Chemokines: established and novel targets in atherosclerosis

scientific article published on 28 October 2011

Chemokines: established and novel targets in atherosclerosis is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1002/EMMM.201100183
P932PMC publication ID3377113
P698PubMed publication ID22038924
P5875ResearchGate publication ID51753522

P50authorRory R. KoenenQ37829140
Christian WeberQ37838769
P2860cites workA Novel RANTES Antagonist Prevents Progression of Established Atherosclerotic Lesions in MiceQ61386199
Platelets regulate CD4+ T-cell differentiation via multiple chemokines in humansQ61684165
Hyperlipidemia-Triggered Neutrophilia Promotes Early AtherosclerosisQ63915146
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Chemokines acting via CXCR2 and CXCR4 control the release of neutrophils from the bone marrow and their return following senescenceQ79175268
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Differential influence of chemokine receptors CCR2 and CXCR3 in development of atherosclerosis in vivoQ80976739
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Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cellsQ83305041
CCR2 receptor blockade alters blood monocyte subpopulations but does not affect atherosclerotic lesions in apoE(-/-) miceQ84741014
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Platelets enhance lymphocyte adhesion and infiltration into arterial thrombusQ85025568
Chemokine receptor 7 knockout attenuates atherosclerotic plaque developmentQ85156583
Chemokines take centre stage in vascular biologyQ95787636
Polymerization of MIP-1 chemokine (CCL3 and CCL4) and clearance of MIP-1 by insulin-degrading enzymeQ24304041
CCR7 and its ligands: balancing immunity and toleranceQ24316090
The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activityQ24632813
Structural Basis of Chemokine Sequestration by a Tick Chemokine Binding Protein: The Crystal Structure of the Complex between Evasin-1 and CCL3Q27658814
CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survivalQ28506756
CXCR2 blockade impairs angiotensin II-induced CC chemokine synthesis and mononuclear leukocyte infiltrationQ28581476
Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejectionQ28752308
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystalsQ29615704
The many roles of chemokines and chemokine receptors in inflammationQ29618880
Monocyte emigration from bone marrow during bacterial infection requires signals mediated by chemokine receptor CCR2Q29622852
Chemokines as mediators of tumor angiogenesis and neovascularizationQ30427886
CXCR6 promotes atherosclerosis by supporting T-cell homing, interferon-gamma production, and macrophage accumulation in the aortic wallQ30444644
Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosisQ30497499
Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodesQ30497539
Dose-response met-RANTES treatment of experimental periodontitis: a narrow edge between the disease severity attenuation and infection controlQ31028208
The chemokine RANTES is a crucial mediator of the progression from acute to chronic colitis in the rat.Q31725223
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Gene expression changes in foam cells and the role of chemokine receptor CCR7 during atherosclerosis regression in ApoE-deficient miceQ33236495
The novel CXCL12gamma isoform encodes an unstructured cationic domain which regulates bioactivity and interaction with both glycosaminoglycans and CXCR4.Q33304448
The chemokine system: redundancy for robust outputsQ33650445
Chemokines and asthma: redundancy of function or a coordinated effort?Q33753439
Antagonists of monocyte chemoattractant protein 1 identified by modification of functionally critical NH2-terminal residuesQ34059219
Chemokine receptor expression on MBP-reactive T cells: CXCR6 is a marker of IFNgamma-producing effector cellsQ34131442
The immune system in atherosclerosisQ34164644
Targeted disruption of the scavenger receptor and chemokine CXCL16 accelerates atherosclerosisQ34652627
Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokinesQ34762409
Decreased atherosclerosis in CX3CR1-/- mice reveals a role for fractalkine in atherogenesisQ34828549
Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe-/- mice during disease regressionQ34876397
Up-regulated expression of the CXCR2 ligand KC/GRO-alpha in atherosclerotic lesions plays a central role in macrophage accumulation and lesion progression.Q35088170
Genetic deletion of chemokine receptor Ccr6 decreases atherogenesis in ApoE-deficient miceQ35151086
Monocyte subsets differentially employ CCR2, CCR5, and CX3CR1 to accumulate within atherosclerotic plaquesQ35250952
Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromataQ35251005
CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in miceQ35572404
Critical roles for CCR2 and MCP-3 in monocyte mobilization from bone marrow and recruitment to inflammatory sitesQ35664094
Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cellsQ35698582
The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL.Q35732501
Chemokine blockers--therapeutics in the making?Q36323784
Schistosoma mansoni secretes a chemokine binding protein with antiinflammatory activityQ36403130
CXCR4-CCR5: a couple modulating T cell functionsQ36786977
An engineered monomer of CCL2 has anti-inflammatory properties emphasizing the importance of oligomerization for chemokine activity in vivo.Q36882279
Highly potent, fully recombinant anti-HIV chemokines: reengineering a low-cost microbicideQ36976659
The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse modelsQ37282249
Chemokine receptor antagonists: overcoming developmental hurdlesQ37349685
Platelet-mediated enhancement of leukocyte adhesionQ37359979
A leukocyte homologue of the IL-8 receptor CXCR-2 mediates the accumulation of macrophages in atherosclerotic lesions of LDL receptor-deficient miceQ37377448
Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the protean effects of "selective" antagonists.Q37431503
Regulation of the migration and survival of monocyte subsets by chemokine receptors and its relevance to atherosclerosisQ37435783
Anti-inflammatory therapy by intravenous delivery of non-heparan sulfate-binding CXCL12.Q37470294
Anti-inflammatory therapeutics for the treatment of atherosclerosisQ37626768
Chemokines in the vascular inflammatory response of atherosclerosisQ37652971
Therapeutic targeting of chemokine interactions in atherosclerosisQ37684793
Phagocyte partnership during the onset and resolution of inflammation.Q37760424
Effect of posttranslational processing on the in vitro and in vivo activity of chemokines.Q37819144
Heterophilic chemokine receptor interactions in chemokine signaling and biologyQ37819146
Chemokine oligomerization and interactions with receptors and glycosaminoglycans: the role of structural dynamics in functionQ37827607
Safety, pharmacokinetics, and antiviral activity of HGS004, a novel fully human IgG4 monoclonal antibody against CCR5, in HIV-1-infected patientsQ39157923
Rationally evolving MCP-1/CCL2 into a decoy protein with potent anti-inflammatory activity in vivoQ39615447
Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in miceQ39639458
A randomized controlled trial with an anti-CCL2 (anti-monocyte chemotactic protein 1) monoclonal antibody in patients with rheumatoid arthritisQ39763545
Ticks produce highly selective chemokine binding proteins with antiinflammatory activityQ40063162
Oligomerization of CXCL10 is necessary for endothelial cell presentation and in vivo activityQ40212535
Three-dimensional structures of alpha and beta chemokines.Q40569716
The unique target specificity of a nonpeptide chemokine receptor antagonist: selective blockade of two Th1 chemokine receptors CCR5 and CXCR3.Q40674317
Deposition of platelet RANTES triggering monocyte recruitment requires P-selectin and is involved in neointima formation after arterial injuryQ40703820
The amino-terminal extracellular domain of the MCP-1 receptor, but not the RANTES/MIP-1alpha receptor, confers chemokine selectivity. Evidence for a two-step mechanism for MCP-1 receptor activationQ41175846
Extension of recombinant human RANTES by the retention of the initiating methionine produces a potent antagonist.Q41229926
Chemokine research moves on.Q41830371
Homocysteine up-regulates vascular transmembrane chemokine CXCL16 and induces CXCR6+ lymphocyte recruitment in vitro and in vivoQ41933923
Cellular dysfunction in inflammatory-related vascular disorders' review series. The inflammatory process: a new dimension of a 19 century old storyQ42389614
CCR7 is required for the in vivo function of CD4+ CD25+ regulatory T cellsQ42767496
Hypercholesterolemia promotes bone marrow cell mobilization by perturbing the SDF-1:CXCR4 axisQ43222603
Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic miceQ43489161
Early application of Met-RANTES ameliorates chronic allograft nephropathyQ43889573
Antagonism of RANTES receptors reduces atherosclerotic plaque formation in miceQ44680905
Overcoming hurdles in developing successful drugs targeting chemokine receptorsQ46441158
HIV entry inhibitor TAK-779 attenuates atherogenesis in low-density lipoprotein receptor-deficient miceQ46766122
Endothelial heparan sulfate deficiency impairs L-selectin- and chemokine-mediated neutrophil trafficking during inflammatory responsesQ46806608
Decreased lesion formation in CCR2-/- mice reveals a role for chemokines in the initiation of atherosclerosisQ46897070
CC chemokine CCL5 plays a central role impacting infarct size and post-infarction heart failure in miceQ47375281
A small molecule CXCR4 antagonist inhibits neointima formation and smooth muscle progenitor cell mobilization after arterial injuryQ47438278
Efficacy and safety of a monoclonal antibody recognizing interleukin-8 in COPD: a pilot studyQ47927665
An engineered CX3CR1 antagonist endowed with anti-inflammatory activity.Q51778397
Heparin displaces interferon-gamma-inducible chemokines (IP-10, I-TAC, and Mig) sequestered in the vasculature and inhibits the transendothelial migration and arterial recruitment of T cells.Q51979776
Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis.Q52583321
Chemokine CCL5/RANTES inhibition reduces myocardial reperfusion injury in atherosclerotic mice.Q53378752
Transmembrane chemokines: versatile 'special agents' in vascular inflammation.Q53555496
Gene profiling in atherosclerosis reveals a key role for small inducible cytokines: validation using a novel monocyte chemoattractant protein monoclonal antibody.Q54658035
Glycosaminoglycans Mediate Cell Surface Oligomerization of ChemokinesQ57019212
A New Monocyte Chemotactic Protein-1/Chemokine CC Motif Ligand-2 Competitor Limiting Neointima Formation and Myocardial Ischemia/Reperfusion Injury in MiceQ57574588
Heterophilic interactions of platelet factor 4 and RANTES promote monocyte arrest on endotheliumQ57574602
Natural regulatory T cells control the development of atherosclerosis in miceQ58149268
Single Administration of the CXC Chemokine-Binding Protein Evasin-3 During Ischemia Prevents Myocardial Reperfusion Injury in MiceQ58197658
P433issue12
P921main subjectatherosclerosisQ12252367
peptideQ172847
chemokineQ421866
P304page(s)713-725
P577publication date2011-10-28
2011-12-01
P1433published inEMBO Molecular MedicineQ15817279
P1476titleChemokines: established and novel targets in atherosclerosis
P478volume3

Reverse relations

cites work (P2860)
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