Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules.

scientific article published on 5 February 2018

Drug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.3390/PH11010015
P932PMC publication ID5874711
P698PubMed publication ID29401734

P50authorPaul J. BrindleyQ51247593
F GartnerQ59089610
P2093author name stringNuno Vale
José M Correia da Costa
Maria João Gouveia
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Sequence and level of endogenous expression of calcium channel beta subunits in Schistosoma mansoni displaying different susceptibilities to praziquantelQ44567644
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Immunomodulatory effects of curcumin treatment on murine schistosomiasis mansoniQ46106188
The effect of antioxidant properties of aqueous garlic extract and Nigella sativa as anti-schistosomiasis agents in mice.Q46125970
The anthelmintic praziquantel is a human serotoninergic G-protein-coupled receptor ligandQ46247381
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Praziquantel binds Schistosoma mansoni adult worm actin.Q46531951
Sativa seeds against Schistosoma mansoni different stagesQ46602116
Schistosoma mansoni: melatonin enhances efficacy of cercarial and soluble worm antigens in the induction of protective immunity against infection in the hamster.Q46709287
Effect of combined low dose praziquantel and oxamniquine on different stages of schistosome maturityQ46915902
Pharmacodynamics of mefloquine and praziquantel combination therapy in mice harbouring juvenile and adult Schistosoma mansoniQ46921243
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Taste, a new incentive to switch to (R)-praziquantel in schistosomiasis treatmentQ21090121
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New insight into the antifibrotic effects of praziquantel on mice in infection with Schistosoma japonicumQ28478257
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Single Versus Double Dose Praziquantel Comparison on Efficacy and Schistosoma mansoni Re-Infection in Preschool-Age Children in Uganda: A Randomized Controlled TrialQ28547483
Curcumin Generates Oxidative Stress and Induces Apoptosis in Adult Schistosoma mansoni WormsQ28553673
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Schistosomiasis therapeutics: whats in the pipeline?Q50966400
Immunological indicators of morbidity in human schistosomiasis mansoni: role of vascular endothelial growth factor and anti-soluble egg antigen IgG4 in disease progression.Q51036241
Effects of praziquantel on different developmental stages of Schistosoma mansoni in vitro and in vivo.Q52266862
Dose-response relationship in Schistosoma mansoni juvenile and adult stages following limonin treatment in experimentally infected mice.Q52672813
Effect of adamantylamide dipeptide as adjuvant therapy to praziquantel in mice infected with different S. mansoni isolates.Q53605480
Dosage trial of a combination of oxamniquine and praziquantel in the treatment of schistosomiasis in Zimbabwean schoolchildren.Q53888452
Praziquantel: is there real resistance and are there alternatives?Q53973326
Effect of a combination of the new antischistosomal drug Ro 15-5458 and praziquantel on different strains of Schistosoma mansoni infected mice.Q54052490
A comparative study of the reproductive system of mature, immature and "unisexual" female Schistosoma mansoni.Q54162318
The anti-schistosomal drug praziquantel is an adenosine antagonistQ58070149
A New Series of 2-Aminomethyltetrahydroquinoline Derivatives displaying Schistosomicidal Activity in Rodents and PrimatesQ59057898
Schistosoma mansoni: cloning the gene encoding glutathione peroxidaseQ61638099
Efficacy of combination therapy with tubercidin and nitrobenzylthioinosine 5'-monophosphate against chronic and advanced stages of schistosomiasisQ67984153
Experimental chemotherapy of Schistosoma mansoni with praziquantel and oxamniquine: differential effect of single or combined formulations of drugs on various strains and on both sexes of the parasiteQ67984511
Antischistosomal action of mevinolin: evidence that 3-hydroxy-methylglutaryl-coenzyme a reductase activity in Schistosoma mansoni is vital for parasite survivalQ68368986
Treatment of schistosomiasis by purine nucleoside analogues in combination with nucleoside transport inhibitorsQ69464117
Combination therapy of Schistosoma japonicum by tubercidin and nitrobenzylthioinosine 5'-monophosphateQ69971848
The treatment of experimental schistosomiasis with a combination of oxamniquine and praziquantelQ71221403
Experimental murine schistosomiasis: reduced hepatic morbidity after pre- and/or post-infection treatment with ibuprofen or diclofenac sodiumQ71576601
What is the effect of combining artesunate and praziquantel in the treatment of Schistosoma mansoni infections?Q73108356
Intranasal administration of Schistosoma mansoni adult worm antigen in combination with cholera toxin induces a Th2 cell responseQ73335588
Effect of praziquantel together with artemether on Schistosoma japonicum parasites of different ages in rabbitsQ73576307
Combination antiretroviral therapy for HIV infectionQ74685124
Schistosome resistance to praziquantelQ80098643
Studies on parasitologic and haematologic activities of an enaminone derivative of 4-hydroxyquinolin-2(1H)-one against murine schistosomiasis mansoniQ80161238
Is actin the praziquantel receptor?Q80584028
Application of adult worm and lung-stage antigens to immunize against Schistosoma mansoni using cytokines as adjuvantsQ83131030
Therapeutic effects of Allium sativum and Allium cepa in Schistosoma mansoni experimental infectionQ84556558
Silymarin treatment reduces granuloma and hepatic fibrosis in experimental schistosomiasisQ84700726
Comparative in vivo antioxidant levels in Schistosoma mansoni infected mice treated with praziquantel or the essential oil of Melaleuca armillaris leavesQ86663950
The action of UK 3883, a novel 2-aminomethyltetra-hydroquinoline derivative, against mature schistosomes in rodents and primatesQ93824345
Schistosomiasis and soil-transmitted helminthiases: number of people treated in 2015Q95383221
Schistosomiasis: number of people treated worldwide in 2013Q95602733
Therapeutic effect of alpha lipoic acid combined with praziquantel on liver fibrosis induced by Schistosoma mansoni challenged miceQ30485364
Experimental schistosomiasis mansoni: modulation of granulomas by inhibition of collagen cross-link formation. Preliminary reportQ31158829
Parasites and poverty: the case of schistosomiasisQ33615662
The global burden of disease study 2010: interpretation and implications for the neglected tropical diseasesQ33945536
The schistosome enzyme that activates oxamniquine has the characteristics of a sulfotransferaseQ34002522
Fixed dose combination of arterolane and piperaquine: a newer prospect in antimalarial therapyQ34162314
Artemether, an effective new agent for chemoprophylaxis against shistosomiasis in China: its in vivo effect on the biochemical metabolism of the Asian schistosomeQ34287092
Human schistosomiasisQ34413522
The potential of artemether for the control of schistosomiasisQ34455017
Break Out: urogenital schistosomiasis and Schistosoma haematobium infection in the post-genomic era.Q34654134
The immunobiology of schistosomiasisQ34718128
Schistosome and liver fluke derived catechol-estrogens and helminth associated cancersQ34763466
Combination chemotherapy of schistosomiasis in laboratory studies and clinical trialsQ34939414
Human schistosomiasis: clinical perspective: reviewQ34951716
Synergy of concurrent low dose oxamniquine and praziquantel in schistosomiasisQ34995195
Drugs for the control of parasitic diseases: current status and development in schistosomiasisQ35569078
Resveratrol and N-acetylcysteine block the cancer-initiating step in MCF-10F cellsQ35586128
Artemisinin-based combinationsQ36300935
Why does infection with some helminths cause cancer?Q36310498
Artemisinins for schistosomiasis and beyond.Q36747308
Chemotherapy of schistosomiasis: present and futureQ36891317
Selection of a trioxaquine as an antimalarial drug candidateQ36965586
MCR synthesis of praziquantel derivativesQ37017439
Human schistosomiasis mansoni: immune responses during acute and chronic phases of the infectionQ37199411
Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasisQ37315241
Current chemotherapy arsenal for schistosomiasis mansoni: alternatives and challengesQ37405246
Combination therapy of schistosomiasis by tubercidin and nitrobenzylthioinosine 5'-monophosphateQ37549813
Schistosoma genomics: new perspectives on schistosome biology and host-parasite interaction.Q37561082
Origins of Combination Therapy for Tuberculosis: Lessons for Future Antimicrobial Development and ApplicationQ37700067
Susceptibility or resistance of praziquantel in human schistosomiasis: a reviewQ38050973
New vaccines for neglected parasitic diseases and dengueQ38098308
Neurotransmitter transporters in schistosomes: structure, function and prospects for drug discoveryQ38116989
The little we know about the pharmacokinetics and pharmacodynamics of praziquantel (racemate and R-enantiomer).Q38175909
Schistosomiasis control: praziquantel forever?Q38222456
The chronic enteropathogenic disease schistosomiasisQ38253817
Efficacy and safety of mefloquine, artesunate, mefloquine-artesunate, and praziquantel against Schistosoma haematobium: randomized, exploratory open-label trialQ38374795
Malaria medicines: a glass half full?Q38497838
Artesunate and praziquantel for the treatment of Schistosoma haematobium infections: a double-blind, randomized, placebo-controlled studyQ38915536
Melatonin reduces oxidative damage and increases survival of mice infected with Schistosoma mansoniQ38990123
IL-4 and reactive oxygen species are elevated in Egyptian patients affected with schistosomal liver diseaseQ38992502
Development of eosinophil peroxidase activity and concomitant alteration of the antioxidant defenses in the liver of mice infected with Schistosoma mansoniQ39021863
Estrogen-like metabolites and DNA-adducts in urogenital schistosomiasis-associated bladder cancer.Q39030300
Schistosomiasis elimination: lessons from the past guide the futureQ39031600
Schistosoma haematobium infections acquired in Corsica, France, August 2013.Q39074543
Interactions of mefloquine with praziquantel in the Schistosoma mansoni mouse model and in vitroQ39126577
Praziquantel for Schistosomiasis: Single-Drug Metabolism Revisited, Mode of Action, and Resistance.Q39164325
The role of estradiol metabolism in urogenital schistosomiasis-induced bladder cancer.Q39201937
Anthelmintic activity in vitro and in vivo of Baccharis trimera (Less) DC against immature and adult worms of Schistosoma mansoniQ39237134
Advancing a vaccine to prevent human schistosomiasisQ39246394
Schistosoma mansoni: in vitro schistosomicidal activity of essential oil of Baccharis trimera (less) DC.Q39318216
Naphthoquine phosphate and its combination with artemisinineQ39385050
Effect of combined treatment with praziquantel and artemether on Schistosoma japonicum and Schistosoma mansoni in experimentally infected animalsQ39544935
A review of clinical experience with oxamniquineQ39602046
Praziquantel: mechanisms of anti-schistosomal activityQ39842409
Novel anti-inflammatory action of edelfosine lacking toxicity with protective effect in experimental colitis.Q39879484
Purine metabolism in the schistosomes: potential targets for chemotherapyQ40208606
In vivo and in vitro activity of oil extract of garlic (Allium sativum Linnaeus) against Schistosoma japonicum cercariaeQ40284457
Resveratrol ameliorates oxidative stress and organ dysfunction in Schistosoma mansoni infected miceQ40342929
Accessory cell signals regulate Th-cell responses: from basic immunology to a model of helminthic diseaseQ40587479
Immunomodulatory effect of garlic oil extract on Schistosoma mansoni infected mice.Q40856555
Efficacy of Synriam™, a new antimalarial combination of OZ277 and piperaquine, against different developmental stages of Schistosoma mansoniQ41587975
Preparation and antimalarial activities of "trioxaquines", new modular molecules with a trioxane skeleton linked to a 4-aminoquinolineQ41917949
Ultrastructure of the attack of eosinophils stimulated by blood mononuclear cell products on schistosomula of Schistosoma mansoniQ42080804
Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosisQ42239154
Schistosoma mansoni: N-acetylcysteine downregulates oxidative stress and enhances the antischistosomal activity of artemether in mice.Q42745282
In vitro schistosomicidal effects of some phloroglucinol derivatives from Dryopteris species against Schistosoma mansoni adult wormsQ43245982
Further study on mefloquine concerning several aspects in experimental treatment of mice and hamsters infected with Schistosoma japonicumQ43268214
Curcumin reduces oxidative and nitrative DNA damage through balancing of oxidant-antioxidant status in hamsters infected with Opisthorchis viverriniQ43276729
Eosinophils from schistosome-induced hepatic granulomas produce superoxide and hydroxyl radicalQ43515480
The effect of Nigella sativa oil against the liver damage induced by Schistosoma mansoni infection in miceQ43823575
Haemin enhances the in vivo efficacy of artemether against juvenile and adult Schistosoma mansoni in miceQ43857691
In vitro and in vivo effects of hesperidin treatment on adult worms of Schistosoma mansoniQ43981019
Efficacy of a new Hoffmann-La Roche compound (Ro 15-5458) against Schistosoma mansoni (Gezira strain, Sudan) in vervet monkeys (Cercopithecus aethiops).Q43988350
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P921main subjectschistosomiasisQ221159
P577publication date2018-02-05
P1433published inPharmaceuticalsQ15750667
P1476titleDrug Repurposing for Schistosomiasis: Combinations of Drugs or Biomolecules
P478volume11

Reverse relations

cites work (P2860)
Q58543612An Abies procera-derived tetracyclic triterpene containing a steroid-like nucleus core and a lactone side chain attenuates in vitro survival of both Fasciola hepatica and Schistosoma mansoni
Q92470282Cannabinoid receptor-1 antagonism: a new perspective on treating a murine schistosomal liver fibrosis model
Q64245750Combination Anthelmintic/Antioxidant Activity Against
Q89920010Current and Novel Therapies Against Helminthic Infections: The Potential of Antioxidants Combined with Drugs
Q55459515Innovation in neglected tropical disease drug discovery and development.
Q90859559Schistosomiasis
Q99550129Single oral fixed-dose praziquantel-miltefosine nanocombination for effective control of experimental schistosomiasis mansoni

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