Targeted secretion inhibitors-innovative protein therapeutics

scientific article published on 03 December 2010

Targeted secretion inhibitors-innovative protein therapeutics is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.3390/TOXINS2122795
P932PMC publication ID3153183
P698PubMed publication ID22069575
P5875ResearchGate publication ID51785355

P2093author name stringChaddock John
Foster Keith
P2860cites workPreparation of specifically activatable endopeptidase derivatives of Clostridium botulinum toxins type A, B, and C and their applicationsQ81421439
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Crystal structure of a catalytically active, non-toxic endopeptidase derivative of Clostridium botulinum toxin AQ27654586
Glycosylated SV2 and Gangliosides as Dual Receptors for Botulinum Neurotoxin Serotype FQ27655649
Structure and activity of a functional derivative of Clostridium botulinum neurotoxin BQ27665891
Crystal structure of botulinum neurotoxin type A and implications for toxicityQ27765727
Reconstituted membrane fusion requires regulatory lipids, SNAREs and synergistic SNARE chaperonesQ27931637
SNAP receptors implicated in vesicle targeting and fusionQ28131653
Regulated exocytosis contributes to protein kinase C potentiation of vanilloid receptor activityQ28254916
Differences in the protease activities of tetanus and botulinum B toxins revealed by the cleavage of vesicle-associated membrane protein and various sized fragmentsQ28609202
Proteolysis of SNAP-25 isoforms by botulinum neurotoxin types A, C, and E: domains and amino acid residues controlling the formation of enzyme-substrate complexes and cleavageQ28609220
SNAREs--engines for membrane fusionQ29547230
The mechanisms of vesicle budding and fusionQ29615234
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The HCC-domain of botulinum neurotoxins A and B exhibits a singular ganglioside binding site displaying serotype specific carbohydrate interactionQ31036598
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OnabotulinumtoxinA for treatment of chronic migraine: pooled results from the double-blind, randomized, placebo-controlled phases of the PREEMPT clinical programQ34116531
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Botulinum Toxin Injection into Extraocular Muscles as an Alternative to Strabismus SurgeryQ34282549
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What is the role of SNARE proteins in membrane fusion?Q35169800
Evidence for antinociceptive activity of botulinum toxin type A in pain managementQ35187501
Identification of the protein receptor binding site of botulinum neurotoxins B and G proves the double-receptor concept.Q35250681
Genetic diversity among Botulinum Neurotoxin-producing clostridial strainsQ35634548
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Synaptotagmins I and II mediate entry of botulinum neurotoxin B into cellsQ36325534
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Glycosylated SV2A and SV2B mediate the entry of botulinum neurotoxin E into neurons.Q36992893
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Development of future indications for BOTOX.Q37496204
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Inhibition of vesicular secretion in both neuronal and nonneuronal cells by a retargeted endopeptidase derivative of Clostridium botulinum neurotoxin type AQ39515519
Reconstitution of Rab- and SNARE-dependent membrane fusion by synthetic endosomes.Q39848704
SV2 is the protein receptor for botulinum neurotoxin A.Q40303506
Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potentialQ42452235
The changed image of botulinum toxinQ42780619
Botulinum neurotoxin B inhibits insulin-stimulated glucose uptake into 3T3-L1 adipocytes and cleaves cellubrevin unlike type A toxin which failed to proteolyze the SNAP-23 presentQ42800833
Catalytic properties of botulinum neurotoxin subtypes A3 and A4.Q43106828
Intragastric injection of botulinum toxin for the treatment of obesity. Where are we?Q43107739
The 26-mer peptide released from SNAP-25 cleavage by botulinum neurotoxin E inhibits vesicle dockingQ43669503
Membrane Interaction of botulinum neurotoxin A translocation (T) domain. The belt region is a regulatory loop for membrane interaction.Q43960895
Comparison of efficacy and immunogenicity of original versus current botulinum toxin in cervical dystoniaQ44394591
Proteolysis of synthetic peptides by type A botulinum neurotoxinQ44592997
Subcutaneous administration of botulinum toxin A reduces formalin-induced painQ44722571
Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of painQ44803129
Synaptotagmins I and II act as nerve cell receptors for botulinum neurotoxin G.Q44881077
Molecular architecture of botulinum neurotoxin E revealed by single particle electron microscopyQ46294932
Decreased sensory receptors P2X3 and TRPV1 in suburothelial nerve fibers following intradetrusor injections of botulinum toxin for human detrusor overactivity.Q46644837
Substrate recognition strategy for botulinum neurotoxin serotype A.Q46801352
Translocation of botulinum neurotoxin light chain protease through the heavy chain channelQ46942366
Novel chimeras of botulinum neurotoxins A and E unveil contributions from the binding, translocation, and protease domains to their functional characteristicsQ47783055
Different types of botulinum toxin in humansQ47935598
The variability in the clinical effect induced by botulinum toxin type A: the role of muscle activity in humans.Q50753274
Different time courses of recovery after poisoning with botulinum neurotoxin serotypes A and E in humans.Q50755840
Xeomin is free from complexing proteins.Q51764777
Uptake of botulinum neurotoxin into cultured neurons.Q52095157
The high-affinity binding of Clostridium botulinum type B neurotoxin to synaptotagmin II associated with gangliosides GT1b/GD1a.Q52312776
Inhibition of release of neurotransmitters from rat dorsal root ganglia by a novel conjugate of a Clostridium botulinum toxin A endopeptidase fragment and Erythrina cristagalli lectin.Q52861424
History of the cosmetic use of Botulinum A exotoxin.Q53565450
Mechanism of substrate recognition by botulinum neurotoxin serotype A.Q53575621
Expression and purification of catalytically active, non-toxic endopeptidase derivatives of Clostridium botulinum toxin type A.Q54541506
How do tetanus and botulinum toxins bind to neuronal membranes?Q56226691
SNAREs and trafficQ56850814
SNARE motif and neurotoxinsQ59098553
Kinetic studies on the interaction between botulinum toxin type A and the cholinergic neuromuscular junctionQ66829168
Cooperative action of the light chain of tetanus toxin and the heavy chain of botulinum toxin type A on the transmitter release of mammalian motor endplatesQ68305272
Tetanus toxin in dissociated spinal cord cultures: long-term characterization of form and actionQ69572834
Botulinum toxin injection into extraocular muscles as an alternative to strabismus surgeryQ71162398
Comparison of therapeutic efficacies of type A and F botulinum toxins for blepharospasm: a double-blind, controlled studyQ72649948
A peptide that mimics the C-terminal sequence of SNAP-25 inhibits secretory vesicle docking in chromaffin cellsQ73009327
A conjugate composed of nerve growth factor coupled to a non-toxic derivative of Clostridium botulinum neurotoxin type A can inhibit neurotransmitter release in vitroQ73043502
Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxinsQ73426186
Capsaicin-stimulated release of substance P from cultured dorsal root ganglion neurons: involvement of two distinct mechanismsQ73634933
Spectroscopic analysis of pH-induced changes in the molecular features of type A botulinum neurotoxin light chainQ73829099
Persistence of botulinum neurotoxin action in cultured spinal cord cellsQ78144026
Influence of nerve‐ending activity and of drugs on the rate of paralysis of rat diaphragm preparation by Cl. botulinum type A toxinQ78931830
Clinical use of non-A botulinum toxins: botulinum toxin type C and botulinum toxin type FQ79753944
P275copyright licenseCreative Commons Attribution 3.0 UnportedQ14947546
P6216copyright statuscopyrightedQ50423863
P433issue12
P921main subjectenzymeQ8047
bacterial proteinQ64923821
P304page(s)2795-2815
P577publication date2010-12-01
2010-12-03
P1433published inToxinsQ15724569
P1476titleTargeted secretion inhibitors-innovative protein therapeutics
P478volume2

Reverse relations

cites work (P2860)
Q36190743A botulinum toxin-derived targeted secretion inhibitor downregulates the GH/IGF1 axis
Q58805104Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q⁻K Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities
Q39039170Botulinum protease-cleaved SNARE fragments induce cytotoxicity in neuroblastoma cells
Q26778129Current status and future directions of botulinum neurotoxins for targeting pain processing
Q26780197Drug therapy of overactive bladder--what is coming next?
Q38584641Emerging drugs for overactive bladder
Q36913556IGF-1 antibody prolongs the effective duration time of botulinum toxin in decreasing muscle strength
Q38265873Innovative pharmacotherapies for women with overactive bladder: where are we now and what is in the pipeline?
Q38406085Novel therapeutic uses and formulations of botulinum neurotoxins: a patent review (2012 - 2014).
Q39157207Stapling of the botulinum type A protease to growth factors and neuropeptides allows selective targeting of neuroendocrine cells