Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus.

scientific article published on 09 April 2012

Novel roles of SUMO in pancreatic β-cells: thinking outside the nucleus. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1139/Y11-134
P698PubMed publication ID22486776

P50authorPatrick E. MacdonaldQ74236752
P2093author name stringJocelyn E Manning Fox
Catherine Hajmrle
P2860cites workIn vitro SUMO-1 modification requires two enzymatic steps, E1 and E2Q22008717
Identification of the enzyme required for activation of the small ubiquitin-like protein SUMO-1Q22009137
SUMOylation regulates Kv2.1 and modulates pancreatic beta-cell excitabilityQ24311712
Modification with SUMO. A role in transcriptional regulationQ24534589
Control of NF-kappa B transcriptional activation by signal induced proteolysis of I kappa B alphaQ24676497
Structural basis for E2-mediated SUMO conjugation revealed by a complex between ubiquitin-conjugating enzyme Ubc9 and RanGAP1Q27637899
Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidationQ27647348
Triggering and amplifying pathways of regulation of insulin secretion by glucoseQ27863677
Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3.Q27863917
Sumoylation regulates diverse biological processesQ27865196
The ubiquitin-like protein Smt3p is activated for conjugation to other proteins by an Aos1p/Uba2p heterodimerQ27933072
UBL1, a human ubiquitin-like protein associating with human RAD51/RAD52 proteinsQ28115876
Functional heterogeneity of small ubiquitin-related protein modifiers SUMO-1 versus SUMO-2/3Q28145507
A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetesQ28268724
A proline-90 residue unique to SUMO-4 prevents maturation and sumoylationQ28274983
Genetic and functional evidence supporting SUMO4 as a type 1 diabetes susceptibility geneQ28275898
SUMO-1 modification of IkappaBalpha inhibits NF-kappaB activationQ28282094
SUMOylation regulates kainate-receptor-mediated synaptic transmissionQ28576922
Pancreas duodenum homeobox-1 transcriptional activation requires interactions with p300Q28584322
Kv2.1 ablation alters glucose-induced islet electrical activity, enhancing insulin secretionQ28588570
Myosin Va transports dense core secretory vesicles in pancreatic MIN6 beta-cellsQ28589310
SUMO-1 conjugation in vivo requires both a consensus modification motif and nuclear targetingQ29619527
Nuclear and unclear functions of SUMOQ29903594
Monitoring of exocytosis and endocytosis of insulin secretory granules in the pancreatic beta-cell line MIN6 using pH-sensitive green fluorescent protein (pHluorin) and confocal laser microscopyQ31043443
The importance of the beta-cell in the pathogenesis of type 2 diabetes mellitusQ33891620
SUMO4 and its role in type 1 diabetes pathogenesisQ34008085
Members of the Kv1 and Kv2 voltage-dependent K(+) channel families regulate insulin secretionQ34084555
Cloning and expression of human homolog HSMT3 to yeast SMT3 suppressor of MIF2 mutations in a centromere protein geneQ34379548
Sumoylation silences the plasma membrane leak K+ channel K2P1.Q34410181
Lack of cholesterol mobilization in islets of hormone-sensitive lipase deficient mice impairs insulin secretionQ34657196
SUMO modification of cell surface Kv2.1 potassium channels regulates the activity of rat hippocampal neuronsQ34865655
Beta-cell dysfunction and insulin resistance in type 2 diabetes: role of metabolic and genetic abnormalitiesQ34996991
Insulin granule dynamics in pancreatic beta cellsQ35184211
Evidence that glucose can control insulin release independently from its action on ATP-sensitive K+ channels in mouse B cellsQ35601028
SUMO modification regulates inactivation of the voltage-gated potassium channel Kv1.5.Q35629481
SUMO: a regulator of gene expression and genome integrity.Q35691533
Molecular defects in insulin secretion in type-2 diabetesQ35711972
Glucose-sensing mechanisms in pancreatic beta-cells.Q36328341
Insulin vesicle release: walk, kiss, pause ... then run.Q36484264
Emerging role of SUMO in pancreatic beta-cellsQ36936894
SNAREing voltage-gated K+ and ATP-sensitive K+ channels: tuning beta-cell excitability with syntaxin-1A and other exocytotic proteinsQ36945339
Core proteins of the secretory machineryQ37026698
DeSUMOylating enzymes--SENPsQ37230112
Type 2 diabetes: new genes, new understandingQ37308665
SUMOylation and De-SUMOylation: wrestling with life's processesQ37325310
The SUMO system: an overviewQ37357956
Emerging roles of desumoylating enzymesQ37375239
SUMO proteases: redox regulation and biological consequencesQ37383353
Sumoylation regulates the transcriptional activity of MafA in pancreatic beta cellsQ38358697
Site of docking and fusion of insulin secretory granules in live MIN6 beta cells analyzed by TAT-conjugated anti-syntaxin 1 antibody and total internal reflection fluorescence microscopyQ40607328
SUMO-1: wrestling with a new ubiquitin-related modifier.Q41633111
SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans.Q41863831
Is a new immune response mediator in the NF-kappaB pathway--SUMO-4--related to type 1 diabetes?Q42976544
Inhibition of Kv2.1 voltage-dependent K+ channels in pancreatic beta-cells enhances glucose-dependent insulin secretion.Q44149480
Sumoylation of Pdx1 is associated with its nuclear localization and insulin gene activationQ44253301
Glucose regulates the cortical actin network through modulation of Cdc42 cycling to stimulate insulin secretionQ44449615
Glucose regulation of insulin gene expression requires the recruitment of p300 by the beta-cell-specific transcription factor Pdx-1.Q44912946
Insulin secretion is highly sensitive to desorption of plasma membrane cholesterol.Q46355168
Delayed-rectifier (KV2.1) regulation of pancreatic beta-cell calcium responses to glucose: inhibitor specificity and modelingQ46598381
The SUMO protease SENP5 is required to maintain mitochondrial morphology and functionQ56907347
P433issue6
P304page(s)765-770
P577publication date2012-04-09
P1433published inCanadian Journal of Physiology and PharmacologyQ5030248
P1476titleNovel roles of SUMO in pancreatic β-cells: thinking outside the nucleus
P478volume90

Reverse relations

cites work (P2860)
Q42739736How do reducing equivalents increase insulin secretion?
Q36165625Isocitrate-to-SENP1 signaling amplifies insulin secretion and rescues dysfunctional β cells
Q34295237Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction
Q88035512SUMO1 enhances cAMP-dependent exocytosis and glucagon secretion from pancreatic α-cells
Q36635942SUMOylation of pancreatic glucokinase regulates its cellular stability and activity
Q34356005SUMOylation protects against IL-1β-induced apoptosis in INS-1 832/13 cells and human islets.
Q38961119Sumoylation Modulates the Susceptibility to Type 1 Diabetes.
Q39136006The Roles of SUMO in Metabolic Regulation
Q40332996Viral Interplay with the Host Sumoylation System

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