Clinical significance of receptor shedding-platelet GPVI as an emerging diagnostic and therapeutic tool.

scientific article

Clinical significance of receptor shedding-platelet GPVI as an emerging diagnostic and therapeutic tool. is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1080/09537104.2016.1227062
P698PubMed publication ID27753514

P50authorMadhumita ChatterjeeQ64858095
P2093author name stringMeinrad Gawaz
P2860cites workEvolutionary divergence and functions of the ADAM and ADAMTS gene familiesQ21245456
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A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesionQ24621493
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Adam meets Eph: an ADAM substrate recognition module acts as a molecular switch for ephrin cleavage in transQ28278222
The GPVI-Fc fusion protein Revacept reduces thrombus formation and improves vascular dysfunction in atherosclerosis without any impact on bleeding timesQ28535276
Noninvasive ultrasound molecular imaging of the effect of statins on endothelial inflammatory phenotype in early atherosclerosisQ30455730
Metalloproteinase inhibitors improve the recovery and hemostatic function of in vitro-aged or -injured mouse plateletsQ33349386
The Fab fragment of a novel anti-GPVI monoclonal antibody, OM4, reduces in vivo thrombosis without bleeding risk in ratsQ33374356
Dual ITAM-mediated proteolytic pathways for irreversible inactivation of platelet receptors: de-ITAM-izing FcgammaRIIaQ33376631
A novel antiplatelet antibody therapy that induces cAMP-dependent endocytosis of the GPVI/Fc receptor gamma-chain complexQ33379144
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Impact of glycoprotein VI and platelet adhesion on atherosclerosis--a possible role of fibronectin.Q50554991
Molecular imaging of inflammation in atherosclerosis with targeted ultrasound detection of vascular cell adhesion molecule-1.Q50970470
The dimeric platelet collagen receptor GPVI-Fc reduces platelet adhesion to activated endothelium and preserves myocardial function after transient ischemia in mice.Q51757699
An acquired inhibitor to the GPVI platelet collagen receptor in a patient with lupus nephritis.Q51778345
Anti-glycoprotein VI monoclonal antibodies directly aggregate platelets independently of FcgammaRIIa and induce GPVI ectodomain shedding.Q51806436
Regulation of platelet glycoprotein VI (GPVI) surface expression and of soluble GPVI in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS).Q51841836
The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletionQ52550457
High-frequency ultrasound-guided disruption of glycoprotein VI-targeted microbubbles targets atheroprogressison in mice.Q52654271
Positron emission tomography/computed tomographic and magnetic resonance imaging in a murine model of progressive atherosclerosis using (64)Cu-labeled glycoprotein VI-Fc.Q53092873
Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases.Q53311584
Platelet glycoprotein VI (GPVI) for early identification of acute coronary syndrome in patients with chest pain.Q54695208
Glycoprotein VI for diagnosis of acute coronary syndrome when ECG is ambiguous.Q54698739
Soluble Glycoprotein VI Is Raised in the Plasma of Patients With Acute Ischemic StrokeQ57306100
Sandwich Immunoassay for Soluble Glycoprotein VI in Patients with Symptomatic Coronary Artery DiseaseQ57735718
Pathologic shear triggers shedding of vascular receptors: a novel mechanism for down-regulation of platelet glycoprotein VI in stenosed coronary vesselsQ59281453
Coagulation-induced shedding of platelet glycoprotein VI mediated by factor XaQ59281458
Restored platelet function after romiplostim treatment in a patient with immune thrombocytopenic purpuraQ59281467
Ligand Binding Rapidly Induces Disulfide-dependent Dimerization of Glycoprotein VI on the Platelet Plasma MembraneQ59281484
Platelet receptor expression and shedding: glycoprotein Ib-IX-V and glycoprotein VI.Q33414254
Design and humanization of a murine scFv that blocks human platelet glycoprotein VI in vitroQ33475093
Coordinating radiometals of copper, gallium, indium, yttrium, and zirconium for PET and SPECT imaging of diseaseQ33870879
A humanized glycoprotein VI (GPVI) mouse model to assess the antithrombotic efficacies of anti-GPVI agents.Q34124802
The first comprehensive and quantitative analysis of human platelet protein composition allows the comparative analysis of structural and functional pathwaysQ34368551
The GPVI-Fc fusion protein Revacept improves cerebral infarct volume and functional outcome in strokeQ34917692
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The role of collagen in thrombosis and hemostasisQ35752946
Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI.Q35848605
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Constitutive dimerization of glycoprotein VI (GPVI) in resting platelets is essential for binding to collagen and activation in flowing bloodQ36215984
Role of calmodulin in platelet receptor functionQ36297698
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Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in miceQ36376147
Molecular imaging of inflammation and platelet adhesion in advanced atherosclerosis effects of antioxidant therapy with NADPH oxidase inhibition.Q36617730
Platelets as immune cells: bridging inflammation and cardiovascular diseaseQ36699744
Platelet receptor proteolysis: a mechanism for downregulating platelet reactivityQ36803375
Radionuclide imaging: a molecular key to the atherosclerotic plaqueQ37196226
Regulation of the proteolytic disintegrin metalloproteinases, the 'Sheddases'.Q37289019
Molecular imaging reveals rapid reduction of endothelial activation in early atherosclerosis with apocynin independent of antioxidative propertiesQ37466636
Diagnostic and therapeutic potentials of platelet glycoprotein VI.Q37736347
Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic strokeQ37903934
Platelet GPVI: a target for antithrombotic therapy?!Q38035484
The future of glycoprotein VI as an antithrombotic target.Q38047358
Glycoprotein VI as a prognostic biomarker for cardiovascular death in patients with symptomatic coronary artery diseaseQ39912642
Controlled shedding of platelet glycoprotein (GP)VI and GPIb-IX-V by ADAM family metalloproteinases.Q40143775
Association of platelet-derived soluble glycoprotein VI in plasma with Alzheimer's diseaseQ40174296
Coronary Plaque DisruptionQ40459835
Surface expression of collagen receptor Fc receptor-gamma/glycoprotein VI is enhanced on platelets in type 2 diabetes and mediates release of CD40 ligand and activation of endothelial cellsQ40531263
The platelet receptor GPVI mediates both adhesion and signaling responses to collagen in a receptor density-dependent fashionQ40766523
A novel viper venom metalloproteinase, alborhagin, is an agonist at the platelet collagen receptor GPVI.Q40807170
Expression of platelet glycoprotein VI is associated with transient ischemic attack and strokeQ43290763
Ex vivoimaging of injured arteries in rabbits using fluorescence-labelled glycoprotein VI-FcQ44156689
Platelet collagen receptor glycoprotein VI as a possible novel indicator for the acute coronary syndromeQ44203026
An adenine insertion in exon 6 of human GP6 generates a truncated protein associated with a bleeding disorder in four Chilean familiesQ44209400
Regulation of platelet membrane levels of glycoprotein VI by a platelet-derived metalloproteinaseQ45016543
Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivoQ45042577
Platelet GPVI binds to collagenous structures in the core region of human atheromatous plaque and is critical for atheroprogression in vivoQ45764285
The immunoadhesin glycoprotein VI-Fc regulates arterial remodelling after mechanical injury in ApoE-/- miceQ46530171
Platelet glycoprotein VI binds to polymerized fibrin and promotes thrombin generationQ48186665
P433issue4
P304page(s)362-371
P577publication date2016-10-18
P1433published inPlateletsQ1573582
P1476titleClinical significance of receptor shedding-platelet GPVI as an emerging diagnostic and therapeutic tool
P478volume28

Reverse relations

cites work (P2860)
Q64263252A novel anti-platelet aggregation target of chinensinaphthol methyl ether and neojusticin B obtained from Rostellularia procumbens (L.) Nees
Q98945656Collagen-dependent platelet dysfunction and its relevance to either mitochondrial ROS or cytosolic superoxide generation: a question about the quality and functional competence of long-stored platelets
Q89820694Imaging Platelet Processes and Function-Current and Emerging Approaches for Imaging in vitro and in vivo
Q50002204Protease-Activated Receptor 4 (PAR4): A Promising Target for Antiplatelet Therapy.
Q59281355Proteolytic processing of platelet receptors
Q48273240The cutting edge of platelets

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