The future of glycoprotein VI as an antithrombotic target.

scientific article published on December 2012

The future of glycoprotein VI as an antithrombotic target. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1111/JTH.12009
P698PubMed publication ID23020554
P5875ResearchGate publication ID264615047

P50authorStephane LoyauQ57067993
Martine Jandrot-PerrusQ57068013
Philippe BillialdQ59706136
P2093author name stringP Mangin
M Zahid
B Hechler
C Gachet
P2860cites workCloning and expression of the platelet-specific collagen receptor glycoprotein VIQ22254152
Glycoprotein VI is the collagen receptor in platelets which underlies tyrosine phosphorylation of the Fc receptor gamma-chainQ24308747
Platelet activation and signal transduction by convulxin, a C-type lectin from Crotalus durissus terrificus (tropical rattlesnake) venom via the p62/GPVI collagen receptorQ24321786
A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesionQ24621493
Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivoQ24669536
Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chainQ28145083
The platelet collagen receptor glycoprotein VI is a member of the immunoglobulin superfamily closely related to FcalphaR and the natural killer receptorsQ28145360
Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic eventsQ28195656
Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagenQ28204718
Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trialQ28209556
Association of Fyn and Lyn with the proline-rich domain of glycoprotein VI regulates intracellular signalingQ28214216
A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human plateletsQ28248776
A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorderQ28249764
GPVI and integrin alphaIIb beta3 signaling in plateletsQ28267414
Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagenQ28364081
Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinaseQ45016543
The immunoadhesin glycoprotein VI-Fc regulates arterial remodelling after mechanical injury in ApoE-/- miceQ46530171
GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolismQ46684669
Gain- and loss-of-function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagenQ46888768
Glycoprotein (GP) VI dimer as a major collagen-binding site of native platelets: direct evidence obtained with dimeric GPVI-specific FabsQ47680746
Structural basis for the platelet-collagen interaction: the smallest motif within collagen that recognizes and activates platelet Glycoprotein VI contains two glycine-proline-hydroxyproline triplets.Q48697081
Impact of glycoprotein VI and platelet adhesion on atherosclerosis--a possible role of fibronectin.Q50554991
An acquired inhibitor to the GPVI platelet collagen receptor in a patient with lupus nephritis.Q51778345
EXP3179 inhibits collagen-dependent platelet activation via glycoprotein receptor-VI independent of AT1-receptor antagonism: potential impact on atherothrombosis.Q51799143
Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcgammaRIIa and induce GPVI ectodomain shedding.Q51806436
Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI.Q51936883
The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletionQ52550457
Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutationsQ55670474
Soluble Glycoprotein VI Is Raised in the Plasma of Patients With Acute Ischemic StrokeQ57306100
Sandwich Immunoassay for Soluble Glycoprotein VI in Patients with Symptomatic Coronary Artery DiseaseQ57735718
Chimeric Fc Receptors Identify Ligand Binding Regions in Human Glycoprotein VIQ58861428
Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vesselsQ59281453
Coagulation-induced shedding of platelet glycoprotein VI mediated by factor XaQ59281458
Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic roleQ30157042
Vav1 and vav3 have critical but redundant roles in mediating platelet activation by collagen.Q30163810
Synergism between platelet collagen receptors defined using receptor-specific collagen-mimetic peptide substrata in flowing bloodQ30495037
Deficiency of P62, a putative collagen receptor, in platelets from a patient with defective collagen‐induced platelet aggregationQ33350522
Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surface.Q33360832
The Fab fragment of a novel anti-GPVI monoclonal antibody, OM4, reduces in vivo thrombosis without bleeding risk in ratsQ33374356
Diverging signaling events control the pathway of GPVI down-regulation in vivoQ33374637
A novel antiplatelet antibody therapy that induces cAMP-dependent endocytosis of the GPVI/Fc receptor gamma-chain complexQ33379144
Compromised ITAM-based platelet receptor function in a patient with immune thrombocytopenic purpura.Q33379632
Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital modelQ33382490
Single domain antibodies against the collagen signalling receptor glycoprotein VI are inhibitors of collagen induced thrombus formationQ33449506
Design and humanization of a murine scFv that blocks human platelet glycoprotein VI in vitroQ33475093
A humanized glycoprotein VI (GPVI) mouse model to assess the antithrombotic efficacies of anti-GPVI agents.Q34124802
Antiplatelet therapy: in search of the 'magic bullet'.Q35550212
Rap1-Rac1 circuits potentiate platelet activationQ35683204
The influence of N-linked glycosylation on the function of platelet glycoprotein VIQ35848393
Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.Q35848605
Platelet collagen receptors and coagulation. A characteristic platelet response as possible target for antithrombotic treatmentQ36205337
A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivoQ36370457
Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in miceQ36376147
The Modifier of hemostasis (Mh) locus on chromosome 4 controls in vivo hemostasis of Gp6-/- miceQ36407118
Platelet glycoprotein VI-related clinical defectsQ36957977
Non-invasive molecular imaging of fibrosis using a collagen-targeted peptidomimetic of the platelet collagen receptor glycoprotein VIQ37188547
Distinct spatio-temporal Ca2+ signaling elicited by integrin alpha2beta1 and glycoprotein VI under flow.Q37372846
Diagnostic and therapeutic potentials of platelet glycoprotein VI.Q37736347
Reperfusion therapy in acute cerebrovascular syndromeQ37811859
Medical treatment in acute and long-term secondary prevention after transient ischaemic attack and ischaemic strokeQ37875489
The evolution of antiplatelet therapy in cardiovascular diseaseQ37900470
Novel antiplatelet drug revacept (Dimeric Glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humansQ38492137
Monomeric (glycine-proline-hydroxyproline)10 repeat sequence is a partial agonist of the platelet collagen receptor glycoprotein VI.Q42260383
Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agentsQ42741745
Structural basis for platelet antiaggregation by angiotensin II type 1 receptor antagonist losartan (DuP-753) via glycoprotein VI.Q43160985
Expression of platelet glycoprotein VI is associated with transient ischemic attack and strokeQ43290763
Evidence for cross-talk between glycoprotein VI and Gi-coupled receptors during collagen-induced platelet aggregation.Q43627737
Identification of the primary collagen-binding surface on human glycoprotein VI by site-directed mutagenesis and by a blocking phage antibodyQ44592655
Platelet receptor interplay regulates collagen-induced thrombus formation in flowing human bloodQ44620766
Principal role of glycoprotein VI in alpha2beta1 and alphaIIbbeta3 activation during collagen-induced thrombus formationQ44961840
P433issue12
P407language of work or nameEnglishQ1860
P304page(s)2418-2427
P577publication date2012-12-01
P1433published inJournal of Thrombosis and HaemostasisQ6296004
P1476titleThe future of glycoprotein VI as an antithrombotic target
P478volume10

Reverse relations

cites work (P2860)
Q41628315ADPase CD39 Fused to Glycoprotein VI-Fc Boosts Local Antithrombotic Effects at Vascular Lesions.
Q37526189Alteration of platelet GPVI signaling in ST-elevation myocardial infarction patients demonstrated by a combination of proteomic, biochemical, and functional approaches.
Q32177061Anti-GPVI Fab SAR264565 effectively blocks GPVI function in ex vivo human platelets under arterial shear in a perfusion chamber
Q38543308Antiplatelet drugs: which targets for which treatments?
Q38990156Basic mechanisms of platelet receptor shedding
Q38983805Clinical significance of receptor shedding-platelet GPVI as an emerging diagnostic and therapeutic tool.
Q28066352Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation
Q47215330Current and future antiplatelet therapies: emphasis on preserving haemostasis
Q40450129Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals.
Q41578105Differential Inhibition of Human Atherosclerotic Plaque-Induced Platelet Activation by Dimeric GPVI-Fc and Anti-GPVI Antibodies: Functional and Imaging Studies
Q36091308Fibrin activates GPVI in human and mouse platelets
Q90480558Glycoprotein VI in securing vascular integrity in inflamed vessels
Q54328623Ibrutinib inhibits collagen-mediated but not ADP-mediated platelet aggregation.
Q38969861Ibrutinib-associated bleeding: pathogenesis, management and risk reduction strategies
Q52730893Immobilized fibrinogen activates human platelets through glycoprotein VI.
Q33624852Pannexin- and Connexin-Mediated Intercellular Communication in Platelet Function.
Q39449769Platelet "first responders" in wound response, cancer, and metastasis
Q34294719Platelets and cancer: a casual or causal relationship: revisited.
Q52729803Post-translational modification of type IV collagen with 3-hydroxyproline affects its interactions with glycoprotein VI and nidogens 1 and 2.
Q38206848Primary haemostasis: newer insights.
Q35846181Regulation of Early Steps of GPVI Signal Transduction by Phosphatases: A Systems Biology Approach
Q57280930Role of platelets and platelet receptors in cancer metastasis
Q33689745Targeting GPVI as a novel antithrombotic strategy
Q43692419The Cape Chacma baboon is not suitable for evaluating human targeted anti-GPVI agents
Q26768149The integrin-collagen connection--a glue for tissue repair?

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