| scholarly article | Q13442814 |
| review article | Q7318358 |
| P2093 | author name string | M Bender | |
| B Nieswandt | |||
| I Pleines | |||
| P2860 | cites work | The contribution of glycoprotein VI to stable platelet adhesion and thrombus formation illustrated by targeted gene deletion | Q52550457 |
| Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases. | Q53311584 | ||
| Multiple integrin-ligand interactions synergize in shear-resistant platelet adhesion at sites of arterial injury in vivo. | Q53921981 | ||
| Kindlin-3: a new gene involved in the pathogenesis of LAD-III. | Q55050555 | ||
| Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations | Q55670474 | ||
| Glycoprotein IIb-IIIa Inhibitors for Acute Ischemic Stroke | Q57278243 | ||
| Soluble Glycoprotein VI Is Raised in the Plasma of Patients With Acute Ischemic Stroke | Q57306100 | ||
| Integrin α2-Deficient Mice Develop Normally, Are Fertile, but Display Partially Defective Platelet Interaction with Collagen | Q57339936 | ||
| Store-operated Ca2+ entry in platelets occurs independently of transient receptor potential (TRP) C1 | Q57987885 | ||
| Targeting of the collagen-binding site on glycoprotein VI is not essential for in vivo depletion of the receptor | Q58897991 | ||
| Coagulation-induced shedding of platelet glycoprotein VI mediated by factor Xa | Q59281458 | ||
| Glanzmann thrombasthenia | Q21203054 | ||
| Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells | Q22253165 | ||
| Perinatal lethality and blocked B-cell development in mice lacking the tyrosine kinase Syk | Q24303475 | ||
| A point mutation in KINDLIN3 ablates activation of three integrin subfamilies in humans | Q24313548 | ||
| Leukocyte adhesion deficiency-III is caused by mutations in KINDLIN3 affecting integrin activation | Q24313629 | ||
| RACK1 associates with CLEC-2 and promotes its ubiquitin-proteasome degradation | Q24319058 | ||
| A patient with platelets deficient in glycoprotein VI that lack both collagen-induced aggregation and adhesion | Q24621493 | ||
| Platelets amplify inflammation in arthritis via collagen-dependent microparticle production | Q24627618 | ||
| Endothelial cell O-glycan deficiency causes blood/lymphatic misconnections and consequent fatty liver disease in mice | Q24652041 | ||
| RIAM activates integrins by linking talin to ras GTPase membrane-targeting sequences | Q24652493 | ||
| Platelet polyphosphates are proinflammatory and procoagulant mediators in vivo | Q24655664 | ||
| Glycoprotein VI-dependent and -independent pathways of thrombus formation in vivo | Q24669536 | ||
| An EF hand mutation in Stim1 causes premature platelet activation and bleeding in mice | Q24675771 | ||
| Integrins: bidirectional, allosteric signaling machines | Q27860700 | ||
| CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation | Q28118463 | ||
| Expression and function of the mouse collagen receptor glycoprotein VI is strictly dependent on its association with the FcRgamma chain | Q28145083 | ||
| Anti-glycoprotein VI treatment severely compromises hemostasis in mice with reduced alpha2beta1 levels or concomitant aspirin therapy | Q28171295 | ||
| Platelet-collagen interaction: is GPVI the central receptor? | Q28185377 | ||
| Clinical aspects of platelet inhibitors and thrombus formation | Q28210313 | ||
| A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex | Q28211474 | ||
| Amelioration of the macrothrombocytopenia associated with the murine Bernard-Soulier syndrome | Q28219298 | ||
| Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data | Q28242645 | ||
| A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder | Q28249764 | ||
| Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling | Q28263181 | ||
| GPVI and integrin alphaIIb beta3 signaling in platelets | Q28267414 | ||
| Integrins: dynamic scaffolds for adhesion and signaling in platelets | Q28267584 | ||
| Calpain Cleavage of the Cytoplasmic Domain of the Integrin β2 Subunit | Q28291851 | ||
| CLEC-2 activates Syk through dimerization | Q41773420 | ||
| A critical role of platelet adhesion in the initiation of atherosclerotic lesion formation | Q41824616 | ||
| Impaired alpha(IIb)beta(3) integrin activation and shear-dependent thrombus formation in mice lacking phospholipase D1. | Q41884542 | ||
| Syk-dependent phosphorylation of CLEC-2: a novel mechanism of hem-immunoreceptor tyrosine-based activation motif signaling | Q41976932 | ||
| Dynamic platelet accumulation at the site of the occluded middle cerebral artery and in downstream microvessels is associated with loss of microvascular integrity after embolic middle cerebral artery occlusion | Q42509508 | ||
| Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. | Q42582678 | ||
| Blockade of bradykinin receptor B1 but not bradykinin receptor B2 provides protection from cerebral infarction and brain edema | Q42602467 | ||
| Activation-independent, antibody-mediated removal of GPVI from circulating human platelets: development of a novel NOD/SCID mouse model to evaluate the in vivo effectiveness of anti-human platelet agents | Q42741745 | ||
| CLEC-2 is not required for platelet aggregation at arteriolar shear | Q42942640 | ||
| Factor XIIa inhibitor recombinant human albumin Infestin-4 abolishes occlusive arterial thrombus formation without affecting bleeding | Q43121714 | ||
| Expression of platelet glycoprotein VI is associated with transient ischemic attack and stroke | Q43290763 | ||
| Aggretin, a heterodimeric C-type lectin from Calloselasma rhodostoma (Malayan pit viper), stimulates platelets by binding to α2β1 integrin and glycoprotein Ib, activating Syk and phospholipase Cγ 2, but does not involve the glycoprotein VI/Fc recept | Q43565303 | ||
| Rhodocytin (aggretin) activates platelets lacking alpha(2)beta(1) integrin, glycoprotein VI, and the ligand-binding domain of glycoprotein Ibalpha | Q43607754 | ||
| Aggretin, a C-type lectin protein, induces platelet aggregation via integrin alpha(2)beta(1) and GPIb in a phosphatidylinositol 3-kinase independent pathway. | Q43674095 | ||
| Tumor necrosis factor-alpha-converting enzyme (ADAM17) mediates GPIbalpha shedding from platelets in vitro and in vivo | Q45042577 | ||
| Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation | Q45331616 | ||
| Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. | Q45967882 | ||
| Rac1 is essential for phospholipase C-gamma2 activation in platelets | Q46428451 | ||
| Platelet adhesion via glycoprotein IIb integrin is critical for atheroprogression and focal cerebral ischemia: an in vivo study in mice lacking glycoprotein IIb. | Q46652724 | ||
| GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism | Q46684669 | ||
| Targeting platelets in acute experimental stroke: impact of glycoprotein Ib, VI, and IIb/IIIa blockade on infarct size, functional outcome, and intracranial bleeding | Q47292508 | ||
| Genetic deletion of mouse platelet glycoprotein Ibbeta produces a Bernard-Soulier phenotype with increased alpha-granule size | Q47303190 | ||
| Binding of von Willebrand factor to collagen and glycoprotein Ibalpha, but not to glycoprotein IIb/IIIa, contributes to ischemic stroke in mice--brief report | Q48134832 | ||
| ADAMTS13 gene deletion aggravates ischemic brain damage: a possible neuroprotective role of ADAMTS13 by ameliorating postischemic hypoperfusion. | Q48386564 | ||
| When recanalization does not improve clinical outcomes | Q48529179 | ||
| Neurological and behavioral outcomes of focal cerebral ischemia in rats | Q48537150 | ||
| Deficiency of von Willebrand factor protects mice from ischemic stroke | Q48775166 | ||
| Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation | Q48895370 | ||
| Photochemically induced endothelial injury in the mouse as a screening model for inhibitors of vascular intimal thickening. | Q50523399 | ||
| Inhibition of the von Willebrand (VWF)-collagen interaction by an antihuman VWF monoclonal antibody results in abolition of in vivo arterial platelet thrombus formation in baboons. | Q52120587 | ||
| Agonist-activated alphavbeta3 on platelets and lymphocytes binds to the matrix protein osteopontin. | Q52524567 | ||
| The C-type lectin receptors CLEC-2 and Dectin-1, but not DC-SIGN, signal via a novel YXXL-dependent signaling cascade | Q40163101 | ||
| The platelet receptor GPVI mediates both adhesion and signaling responses to collagen in a receptor density-dependent fashion | Q40766523 | ||
| Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen | Q28364081 | ||
| Targeting coagulation factor XII provides protection from pathological thrombosis in cerebral ischemia without interfering with hemostasis | Q28508572 | ||
| Thrombin-initiated platelet activation in vivo is vWF independent during thrombus formation in a laser injury model | Q28509120 | ||
| Generation and rescue of a murine model of platelet dysfunction: the Bernard-Soulier syndrome | Q28509360 | ||
| A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis | Q28586884 | ||
| Syk tyrosine kinase required for mouse viability and B-cell development | Q28586985 | ||
| Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk. | Q28588103 | ||
| Kindlin-3 is essential for integrin activation and platelet aggregation | Q28595084 | ||
| Talin Binding to Integrin ß Tails: A Final Common Step in Integrin Activation | Q29617809 | ||
| Novel function for blood platelets and podoplanin in developmental separation of blood and lymphatic circulation. | Q30090176 | ||
| The role of platelet adhesion receptor GPIbalpha far exceeds that of its main ligand, von Willebrand factor, in arterial thrombosis | Q30478277 | ||
| Activation-independent platelet adhesion and aggregation under elevated shear stress | Q30479636 | ||
| The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction | Q30482557 | ||
| Rhodocytin induces platelet aggregation by interacting with glycoprotein Ia/IIa (GPIa/IIa, Integrin alpha 2beta 1). Involvement of GPIa/IIa-associated src and protein tyrosine phosphorylation | Q31473281 | ||
| Deficiency or inhibition of Gas6 causes platelet dysfunction and protects mice against thrombosis. | Q31929744 | ||
| Mice deficient in Mac-1 (CD11b/CD18) are less susceptible to cerebral ischemia/reperfusion injury | Q31938092 | ||
| Reduced microvascular thrombosis and improved outcome in acute murine stroke by inhibiting GP IIb/IIIa receptor-mediated platelet aggregation | Q32000831 | ||
| Platelet PECAM-1 inhibits thrombus formation in vivo. | Q33223436 | ||
| Decreased thrombotic tendency in mouse models of the Bernard-Soulier syndrome | Q33263186 | ||
| Antithrombotic effect of platelet glycoprotein Ib-blocking monoclonal antibody Fab fragments in nonhuman primates. | Q33332419 | ||
| Critical role of FcR gamma-chain, LAT, PLCgamma2 and thrombin in arteriolar thrombus formation upon mild, laser-induced endothelial injury in vivo | Q33332518 | ||
| Anti-GPVI-associated ITP: an acquired platelet disorder caused by autoantibody-mediated clearance of the GPVI/FcRgamma-chain complex from the human platelet surface. | Q33360832 | ||
| Diverging signaling events control the pathway of GPVI down-regulation in vivo | Q33374637 | ||
| Multiple alterations of platelet functions dominated by increased secretion in mice lacking Cdc42 in platelets. | Q33388172 | ||
| Dissolution of arterial platelet thrombi in vivo with a bifunctional platelet GPIIIa49-66 ligand which specifically targets the platelet thrombus | Q33389941 | ||
| Endothelial cell specific adhesion molecule (ESAM) localizes to platelet-platelet contacts and regulates thrombus formation in vivo | Q33501329 | ||
| Rodent models of focal cerebral ischemia: procedural pitfalls and translational problems | Q33647103 | ||
| G protein subunit Galpha13 binds to integrin alphaIIbbeta3 and mediates integrin "outside-in" signaling | Q33743722 | ||
| Rap1b is required for normal platelet function and hemostasis in mice | Q33778323 | ||
| Beta3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. | Q33835366 | ||
| Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets. | Q33895889 | ||
| The final steps of integrin activation: the end game | Q34106011 | ||
| A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. | Q34452496 | ||
| Molecular characterization of two novel isoforms and a soluble form of mouse CLEC-2. | Q34655942 | ||
| Platelets in atherothrombosis | Q34986345 | ||
| Regulated surface expression and shedding support a dual role for semaphorin 4D in platelet responses to vascular injury | Q35616359 | ||
| Minimal regulation of platelet activity by PECAM-1. | Q35689559 | ||
| Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke | Q35802442 | ||
| Laminin stimulates spreading of platelets through integrin alpha6beta1-dependent activation of GPVI. | Q35848605 | ||
| Platelets regulate lymphatic vascular development through CLEC-2-SLP-76 signaling | Q35883118 | ||
| Signalling through the platelet glycoprotein Ib-V-IX complex | Q35894162 | ||
| Platelet glycoprotein VI: its structure and function | Q35894228 | ||
| Acute anti‐inflammatory approaches to ischemic stroke | Q36003814 | ||
| Integrin regulation | Q36229087 | ||
| Platelet GPIb-IX-V-dependent signaling | Q36230867 | ||
| Talin is required for integrin-mediated platelet function in hemostasis and thrombosis | Q36294415 | ||
| Critical roles for the COOH-terminal NITY and RGT sequences of the integrin beta3 cytoplasmic domain in inside-out and outside-in signaling | Q36323239 | ||
| A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo | Q36370457 | ||
| Long-term antithrombotic protection by in vivo depletion of platelet glycoprotein VI in mice | Q36376147 | ||
| Activation of platelet function through G protein-coupled receptors | Q36678570 | ||
| Platelet receptor proteolysis: a mechanism for downregulating platelet reactivity | Q36803375 | ||
| Mechanics of proplatelet elaboration | Q36884299 | ||
| Platelet glycoprotein VI-related clinical defects | Q36957977 | ||
| T- and B-cell-deficient mice with experimental stroke have reduced lesion size and inflammation | Q36992998 | ||
| Novel therapeutic targets at the platelet vascular interface. | Q37049864 | ||
| Platelet receptors and signaling in the dynamics of thrombus formation. | Q37175605 | ||
| Molecular mechanisms of thrombus formation in ischemic stroke: novel insights and targets for treatment | Q37234173 | ||
| Novel roles for factor XII-driven plasma contact activation system | Q37241548 | ||
| Thrombomodulation via CLEC-2 targeting | Q37353396 | ||
| von Willebrand factor-cleaving protease ADAMTS13 reduces ischemic brain injury in experimental stroke | Q37381709 | ||
| Calcium signaling in platelets | Q37473529 | ||
| Novel molecules in calcium signaling in platelets | Q37561536 | ||
| Integrins in platelet activation | Q37561554 | ||
| GPVI and CLEC-2 in hemostasis and vascular integrity | Q37719682 | ||
| Combating innate inflammation: a new paradigm for acute treatment of stroke? | Q37801001 | ||
| Platelets: covert regulators of lymphatic development | Q37808903 | ||
| The platelet receptor CLEC-2 is active as a dimer | Q39788096 | ||
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | thrombosis | Q261327 |
| P304 | page(s) | 92-104 | |
| P577 | publication date | 2011-07-01 | |
| P1433 | published in | Journal of Thrombosis and Haemostasis | Q6296004 |
| P1476 | title | Platelet adhesion and activation mechanisms in arterial thrombosis and ischaemic stroke | |
| P478 | volume | 9 Suppl 1 |
| Q35331687 | A novel atherothrombotic model of ischemic stroke induced by injection of collagen into the cerebral vasculature |
| Q34775072 | A novel role of Eruca sativa Mill. (rocket) extract: antiplatelet (NF-κB inhibition) and antithrombotic activities |
| Q57052641 | A synthesis approach of mouse studies to identify genes and proteins in arterial thrombosis and bleeding |
| Q38543304 | Acute and persistent platelet and coagulant activities in atherothrombosis. |
| Q38804583 | Adhesion Molecules: Master Controllers of the Circulatory System. |
| Q37526189 | Alteration of platelet GPVI signaling in ST-elevation myocardial infarction patients demonstrated by a combination of proteomic, biochemical, and functional approaches. |
| Q38788350 | Analysis of serum markers of cellular immune activation in patients with bullous pemphigoid |
| Q90720964 | Antithrombotic Effects of Paeoniflorin from Paeonia suffruticosa by Selective Inhibition on Shear Stress-Induced Platelet Aggregation |
| Q41008620 | Assessment of the Diagnostic Value of Plasma Levels, Activities, and Their Ratios of von Willebrand Factor and ADAMTS13 in Patients with Cerebral Infarction |
| Q35854514 | Association between polymorphisms of platelet membrane glycoprotein Ibα and risk of coronary heart disease in Han Chinese, Henan, China |
| Q38867733 | Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke |
| Q99616004 | COVID-19 infection and high intracoronary thrombus burden |
| Q34937666 | Cathepsin G-dependent modulation of platelet thrombus formation in vivo by blood neutrophils |
| Q37524901 | Cell biology of ischemia/reperfusion injury |
| Q92421869 | Characterisation of the Ral GTPase inhibitor RBC8 in human and mouse platelets |
| Q38983805 | Clinical significance of receptor shedding-platelet GPVI as an emerging diagnostic and therapeutic tool. |
| Q51828070 | Combined in vivo depletion of glycoprotein VI and C-type lectin-like receptor 2 severely compromises hemostasis and abrogates arterial thrombosis in mice. |
| Q38857206 | Common genetic variants in platelet surface receptors and its association with ischemic stroke |
| Q55068394 | Critical off-target effects of the widely used Rac1 inhibitors NSC23766 and EHT1864 in mouse platelets. |
| Q33442579 | Design, development and characterization of ACT017, a humanized Fab that blocks platelet's glycoprotein VI function without causing bleeding risks |
| Q42565906 | Development of antithrombotic nanoconjugate blocking integrin α2β1-collagen interactions |
| Q92857675 | Early Host Interactions That Drive the Dysregulated Response in Sepsis |
| Q33426819 | Eltrombopag enhances platelet adhesion by upregulating the expression of glycoprotein VI in patients with chronic immune thrombocytopenic purpura |
| Q38953860 | Fucoidan from Fucus vesiculosus Fails to Improve Outcomes Following Intracerebral Hemorrhage in Mice |
| Q35646500 | Genome-wide association study of platelet aggregation in African Americans |
| Q39857872 | Growth factor receptor-bound protein 2 contributes to (hem)immunoreceptor tyrosine-based activation motif-mediated signaling in platelets |
| Q38734794 | Hematoma Expansion following Intracerebral Hemorrhage: Mechanisms Targeting the Coagulation Cascade and Platelet Activation. |
| Q48109054 | Human endoglin as a potential new partner involved in platelet-endothelium interactions |
| Q35106314 | Ischaemic strokes in patients with pulmonary arteriovenous malformations and hereditary hemorrhagic telangiectasia: associations with iron deficiency and platelets |
| Q39109413 | Ischemia/Reperfusion |
| Q38680665 | Licochalcone A Prevents Platelet Activation and Thrombus Formation through the Inhibition of PLCγ2-PKC, Akt, and MAPK Pathways |
| Q37038711 | Mechanisms of Cardiotoxicity of Cancer Chemotherapeutic Agents: Cardiomyopathy and Beyond |
| Q35738656 | Mechanisms of thrombogenesis in polycythemia vera |
| Q38803630 | Medicinal Plants with Antiplatelet Activity. |
| Q34796596 | Mice lacking the SLAM family member CD84 display unaltered platelet function in hemostasis and thrombosis |
| Q51534595 | Microfluidic impedance cytometer for platelet analysis. |
| Q38874473 | Model systems for platelet receptor shedding |
| Q36250947 | Munc18b/STXBP2 is required for platelet secretion. |
| Q30840174 | Mutations in tropomyosin 4 underlie a rare form of human macrothrombocytopenia |
| Q89830458 | Neuroprotective effects of Yiqihuoxue calm wind capsule on ischemic stroke in rats |
| Q51664210 | New approaches in tail-bleeding assay in mice: improving an important method for designing new anti-thrombotic agents. |
| Q52325694 | No indications for platelet activation in acute clinical myocardial or renal ischemia/reperfusion injury. |
| Q27302230 | Normal Platelet Integrin Function in Mice Lacking Hydrogen Peroxide-Induced Clone-5 (Hic-5) |
| Q63916614 | Ontogeny of platelet function |
| Q93061149 | Organ Preservation into the 2020s: The Era of Dynamic Intervention |
| Q89575454 | Pathophysiologic and Therapeutic Perspectives Based on Thrombus Histology in Stroke |
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| Q35644702 | Platelet Gi protein Gαi2 is an essential mediator of thrombo-inflammatory organ damage in mice |
| Q52644169 | Platelet Signaling Pathways and New Inhibitors. |
| Q33419774 | Platelet transfusions in platelet consumptive disorders are associated with arterial thrombosis and in-hospital mortality |
| Q36060003 | Platelets Proteomic Profiles of Acute Ischemic Stroke Patients. |
| Q37081746 | Platelets as cellular effectors of inflammation in vascular diseases |
| Q28085020 | Platelets in inflammation and atherogenesis |
| Q36070471 | Platelets induce apoptosis via membrane-bound FasL. |
| Q38032475 | Platelets: active players in the pathogenesis of arthritis and SLE. |
| Q58761411 | Ponatinib Activates an Inflammatory Response in Endothelial Cells via ERK5 SUMOylation |
| Q42423815 | Post-translational arginylation as a novel regulator of platelet function |
| Q38132915 | Proteomic profiling of platelet signalling |
| Q35044725 | Pulmonary arteriovenous malformations |
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| Q34802412 | SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice |
| Q50246351 | Simplified platelet sample preparation for SDS-PAGE-based proteomic studies. |
| Q47598562 | Soluble fibrin causes an acquired platelet glycoprotein VI signaling defect: implications for coagulopathy |
| Q33421358 | Targeted downregulation of platelet CLEC-2 occurs through Syk-independent internalization |
| Q47789592 | The Lung in Hereditary Hemorrhagic Telangiectasia. |
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| Q35268738 | The adaptor protein Swiprosin-1/EFhd2 is dispensable for platelet function in mice |
| Q43574044 | The apoptotic actions of platelets in acute ischemic stroke. |
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