-Shore Communities, Northwestern Tanzania
Q35754687The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection
Q46242772The RIO protein kinase-encoding gene Sj-riok-2 is involved in key reproductive processes in Schistosoma japonicum
Q28552173The Schistosomiasis Clinical Trials Landscape: A Systematic Review of Antischistosomal Treatment Efficacy Studies and a Case for Sharing Individual Participant-Level Data (IPD)
Q39002257The Schistosomiasis Control Initiative (SCI): rationale, development and implementation from 2002-2008.
Q92912352The antioxidants resveratrol and N-acetylcysteine enhance anthelmintic activity of praziquantel and artesunate against Schistosoma mansoni
Q34125793The drugs we have and the drugs we need against major helminth infections
Q35172249The effect of praziquantel and Carica papaya seeds on Hymenolepis nana infection in mice using scanning electron microscope
Q52325706The effects of subcurative praziquantel treatment on life-history traits and trade-offs in drug-resistant Schistosoma mansoni.
Q91898993The impact of cinnarizine and griseofulvin on juvenile and adult stages of Schistosoma mansoni
Q43256185The in vitro effect of mefloquine and praziquantel against juvenile and adult Schistosoma japonicum
Q60526096The inability of tapeworm Hymenolepis diminuta and fluke Dicrocoelium dendriticum to metabolize praziquantel
Q30502461The nature and combination of subunits used in epitope-based Schistosoma japonicum vaccine formulations affect their efficacy
Q26829701The redox biology of schistosome parasites and applications for drug development
Q37726847The role of artesunate for the treatment of urinary schistosomiasis in schoolchildren: a systematic review and meta-analysis
Q27694660The roles of water, sanitation and hygiene in reducing schistosomiasis: a review
Q30155988The β Subunit of Voltage-Gated Ca2+Channels
Q24201041Therapeutic and prophylactic drug interventions for Schistosomiasis japonicum
Q97517000Therapeutic efficacy of a newly synthesized benzimidazole compound BTP-OH against murine schistosomiasis mansoni
Q35535825Thioredoxin glutathione reductase: its role in redox biology and potential as a target for drugs against neglected diseases.
Q38495068Toward organometallic antischistosomal drug candidates
Q28472811Transcriptional changes in Schistosoma mansoni during early schistosomula development and in the presence of erythrocytes
Q28489110Transcriptional responses of in vivo praziquantel exposure in schistosomes identifies a functional role for calcium signalling pathway member CamKII
Q36125948Treatment of schistosomiasis in African infants and preschool-aged children: downward extension and biometric optimization of the current praziquantel dose pole
Q37506661Treatment of urinary schistosomiasis: methodological issues and research needs identified through a Cochrane systematic review
Q35228681Treatment with anthelminthics during pregnancy: what gains and what risks for the mother and child?
Q42672174Tyrosine kinase 4 is involved in the reproduction of the platyhelminth parasite Schistosoma japonicum
Q37705721Ultrastructural alterations in Schistosoma mansoni juvenile and adult male worms after in vitro incubation with primaquine.
Q47985342Ultrastructural alterations of juvenile Schistosoma japonicum harbored in mice following mefloquine administration
Q46497362Ultrastructural changes of adult Schistosoma mansoni worms recovered from C57BL/6 mice passively immunized with normal and vaccinated rabbit sera in vivo
Q28065987Universal Stress Proteins as New Targets for Environmental and Therapeutic Interventions of Schistosomiasis
Q90914855Unpacking the Pathogen Box-An Open Source Tool for Fighting Neglected Tropical Disease
Q39569583Ureteric obstruction secondary to schistosomiasis 2 years after praziquantel therapy: a case report
Q33684408Use of an Sm-p80-based therapeutic vaccine to kill established adult schistosome parasites in chronically infected baboons
Q98188993Use of kinase inhibitors against schistosomes to improve and broaden praziquantel efficacy
Q86743127Vector-mediated microRNA-21 silencing ameliorates granulomatous liver fibrosis in Schistosoma japonicum infection
Q33686019Venus kinase receptors control reproduction in the platyhelminth parasite Schistosoma mansoni
Q64232154WIPO Re:Search-A Platform for Product-Centered Cross-Sector Partnerships for the Elimination of Schistosomiasis
Q28254042WIPO Re:Search: Accelerating anthelmintic development through cross-sector partnerships
Q30049251Water, Sanitation, and Hygiene (WASH): A Critical Component for Sustainable Soil-Transmitted Helminth and Schistosomiasis Control
Q21144493Whole organism high-content screening by label-free, image-based Bayesian classification for parasitic diseases
Q22122084Whole-genome sequence of Schistosoma haematobium
Q28534863Whole-organ isolation approach as a basis for tissue-specific analyses in Schistosoma mansoni
Q45340054[(η(6)-Praziquantel)Cr(CO)3] derivatives with remarkable in vitro anti-schistosomal activity

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