Novel antimalarial drug targets: hope for new antimalarial drugs.

scientific article published on September 2009

Novel antimalarial drug targets: hope for new antimalarial drugs. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1586/ECP.09.28
P698PubMed publication ID22112223
P5875ResearchGate publication ID51827425

P50authorPallab MaityQ47975156
Sumanta DeyQ80979023
P2093author name stringUday Bandyopadhyay
Athar Alam
Chinmay Pal
Manish Goyal
Mohd Shameel Iqbal
Samik Bindu
P2860cites workMalaria in 2002Q21032486
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Human glutathione transferase A4-4 crystal structures and mutagenesis reveal the basis of high catalytic efficiency with toxic lipid peroxidation productsQ22010032
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Artemisinins target the SERCA of Plasmodium falciparumQ22061877
1,2-dithiole-3-ones as potent inhibitors of the bacterial 3-ketoacyl acyl carrier protein synthase III (FabH)Q24564306
Inhibition of Plasmodium falciparum choline kinase by hexadecyltrimethylammonium bromide: a possible antimalarial mechanismQ24675578
MINT: the Molecular INTeraction databaseQ24675827
Similarities and differences in genome-wide expression data of six organismsQ24800747
RAP1 controls rhoptry targeting of RAP2 in the malaria parasite Plasmodium falciparumQ27230048
Release of sequestered malaria parasites upon injection of a glycosaminoglycanQ27320094
Insights into antifolate resistance from malarial DHFR-TS structuresQ27641016
Structural and Functional Relationships in the Virulence-associated Cathepsin L Proteases of the Parasitic Liver Fluke, Fasciola hepaticaQ27649433
Structural basis for the inhibition of the essential Plasmodium falciparum M1 neutral aminopeptidaseQ27653672
Mutations in dihydropteroate synthase are responsible for sulfone and sulfonamide resistance in Plasmodium falciparumQ27861947
A Plasmodium falciparum dipeptidyl aminopeptidase I participates in vacuolar hemoglobin degradationQ27972584
Roles for two aminopeptidases in vacuolar hemoglobin catabolism in Plasmodium falciparumQ27972941
Plasmodium hemozoin formation mediated by histidine-rich proteinsQ27972955
Critical role of a K+ channel in Plasmodium berghei transmission revealed by targeted gene disruptionQ36608978
P. falciparum dihydrofolate reductase and dihydropteroate synthase mutations: epidemiology and role in clinical resistance to antifolatesQ36648400
Antimalarial drugs inhibiting hemozoin (beta-hematin) formation: a mechanistic updateQ36678059
Molecular Cloning of CTP: Phosphocholine Cytidylyltransferase from Plasmodium falciparumQ36684908
Isoprenoid biosynthesis of the apicoplast as drug targetQ36723914
Novel molecular targets for antimalarial chemotherapyQ36752434
Nucleoside transport as a potential target for chemotherapy in malariaQ36754629
The sensitivity of Plasmodium protein synthesis to prokaryotic ribosomal inhibitorsQ36847579
Helicases - feasible antimalarial drug target for Plasmodium falciparumQ36933788
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Coenzyme A biosynthesis: an antimicrobial drug targetQ37049372
The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugsQ37066163
Assessing the polyamine metabolism of Plasmodium falciparum as chemotherapeutic target.Q37153904
Type II fatty acid synthesis is essential only for malaria parasite late liver stage developmentQ37208067
Mitochondria in malaria and related parasites: ancient, diverse and streamlined.Q37278195
Identification of a metabolically stable triazolopyrimidine-based dihydroorotate dehydrogenase inhibitor with antimalarial activity in miceQ37352712
Prodrugs of bisthiazolium salts are orally potent antimalarialsQ37585368
Plasmodium falciparum signal peptide peptidase is a promising drug target against blood stage malariaQ37649200
Thymidylate synthase-dihydrofolate reductase in protozoaQ37905656
Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytesQ38321747
Kinetic and biochemical characterization of Plasmodium falciparum GMP synthetaseQ27973021
Functional characterization and target validation of alternative complex I of Plasmodium falciparum mitochondriaQ27973427
Cyclin H activation and drug susceptibility of the Pfmrk cyclin dependent protein kinase from Plasmodium falciparumQ27973602
Localization of the Plasmodium falciparum PfNT1 nucleoside transporter to the parasite plasma membraneQ27973846
A subset of Plasmodium falciparum SERA genes are expressed and appear to play an important role in the erythrocytic cycleQ27974188
Glutathione S-transferase of the malarial parasite Plasmodium falciparum: characterization of a potential drug targetQ27974461
The initiating steps of a type II fatty acid synthase in Plasmodium falciparum are catalyzed by pfACP, pfMCAT, and pfKASIIIQ27974582
Plasmodium falciparum protein kinase 5 and the malarial nuclear division cyclesQ27976464
Inhibitors of the nonmevalonate pathway of isoprenoid biosynthesis as antimalarial drugsQ28143905
The apicoplast as an antimalarial drug targetQ28214224
The catalytic mechanism and structure of thymidylate synthaseQ28290270
Deletion of the parasite-specific insertions and mutation of the catalytic triad in glutathione reductase from chloroquine-sensitive Plasmodium falciparum 3D7Q28377536
A plant-derived morphinan as a novel lead compound active against malaria liver stagesQ28469086
Drug development papers in PLoS Medicine: how we try to spot a winnerQ28469092
Safety and efficacy of methylene blue combined with artesunate or amodiaquine for uncomplicated falciparum malaria: a randomized controlled trial from Burkina FasoQ28472182
Evolutionary patterning: a novel approach to the identification of potential drug target sites in Plasmodium falciparumQ28473999
A gene-coexpression network for global discovery of conserved genetic modulesQ29614451
Mutations in the P. falciparum digestive vacuole transmembrane protein PfCRT and evidence for their role in chloroquine resistanceQ29615118
Invasion of red blood cells by malaria parasitesQ29618806
Opportunities and Challenges in Antiparasitic Drug DiscoveryQ29999214
Intraerythrocytic Plasmodium falciparum expresses a high affinity facilitative hexose transporterQ30039208
Metabolic maps and functions of the Plasmodium mitochondrionQ30039501
Enzymes for heme biosynthesis are found in both the mitochondrion and plastid of the malaria parasite Plasmodium falciparumQ30040491
Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparumQ30041439
Subcellular localization and characterization of chorismate synthase in the apicomplexan Plasmodium falciparumQ30041832
Phenotypic variation of Plasmodium falciparum merozoite proteins directs receptor targeting for invasion of human erythrocytesQ30042170
A Plasmodium falciparum homologue of Plasmodium vivax reticulocyte binding protein (PvRBP1) defines a trypsin-resistant erythrocyte invasion pathwayQ30043024
Subcellular discharge of a serine protease mediates release of invasive malaria parasites from host erythrocytesQ30043441
Recombinant Plasmodium falciparum reticulocyte homology protein 4 binds to erythrocytes and blocks invasionQ30043667
Molecular characterization of a 2-Cys peroxiredoxin from the human malaria parasite Plasmodium falciparumQ30047901
Triclosan offers protection against blood stages of malaria by inhibiting enoyl-ACP reductase of Plasmodium falciparumQ30049704
Tropical infectious diseases: metabolic maps and functions of the Plasmodium falciparum apicoplastQ30080014
Structural insights into the Plasmodium falciparum histone deacetylase 1 (PfHDAC-1): A novel target for the development of antimalarial therapy.Q30368412
Irreversible effect of cysteine protease inhibitors on the release of malaria parasites from infected erythrocytesQ30494843
Genetic complementation in apicomplexan parasitesQ30701283
Channels and transporters as drug targets in the Plasmodium-infected erythrocyteQ35639409
Plasmodium falciparum thioredoxins and glutaredoxins as central players in redox metabolismQ35666792
Ferriprotoporphyrin IX, phospholipids, and the antimalarial actions of quinoline drugsQ35669039
Targeting ion channels of Plasmodium falciparum-infected human erythrocytes for antimalarial developmentQ35698879
Oxidative stress in malaria parasite-infected erythrocytes: host-parasite interactionsQ35704960
Fatty Acid synthesis as a target for antimalarial drug discovery.Q36047933
Parasite plastids: approaching the endgameQ36052586
Free heme toxicity and its detoxification systems in humanQ36139710
Functional conservation of the malaria vaccine antigen MSP-119across distantly related Plasmodium speciesQ47857319
Plasmodium falciparum: isolation and characterisation of a gene encoding protozoan GMP synthaseQ47857723
A voltage-dependent channel involved in nutrient uptake by red blood cells infected with the malaria parasiteQ47871147
Design and synthesis of amidoxime derivatives for orally potent C-alkylamidine-based antimalarial agents.Q47891646
Oxindole-based compounds are selective inhibitors of Plasmodium falciparum cyclin dependent protein kinasesQ47934737
Cell volume control in the Plasmodium-infected erythrocyteQ47972623
Haem polymerization in malariaQ47998079
The methionine synthesis cycle and salvage of methyltetrahydrofolate from host red cells in the malaria parasite (Plasmodium falciparum).Q48020701
Inhibition of Plasmodium falciparum hypoxanthine-guanine phosphoribosyltransferase mRNA by antisense oligodeoxynucleotide sequenceQ48020981
Kinetic characterization of Na+/H+ antiport of Plasmodium falciparum membraneQ48021291
Antimalarial activity of molecules interfering with Plasmodium falciparum phospholipid metabolism. Structure-activity relationship analysisQ48037569
Excess hemoglobin digestion and the osmotic stability of Plasmodium falciparum-infected red blood cells.Q52024420
Purification and properties of Plasmodium falciparum malate dehydrogenaseQ54279115
Inhibiting enoyl-ACP reductase (FabI) across pathogenic microorganisms by linear sesquiterpene lactones from Anthemis auriculata.Q54423737
Physcomitrella and Arabidopsis: the David and Goliath of reverse geneticsQ55872486
Characterisation of the gene encoding adenylosuccinate lyase of Plasmodium falciparum1Note: Nucleotide sequence data reported in this paper available in the GenBank™ data base under the accession number U84403.1Q56567665
A nutrient-permeable channel on the intraerythrocytic malaria parasiteQ59086409
Heat shock protein 90 function is essential for Plasmodium falciparum growth in human erythrocytes.Q38357729
Sulfated cyclodextrins inhibit the entry of Plasmodium into red blood cells. Implications for malarial therapyQ38955846
Structure-activity relationships for antiplasmodial activity among 7-substituted 4-aminoquinolines.Q38965197
Recombinant Plasmodium falciparum glutathione reductase is inhibited by the antimalarial dye methylene blueQ39014575
Peptidomimetic inhibitors of protein farnesyltransferase show potent antimalarial activityQ39318586
Identification of additional rRNA fragments encoded by the Plasmodium falciparum 6 kb elementQ39718842
Chemosensitization of Plasmodium falciparum by probenecid in vitroQ39776217
In vivo antimalarial activities of mono- and bis quaternary ammonium salts interfering with Plasmodium phospholipid metabolismQ39792613
A class of potent antimalarials and their specific accumulation in infected erythrocytesQ40750735
H+-coupled pantothenate transport in the intracellular malaria parasite.Q40816708
The mode of action of the antimalarial artemisinin and its derivativesQ41148700
Unraveling the mode of action of the antimalarial choline analog G25 in Plasmodium falciparum and Saccharomyces cerevisiaeQ41269199
Plasmodium falciparum purine nucleoside phosphorylase is critical for viability of malaria parasitesQ41771473
Involvement of delta-aminolaevulinate synthase encoded by the parasite gene in de novo haem synthesis by Plasmodium falciparumQ41824191
Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitorsQ41838047
Antiplasmodial activity of [(aryl)arylsulfanylmethyl]PyridineQ41886196
Synthesis and evaluation of new antimalarial phenylurenyl chalcone derivativesQ41912288
Novel short chain chloroquine analogues retain activity against chloroquine resistant K1 Plasmodium falciparumQ41916719
Ferriprotoporphyrin IX fulfills the criteria for identification as the chloroquine receptor of malaria parasitesQ41926939
The efficacy of benzimidazole drugs against Plasmodium falciparum in vitroQ41927133
Malarial haemozoin/beta-haematin supports haem polymerization in the absence of proteinQ41933334
Quinoline anti-malarial drugs inhibit spontaneous formation of beta-haematin (malaria pigment).Q41934645
Synthesis of novel thiourea, thiazolidinedione and thioparabanic acid derivatives of 4-aminoquinoline as potent antimalarialsQ41938749
Overcoming drug resistance to heme-targeted antimalarials by systematic side chain variation of 7-chloro-4-aminoquinolinesQ41941261
High antiplasmodial activity of novel plasmepsins I and II inhibitors.Q41944053
Localization of ferrochelatase in Plasmodium falciparumQ42042589
Isoprenoid biosynthesis as a target for antibacterial and antiparasitic drugs: phosphonohydroxamic acids as inhibitors of deoxyxylulose phosphate reducto-isomeraseQ42156581
Plasmodium falciparum carbonic anhydrase is a possible target for malaria chemotherapyQ42638709
Re-evaluation of how artemisinins work in light of emerging evidence of in vitro resistanceQ43127250
Rapid optimization of a peptide inhibitor of malaria parasite invasion by comprehensive N-methyl scanningQ43148430
Inhibitory monoclonal antibodies recognise epitopes adjacent to a proteolytic cleavage site on the RAP-1 protein of Plasmodium falciparumQ43570770
Intraerythrocytic Plasmodium falciparum utilizes only a fraction of the amino acids derived from the digestion of host cell cytosol for the biosynthesis of its proteinsQ43868723
Identification and characterization of allophenylnorstatine-based inhibitors of plasmepsin II, an antimalarial target.Q43883477
Potent antimalarial and transmission-blocking activities of centanamycin, a novel DNA-binding agentQ44140206
De novo and salvage biosynthesis of pteroylpentaglutamates in the human malaria parasite, Plasmodium falciparumQ44219537
Enzymic, phylogenetic, and structural characterization of the unusual papain-like protease domain of Plasmodium falciparum SERA5.Q44588572
Erythrocyte G Protein-Coupled Receptor Signaling in Malarial InfectionQ44590989
Delta-aminolevulinic acid dehydratase from Plasmodium falciparum: indigenous versus imported.Q44669060
Protein farnesyltransferase inhibitors exhibit potent antimalarial activityQ44713096
Reticulocyte-binding protein homologue 1 is required for sialic acid-dependent invasion into human erythrocytes by Plasmodium falciparumQ45197048
Pyrimidine biosynthesis in parasitic protozoa: purification of a monofunctional dihydroorotase from Plasmodium berghei and Crithidia fasciculata.Q46011810
Selective inhibition of Pfmrk, a Plasmodium falciparum CDK, by antimalarial 1,3-diaryl-2-propenonesQ46105200
Roles of 1-Cys peroxiredoxin in haem detoxification in the human malaria parasite Plasmodium falciparumQ46407800
Clotrimazole inhibits hemoperoxidase of Plasmodium falciparum and induces oxidative stress. Proposed antimalarial mechanism of clotrimazoleQ46465773
An unprecedented twist to ODCase catalytic activityQ46773972
Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6.Q46833947
Bilirubin inhibits Plasmodium falciparum growth through the generation of reactive oxygen speciesQ46857258
Parasite mitochondria as a target of chemotherapy: inhibitory effect of licochalcone A on the Plasmodium falciparum respiratory chainQ46875131
A rhoptry antigen of Plasmodium falciparum contains conserved and variable epitopes recognized by inhibitory monoclonal antibodiesQ46949677
Genomics-based drug design targets the AT-rich malaria parasite: implications for antiparasite chemotherapyQ46959461
Expression and activity of p67 are induced during heat shockQ47680421
S-adenosyl-L-homocysteine hydrolase as an attractive target for antimicrobial drugsQ47834141
Molecular cloning and characterization of a peroxiredoxin from the human malaria parasite Plasmodium falciparumQ47834424
An alternative model for heme biosynthesis in the malarial parasiteQ47846009
Antibiotic inhibitors of organellar protein synthesis in Plasmodium falciparumQ47854324
pH regulation in the intracellular malaria parasite, Plasmodium falciparum. H(+) extrusion via a V-type H(+)-ATPaseQ47855660
Mutations in the cytochrome b gene of Plasmodium berghei conferring resistance to atovaquoneQ30826460
Rich-club phenomenon in the interactome of P. falciparum--artifact or signature of a parasitic life style?Q30830693
Antimalarial activity of new gossypol derivativesQ30908680
The plasmodium digestive vacuole: metabolic headquarters and choice drug targetQ33205197
The pathway of hemoglobin degradation in malaria parasitesQ33207594
Inhibitors of Plasmodium falciparum methionine aminopeptidase 1b possess antimalarial activityQ33257977
Identification of proteases that regulate erythrocyte rupture by the malaria parasite Plasmodium falciparumQ33317962
Inhibition of malaria parasite development by a cyclic peptide that targets the vital parasite protein SERA5.Q33347981
A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparumQ33381401
High throughput functional assays of the variant antigen PfEMP1 reveal a single domain in the 3D7 Plasmodium falciparum genome that binds ICAM1 with high affinity and is targeted by naturally acquired neutralizing antibodiesQ33432676
An overview of chemotherapeutic targets for antimalarial drug discoveryQ33586646
Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agentsQ33605124
Apicomplexan plastids as drug targetsQ33702247
Enzymes of parasite thiol metabolism as drug targetsQ33730332
Glutathione and trypanothione in parasitic hydroperoxide metabolismQ33777935
Peptide deformylase of eukaryotic protists: a target for new antiparasitic agents?Q33868245
Potent and selective activity of a combination of thymidine and 1843U89, a folate-based thymidylate synthase inhibitor, against Plasmodium falciparumQ33979229
Specific role of mitochondrial electron transport in blood-stage Plasmodium falciparumQ34002708
Synthesis and evaluation of cryptolepine analogues for their potential as new antimalarial agents.Q34090100
Mode of action and mechanisms of resistance for antimalarial drugsQ34228129
Large-scale analysis of 73 329 physcomitrella plants transformed with different gene disruption libraries: production parameters and mutant phenotypesQ34420935
Uncovering the molecular mode of action of the antimalarial drug atovaquone using a bacterial system.Q34499482
Hydrolysis of erythrocyte proteins by proteases of malaria parasitesQ34531043
The thioredoxin system of Plasmodium falciparum and other parasitesQ34777950
Band 3 is a host receptor binding merozoite surface protein 1 during thePlasmodium falciparuminvasion of erythrocytesQ34982236
Cyclin-dependent protein kinases as therapeutic drug targets for antimalarial drug developmentQ35056015
Validation of the hexose transporter of Plasmodium falciparum as a novel drug target.Q35145816
Potent inhibitors of Plasmodium phospholipid metabolism with a broad spectrum of in vitro antimalarial activitiesQ35166107
Specific inhibition of the plasmodial surface anion channel by dantroleneQ35216701
Why is the Plasmodium falciparum hexose transporter a promising new drug target?Q35537890
Molecular monitoring of Plasmodium falciparum resistance to artemisinin in TanzaniaQ35574214
A blasticidin S-resistant Plasmodium falciparum mutant with a defective plasmodial surface anion channelQ35612124
Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen speciesQ35635984
Synergistic interactions of the antiretroviral protease inhibitors saquinavir and ritonavir with chloroquine and mefloquine against Plasmodium falciparum in vitro.Q35636034
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectantimalarialQ521616
P304page(s)469-489
P577publication date2009-09-01
P1433published inExpert Review of Clinical PharmacologyQ15793519
P1476titleNovel antimalarial drug targets: hope for new antimalarial drugs
P478volume2

Reverse relations

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Q39369233In silico identification of promiscuous scaffolds as potential inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase for treatment of Falciparum malaria
Q64062417Structural Insights Into Key Proteases as Therapeutic Drug Targets

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