Germ cell specification

scientific article published on January 2013

Germ cell specification is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/978-1-4614-4015-4_2
P932PMC publication ID4966528
P698PubMed publication ID22872473

P50authorGeraldine SeydouxQ5549793
Jennifer T WangQ56993329
P2860cites workA maternal factor unique to ascidians silences the germline via binding to P-TEFb and RNAP II regulation.Q54572336
Identification of genes required for cytoplasmic localization in early C. elegans embryosQ68273724
Segregation of germline granules in early embryos of Caenorhabditis elegans: an electron microscopic analysisQ71233601
Transformation of the germ line into muscle in mes-1 mutant embryos of C. elegansQ71733931
DNA replication defects delay cell division and disrupt cell polarity in early Caenorhabditis elegans embryosQ73286817
The Sm proteins regulate germ cell specification during early C. elegans embryogenesisQ82264705
PGL proteins self associate and bind RNPs to mediate germ granule assembly in C. elegansQ24632882
C. elegans PAR proteins function by mobilizing and stabilizing asymmetrically localized protein complexesQ28265914
The embryonic cell lineage of the nematode Caenorhabditis elegansQ28271877
On the control of germ cell development in Caenorhabditis elegansQ28279917
Integrative analysis of the Caenorhabditis elegans genome by the modENCODE projectQ28301622
par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributedQ28301842
Asymmetric cell division and axis formation in the embryoQ29306222
Extracellular control of PAR protein localization during asymmetric cell division in the C. elegans embryoQ30496455
Internalization of multiple cells during C. elegans gastrulation depends on common cytoskeletal mechanisms but different cell polarity and cell fate regulatorsQ30497921
Repression of zygotic gene expression in the Xenopus germlineQ33684273
The histone H3K36 methyltransferase MES-4 acts epigenetically to transmit the memory of germline gene expression to progeny.Q33686906
Translational repression: a duet of Nanos and PumilioQ33831344
Identification of grandchildless loci whose products are required for normal germ-line development in the nematode Caenorhabditis elegansQ33958810
Phenotypic and molecular analysis of mes-3, a maternal-effect gene required for proliferation and viability of the germ line in C. elegansQ33966270
P granule assembly and function in Caenorhabditis elegans germ cellsQ34001356
Pathway to totipotency: lessons from germ cellsQ34585032
synMuv B proteins antagonize germline fate in the intestine and ensure C. elegans survivalQ34592502
Molecular basis of RNA recognition by the embryonic polarity determinant MEX-5.Q34607717
Trans-generational epigenetic regulation of C. elegans primordial germ cellsQ34622455
The PGL family proteins associate with germ granules and function redundantly in Caenorhabditis elegans germline developmentQ34644841
P granules extend the nuclear pore complex environment in the C. elegans germ lineQ34712466
A spatial and temporal map of C. elegans gene expressionQ42588671
Exclusion of germ plasm proteins from somatic lineages by cullin-dependent degradationQ42745906
SEPA-1 mediates the specific recognition and degradation of P granule components by autophagy in C. elegans.Q43985030
SRC-1 and Wnt signaling act together to specify endoderm and to control cleavage orientation in early C. elegans embryosQ44057731
The pie-1 and mex-1 genes and maternal control of blastomere identity in early C. elegans embryosQ44058539
Differential activation of the DNA replication checkpoint contributes to asynchrony of cell division in C. elegans embryosQ44441589
MEX-5 asymmetry in one-cell C. elegans embryos requires PAR-4- and PAR-1-dependent phosphorylation.Q45211998
C. elegans DAF-18/PTEN mediates nutrient-dependent arrest of cell cycle and growth in the germline.Q46025317
DYRK2 and GSK-3 phosphorylate and promote the timely degradation of OMA-1, a key regulator of the oocyte-to-embryo transition in C. elegansQ46804755
Polo kinases regulate C. elegans embryonic polarity via binding to DYRK2-primed MEX-5 and MEX-6.Q46805083
The MES-2/MES-3/MES-6 complex and regulation of histone H3 methylation in C. elegansQ47068688
Combinatorial RNA interference indicates GLH-4 can compensate for GLH-1; these two P granule components are critical for fertility in C. elegans.Q47068814
nos-1 and nos-2, two genes related to Drosophila nanos, regulate primordial germ cell development and survival in Caenorhabditis elegansQ47068836
PGL-1, a predicted RNA-binding component of germ granules, is essential for fertility in C. elegansQ47068903
pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegansQ47068917
The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegansQ47069086
MEX-3 is a KH domain protein that regulates blastomere identity in early C. elegans embryosQ47069183
MEX-5 and MEX-6 function to establish soma/germline asymmetry in early C. elegans embryosQ47069199
Soma-germline asymmetry in the distributions of embryonic RNAs in Caenorhabditis elegansQ47069204
Coordinate activation of maternal protein degradation during the egg-to-embryo transition in C. elegansQ47069248
The maternal gene skn-1 encodes a protein that is distributed unequally in early C. elegans embryosQ47069315
MEP-1 and a homolog of the NURD complex component Mi-2 act together to maintain germline-soma distinctions in C. elegansQ47069337
A sex-determining gene, fem-1, required for both male and hermaphrodite development in Caenorhabditis elegansQ47069368
A novel function for the Sm proteins in germ granule localization during C. elegans embryogenesisQ47069396
The C. elegans MEX-1 protein is present in germline blastomeres and is a P granule componentQ47069423
The PIE-1 protein and germline specification in C. elegans embryosQ47069462
Processing bodies and germ granules are distinct RNA granules that interact in C. elegans embryosQ47069466
The C. elegans DYRK Kinase MBK-2 Marks Oocyte Proteins for Degradation in Response to Meiotic MaturationQ47069584
Germline P granules are liquid droplets that localize by controlled dissolution/condensationQ47748097
Transcriptionally repressed germ cells lack a subpopulation of phosphorylated RNA polymerase II in early embryos of Caenorhabditis elegans and Drosophila melanogaster.Q47912453
Repression of gene expression in the embryonic germ lineage of C. elegansQ47915934
C. elegans meg-1 and meg-2 differentially interact with nanos family members to either promote or inhibit germ cell proliferation and survival.Q50546213
Translational repression restricts expression of the C. elegans Nanos homolog NOS-2 to the embryonic germline.Q50652230
Multiple RNA-binding proteins function combinatorially to control the soma-restricted expression pattern of the E3 ligase subunit ZIF-1.Q51822757
Epigenetic licensing of germline gene expression by maternal RNA in C. elegans.Q51855441
Ci-Pem-1 localizes to the nucleus and represses somatic gene transcription in the germline of Ciona intestinalis embryos.Q51863412
Somatic misexpression of germline P granules and enhanced RNA interference in retinoblastoma pathway mutants.Q52043143
Composition and dynamics of the Caenorhabditis elegans early embryonic transcriptome.Q52110050
PLK-1 asymmetry contributes to asynchronous cell division of C. elegans embryos.Q53495600
Cytoplasmic partitioning of P granule components is not required to specify the germline in C. elegansQ34773638
PIE-1 is a bifunctional protein that regulates maternal and zygotic gene expression in the embryonic germ line of Caenorhabditis elegansQ35078092
Transcriptional repression by the Caenorhabditis elegans germ-line protein PIE-1.Q35186960
Regulation of the MEX-5 gradient by a spatially segregated kinase/phosphatase cycleQ35446919
The Caenorhabditis elegans maternal-effect sterile proteins, MES-2, MES-3, and MES-6, are associated in a complex in embryosQ35862584
Localization and segregation of lineage-specific cleavage potential in embryos of Caenorhabditis elegansQ36311940
Inhibition of transcription by the Caenorhabditis elegans germline protein PIE-1: genetic evidence for distinct mechanisms targeting initiation and elongationQ36391813
MEG-1 and MEG-2 are embryo-specific P-granule components required for germline development in Caenorhabditis elegansQ36391837
Reversal of cellular polarity and early cell-cell interaction in the embryos of Caenorhabditis elegansQ36467585
PAR proteins direct asymmetry of the cell cycle regulators Polo-like kinase and Cdc25.Q36491719
Genetic analysis of the Caenorhabditis elegans GLH family of P-granule proteinsQ36571751
glh-1, a germ-line putative RNA helicase from Caenorhabditis, has four zinc fingersQ36585340
MES-1, a protein required for unequal divisions of the germline in early C. elegans embryos, resembles receptor tyrosine kinases and is localized to the boundary between the germline and gut cellsQ36731904
MRG-1, an autosome-associated protein, silences X-linked genes and protects germline immortality in Caenorhabditis elegansQ36731912
Regulation of the different chromatin states of autosomes and X chromosomes in the germ line of C. elegansQ36731933
MES-4: an autosome-associated histone methyltransferase that participates in silencing the X chromosomes in the C. elegans germ line.Q36731942
Germ versus soma decisions: lessons from flies and wormsQ36796578
Segregation of germ granules in living Caenorhabditis elegans embryos: cell-type-specific mechanisms for cytoplasmic localisationQ36797903
Multiple maternal proteins coordinate to restrict the translation of C. elegans nanos-2 to primordial germ cellsQ36949298
Specification of the germ lineQ37020491
Germline genomicsQ37020708
Germline chromatinQ37020713
Asymmetric enrichment of PIE-1 in the Caenorhabditis elegans zygote mediated by binary counterdiffusionQ37124367
Less is more: specification of the germline by transcriptional repressionQ37321822
An eIF4E-binding protein regulates katanin protein levels in C. elegans embryosQ37387856
MAP kinase signaling antagonizes PAR-1 function during polarization of the early Caenorhabditis elegans embryoQ37425052
Transplantation of posterior polar plasm in Drosophila. Induction of germ cells at the anterior pole of the eggQ37436465
RNA recognition by the embryonic cell fate determinant and germline totipotency factor MEX-3.Q37453506
Translational control in the Caenorhabditis elegans germ lineQ38032806
The oocyte-to-embryo transitionQ38032809
PAR-2 is asymmetrically distributed and promotes association of P granules and PAR-1 with the cortex in C. elegans embryosQ39758007
Drosophila Pgc protein inhibits P-TEFb recruitment to chromatin in primordial germ cellsQ40024356
RNA target specificity of the embryonic cell fate determinant POS-1.Q41490235
A conserved chromatin architecture marks and maintains the restricted germ cell lineage in worms and fliesQ41875362
zif-1 translational repression defines a second, mutually exclusive OMA function in germline transcriptional repressionQ41942757
Polarization of the C. elegans zygote proceeds via distinct establishment and maintenance phasesQ42149368
Global transcriptional repression in C. elegans germline precursors by regulated sequestration of TAF-4Q42178390
P407language of work or nameEnglishQ1860
P304page(s)17-39
P577publication date2013-01-01
P1433published inAdvances in Experimental Medicine and BiologyQ4686385
P1476titleGerm cell specification
P478volume757

Reverse relations

cites work (P2860)
Q92487276A high-content imaging approach to profile C. elegans embryonic development
Q37016037A twist of fate: How a meiotic protein is providing new perspectives on germ cell development.
Q50091958Actomyosin contractility regulators stabilize the cytoplasmic bridge between the two primordial germ cells during Caenorhabditis elegans embryogenesis.
Q35392744Asymmetric transcript discovery by RNA-seq in C. elegans blastomeres identifies neg-1, a gene important for anterior morphogenesis.
Q30583153C. elegans Anillin proteins regulate intercellular bridge stability and germline syncytial organization
Q92740666Comparative Proteomics Reveal Me31B's Interactome Dynamics, Expression Regulation, and Assembly Mechanism into Germ Granules during Drosophila Germline Development
Q36000713Coupling between cytoplasmic concentration gradients through local control of protein mobility in the Caenorhabditis elegans zygote
Q38375486Cytoplasmic localization and asymmetric division in the early embryo of Caenorhabditis elegans
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Q36012704Enrichment of H3K9me2 on Unsynapsed Chromatin in Caenorhabditis elegans Does Not Target de Novo Sites
Q26830468Introduction to germ cell development in Caenorhabditis elegans
Q37702564LET-418/Mi2 and SPR-5/LSD1 cooperatively prevent somatic reprogramming of C. elegans germline stem cells
Q57046164PIE-1 Translation in the Germline Lineage Contributes to PIE-1 Asymmetry in the Early Embryo
Q64928288Rapid diffusion-state switching underlies stable cytoplasmic gradients in the Caenorhabditis elegans zygote.
Q39150579Regulation of Cell Polarity by PAR-1/MARK Kinase
Q52904683Restricted distribution of mrg-1 mRNA in C. elegans primordial germ cells through germ granule-independent regulation.
Q34025612Temporal control over the initiation of cell motility by a regulator of G-protein signaling
Q47372758The Germline-Specific Factor OEF-1 Facilitates Coordinated Progression Through Germ Cell Development in Caenorhabditis elegans
Q27313726The specification and global reprogramming of histone epigenetic marks during gamete formation and early embryo development in C. elegans

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