review article | Q7318358 |
scholarly article | Q13442814 |
P2093 | author name string | Chaddock John | |
Foster Keith | |||
P2860 | cites work | Preparation of specifically activatable endopeptidase derivatives of Clostridium botulinum toxins type A, B, and C and their applications | Q81421439 |
Botulinum toxin products overview | Q82022191 | ||
Recovery from botulinum neurotoxin poisoning in vivo | Q82612352 | ||
Botulism | Q21994439 | ||
Botulinum Toxin as a Biological Weapon: Medical and Public Health Management | Q23832736 | ||
Identification of a novel syntaxin- and synaptobrevin/VAMP-binding protein, SNAP-23, expressed in non-neuronal tissues | Q24321205 | ||
Domain organization in Clostridium botulinum neurotoxin type E is unique: its implication in faster translocation | Q27653311 | ||
Crystal structure of a catalytically active, non-toxic endopeptidase derivative of Clostridium botulinum toxin A | Q27654586 | ||
Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype F | Q27655649 | ||
Structure and activity of a functional derivative of Clostridium botulinum neurotoxin B | Q27665891 | ||
Crystal structure of botulinum neurotoxin type A and implications for toxicity | Q27765727 | ||
Reconstituted membrane fusion requires regulatory lipids, SNAREs and synergistic SNARE chaperones | Q27931637 | ||
SNAP receptors implicated in vesicle targeting and fusion | Q28131653 | ||
Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activity | Q28254916 | ||
Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragments | Q28609202 | ||
Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavage | Q28609220 | ||
SNAREs--engines for membrane fusion | Q29547230 | ||
The mechanisms of vesicle budding and fusion | Q29615234 | ||
Clostridial neurotoxins: structure-function led design of new therapeutics | Q30231439 | ||
The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interaction | Q31036598 | ||
Botulinum neurotoxin heavy chain belt as an intramolecular chaperone for the light chain | Q33301010 | ||
Botulinum toxin in the treatment of neurological disorders of the autonomic nervous system | Q33712120 | ||
Neurotoxins affecting neuroexocytosis | Q33881286 | ||
OnabotulinumtoxinA for treatment of chronic migraine: pooled results from the double-blind, randomized, placebo-controlled phases of the PREEMPT clinical program | Q34116531 | ||
Evaluation of the therapeutic usefulness of botulinum neurotoxin B, C1, E, and F compared with the long lasting type A. Basis for distinct durations of inhibition of exocytosis in central neurons | Q34154552 | ||
Botulinum Toxin Injection into Extraocular Muscles as an Alternative to Strabismus Surgery | Q34282549 | ||
Treatment of Glabellar Frown Lines with C. Botulinum-A Exotoxin | Q34615234 | ||
Assessment: Botulinum neurotoxin in the treatment of autonomic disorders and pain (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology | Q34776040 | ||
What is the role of SNARE proteins in membrane fusion? | Q35169800 | ||
Evidence for antinociceptive activity of botulinum toxin type A in pain management | Q35187501 | ||
Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept. | Q35250681 | ||
Genetic diversity among Botulinum Neurotoxin-producing clostridial strains | Q35634548 | ||
Identification of the major steps in botulinum toxin action | Q35639122 | ||
Botulinum toxin in clinical practice | Q35807826 | ||
Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cells | Q36325534 | ||
Proposed mechanism for the efficacy of injected botulinum toxin in the treatment of human detrusor overactivity. | Q36373708 | ||
Botulinum neurotoxin - from laboratory to bedside | Q36511588 | ||
Mechanism of botulinum neurotoxin B and G entry into hippocampal neurons | Q36639118 | ||
From poison to remedy: the chequered history of botulinum toxin | Q36801432 | ||
Future aspects of botulinum neurotoxins | Q36844148 | ||
Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons. | Q36992893 | ||
Botulinum toxin drugs: future developments | Q37117645 | ||
Assessment: Botulinum neurotoxin for the treatment of spasticity (an evidence-based review): report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology | Q37155197 | ||
Engineering botulinum neurotoxin to extend therapeutic intervention. | Q37224285 | ||
Botulinum neurotoxins in the treatment of refractory pain | Q37337947 | ||
Disease-oriented approach to botulinum toxin use. | Q37346370 | ||
Engineered toxins: new therapeutics | Q37407389 | ||
NeuroBloc/Myobloc: unique features and findings | Q37414847 | ||
Development of future indications for BOTOX. | Q37496204 | ||
Botulinum neurotoxin: a marvel of protein design | Q37710092 | ||
Re-engineering clostridial neurotoxins for the treatment of chronic pain: current status and future prospects | Q37749805 | ||
Inhibition of vesicular secretion in both neuronal and nonneuronal cells by a retargeted endopeptidase derivative of Clostridium botulinum neurotoxin type A | Q39515519 | ||
Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes. | Q39848704 | ||
SV2 is the protein receptor for botulinum neurotoxin A. | Q40303506 | ||
Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential | Q42452235 | ||
The changed image of botulinum toxin | Q42780619 | ||
Botulinum neurotoxin B inhibits insulin-stimulated glucose uptake into 3T3-L1 adipocytes and cleaves cellubrevin unlike type A toxin which failed to proteolyze the SNAP-23 present | Q42800833 | ||
Catalytic properties of botulinum neurotoxin subtypes A3 and A4. | Q43106828 | ||
Intragastric injection of botulinum toxin for the treatment of obesity. Where are we? | Q43107739 | ||
The 26-mer peptide released from SNAP-25 cleavage by botulinum neurotoxin E inhibits vesicle docking | Q43669503 | ||
Membrane Interaction of botulinum neurotoxin A translocation (T) domain. The belt region is a regulatory loop for membrane interaction. | Q43960895 | ||
Comparison of efficacy and immunogenicity of original versus current botulinum toxin in cervical dystonia | Q44394591 | ||
Proteolysis of synthetic peptides by type A botulinum neurotoxin | Q44592997 | ||
Subcutaneous administration of botulinum toxin A reduces formalin-induced pain | Q44722571 | ||
Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain | Q44803129 | ||
Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G. | Q44881077 | ||
Molecular architecture of botulinum neurotoxin E revealed by single particle electron microscopy | Q46294932 | ||
Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity. | Q46644837 | ||
Substrate recognition strategy for botulinum neurotoxin serotype A. | Q46801352 | ||
Translocation of botulinum neurotoxin light chain protease through the heavy chain channel | Q46942366 | ||
Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristics | Q47783055 | ||
Different types of botulinum toxin in humans | Q47935598 | ||
The variability in the clinical effect induced by botulinum toxin type A: the role of muscle activity in humans. | Q50753274 | ||
Different time courses of recovery after poisoning with botulinum neurotoxin serotypes A and E in humans. | Q50755840 | ||
Xeomin is free from complexing proteins. | Q51764777 | ||
Uptake of botulinum neurotoxin into cultured neurons. | Q52095157 | ||
The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a. | Q52312776 | ||
Inhibition of release of neurotransmitters from rat dorsal root ganglia by a novel conjugate of a Clostridium botulinum toxin A endopeptidase fragment and Erythrina cristagalli lectin. | Q52861424 | ||
History of the cosmetic use of Botulinum A exotoxin. | Q53565450 | ||
Mechanism of substrate recognition by botulinum neurotoxin serotype A. | Q53575621 | ||
Expression and purification of catalytically active, non-toxic endopeptidase derivatives of Clostridium botulinum toxin type A. | Q54541506 | ||
How do tetanus and botulinum toxins bind to neuronal membranes? | Q56226691 | ||
SNAREs and traffic | Q56850814 | ||
SNARE motif and neurotoxins | Q59098553 | ||
Kinetic studies on the interaction between botulinum toxin type A and the cholinergic neuromuscular junction | Q66829168 | ||
Cooperative action of the light chain of tetanus toxin and the heavy chain of botulinum toxin type A on the transmitter release of mammalian motor endplates | Q68305272 | ||
Tetanus toxin in dissociated spinal cord cultures: long-term characterization of form and action | Q69572834 | ||
Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgery | Q71162398 | ||
Comparison of therapeutic efficacies of type A and F botulinum toxins for blepharospasm: a double-blind, controlled study | Q72649948 | ||
A peptide that mimics the C-terminal sequence of SNAP-25 inhibits secretory vesicle docking in chromaffin cells | Q73009327 | ||
A conjugate composed of nerve growth factor coupled to a non-toxic derivative of Clostridium botulinum neurotoxin type A can inhibit neurotransmitter release in vitro | Q73043502 | ||
Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins | Q73426186 | ||
Capsaicin-stimulated release of substance P from cultured dorsal root ganglion neurons: involvement of two distinct mechanisms | Q73634933 | ||
Spectroscopic analysis of pH-induced changes in the molecular features of type A botulinum neurotoxin light chain | Q73829099 | ||
Persistence of botulinum neurotoxin action in cultured spinal cord cells | Q78144026 | ||
Influence of nerve‐ending activity and of drugs on the rate of paralysis of rat diaphragm preparation by Cl. botulinum type A toxin | Q78931830 | ||
Clinical use of non-A botulinum toxins: botulinum toxin type C and botulinum toxin type F | Q79753944 | ||
P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 12 | |
P921 | main subject | enzyme | Q8047 |
bacterial protein | Q64923821 | ||
P304 | page(s) | 2795-2815 | |
P577 | publication date | 2010-12-01 | |
2010-12-03 | |||
P1433 | published in | Toxins | Q15724569 |
P1476 | title | Targeted secretion inhibitors-innovative protein therapeutics | |
P478 | volume | 2 |
Q36190743 | A botulinum toxin-derived targeted secretion inhibitor downregulates the GH/IGF1 axis |
Q58805104 | Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q⁻K Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities |
Q39039170 | Botulinum protease-cleaved SNARE fragments induce cytotoxicity in neuroblastoma cells |
Q26778129 | Current status and future directions of botulinum neurotoxins for targeting pain processing |
Q26780197 | Drug therapy of overactive bladder--what is coming next? |
Q38584641 | Emerging drugs for overactive bladder |
Q36913556 | IGF-1 antibody prolongs the effective duration time of botulinum toxin in decreasing muscle strength |
Q38265873 | Innovative pharmacotherapies for women with overactive bladder: where are we now and what is in the pipeline? |
Q38406085 | Novel therapeutic uses and formulations of botulinum neurotoxins: a patent review (2012 - 2014). |
Q39157207 | Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cells |