Treatment strategies in relapsed and refractory multiple myeloma: a focus on drug sequencing and 'retreatment' approaches in the era of novel agents.

scientific article published on 25 October 2011

Treatment strategies in relapsed and refractory multiple myeloma: a focus on drug sequencing and 'retreatment' approaches in the era of novel agents. is …
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scholarly articleQ13442814

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P356DOI10.1038/LEU.2011.310
P698PubMed publication ID22024721
P5875ResearchGate publication ID51742943

P50authorIbrahim Yakoub-AghaQ58191171
Herve Avet-LoiseauQ61112732
P2093author name stringB Mohty
M Mohty
P Moreau
J El-Cheikh
P2860cites workComplete response correlates with long-term progression-free and overall survival in elderly myeloma treated with novel agents: analysis of 1175 patientsQ83179100
Relapsed multiple myelomaQ83217330
Prolonged overall survival with second on-demand autologous transplant in multiple myelomaQ83300465
Re-transplantation after bortezomib-based therapyQ83319265
Previous thalidomide therapy may not affect lenalidomide response and outcome in relapse or refractory multiple myeloma patientsQ83444693
Comparison of immunofixation, serum free light chain, and immunophenotyping for response evaluation and prognostication in multiple myelomaQ83608464
Toward deeper response in MMQ83638825
Achievement of at least very good partial response is a simple and robust prognostic factor in patients with multiple myeloma treated with high-dose therapy: long-term analysis of the IFM 99-02 and 99-04 TrialsQ84715517
Lenalidomide in combination with dexamethasone: effective regimen in patients with relapsed or refractory multiple myeloma complicated by renal impairmentQ85059501
Addition of thalidomide to oral melphalan/prednisone in patients with multiple myeloma not eligible for transplantation: results of a randomized trial from the Turkish Myeloma Study GroupQ85187993
Melphalan and prednisone plus thalidomide versus melphalan and prednisone alone or reduced-intensity autologous stem cell transplantation in elderly patients with multiple myeloma (IFM 99-06): a randomised trialQ28252396
Lenalidomide plus high-dose dexamethasone versus lenalidomide plus low-dose dexamethasone as initial therapy for newly diagnosed multiple myeloma: an open-label randomised controlled trialQ30433139
Bortezomib in combination with intermediate-dose dexamethasone and continuous low-dose oral cyclophosphamide for relapsed multiple myelomaQ33375805
Randomized phase III study of pegylated liposomal doxorubicin plus bortezomib compared with bortezomib alone in relapsed or refractory multiple myeloma: combination therapy improves time to progressionQ33376149
Lenalidomide plus dexamethasone for relapsed or refractory multiple myelomaQ33377526
Bortezomib, doxorubicin and dexamethasone in advanced multiple myeloma.Q33378895
High response rate to bortezomib with or without dexamethasone in patients with relapsed or refractory multiple myeloma: results of a global phase 3b expanded access programQ33382175
Lenalidomide, adriamycin, and dexamethasone (RAD) in patients with relapsed and refractory multiple myeloma: a report from the German Myeloma Study Group DSMM (Deutsche Studiengruppe Multiples Myelom).Q33383048
Multicenter, phase I, dose-escalation trial of lenalidomide plus bortezomib for relapsed and relapsed/refractory multiple myelomaQ33386405
Bortezomib as induction before autologous transplantation, followed by lenalidomide as consolidation-maintenance in untreated multiple myeloma patientsQ33387698
Lenalidomide, melphalan, prednisone and thalidomide (RMPT) for relapsed/refractory multiple myeloma.Q33389075
The efficacy and safety of lenalidomide plus dexamethasone in relapsed and/or refractory multiple myeloma patients with impaired renal functionQ33390284
Pomalidomide (CC4047) plus low dose dexamethasone (Pom/dex) is active and well tolerated in lenalidomide refractory multiple myeloma (MM).Q33391803
Weekly bortezomib in combination with temsirolimus in relapsed or relapsed and refractory multiple myeloma: a multicentre, phase 1/2, open-label, dose-escalation studyQ33394281
Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority studyQ33394981
Repeat administration of high dose melphalan in relapsed myelomaQ33492940
Peripheral neuropathy and new treatments for multiple myeloma: background and practical recommendations.Q33632270
Abnormal modulation of cell protective systems in response to ischemic/reperfusion injury is important in the development of mouse sickle cell hepatopathy.Q33695612
Mechanisms of peripheral neuropathy associated with bortezomib and vincristine in patients with newly diagnosed multiple myeloma: a prospective analysis of data from the HOVON-65/GMMG-HD4 trialQ33701381
Total Therapy 3 for multiple myeloma: prognostic implications of cumulative dosing and premature discontinuation of VTD maintenance components, bortezomib, thalidomide, and dexamethasone, relevant to all phases of therapyQ34122646
Better quality of response to lenalidomide plus dexamethasone is associated with improved clinical outcomes in patients with relapsed or refractory multiple myelomaQ34166574
The medical review article: state of the scienceQ34191468
Lenalidomide plus dexamethasone for relapsed multiple myeloma in North AmericaQ34585268
The relationship between quality of response and clinical benefit for patients treated on the bortezomib arm of the international, randomized, phase 3 APEX trial in relapsed multiple myelomaQ34595043
The use of novel agents in the treatment of relapsed and refractory multiple myelomaQ35097319
Efficacy of retreatment with immunomodulatory drugs (IMiDs) in patients receiving IMiDs for initial therapy of newly diagnosed multiple myelomaQ35172445
Improved survival in multiple myeloma and the impact of novel therapiesQ36478461
Checklists for review articlesQ36887882
Thalidomide arm of Total Therapy 2 improves complete remission duration and survival in myeloma patients with metaphase cytogenetic abnormalitiesQ36941047
Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantationQ36969778
Complete response correlates with long-term survival and progression-free survival in high-dose therapy in multiple myelomaQ37007113
Prevention of thalidomide- and lenalidomide-associated thrombosis in myelomaQ37038414
An observational, retrospective analysis of retreatment with bortezomib for multiple myelomaQ37224994
Lenalidomide in combination with dexamethasone at first relapse in comparison with its use as later salvage therapy in relapsed or refractory multiple myeloma.Q37248327
Second auto-SCT is safe and effective salvage therapy for relapsed multiple myelomaQ37375819
Treatment of relapsed/refractory multiple myelomaQ37457291
The role of complete response in multiple myelomaQ37564828
CR represents an early index of potential long survival in multiple myelomaQ49184612
Impact of early relapse after auto-SCT for multiple myeloma.Q53469257
Multiple MyelomaQ56453538
Effects of Lenalidomide and Dexamethasone Treatment Duration on Survival in Patients With Relapsed or Refractory Multiple Myeloma Treated With Lenalidomide and DexamethasoneQ57904548
Tandem autologous non-myeloablative allogeneic transplantation in patients with multiple myeloma relapsing after a first high dose therapyQ58415992
Bortezomib, melphalan, and prednisone versus bortezomib, thalidomide, and prednisone as induction therapy followed by maintenance treatment with bortezomib and thalidomide versus bortezomib and prednisone in elderly patients with untreated multiple mQ60203634
High-dose melphalan with autotransplantation for refractory multiple myeloma: results of a Southwest Oncology Group phase II trialQ73181635
Delayed stem cell transplantation for the management of relapsed or refractory multiple myelomaQ74082581
Bortezomib, melphalan, prednisone, and thalidomide for relapsed multiple myelomaQ79407795
Maintenance therapy with thalidomide improves survival in patients with multiple myelomaQ80011690
Reduced-intensity conditioning allogeneic SCT as salvage treatment for relapsed multiple myelomaQ80764931
Achievement of VGPR to induction therapy is an important prognostic factor for longer PFS in the IFM 2005-01 trialQ82564216
Importance of achieving a complete response in multiple myeloma, and the impact of novel agentsQ37729617
International Myeloma Working Group consensus statement regarding the current status of allogeneic stem-cell transplantation for multiple myelomaQ37778947
Treatment of relapsed and refractory multiple myeloma in the era of novel agentsQ37791639
Emerging therapies for the treatment of relapsed or refractory multiple myelomaQ37799862
Renal impairment in patients with multiple myeloma: a consensus statement on behalf of the International Myeloma Working GroupQ37801221
Evidence-based mini-review: treatment options for patients with relapsed/refractory myeloma previously treated with novel agents and high-dose chemotherapy and autologous stem-cell transplantationQ37829230
Ultra high-risk myelomaQ37829258
Consensus recommendations for the uniform reporting of clinical trials: report of the International Myeloma Workshop Consensus Panel 1.Q37835571
Optimizing the use of lenalidomide in relapsed or refractory multiple myeloma: consensus statementQ37835695
Multiple myeloma treatment strategies with novel agents in 2011: a European perspectiveQ37858327
Patterns of survival in multiple myeloma: a population-based study of patients diagnosed in Sweden from 1973 to 2003.Q38463036
Rapid early monoclonal protein reduction after therapy with bortezomib or bortezomib and pegylated liposomal doxorubicin in relapsed/refractory myeloma is associated with a longer time to progressionQ41874321
The incidence of pleural and pericardial effusion is not higher in patients receiving dasatinib at low doses. (Reply).Q42708667
Renal insufficiency and failureQ42757287
Bortezomib with thalidomide plus dexamethasone compared with thalidomide plus dexamethasone as induction therapy before, and consolidation therapy after, double autologous stem-cell transplantation in newly diagnosed multiple myeloma: a randomised pQ42781523
Bortezomib-melphalan-prednisone-thalidomide followed by maintenance with bortezomib-thalidomide compared with bortezomib-melphalan-prednisone for initial treatment of multiple myeloma: a randomized controlled trialQ42861085
Efficacy and safety of once-weekly bortezomib in multiple myeloma patients.Q42921022
Decitabine versus 5-azacitidine for the treatment of myelodysplastic syndrome: adjusted indirect meta-analysisQ42922537
Treatment of patients with relapsed/refractory multiple myeloma with lenalidomide and dexamethasone with or without bortezomib: prospective evaluation of the impact of cytogenetic abnormalities and of previous therapiesQ42925566
Bortezomib plus dexamethasone induction improves outcome of patients with t(4;14) myeloma but not outcome of patients with del(17p).Q42965343
Superior outcomes associated with complete response in newly diagnosed multiple myeloma patients treated with nonintensive therapy: analysis of the phase 3 VISTA study of bortezomib plus melphalan-prednisone versus melphalan-prednisoneQ42971327
Meeting the unmet needs in anticoagulant therapyQ43018499
The addition of cyclophosphamide to lenalidomide and dexamethasone in multiply relapsed/refractory myeloma patients; a phase I/II study.Q43018754
Phase III study of the value of thalidomide added to melphalan plus prednisone in elderly patients with newly diagnosed multiple myeloma: the HOVON 49 StudyQ43048164
Melphalan and prednisone plus thalidomide or placebo in elderly patients with multiple myelomaQ43071494
Bortezomib plus melphalan and prednisone compared with melphalan and prednisone in previously untreated multiple myeloma: updated follow-up and impact of subsequent therapy in the phase III VISTA trialQ43109172
Major tumor shrinking and persistent molecular remissions after consolidation with bortezomib, thalidomide, and dexamethasone in patients with autografted myelomaQ43121688
Impact of high-risk cytogenetics and prior therapy on outcomes in patients with advanced relapsed or refractory multiple myeloma treated with lenalidomide plus dexaméthasoneQ43195076
A randomized phase 3 study on the effect of thalidomide combined with adriamycin, dexamethasone, and high-dose melphalan, followed by thalidomide maintenance in patients with multiple myelomaQ43251148
Relapse/Refractory myeloma patient: potential treatment guidelines.Q43270040
Retreatment with bortezomib alone or in combination for patients with multiple myeloma following an initial response to bortezomibQ43280884
Second autologous or allogeneic transplantation after the failure of first autograft in patients with multiple myelomaQ43632773
Long-term follow-up on overall survival from the MM-009 and MM-010 phase III trials of lenalidomide plus dexamethasone in patients with relapsed or refractory multiple myelomaQ43726973
Transplantation as salvage therapy for high-risk patients with myeloma in relapseQ44245114
Lenalidomide plus dexamethasone is more effective than dexamethasone alone in patients with relapsed or refractory multiple myeloma regardless of prior thalidomide exposureQ44620764
Long-term prognostic significance of response in multiple myeloma after stem cell transplantation.Q45911819
Efficacy of melphalan and prednisone plus thalidomide in patients older than 75 years with newly diagnosed multiple myeloma: IFM 01/01 trial.Q46006794
Consolidation therapy with low-dose thalidomide and prednisolone prolongs the survival of multiple myeloma patients undergoing a single autologous stem-cell transplantation procedureQ46094234
Improved survival of patients with multiple myeloma after the introduction of novel agents and the applicability of the International Staging System (ISS): an analysis of the Greek Myeloma Study Group (GMSG).Q46118120
Influence of pre- and post-transplantation responses on outcome of patients with multiple myeloma: sequential improvement of response and achievement of complete response are associated with longer survivalQ46253134
Oral melphalan, prednisone, and thalidomide in elderly patients with multiple myeloma: updated results of a randomized controlled trial.Q46573449
High-dose therapy and autologous blood stem-cell transplantation compared with conventional treatment in myeloma patients aged 55 to 65 years: long-term results of a randomized control trial from the Group Myelome-AutogreffeQ46795068
Recent major improvement in long-term survival of younger patients with multiple myelomaQ46977305
Thalidomide and hematopoietic-cell transplantation for multiple myelomaQ46981475
Oral melphalan and prednisone chemotherapy plus thalidomide compared with melphalan and prednisone alone in elderly patients with multiple myeloma: randomised controlled trialQ46985882
Salvage autologous or allogeneic transplantation for multiple myeloma refractory to or relapsing after a first-line autograft?Q48011772
P433issue1
P921main subjectmultiple myelomaQ467635
P304page(s)73-85
P577publication date2011-10-25
P1433published inLeukemiaQ6534498
P1476titleTreatment strategies in relapsed and refractory multiple myeloma: a focus on drug sequencing and 'retreatment' approaches in the era of novel agents
P478volume26