Genes associate with abnormal bone cell activity in bone metastasis

scientific article published on December 2012

Genes associate with abnormal bone cell activity in bone metastasis is …
instance of (P31):
scholarly articleQ13442814

External links are
P6179Dimensions Publication ID1019211357
P356DOI10.1007/S10555-012-9372-X
P698PubMed publication ID22706844

P2093author name stringG David Roodman
P2860cites workOsteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activationQ24311588
RANK is essential for osteoclast and lymph node developmentQ24598872
Metastatic bone disease: clinical features, pathophysiology and treatment strategiesQ28202792
The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myelomaQ28236113
RANK ligand mediates progestin-induced mammary epithelial proliferation and carcinogenesisQ28294501
Metastasis to bone: causes, consequences and therapeutic opportunitiesQ29614310
Dickkopf homolog 1 mediates endothelin-1-stimulated new bone formationQ30441987
Macrophage inflammatory protein-1alpha is an osteoclastogenic factor in myeloma that is independent of receptor activator of nuclear factor kappaB ligandQ30670375
A molecular compendium of genes expressed in multiple myelomaQ31105650
Cloning and characterization of the annexin II receptor on human marrow stromal cellsQ33253275
Cell biology of the osteoclastQ33700885
Activin A promotes multiple myeloma-induced osteolysis and is a promising target for myeloma bone diseaseQ33740176
The roles of osteoprotegerin and osteoprotegerin ligand in the paracrine regulation of bone resorption.Q33823576
TGF-beta signaling blockade inhibits PTHrP secretion by breast cancer cells and bone metastases developmentQ33834762
Molecular mechanisms of osteolytic bone metastasesQ33909842
Role of endothelin-1 in osteoblastic bone metastasesQ33963981
Mechanisms of bone metastasisQ33977526
Receptor activator of nuclear factor-kappaB ligand and osteoprotegerin: potential implications for the pathogenesis and treatment of malignant bone diseasesQ34086847
Management of bone metastasesQ34100900
Interleukin-6 enhances hypercalcemia and bone resorption mediated by parathyroid hormone-related protein in vivoQ34224284
Annexins--unique membrane binding proteins with diverse functionsQ34323662
Novel therapies targeting the myeloma cell and its bone marrow microenvironmentQ34461557
Transcription factors in bone: developmental and pathological aspectsQ34735288
Gfi1 expressed in bone marrow stromal cells is a novel osteoblast suppressor in patients with multiple myeloma bone diseaseQ35631319
Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivoQ35642745
Metastatic breast cancer cells inhibit osteoblast differentiation through the Runx2/CBFβ-dependent expression of the Wnt antagonist, sclerostinQ35683618
Annexin II interactions with the annexin II receptor enhance multiple myeloma cell adhesion and growth in the bone marrow microenvironmentQ35802226
MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts.Q36141697
Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone diseaseQ36169814
RANKing intracellular signaling in osteoclastsQ36191485
TRANCE is necessary and sufficient for osteoblast-mediated activation of bone resorption in osteoclasts.Q36404187
Role of decorin in the antimyeloma effects of osteoblastsQ36732801
Transforming growth factor-beta signaling: emerging stem cell target in metastatic breast cancer?Q37219226
Anti-DKK1 mAb (BHQ880) as a potential therapeutic agent for multiple myelomaQ37271048
Evidence for a causal role of parathyroid hormone-related protein in the pathogenesis of human breast cancer-mediated osteolysisQ37360238
Osteoclasts are important for bone angiogenesisQ37706007
Sclerostin: a gem from the genome leads to bone-building antibodiesQ37766538
Osteoblast function in myelomaQ37769965
Tumor-host cell interactions in the bone disease of myelomaQ37771082
Advances in the biology and treatment of bone disease in multiple myelomaQ37853737
Parathyroid hormone related protein (PTHrP) in tumor progressionQ37929046
Myeloma cells block RUNX2/CBFA1 activity in human bone marrow osteoblast progenitors and inhibit osteoblast formation and differentiationQ38325516
Osteoclast differentiation factor mediates an essential signal for bone resorption induced by 1 alpha,25-dihydroxyvitamin D3, prostaglandin E2, or parathyroid hormone in the microenvironment of boneQ39116021
Sclerostin is overexpressed by plasma cells from multiple myeloma patientsQ39443327
Annexin II/annexin II receptor axis regulates adhesion, migration, homing, and growth of prostate cancerQ39534721
Inhibiting activin-A signaling stimulates bone formation and prevents cancer-induced bone destruction in vivoQ39695455
Inhibition of RANKL increases the anti-tumor effect of the EGFR inhibitor panitumumab in a murine model of bone metastasisQ39730235
RUNX2 regulates the effects of TNFalpha on proliferation and apoptosis in SaOs-2 cellsQ39755402
The effect of timing in the administration of hepatocyte growth factor to modulate BMP-2-induced osteoblast differentiation.Q39774810
Overexpression of Annexin II affects the proliferation, apoptosis, invasion and production of proangiogenic factors in multiple myelomaQ39827635
Inhibition of RANKL blocks skeletal tumor progression and improves survival in a mouse model of breast cancer bone metastasisQ40038407
Regulation of cancer cell migration and bone metastasis by RANKL.Q40298349
Bone morphogenetic protein-6 promotes osteoblastic prostate cancer bone metastases through a dual mechanismQ40372846
IL-3 is a potential inhibitor of osteoblast differentiation in multiple myelomaQ40425654
MIP-1alpha utilizes both CCR1 and CCR5 to induce osteoclast formation and increase adhesion of myeloma cells to marrow stromal cells.Q40454635
Effects of selective endothelin ET(A) receptor antagonists on endothelin-1-induced potentiation of cancer painQ40549071
IL-3 expression by myeloma cells increases both osteoclast formation and growth of myeloma cellsQ40616669
Distinct IL-6 signal transduction leads to growth arrest and death in B cells or growth promotion and cell survival in myeloma cellsQ40728134
Endothelin-1 production by prostate cancer cell lines is up-regulated by factors involved in cancer progression and down-regulated by androgensQ40762950
Annexin II tetramer: structure and functionQ40950533
Marked osteoblastopenia and reduced bone formation in a model of multiple myeloma bone disease in severe combined immunodeficiency miceQ40975330
Denosumab versus zoledronic acid for treatment of bone metastases in men with castration-resistant prostate cancer: a randomised, double-blind studyQ41904942
Annexin II expressed by osteoblasts and endothelial cells regulates stem cell adhesion, homing, and engraftment following transplantationQ42219222
Denosumab compared with zoledronic acid for the treatment of bone metastases in patients with advanced breast cancer: a randomized, double-blind studyQ42829926
Tumour cells produce receptor activator of NF-kappaB ligand (RANKL) in skeletal metastasesQ43011355
Tumor necrosis factor inhibits mesenchymal stem cell differentiation into osteoblasts via the ubiquitin E3 ligase Wwp1.Q43095887
A soluble activin receptor Type IIA fusion protein (ACE-011) increases bone mass via a dual anabolic-antiresorptive effect in Cynomolgus monkeysQ43192115
Long-term efficacy and safety of zoledronic acid compared with pamidronate disodium in the treatment of skeletal complications in patients with advanced multiple myeloma or breast carcinoma: a randomized, double-blind, multicenter, comparative trialQ44611376
Myeloma cells suppress bone formation by secreting a soluble Wnt inhibitor, sFRP-2.Q46283393
Dual effects of macrophage inflammatory protein-1alpha on osteolysis and tumor burden in the murine 5TGM1 model of myeloma bone diseaseQ48022318
Randomized, double-blind study of denosumab versus zoledronic acid in the treatment of bone metastases in patients with advanced cancer (excluding breast and prostate cancer) or multiple myeloma.Q51054343
PI3-K/AKT/FKHR and MAPK signaling cascades are redundantly stimulated by a variety of cytokines and contribute independently to proliferation and survival of multiple myeloma cells.Q52942846
The effect of zoledronic acid and osteoprotegerin on growth of human lung cancer in the tibias of nude mice.Q53621774
Elucidating prognosis and biology of breast cancer arising in young women using gene expression profiling.Q54535173
Increased expression of macrophage inflammatory protein-1α on trephine biopsies correlates with extensive bone disease, increased angiogenesis and advanced stage in newly diagnosed patients with multiple myelomaQ57904674
P433issue3-4
P304page(s)569-578
P577publication date2012-12-01
P1433published inCancer and Metastasis ReviewsQ2647982
P1476titleGenes associate with abnormal bone cell activity in bone metastasis
P478volume31