MicroRNAs in cancer diagnosis and therapy: from bench to bedside

scientific article

MicroRNAs in cancer diagnosis and therapy: from bench to bedside is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1007/S00595-012-0392-5
P698PubMed publication ID23129027

P2093author name stringHisahiro Matsubara
Isamu Hoshino
P2860cites workThe Hallmarks of CancerQ221226
Principles of microRNA-target recognitionQ21146368
MicroRNAs and their target gene networks in breast cancerQ21195211
Translating the Histone CodeQ22065840
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemiaQ24539231
Accumulation of miR-155 and BIC RNA in human B cell lymphomasQ24556523
MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemiasQ24564008
Characterization of extracellular circulating microRNAQ24603537
miR-9, a MYC/MYCN-activated microRNA, regulates E-cadherin and cancer metastasisQ24613599
Epigenetics and environmental chemicalsQ24629035
miR-210 links hypoxia with cell cycle regulation and is deleted in human epithelial ovarian cancerQ24630894
MicroRNA-21 targets tumor suppressor genes ANP32A and SMARCA4Q24633718
MicroRNAs: new players in cardiac injury and protectionQ24635236
MicroRNA let-7: an emerging next-generation cancer therapeuticQ24644251
Low-level expression of microRNAs let-7d and miR-205 are prognostic markers of head and neck squamous cell carcinomaQ24646667
A pleiotropically acting microRNA, miR-31, inhibits breast cancer metastasisQ24649156
Circulating microRNAs as stable blood-based markers for cancer detectionQ24652098
MicroRNA-373 induces expression of genes with complementary promoter sequencesQ24652547
miR-34a repression of SIRT1 regulates apoptosisQ24652720
Effects of let-7 microRNA on Cell Growth and Differentiation of Papillary Thyroid CancerQ24652758
MicroRNA expression profiles associated with prognosis and therapeutic outcome in colon adenocarcinomaQ24653676
Elevated expression of the miR-17-92 polycistron and miR-21 in hepadnavirus-associated hepatocellular carcinoma contributes to the malignant phenotypeQ24656088
Epstein-Barr virus latent membrane protein 1 trans-activates miR-155 transcription through the NF-kappaB pathwayQ24657973
Abnormal microRNA-16 locus with synteny to human 13q14 linked to CLL in NZB miceQ24675006
Phase 2 trial of oral vorinostat (suberoylanilide hydroxamic acid, SAHA) for refractory cutaneous T-cell lymphoma (CTCL)Q24681480
Hidden reach of the micromanagers.Q27692612
Unique microRNA molecular profiles in lung cancer diagnosis and prognosisQ27860631
MicroRNA gene expression deregulation in human breast cancerQ27860690
c-Myc-regulated microRNAs modulate E2F1 expressionQ27861046
MicroRNA expression profiles classify human cancersQ28032481
Characterization of microRNAs in serum: a novel class of biomarkers for diagnosis of cancer and other diseasesQ28131780
MicroRNA-directed cleavage of HOXB8 mRNAQ28131834
let-7 microRNA functions as a potential growth suppressor in human colon cancer cellsQ28237683
The miR-34 family in cancer and apoptosisQ28245865
Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cellsQ28249223
The role of let-7 in cell differentiation and cancerQ28259549
let-7 regulates self renewal and tumorigenicity of breast cancer cellsQ28261263
Reduced expression of the let-7 microRNAs in human lung cancers in association with shortened postoperative survivalQ28264400
The let-7 microRNA reduces tumor growth in mouse models of lung cancerQ28272817
MicroRNA-10a binds the 5'UTR of ribosomal protein mRNAs and enhances their translationQ28281118
Let-7 microRNA inhibits the proliferation of human glioblastoma cellsQ28287254
A microRNA component of the p53 tumour suppressor networkQ28305330
Regulatory circuit of human microRNA biogenesisQ35753722
Cancer epigenetics: above and beyondQ35844494
Expression profiling of microRNA using oligo DNA arraysQ35876067
Therapeutic inhibition of miR-208a improves cardiac function and survival during heart failureQ35964249
Array comparative genomic hybridization and its applications in cancerQ36141621
MicroRNAs in body fluids--the mix of hormones and biomarkersQ36176435
MicroRNA expression profiles of esophageal cancerQ36490960
Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancerQ36657641
Loss of imprinting and cancerQ36687286
Mechanisms of disease: methyl-binding domain proteins as potential therapeutic targets in cancerQ36803783
CpG island hypermethylation of tumor suppressor microRNAs in human cancerQ36854202
Phase I study of oral azacitidine in myelodysplastic syndromes, chronic myelomonocytic leukemia, and acute myeloid leukemiaQ36910441
Epigenetics: relations to disease and laboratory findingsQ36990253
Chromatin-remodelling mechanisms in cancer.Q37134923
HMGA2 maintains oncogenic RAS-induced epithelial-mesenchymal transition in human pancreatic cancer cellsQ37150773
14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival.Q37165239
C19MC microRNAs are processed from introns of large Pol-II, non-protein-coding transcriptsQ37215383
microRNAs and cancer: an overviewQ37249283
Beyond HPV: oncomirs as new players in cervical cancerQ37334551
SNPs in human miRNA genes affect biogenesis and functionQ37344542
Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivoQ37346696
Phase I trial of vorinostat and doxorubicin in solid tumours: histone deacetylase 2 expression as a predictive marker.Q37400592
MicroRNA regulatory network in human colorectal cancerQ37551006
Genome-wide hypomethylation in cancer may be a passive consequence of transformationQ37732576
PI(3)king apart PTEN's role in cancer.Q37771785
Dysregulation of microRNAs in cancer: playing with fireQ37779828
Recent advances in histone deacetylase targeted cancer therapyQ37782569
MicroRNA dysregulation in gastric cancer: a new player enters the gameQ37783909
MicroRNAs, epigenetics and diseaseQ37785997
Histone modifications and cancerQ37797690
Histone lysine methylation and demethylation pathways in cancerQ37800638
Methods for the discovery of low-abundance biomarkers for urinary bladder cancer in biological fluids.Q37810251
Oncogenic microRNAs (OncomiRs) as a new class of cancer biomarkersQ37812094
Epigenetic aberrations during oncogenesis.Q37830385
Clinical significance of astrocyte elevated gene-1 expression in human epithelial ovarian carcinomaQ44696506
Profiling of Epstein-Barr virus-encoded microRNAs in nasopharyngeal carcinoma reveals potential biomarkers and oncomirs.Q44833814
14-3-3ζ positive expression is associated with a poor prognosis in patients with glioblastomaQ46717742
Lats2 is an essential mitotic regulator required for the coordination of cell division.Q51987013
Expression of astrocyte elevated gene-1: a novel marker of the pathogenesis, progression, and poor prognosis for endometrial cancer.Q53155160
miR-34a as a prognostic marker of relapse in surgically resected non-small-cell lung cancer.Q53306726
MicroRNA-373 (miR-373) post-transcriptionally regulates large tumor suppressor, homolog 2 (LATS2) and stimulates proliferation in human esophageal cancer.Q53309576
miRNA profiling for clear cell renal cell carcinoma: biomarker discovery and identification of potential controls and consequences of miRNA dysregulation.Q54357850
Clinicopathological and prognostic value of microRNA-21 and microRNA-155 in colorectal cancer.Q54382778
miR-21 microRNA expression in human gastric carcinomas and its clinical associationQ81346254
Demonstration of additional benefit in adding lenalidomide to azacitidine in patients with higher-risk myelodysplastic syndromesQ82468133
Significance of AEG-1 expression in correlation with VEGF, microvessel density and clinicopathological characteristics in triple-negative breast cancerQ83275662
Phase I study of decitabine in combination with vorinostat in patients with advanced solid tumors and non-Hodgkin's lymphomasQ83324615
DNA hypermethylation of microRNA-34b/c has prognostic value for stage Ⅰ non-small cell lung cancerQ83557235
MicroRNA regulation of DNA repair gene expression in hypoxic stressQ28306694
CpG islands and the regulation of transcriptionQ28315762
Tissue and serum microRNAs in the Kras(G12D) transgenic animal model and in patients with pancreatic cancerQ28478758
MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancerQ29547523
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosisQ29547575
Detection of elevated levels of tumour-associated microRNAs in serum of patients with diffuse large B-cell lymphomaQ29614238
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumorsQ29614399
Non-coding RNAs in human diseaseQ29618039
Transcriptional activation of miR-34a contributes to p53-mediated apoptosisQ29619556
Towards the human cancer epigenome: a first draft of histone modificationsQ33341651
microRNAs join the p53 network--another piece in the tumour-suppression puzzleQ33344707
Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growthQ33348593
FDA drug approval summary: azacitidine (5-azacytidine, Vidaza) for injectable suspensionQ33365592
Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheresQ33370714
Phase I and pharmacokinetic study of vorinostat (suberoylanilide hydroxamic acid) in Japanese patients with solid tumors.Q33385245
Features of mammalian microRNA promoters emerge from polymerase II chromatin immunoprecipitation dataQ33434396
Detection of cancer with serum miRNAs on an oligonucleotide microarrayQ33481633
MicroRNA let-7a inhibits proliferation of human prostate cancer cells in vitro and in vivo by targeting E2F2 and CCND2.Q33564111
Frequent downregulation of miR-34 family in human ovarian cancersQ33658229
Structure and activity of putative intronic miRNA promotersQ33658452
MicroRNA-21 is overexpressed in pancreatic cancer and a potential predictor of survivalQ33748264
Deregulation of MYCN, LIN28B and LET7 in a molecular subtype of aggressive high-grade serous ovarian cancersQ33886925
Binding of NF-kappaB p65 subunit to the promoter elements is involved in LPS-induced transactivation of miRNA genes in human biliary epithelial cellsQ33889371
Upregulation of MiR-155 in nasopharyngeal carcinoma is partly driven by LMP1 and LMP2A and downregulates a negative prognostic marker JMJD1A.Q33889404
MicroRNA delivery by cationic lipoplexes for lung cancer therapyQ34060310
Comprehensive MicroRNA profiling for head and neck squamous cell carcinomasQ34097908
MicroRNA-375 is downregulated in gastric carcinomas and regulates cell survival by targeting PDK1 and 14-3-3zetaQ34103001
MicroRNA-155 functions as an OncomiR in breast cancer by targeting the suppressor of cytokine signaling 1 geneQ34107532
Tumor-suppressive mir-663 gene induces mitotic catastrophe growth arrest in human gastric cancer cellsQ34118383
Active DNA demethylation: many roads lead to Rome.Q34129576
OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma.Q34130311
Exosomes/microvesicles as a mechanism of cell-to-cell communicationQ34130853
MicroRNA sponges: progress and possibilitiesQ34139023
Targeting microRNAs in cancer: rationale, strategies and challengesQ34141089
Connecting chromosomes, crisis, and cancerQ34141381
Circulating microRNAs: possible prediction biomarkers for personalized therapy of non-small-cell lung carcinomaQ37832870
MicroRNAs and epigeneticsQ37852129
MicroRNAs as therapeutic targets in cancerQ37855085
MicroRNAs as biomarkers of disease onset.Q37872226
DNA methylation in cancer development, diagnosis and therapy--multiple opportunities for genotoxic agents to act as methylome disruptors or remediators.Q37873228
Romidepsin: a novel histone deacetylase inhibitor for cancerQ37893664
MicroRNA regulation by RNA-binding proteins and its implications for cancerQ37913018
Big roles of microRNAs in tumorigenesis and tumor developmentQ37922684
Regulation of microRNA expression and function by nuclear receptor signalingQ37936584
MicroRNAs in rhabdomyosarcoma: pathogenetic implications and translational potentialityQ37937737
Evaluation of online miRNA resources for biomedical applications.Q37955258
DNA methylation of tumor suppressor miRNA genes: a lesson from the miR-34 familyQ37962577
Circulating microRNAs: a novel class of biomarkers to diagnose and monitor human cancersQ37989885
MicroRNA expression profiles in head and neck cancer cell linesQ38302158
MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1).Q38303663
Histone deacetylase inhibitor FK228 activates tumor suppressor Prdx1 with apoptosis induction in esophageal cancer cells.Q38318992
Overexpression of AEG-1 in renal cell carcinoma and its correlation with tumor nuclear grade and progressionQ38414708
MicroRNA-375 targets AEG-1 in hepatocellular carcinoma and suppresses liver cancer cell growth in vitro and in vivoQ39447513
Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancerQ39448960
Aberrant expression of microRNA 155 may accelerate cell proliferation by targeting sex-determining region Y box 6 in hepatocellular carcinoma.Q39459780
MicroRNA-375 inhibits tumour growth and metastasis in oesophageal squamous cell carcinoma through repressing insulin-like growth factor 1 receptorQ39495719
Tumor suppressive microRNA-375 regulates oncogene AEG-1/MTDH in head and neck squamous cell carcinoma (HNSCC).Q39507167
Epigenetic regulation of microRNA-375 and its role in melanoma development in humans.Q39514244
Epigenetic silencing of microRNA-375 regulates PDK1 expression in esophageal cancerQ39550203
Regulation of Axl receptor tyrosine kinase expression by miR-34a and miR-199a/b in solid cancerQ39592978
Frequent concomitant inactivation of miR-34a and miR-34b/c by CpG methylation in colorectal, pancreatic, mammary, ovarian, urothelial, and renal cell carcinomas and soft tissue sarcomasQ39608984
Signatures of microRNAs and selected microRNA target genes in human melanoma.Q39707682
miR-21: an oncomir on strike in prostate cancer.Q39749407
Nuclear factor-{kappa}B contributes to anaplastic thyroid carcinomas through up-regulation of miR-146aQ39753969
MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation.Q39786661
MiR-21 indicates poor prognosis in tongue squamous cell carcinomas as an apoptosis inhibitorQ39840690
Specificity and functionality of microRNA inhibitorsQ39886691
MicroRNA-like off-target transcript regulation by siRNAs is species specific.Q39895165
MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomasQ40073679
p53-mediated activation of miRNA34 candidate tumor-suppressor genes.Q40102003
Selective silencing of the hypoxia-inducible factor 1 target gene BNIP3 by histone deacetylation and methylation in colorectal cancerQ40262845
Sequence variations of microRNAs in human cancer: alterations in predicted secondary structure do not affect processing.Q40267038
Spi-1/PU.1: an oncogene of the Ets familyQ40567919
MicroRNAs 373 and 520c are downregulated in prostate cancer, suppress CD44 translation and enhance invasion of prostate cancer cells in vitro.Q42147457
Transcriptional repression of miR-34 family contributes to p63-mediated cell cycle progression in epidermal cellsQ42466132
Final results from a multicenter, international, pivotal study of romidepsin in refractory cutaneous T-cell lymphomaQ42942114
Downregulation of miR-21 enhances chemotherapeutic effect of taxol in breast carcinoma cellsQ43191223
MiR-195, miR-196b, miR-181c, miR-21 expression levels and O-6-methylguanine-DNA methyltransferase methylation status are associated with clinical outcome in glioblastoma patientsQ44273844
NF-kappaB down-regulates expression of the B-lymphoma marker CD10 through a miR-155/PU.1 pathwayQ34143653
Circulating microRNAs (miRNA) in serum of patients with prostate cancerQ34182161
Nanoparticles modified with tumor-targeting scFv deliver siRNA and miRNA for cancer therapy.Q34209735
14-3-3ζ as a prognostic marker and therapeutic target for cancerQ34473399
Epigenetic gene silencing in cancer: the DNA hypermethylomeQ34646556
Phase 1b-2a study to reverse platinum resistance through use of a hypomethylating agent, azacitidine, in patients with platinum-resistant or platinum-refractory epithelial ovarian cancerQ34711457
Epigenetic silencing of the myelopoiesis regulator microRNA-223 by the AML1/ETO oncoprotein.Q34712578
Epigenetics: a historical overviewQ34713017
Mutator activity induced by microRNA-155 (miR-155) links inflammation and cancerQ34720476
MicroRNA expression profiling of thyroid tumors: biological significance and diagnostic utilityQ34749465
Prognostic value of mature microRNA-21 and microRNA-205 overexpression in non-small cell lung cancer by quantitative real-time RT-PCR.Q34811436
Latent membrane protein-1 of Epstein-Barr virus induces the expression of B-cell integration cluster, a precursor form of microRNA-155, in B lymphoma cell linesQ34858379
MiR-34, SIRT1 and p53: the feedback loopQ34946471
Elevated expression of microRNAs 155, 203, 210 and 222 in pancreatic tumors is associated with poorer survivalQ34988674
MicroRNA in central nervous system trauma and degenerative disordersQ35033677
Shielding the messenger (RNA): microRNA-based anticancer therapiesQ35070602
MicroRNA-21 is overexpressed in human cholangiocarcinoma and regulates programmed cell death 4 and tissue inhibitor of metalloproteinase 3.Q35070803
Human cytomegalovirus US7 is regulated synergistically by two virally encoded microRNAs and by two distinct mechanisms.Q35531336
Linking the epigenetic 'language' of covalent histone modifications to cancerQ35670206
Transcriptional signature of histone deacetylase inhibition in multiple myeloma: biological and clinical implicationsQ35734509
P433issue5
P921main subjectmicroRNAQ310899
cancer diagnosisQ110324059
P304page(s)467-478
P577publication date2012-11-06
P1433published inSurgery TodayQ15765823
P1476titleMicroRNAs in cancer diagnosis and therapy: from bench to bedside
P478volume43

Reverse relations

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