Tedizolid (TR-701): a new oxazolidinone with enhanced potency

scientific article published on 13 February 2012

Tedizolid (TR-701): a new oxazolidinone with enhanced potency is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1517/13543784.2012.660250
P698PubMed publication ID22324973

P2093author name stringG Ralph Corey
Zeina A Kanafani
P2860cites workDaptomycin therapy failure in an adolescent with methicillin-resistant Staphylococcus aureus bacteremia.Q37417427
Emergence of daptomycin resistance following vancomycin-unresponsive Staphylococcus aureus bacteraemia in a daptomycin-naïve patient--a review of the literatureQ37824612
Antivirulence potential of TR-700 and clindamycin on clinical isolates of Staphylococcus aureus producing phenol-soluble modulins.Q38282658
Cellular pharmacokinetics and intracellular activity of torezolid (TR-700): studies with human macrophage (THP-1) and endothelial (HUVEC) cell linesQ39798802
Comparative in vitro antimicrobial activities of torezolid (TR-700), the active moiety of a new oxazolidinone, torezolid phosphate (TR-701), determination of tentative disk diffusion interpretive criteria, and quality control rangesQ40334689
Comparative activities of TR-700 (torezolid) against staphylococcal blood isolates collected in Spain.Q40336550
In vitro activity of TR-700, the antibacterial moiety of the prodrug TR-701, against linezolid-resistant strains.Q41389487
Novel ribosomal mutations in Staphylococcus aureus strains identified through selection with the oxazolidinones linezolid and torezolid (TR-700).Q42024058
Comparative In Vitro Activities of Torezolid (DA-7157) against Clinical Isolates of Aerobic and Anaerobic Bacteria in South KoreaQ42111215
Clinical outbreak of linezolid-resistant Staphylococcus aureus in an intensive care unit.Q43041506
First outbreak of vancomycin-resistant enterococci in a tertiary hospital in TurkeyQ44121045
Secular trends of hospitalization with vancomycin-resistant enterococcus infection in the United States, 2000-2006.Q44773178
Endocarditis caused by Staphylococcus aureus with reduced susceptibility to vancomycinQ44850137
TR-700 in vitro activity against and resistance mutation frequencies among Gram-positive pathogensQ46121561
Methicillin-resistant Staphylococcus aureus disease in three communitiesQ46426018
Daptomycin-resistant, methicillin-resistant Staphylococcus aureus bacteremia.Q46433642
Discovery of torezolid as a novel 5-hydroxymethyl-oxazolidinone antibacterial agent.Q53439713
The site of action of oxazolidinone antibiotics in living bacteria and in human mitochondria.Q54441462
Methicillin-resistant Staphylococcus aureus clinical strain with reduced vancomycin susceptibility.Q55067143
National Nosocomial Infections Surveillance (NNIS) System Report, Data Summary from January 1992-June 2001, issued August 2001Q56898125
Vancomycin for Staphylococcus aureus endocarditis in intravenous drug usersQ24675979
Linezolid for the treatment of patients with endocarditis: a systematic review of the published evidenceQ33371390
Emergence of vancomycin-resistant enterococci at a university hospital in Taiwan: persistence of multiple species and multiple clones.Q33805805
Epidemiology and susceptibility of 3,051 Staphylococcus aureus isolates from 25 university hospitals participating in the European SENTRY studyQ33973732
Linezolid: the first oxazolidinone antimicrobialQ34170643
Infection with vancomycin-resistant Staphylococcus aureus containing the vanA resistance geneQ34188059
Cross-linking in the Living Cell Locates the Site of Action of Oxazolidinone AntibioticsQ34189984
Phase 2, randomized, double-blind, dose-ranging study evaluating the safety, tolerability, population pharmacokinetics, and efficacy of oral torezolid phosphate in patients with complicated skin and skin structure infections.Q34529205
Relationship of MIC and bactericidal activity to efficacy of vancomycin for treatment of methicillin-resistant Staphylococcus aureus bacteremiaQ34783668
Activity of oxazolidinone TR-700 against linezolid-susceptible and -resistant staphylococci and enterococciQ34928138
In vitro activity of TR-700, the active ingredient of the antibacterial prodrug TR-701, a novel oxazolidinone antibacterial agentQ34986954
In vivo pharmacodynamics of torezolid phosphate (TR-701), a new oxazolidinone antibiotic, against methicillin-susceptible and methicillin-resistant Staphylococcus aureus strains in a mouse thigh infection modelQ35065908
Community-acquired meticillin-resistant Staphylococcus aureus: an emerging threatQ36108084
High-level vancomycin-resistant enterococci causing hospital infectionsQ36473265
New oxazolidinonesQ36967558
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)515-522
P577publication date2012-02-13
P1433published inExpert Opinion on Investigational DrugsQ5421208
P1476titleTedizolid (TR-701): a new oxazolidinone with enhanced potency
P478volume21

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cites work (P2860)
Q41789967An azido-oxazolidinone antibiotic for live bacterial cell imaging and generation of antibiotic variants
Q38133967Antibiotics in the clinical pipeline in 2013.
Q38241139Antimicrobial stewardship and linezolid
Q52659763Combination of Tedizolid and Daptomycin against Methicillin-Resistant Staphylococcus aureus in an In Vitro Model of Simulated Endocardial Vegetations.
Q47684025Construction and evaluation in vitro and in vivo of tedizolid phosphate loaded cationic liposomes
Q39067666Critical role of tedizolid in the treatment of acute bacterial skin and skin structure infections
Q38123255Current and prospective treatments for multidrug-resistant gram-positive infections.
Q38123247Current strategies for the treatment of complicated intraabdominal infections
Q38121142Emerging drugs on methicillin-resistant Staphylococcus aureus
Q46304818In Vitro Susceptibility Testing of Tedizolid against Isolates of Nocardia
Q40283050In Vitro Susceptibility Testing of Tedizolid against Nontuberculous Mycobacteria
Q40525718In vitro activity of tedizolid against Staphylococcus aureus and Streptococcus pneumoniae collected in 2013 and 2014 from sites in Latin American countries, Australia, New Zealand, and China
Q34375204Investigational antimicrobial agents of 2013.
Q26780246Investigational drugs to treat methicillin-resistant Staphylococcus aureus
Q33438834Pharmacokinetic drug evaluation of tedizolid for the treatment of skin infections
Q34596658Pharmacokinetics of tedizolid in subjects with renal or hepatic impairment
Q38958278Recent Advances in the Rational Design and Optimization of Antibacterial Agents
Q24561509Tedizolid phosphate (sivextro): a second-generation oxazolidinone to treat acute bacterial skin and skin structure infections
Q34660917Tedizolid: a new oxazolidinone antimicrobial.
Q38352171Tedizolid: a novel oxazolidinone with potent activity against multidrug-resistant gram-positive pathogens.
Q99633705Telacebec (Q203)-containing intermittent oral regimens sterilized mice infected with Mycobacterium ulcerans after only 16 doses
Q38522574Telavancin (VIBATIV) for the treatment of complicated skin and skin structure infections

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