| scholarly article | Q13442814 |
| P356 | DOI | 10.1111/J.1463-1326.2012.01647.X |
| P698 | PubMed publication ID | 22928576 |
| P2093 | author name string | R N Kulkarni | |
| A B Goldfine | |||
| P2860 | cites work | AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1 | Q22254000 |
| Disruption of IRS-2 causes type 2 diabetes in mice | Q24316112 | ||
| AKT/PKB signaling: navigating downstream | Q24657857 | ||
| Triggering and amplifying pathways of regulation of insulin secretion by glucose | Q27863677 | ||
| High glucose causes apoptosis in cultured human pancreatic islets of Langerhans: a potential role for regulation of specific Bcl family genes toward an apoptotic cell death program | Q28190664 | ||
| Glycogen synthase kinase-3beta regulates cyclin D1 proteolysis and subcellular localization | Q28290083 | ||
| The Gly972-->Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells | Q28343482 | ||
| The forkhead transcription factor Foxo1 links insulin signaling to Pdx1 regulation of pancreatic beta cell growth | Q28508976 | ||
| Effects of mutations in the insulin-like growth factor signaling system on embryonic pancreas development and beta-cell compensation to insulin resistance | Q28512935 | ||
| Multiple roles of the PI3K/PKB (Akt) pathway in cell cycle progression | Q28679187 | ||
| Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKB beta) | Q29615537 | ||
| Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes | Q29619192 | ||
| Insulin enhances glucose-stimulated insulin secretion in healthy humans | Q33740824 | ||
| Cyclin D2 is essential for the compensatory beta-cell hyperplastic response to insulin resistance in rodents | Q33750760 | ||
| ATP-gated P2X3 receptors constitute a positive autocrine signal for insulin release in the human pancreatic beta cell | Q33778734 | ||
| Altered function of insulin receptor substrate-1-deficient mouse islets and cultured beta-cell lines | Q33903502 | ||
| Altered insulin receptor signalling and β-cell cycle dynamics in type 2 diabetes mellitus | Q34091221 | ||
| Regulation of pancreatic duct cell differentiation by phosphatidylinositol-3 kinase. | Q34110611 | ||
| Insulin infusion during normoglycemia modulates insulin secretion according to whole-body insulin sensitivity | Q34507235 | ||
| Modeling phasic insulin release: immediate and time-dependent effects of glucose | Q34508732 | ||
| Lack of direct inhibition of insulin secretion by exogenous insulin in the canine pancreas | Q34545743 | ||
| Cannabinoids inhibit insulin receptor signaling in pancreatic β-cells | Q34718769 | ||
| The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of Type 2 diabetes | Q35085591 | ||
| Influence of hyperinsulinemia and insulin resistance on in vivo β-cell function: their role in human β-cell dysfunction | Q35561076 | ||
| Exogenous insulin enhances glucose-stimulated insulin response in healthy humans independent of changes in free fatty acids | Q35597914 | ||
| Insulin augmentation of glucose-stimulated insulin secretion is impaired in insulin-resistant humans | Q35696531 | ||
| Insulin receptors in beta-cells are critical for islet compensatory growth response to insulin resistance | Q35829169 | ||
| RNA-binding protein HuD controls insulin translation | Q35869792 | ||
| Mouse models created to study the pathophysiology of Type 2 diabetes | Q36231442 | ||
| Cannabinoids induce pancreatic β-cell death by directly inhibiting insulin receptor activation | Q36473356 | ||
| Fatty acid signaling in the beta-cell and insulin secretion | Q36666157 | ||
| Role of FoxO Proteins in Pancreatic beta Cells | Q36825554 | ||
| Regulation of beta-cell mass and function by the Akt/protein kinase B signalling pathway | Q36962192 | ||
| Insulin receptor substrate 2 plays a crucial role in beta cells and the hypothalamus | Q37532741 | ||
| Loss of ARNT/HIF1beta mediates altered gene expression and pancreatic-islet dysfunction in human type 2 diabetes | Q38322289 | ||
| Only Akt1 is required for proliferation, while Akt2 promotes cell cycle exit through p21 binding. | Q39126224 | ||
| Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor | Q39738488 | ||
| Defective insulin secretion and increased susceptibility to experimental diabetes are induced by reduced Akt activity in pancreatic islet beta cells | Q40051013 | ||
| Immediate and time-dependent effects of glucose on insulin release from rat pancreatic tissue. Evidence for different mechanisms of action | Q40152489 | ||
| Stabilization of Mdm2 via decreased ubiquitination is mediated by protein kinase B/Akt-dependent phosphorylation | Q40550797 | ||
| Distinct roles for insulin and insulin-like growth factor-1 receptors in pancreatic beta-cell glucose sensing revealed by RNA silencing | Q40625549 | ||
| A novel mechanism of gene regulation and tumor suppression by the transcription factor FKHR. | Q40714220 | ||
| Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells | Q40791254 | ||
| Glucose effects on beta-cell growth and survival require activation of insulin receptors and insulin receptor substrate 2. | Q41870014 | ||
| Circulating fatty acids are essential for efficient glucose-stimulated insulin secretion after prolonged fasting in humans | Q42461702 | ||
| Feedback inhibition of insulin secretion by insulin: relation to the hyperinsulinemia of obesity | Q42467547 | ||
| Acute effects of insulin on beta-cells from transplantable human islets | Q42482631 | ||
| Akt induces beta-cell proliferation by regulating cyclin D1, cyclin D2, and p21 levels and cyclin-dependent kinase-4 activity | Q42490110 | ||
| Insulin secretory responses to rising and falling glucose concentrations are delayed in subjects with impaired glucose tolerance | Q42521784 | ||
| GSK3 beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. | Q42834476 | ||
| Identification of functional insulin receptors on membranes from an insulin-producing cell line (RINm5F). | Q42849294 | ||
| Regulation of pancreatic beta-cell growth and survival by the serine/threonine protein kinase Akt1/PKBalpha | Q43759225 | ||
| Glucose-dependent promotion of insulin release from mouse pancreatic islets by the insulin-mimetic compound L-783,281. | Q43869333 | ||
| Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-->Arg IRS-1 polymorphism | Q43972535 | ||
| Reduced β-cell mass and altered glucose sensing impair insulin-secretory function in βIRKO mice | Q44602874 | ||
| Islet secretory defect in insulin receptor substrate 1 null mice is linked with reduced calcium signaling and expression of sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA)-2b and -3. | Q44909452 | ||
| beta-Cell function in subjects spanning the range from normal glucose tolerance to overt diabetes: a new analysis | Q45105931 | ||
| Aminoacid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. | Q51598640 | ||
| Failure of insulin infusion during euglycemia to influence endogenous basal insulin secretion | Q51646788 | ||
| Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene. | Q52507538 | ||
| Roles of insulin receptor substrate-1, phosphatidylinositol 3-kinase, and release of intracellular Ca2+ stores in insulin-stimulated insulin secretion in beta -cells. | Q52538800 | ||
| Disruption of insulin receptor substrate 2 causes type 2 diabetes because of liver insulin resistance and lack of compensatory beta-cell hyperplasia. | Q52541535 | ||
| Progressive loss of beta-cell function leads to worsening glucose tolerance in first-degree relatives of subjects with type 2 diabetes. | Q53568627 | ||
| Identification of insulin signaling elements in human beta-cells: autocrine regulation of insulin gene expression. | Q53596978 | ||
| Alterations in growth and apoptosis of insulin receptor substrate-1-deficient beta-cells. | Q53861068 | ||
| Insulin-stimulated insulin secretion in single pancreatic beta cells. | Q54104324 | ||
| Tissue-specific knockout of the insulin receptor in pancreatic beta cells creates an insulin secretory defect similar to that in type 2 diabetes. | Q54104864 | ||
| P304 | page(s) | 152-160 | |
| P577 | publication date | 2012-10-01 | |
| P1433 | published in | Diabetes, Obesity and Metabolism | Q5270109 |
| P1476 | title | Modulation of β-cell function: a translational journey from the bench to the bedside | |
| P478 | volume | 14 Suppl 3 |
| Q37535198 | DHEA supplementation in ovariectomized rats reduces impaired glucose-stimulated insulin secretion induced by a high-fat diet |
| Q64885974 | Diet-induced β-cell insulin resistance results in reversible loss of functional β-cell mass. |
| Q37014947 | Direct autocrine action of insulin on β-cells: does it make physiological sense? |
| Q37670818 | Effect of Human Myotubes-Derived Media on Glucose-Stimulated Insulin Secretion. |
| Q92994273 | Hepatic Insulin Clearance: Mechanism and Physiology |
| Q42459554 | Imatinib mesylate stimulates low-density lipoprotein receptor-related protein 1-mediated ERK phosphorylation in insulin-producing cells |
| Q51182748 | Loss of Cyclin-dependent Kinase 2 in the Pancreas Links Primary β-Cell Dysfunction to Progressive Depletion of β-Cell Mass and Diabetes. |
| Q38233063 | Novel approaches to drug discovery for the treatment of type 2 diabetes |
| Q39480247 | Nuclear Export of FoxO1 Is Associated with ERK Signaling in β-Cells Lacking Insulin Receptors. |
| Q55397307 | Palmitate and insulin counteract glucose-induced thioredoxin interacting protein (TXNIP) expression in insulin secreting cells via distinct mechanisms. |
| Q92705363 | Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells |
| Q90539644 | Potential Protection Against Type 2 Diabetes in Obesity Through Lower CD36 Expression and Improved Exocytosis in β-Cells |
| Q37082630 | Saxagliptin and metformin in fixed combination for the treatment of type 2 diabetes in adults |
| Q52372557 | The pseudophosphatase phogrin enables glucose-stimulated insulin signaling in pancreatic β cells. |
| Q61315205 | β-Arrestin2 plays a key role in the modulation of the pancreatic beta cell mass in mice |
| Q36935383 | β-Cell Glucose Sensitivity Is Linked to Insulin/Glucagon Bihormonal Cells in Nondiabetic Humans. |
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