Transaminases for the synthesis of enantiopure beta-amino acids

scientific article published on 31 January 2012

Transaminases for the synthesis of enantiopure beta-amino acids is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1051082040
P356DOI10.1186/2191-0855-2-11
P932PMC publication ID3281772
P698PubMed publication ID22293122
P5875ResearchGate publication ID221794376

P50authorChristoph SyldatkQ1085966
P2093author name stringJens Rudat
Birgit R Brucher
P2860cites workRapid and sensitive kinetic assay for characterization of omega-transaminasesQ43279267
Enhanced conversion of racemic alpha-arylalanines to (R)-beta-arylalanines by coupled racemase/aminomutase catalysis.Q43284988
Exploring the active site of amine:pyruvate aminotransferase on the basis of the substrate structure-reactivity relationship: how the enzyme controls substrate specificity and stereoselectivityQ43970667
Microbial synthesis of (R)- and (S)-3,4-dimethoxyamphetamines through stereoselective transaminationQ44694681
Probing the proteolytic stability of beta-peptides containing alpha-fluoro- and alpha-hydroxy-beta-amino acidsQ44880172
Rapid screening and scale-up of transaminase catalysed reactionsQ46182856
Microbial synthesis of chiral amines by (R)-specific transamination with Arthrobacter sp. KNK168.Q46589379
Identification of ω-aminotransferase from Caulobacter crescentus and site-directed mutagenesis to broaden substrate specificityQ46779430
Stereoselective hydrolysis of aryl-substituted dihydropyrimidines by hydantoinasesQ48054252
A new macromolecular antitumor antibiotic, C-1027. I. Discovery, taxonomy of producing organism, fermentation and biological activity.Q50706646
An amine: hydroxyacetone aminotransferase from Moraxella lacunata WZ34 for alaninol synthesis.Q50914577
Microbial production of optically active beta-phenylalanine through stereoselective degradation of racemic beta-phenylalanine.Q53607938
Betas are brought into the fold.Q53796267
β-Amino acid-containing hybrid peptides—new opportunities in peptidomimeticsQ56917343
Exploiting the Regioselectivity of Baeyer-Villiger Monooxygenases for the Formation of β-Amino Acids and β-Amino AlcoholsQ57189311
A fast and sensitive assay for measuring the activity and enantioselectivity of transaminasesQ58048733
The outstanding biological stability of beta- and gamma-peptides toward proteolytic enzymes: an in vitro investigation with fifteen peptidasesQ64027847
Purification and crystallization of bacterial omega-amino acid-pyruvate aminotransferaseQ67864733
Electronic Factors Influencing the Decarboxylation of beta-Keto Acids. A Model Enzyme StudyQ74823929
Asymmetric synthesis of chiral amines with omega-transaminaseQ78162609
The Pfam protein families databaseQ24644670
Modeling of the spatial structure of eukaryotic ornithine decarboxylasesQ24675092
Structural and biological mimicry of protein surface recognition by  / -peptide foldamersQ27657158
Novel biosynthetic approaches to the production of unnatural amino acids using transaminasesQ28288132
Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerationsQ29620045
Proteolytic stability of beta-peptide bonds probed using quenched fluorescent substrates incorporating a hemoglobin cleavage siteQ30723853
Purification, characterization, and molecular cloning of a novel amine:pyruvate transaminase from Vibrio fluvialis JS17.Q30914385
Cloning and characterization of a novel beta-transaminase from Mesorhizobium sp. strain LUK: a new biocatalyst for the synthesis of enantiomerically pure beta-amino acidsQ33270635
Beta-amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitorsQ33330573
The B6 database: a tool for the description and classification of vitamin B6-dependent enzymatic activities and of the corresponding protein familiesQ33499094
The manifold of vitamin B6 dependent enzymes.Q33836870
Crystallization and preliminary X-ray crystallographic studies of omega-transaminase fromVibrio fluvialisJS17Q34049161
Cloning-independent expression and analysis of omega-transaminases by use of a cell-free protein synthesis systemQ34119598
Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufactureQ34121402
Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifoliaQ34235776
An appreciation of Professor Alexander E. Braunstein. The discovery and scope of enzymatic transaminationQ34429355
Crystallization and preliminary X-ray crystallographic studies of β-transaminase from Mesorhizobium sp. strain LUK.Q34555830
Beta-amino acids: versatile peptidomimeticsQ34609245
Strain and catalysis in aspartate aminotransferaseQ35103547
omega-Amino acid:pyruvate transaminase from Alcaligenes denitrificans Y2k-2: a new catalyst for kinetic resolution of beta-amino acids and aminesQ37314315
Design, synthesis, biological evaluation, and structural characterization of potent histone deacetylase inhibitors based on cyclic alpha/beta-tetrapeptide architectures.Q37362478
Recent advances in the catalytic asymmetric synthesis of beta-amino acidsQ37737099
omega-Transaminases for the synthesis of non-racemic alpha-chiral primary aminesQ37739615
Aminomutases: mechanistic diversity, biotechnological applications and future perspectivesQ37863313
Beta-peptidic peptidomimeticsQ38572449
A quantitative study of succinic acid in muscle: Glutamic and aspartic acids as precursorsQ41970385
Conductometric method for the rapid characterization of the substrate specificity of amine-transaminasesQ43165590
P433issue1
P304page(s)11
P577publication date2012-01-31
P1433published inAMB ExpressQ27723718
P1476titleTransaminases for the synthesis of enantiopure beta-amino acids
P478volume2

Reverse relations

cites work (P2860)
Q92070685An Aminotransferase from Enhydrobacter aerosaccus to Obtain Optically Pure β-Phenylalanine
Q50920854Asymmetric synthesis of aromatic β-amino acids using ω-transaminase: Optimizing the lipase concentration to obtain thermodynamically unstable β-keto acids.
Q27674660Biochemical Properties and Crystal Structure of a  -Phenylalanine Aminotransferase from Variovorax paradoxus
Q58559806Bioprospecting reveals class III ω-transaminases converting bulky ketones and environmentally relevant polyamines
Q50995964Biotransformation of β-keto nitriles to chiral (S)-β-amino acids using nitrilase and ω-transaminase.
Q53798195Characterization of aromatic aminotransferases from Ephedra sinica Stapf.
Q42272601Chemical synthesis and enzymatic, stereoselective hydrolysis of a functionalized dihydropyrimidine for the synthesis of β-amino acids
Q91919025Crystal structure of the apo form of a β-transaminase from Mesorhizobium sp. strain LUK
Q27683595Crystal structure of the ω-aminotransferase from Paracoccus denitrificans and its phylogenetic relationship with other class III aminotransferases that have biotechnological potential
Q27689937Crystallographic characterization of the (R)-selective amine transaminase from Aspergillus fumigatus
Q54282193Enzymatic synthesis of chiral γ-amino acids using ω-transaminase.
Q45344485Expanding dynamic kinetic protocols: transaminase-catalyzed synthesis of α-substituted β-amino ester derivatives.
Q46502014Hydrolysis of nitriles by soil bacteria: variation with soil origin
Q47365936Improvement in the Thermostability of a β-Amino Acid Converting ω-Transaminase by Using FoldX.
Q37684585Metabolomics analysis identifies d-Alanine-d-Alanine ligase as the primary lethal target of d-Cycloserine in mycobacteria
Q98771610Overview on Multienzymatic Cascades for the Production of Non-canonical α-Amino Acids
Q47271189Percolation in protein sequence space.
Q38306195Recent developments in biocatalysis beyond the laboratory
Q35885047Statistical Evaluation of HTS Assays for Enzymatic Hydrolysis of β-Keto Esters
Q48312316Stereoelectronic effects in the reaction of aromatic substrates catalysed by Halomonas elongata transaminase and its mutants
Q38685724The Industrial Age of Biocatalytic Transamination
Q53284658Two subtle amino Acid changes in a transaminase substantially enhance or invert enantiopreference in cascade syntheses.
Q57189183β-Phenylalanine Ester Synthesis from Stable β-Keto Ester Substrate Using Engineered ω-Transaminases

Search more.