scholarly article | Q13442814 |
P2093 | author name string | Maciek R Antoniewicz | |
Woo Suk Ahn | |||
P2860 | cites work | Effects of ammonia and lactate on growth, metabolism, and productivity of BHK cells | Q58754717 |
13C NMR isotopomer analysis reveals a connection between pyruvate cycling and glucose-stimulated insulin secretion (GSIS) | Q24530767 | ||
Understanding the Warburg effect: the metabolic requirements of cell proliferation | Q24604760 | ||
On the Origin of Cancer Cells | Q27861025 | ||
TIGAR, a p53-inducible regulator of glycolysis and apoptosis | Q28118306 | ||
Importance of glucose-6-phosphate dehydrogenase activity for cell growth | Q28268412 | ||
The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth | Q29547680 | ||
Proteomic investigation of metabolic shift in mammalian cell culture | Q30773815 | ||
Growth, metabolic, and antibody production kinetics of hybridoma cell culture: 1. Analysis of data from controlled batch reactors | Q30844886 | ||
Metabolic flux analysis in Escherichia coli by integrating isotopic dynamic and isotopic stationary 13C labeling data | Q31134869 | ||
A procedure for the estimation over time of metabolic fluxes in scenarios where measurements are uncertain and/or insufficient | Q33304395 | ||
Systems-level metabolic flux profiling identifies fatty acid synthesis as a target for antiviral therapy | Q33675261 | ||
Metabolic genes in cancer: their roles in tumor progression and clinical implications | Q33772469 | ||
Isozymes of mammalian hexokinase: structure, subcellular localization and metabolic function | Q33966115 | ||
Production of recombinant protein therapeutics in cultivated mammalian cells | Q33982884 | ||
13C metabolic flux analysis | Q34084355 | ||
Glucose-6-phosphate dehydrogenase plays a crucial role in protection from redox-stress-induced apoptosis | Q34308875 | ||
Evaluation of 13C isotopic tracers for metabolic flux analysis in mammalian cells | Q34517790 | ||
Metabolic design of macroscopic bioreaction models: application to Chinese hamster ovary cells | Q35574608 | ||
Engineering mammalian cell factories for improved recombinant monoclonal antibody production: lessons from nature? | Q36120108 | ||
Characterisation of G418-induced metabolic load in recombinant CHO and BHK cells: effect on the activity and expression of central metabolic enzymes | Q36255205 | ||
Metabolic cycling in control of glucose-stimulated insulin secretion | Q37016691 | ||
Overexpression of transketolase-like gene 1 is associated with cell proliferation in uterine cervix cancer | Q37158479 | ||
Linking high-resolution metabolic flux phenotypes and transcriptional regulation in yeast modulated by the global regulator Gcn4p | Q37167828 | ||
Emerging trends in plasma-free manufacturing of recombinant protein therapeutics expressed in mammalian cells | Q37234113 | ||
Implementation of advanced technologies in commercial monoclonal antibody production | Q37256640 | ||
Metabolic flux analysis in mammalian cell culture | Q37615599 | ||
Metabolic flux analysis and pharmaceutical production | Q37622534 | ||
Metabolic flux analysis in eukaryotes | Q37694051 | ||
13C metabolic flux analysis in complex systems. | Q37787585 | ||
Metabolic effects on recombinant interferon-gamma glycosylation in continuous culture of Chinese hamster ovary cells | Q38326531 | ||
An elementary metabolite unit (EMU) based method of isotopically nonstationary flux analysis. | Q50919450 | ||
Determination of confidence intervals of metabolic fluxes estimated from stable isotope measurements. | Q51220949 | ||
Dynamic metabolic flux analysis (DMFA): a framework for determining fluxes at metabolic non-steady state. | Q51518128 | ||
Metabolic flux analysis of CHO cell metabolism in the late non-growth phase. | Q51772488 | ||
Towards a metabolic and isotopic steady state in CHO batch cultures for reliable isotope-based metabolic profiling. | Q51781767 | ||
Effect of culture temperature on erythropoietin production and glycosylation in a perfusion culture of recombinant CHO cells. | Q51785246 | ||
Growth characteristics in fed-batch culture of hybridoma cells with control of glucose and glutamine concentrations. | Q52375664 | ||
Cell death in bioreactors: a role for apoptosis. | Q52692588 | ||
Metabolic flux analysis in a nonstationary system: fed-batch fermentation of a high yielding strain of E. coli producing 1,3-propanediol | Q39236380 | ||
The enzymic hydrolysis of glutamine and its spontaneous decomposition in buffer solutions | Q39428921 | ||
Metabolic flux analysis of CHO cells at growth and non-growth phases using isotopic tracers and mass spectrometry | Q39494168 | ||
Development of a mathematical model for evaluating the dynamics of normal and apoptotic Chinese hamster ovary cells | Q39535172 | ||
Hexokinase 2 is a key mediator of aerobic glycolysis and promotes tumor growth in human glioblastoma multiforme | Q39606772 | ||
Quantitative characterization of metabolism and metabolic shifts during growth of the new human cell line AGE1.HN using time resolved metabolic flux analysis. | Q39615011 | ||
CHO-K1 host cells adapted to growth in glutamine-free medium by FACS-assisted evolution | Q39646825 | ||
The glucose transporter of mammalian cells | Q39819660 | ||
Expression of anti-apoptosis genes alters lactate metabolism of Chinese Hamster Ovary cells in culture | Q39880044 | ||
Quantifying reductive carboxylation flux of glutamine to lipid in a brown adipocyte cell line | Q39998829 | ||
Functional expression of human pyruvate carboxylase for reduced lactic acid formation of Chinese hamster ovary cells (DG44). | Q40116841 | ||
Down-regulation of lactate dehydrogenase-A by siRNAs for reduced lactic acid formation of Chinese hamster ovary cells producing thrombopoietin | Q40211655 | ||
Antibody production | Q40258663 | ||
Considerations on the lactate consumption by CHO cells in the presence of galactose | Q40258669 | ||
Metabolism of PER.C6 cells cultivated under fed-batch conditions at low glucose and glutamine levels | Q40307631 | ||
Effects of lactate dehydrogenase suppression and glycerol-3-phosphate dehydrogenase overexpression on cellular metabolism | Q40316588 | ||
Impact of dynamic online fed-batch strategies on metabolism, productivity and N-glycosylation quality in CHO cell cultures. | Q40461540 | ||
Impact of temperature reduction and expression of yeast pyruvate carboxylase on hGM-CSF-producing CHO cells | Q40570353 | ||
Large scale gene expression profiling of metabolic shift of mammalian cells in culture | Q40605473 | ||
Expression of recombinant cytoplasmic yeast pyruvate carboxylase for the improvement of the production of human erythropoietin by recombinant BHK-21 cells | Q40760951 | ||
Engineering of a mammalian cell line for reduction of lactate formation and high monoclonal antibody production | Q40841544 | ||
Glucose-6-phosphate dehydrogenase and the oxidative pentose phosphate cycle protect cells against apoptosis induced by low doses of ionizing radiation | Q40877669 | ||
Improvement of CHO cell culture medium formulation: simultaneous substitution of glucose and glutamine | Q40901774 | ||
Improvement of the primary metabolism of cell cultures by introducing a new cytoplasmic pyruvate carboxylase reaction | Q40915316 | ||
Metabolic shifts by nutrient manipulation in continuous cultures of BHK cells | Q40917436 | ||
Regulation of glutaminase activity and glutamine metabolism | Q40926056 | ||
Elevated glutamate dehydrogenase flux in glucose-deprived hybridoma and myeloma cells: evidence from 1H/15N NMR. | Q40963412 | ||
The importance of ammonia in mammalian cell culture | Q41009633 | ||
Effects of ammonium and lactate on growth and metabolism of a recombinant Chinese hamster ovary cell culture | Q41086618 | ||
High viable cell concentration fed-batch cultures of hybridoma cells through on-line nutrient feeding | Q41334125 | ||
Elementary metabolite units (EMU): a novel framework for modeling isotopic distributions | Q41374953 | ||
Influence of ammonium on growth, metabolism, and productivity of a continuous suspension Chinese hamster ovary cell culture | Q41505216 | ||
Glucose and glutamine metabolism of a murine B-lymphocyte hybridoma grown in batch culture | Q41516271 | ||
Characterization of glutamine metabolism in two related murine hybridomas | Q41632841 | ||
Effects of ammonia and lactate on hybridoma growth, metabolism, and antibody production | Q41639279 | ||
High-level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker | Q41642360 | ||
Growth inhibition in animal cell culture. The effect of lactate and ammonia | Q41676171 | ||
High level expression of tissue inhibitor of metalloproteinases in Chinese hamster ovary cells using glutamine synthetase gene amplification | Q41730174 | ||
Chemical decomposition of glutamine in cell culture media: effect of media type, pH, and serum concentration | Q41743417 | ||
Chloroquine and ammonium chloride prevent terminal glycosylation of immunoglobulins in plasma cells without affecting secretion | Q41915360 | ||
Effects of ammonia on CHO cell growth, erythropoietin production, and glycosylation | Q41921972 | ||
The effect of ammonia on the O-linked glycosylation of granulocyte colony-stimulating factor produced by chinese hamster ovary cells | Q41932731 | ||
Improving glucose and glutamine metabolism of human HEK 293 and Trichoplusia ni insect cells engineered to express a cytosolic pyruvate carboxylase enzyme | Q42049015 | ||
Dynamic metabolic flux analysis demonstrated on cultures where the limiting substrate is changed from carbon to nitrogen and vice versa | Q42430397 | ||
A 1H/15N n.m.r. study of nitrogen metabolism in cultured mammalian cells | Q42797179 | ||
A detailed metabolic flux analysis of an underdetermined network of CHO cells | Q42876917 | ||
Measuring deuterium enrichment of glucose hydrogen atoms by gas chromatography/mass spectrometry | Q43138152 | ||
Feed development for fed-batch CHO production process by semisteady state analysis | Q43219132 | ||
Metabolic flux analysis of CHO cells in perfusion culture by metabolite balancing and 2D [13C, 1H] COSY NMR spectroscopy | Q43246624 | ||
Dynamic model of CHO cell metabolism. | Q43711578 | ||
Analysis of CHO cells metabolic redistribution in a glutamate-based defined medium in continuous culture. | Q43817062 | ||
Effects of ammonia and glucosamine on the heterogeneity of erythropoietin glycoforms. | Q43873679 | ||
Effect of low culture temperature on specific productivity, transcription level, and heterogeneity of erythropoietin in Chinese hamster ovary cells | Q44323806 | ||
Effect of culture pH on erythropoietin production by Chinese hamster ovary cells grown in suspension at 32.5 and 37.0 degrees C. | Q45206706 | ||
Error propagation from prime variables into specific rates and metabolic fluxes for mammalian cells in perfusion culture. | Q45955314 | ||
Effects of elevated pCO2 and osmolality on growth of CHO cells and production of antibody-fusion protein B1: a case study | Q46498440 | ||
Analysis of cellular metabolism of hybridoma cells at distinct physiological states | Q46760109 | ||
Ammonia affects the glycosylation patterns of recombinant mouse placental lactogen-I by chinese hamster ovary cells in a pH-dependent manner | Q47866641 | ||
A GFP-based method facilitates clonal selection of transfected CHO cells. | Q50584043 | ||
Accurate assessment of amino acid mass isotopomer distributions for metabolic flux analysis. | Q50917980 | ||
P433 | issue | 1 | |
P304 | page(s) | 61-74 | |
P577 | publication date | 2011-11-21 | |
P1433 | published in | Biotechnology Journal | Q15716480 |
P1476 | title | Towards dynamic metabolic flux analysis in CHO cell cultures | |
P478 | volume | 7 |
Q30994004 | A Method to Constrain Genome-Scale Models with 13C Labeling Data |
Q52587324 | A guide to 13C metabolic flux analysis for the cancer biologist. |
Q50258937 | A mechanistic kinetic description of lactate dehydrogenase elucidating cancer diagnosis and inhibitor evaluation. |
Q27003299 | A roadmap for interpreting (13)C metabolite labeling patterns from cells |
Q42738201 | Application of stable isotope-assisted metabolomics for cell metabolism studies |
Q54304180 | COMPLETE-MFA: complementary parallel labeling experiments technique for metabolic flux analysis. |
Q35879758 | Catabolism of Branched Chain Amino Acids Contributes Significantly to Synthesis of Odd-Chain and Even-Chain Fatty Acids in 3T3-L1 Adipocytes |
Q31001923 | Combining mechanistic and data-driven approaches to gain process knowledge on the control of the metabolic shift to lactate uptake in a fed-batch CHO process. |
Q34785750 | Computational strategies for a system-level understanding of metabolism |
Q48225243 | Deuterium- and Tritium-Labelled Compounds: Applications in the Life Sciences. |
Q51750774 | Dynamics of growth and metabolism controlled by glutamine availability in Chinese hamster ovary cells. |
Q51531891 | Electrostatic engineering of the interface between heavy and light chains promotes antibody Fab fragment production. |
Q97094598 | Elevated pCO2 affects the lactate metabolic shift in CHO cell culture processes |
Q51730505 | Glyco-Mapper: A Chinese hamster ovary (CHO) genome-specific glycosylation prediction tool. |
Q61032469 | High-Confidence Predictions in Systems Biology Dynamic Models |
Q39240027 | Identification of active constraints in dynamic flux balance analysis |
Q45258279 | Investigation of metabolic variability observed in extended fed batch cell culture |
Q40853167 | Low glucose depletes glycan precursors, reduces site occupancy and galactosylation of a monoclonal antibody in CHO cell culture. |
Q26801210 | Macroscopic modeling of mammalian cell growth and metabolism |
Q39762220 | Metabolic engineering for L-glutamine overproduction by using DNA gyrase mutations in Escherichia coli |
Q38111036 | Metabolic flux rewiring in mammalian cell cultures |
Q39398074 | Metabolic signatures of GS-CHO cell clones associated with butyrate treatment and culture phase transition |
Q38329071 | Methods and advances in metabolic flux analysis: a mini-review. |
Q35158693 | Non-stationary 13C metabolic flux analysis of Chinese hamster ovary cells in batch culture using extracellular labeling highlights metabolic reversibility and compartmentation |
Q38067994 | Parallel labeling experiments and metabolic flux analysis: Past, present and future methodologies |
Q46520357 | Parallel labeling experiments with [1,2-(13)C]glucose and [U-(13)C]glutamine provide new insights into CHO cell metabolism |
Q39590088 | Parallel labeling experiments with [U-13C]glucose validate E. coli metabolic network model for 13C metabolic flux analysis |
Q51754828 | Peak antibody production is associated with increased oxidative metabolism in an industrially relevant fed-batch CHO cell culture. |
Q38136389 | Publishing 13C metabolic flux analysis studies: a review and future perspectives |
Q38697277 | Quantitative intracellular flux modeling and applications in biotherapeutic development and production using CHO cell cultures. |
Q34271662 | Rational design of ¹³C-labeling experiments for metabolic flux analysis in mammalian cells |
Q90130329 | Reprogramming AA catabolism in CHO cells with CRISPR/Cas9 genome editing improves cell growth and reduces byproduct secretion |
Q83158699 | Selection of tracers for 13C-metabolic flux analysis using elementary metabolite units (EMU) basis vector methodology |
Q39320807 | Strategies for Extending Metabolomics Studies with Stable Isotope Labelling and Fluxomics. |
Q38416739 | Tailoring recombinant protein quality by rational media design |
Q51747773 | The impact of anti-apoptotic gene Bcl-2∆ expression on CHO central metabolism. |
Search more.