Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres

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Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1022974974
P356DOI10.1186/1471-2407-8-266
P932PMC publication ID2564978
P698PubMed publication ID18803879
P5875ResearchGate publication ID23268993

P50authorXinbao HaoQ55122011
P2093author name stringMin Zhang
Daiming Fan
Liang Xu
Yang Meng
Qing Ji
Jeffrey Desano
P2860cites workRole of Notch signaling in cell-fate determination of human mammary stem/progenitor cellsQ21195157
The Bcl-2 apoptotic switch in cancer development and therapyQ24620437
ALDH1 is a marker of normal and malignant human mammary stem cells and a predictor of poor clinical outcomeQ24657877
Hedgehog signaling and Bmi-1 regulate self-renewal of normal and malignant human mammary stem cellsQ28246460
Tumor-suppressive miR-34a induces senescence-like growth arrest through modulation of the E2F pathway in human colon cancer cellsQ28249223
Identification and expansion of the tumorigenic lung cancer stem cell populationQ28259332
let-7 regulates self renewal and tumorigenicity of breast cancer cellsQ28261263
Identification of pancreatic cancer stem cellsQ28286997
MicroRNA-34a functions as a potential tumor suppressor by inducing apoptosis in neuroblastoma cellsQ28287986
A microRNA component of the p53 tumour suppressor networkQ28305330
Systemic p53 gene therapy of cancer with immunolipoplexes targeted by anti-transferrin receptor scFvQ28364442
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosisQ29547575
An inhibitor of Bcl-2 family proteins induces regression of solid tumoursQ29547595
Transcriptional activation of miR-34a contributes to p53-mediated apoptosisQ29619556
Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinomaQ29620604
The response of CD24(-/low)/CD44+ breast cancer-initiating cells to radiationQ29620694
Ovarian cancer side population defines cells with stem cell-like characteristics and Mullerian Inhibiting Substance responsivenessQ33250633
Overcoming bcl-2- and p53-mediated resistance in prostate cancerQ33586871
BCL-2 in prostate cancer: a minireviewQ34168174
Tumor-targeted p53-gene therapy enhances the efficacy of conventional chemo/radiotherapyQ34328569
BCL-2 family: regulators of cell deathQ34468840
Stem cells in normal breast development and breast cancerQ35548236
An androgen-regulated miRNA suppresses Bak1 expression and induces androgen-independent growth of prostate cancer cellsQ36288990
The role of apoptosis in the regulation of hematopoietic stem cells: Overexpression of Bcl-2 increases both their number and repopulation potentialQ36375771
BCL2 family in DNA damage and cell cycle controlQ36501194
Cancer stem cells and oncology therapeuticsQ36667691
Dysregulation of stem cell signaling network due to germline mutation, SNP, Helicobacter pylori infection, epigenetic change and genetic alteration in gastric cancerQ36849195
OncomiRs: the discovery and progress of microRNAs in cancersQ36951319
microRNA and stem cell functionQ36995222
The guardian's little helper: microRNAs in the p53 tumor suppressor networkQ37023130
MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growthQ38298486
Natural BH3 mimetic (-)-gossypol chemosensitizes human prostate cancer via Bcl-xL inhibition accompanied by increase of Puma and NoxaQ39958561
MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomasQ40073679
p53-mediated activation of miRNA34 candidate tumor-suppressor genes.Q40102003
Isolation and characterization of human gastric cell lines with stem cell phenotypesQ40103732
Double identity for proteins of the Bcl-2 familyQ41508318
Bcl-2 family proteins: strategies for overcoming chemoresistance in cancerQ41515360
Bcl-2 family proteins: regulators of apoptosis and chemoresistance in hematologic malignancies.Q41668626
Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes.Q44254389
Self-assembly of a virus-mimicking nanostructure system for efficient tumor-targeted gene deliveryQ45733650
Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrestQ48078984
Systemic overexpression of BCL-2 in the hematopoietic system protects transgenic mice from the consequences of lethal irradiation.Q52188936
Bcl-2 family proteins and mitochondria.Q53947366
Cancer stem cells in radiation resistance.Q55467719
Apoptosis and cancer chemotherapyQ58282847
Bcl-2 accelerates multistep prostate carcinogenesis in vivoQ73187748
BCL-2 gene family and the regulation of programmed cell deathQ77303933
Expression of bcl-2 and the progression of human and rodent prostatic cancersQ77556616
Cancer stem cells and metastasis: lethal seedsQ79188271
Phospho Akt mediates multidrug resistance of gastric cancer cells through regulation of P-gp, Bcl-2 and BaxQ80856775
Breast cancer stem cells: the other side of the storyQ81303745
Breast stem cells and cancerQ81447020
P407language of work or nameEnglishQ1860
P304page(s)266
P577publication date2008-09-21
P1433published inBMC CancerQ326300
P1476titleRestoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheres
P478volume8

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cites work (P2860)
Q33515420A Smac-mimetic sensitizes prostate cancer cells to TRAIL-induced apoptosis via modulating both IAPs and NF-kappaB.
Q41758245A functional variant at miR-34a binding site in toll-like receptor 4 gene alters susceptibility to hepatocellular carcinoma in a Chinese Han population
Q36016499A p53 axis regulates B cell receptor-triggered, innate immune system-driven B cell clonal expansion
Q34210459A p53-dependent promoter associated with polymorphic tandem repeats controls the expression of a viral transcript encoding clustered microRNAs
Q38434033A subset of microRNAs defining the side population of a human malignant mesothelioma cell line
Q33577624A unified model of the hierarchical and stochastic theories of gastric cancer
Q54217180Antiproliferative effect of urolithin A, the ellagic acid-derived colonic metabolite, on hepatocellular carcinoma HepG2.2.15 cells by targeting Lin28a/let-7a axis.
Q35088734Apoptotic cell signaling in cancer progression and therapy
Q35345374Association between miR34b/c polymorphism rs4938723 and cancer risk: a meta-analysis of 11 studies including 6169 cases and 6337 controls
Q39735837C-T variant in a miRNA target site of BCL2 is associated with increased risk of human papilloma virus related cervical cancer--an in silico approach
Q27022017Can nanomedicines kill cancer stem cells?
Q38166579Cancer stem cells in pancreatic cancer
Q38713728Cancer stem cells in prostate cancer
Q38062840Cancer stem cells: the 'heartbeat' of gastric cancer
Q40339127Carbonic Anhydrase 9 mRNA/microRNA34a Interplay in Hypoxic Human Mammospheres
Q34391443Cardio-miRNAs and onco-miRNAs: circulating miRNA-based diagnostics for non-cancerous and cancerous diseases
Q26829583Clinical application of microRNA in gastric cancer in Eastern Asian area
Q26777882Common stemness regulators of embryonic and cancer stem cells
Q26771422Comparison of Prognostic MicroRNA Biomarkers in Blood and Tissues for Gastric Cancer
Q33801752Cross-talk between miRNA and Notch signaling pathways in tumor development and progression
Q46102699Crosstalk between miR-34a and Notch Signaling Promotes Differentiation in Apical Papilla Stem Cells (SCAPs).
Q47101032Crosstalk between the Notch signaling pathway and non-coding RNAs in gastrointestinal cancers
Q38020153DNA methylation of microRNA genes in multiple myeloma
Q37962577DNA methylation of tumor suppressor miRNA genes: a lesson from the miR-34 family
Q37229033DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway
Q36406800Decreased expression of microRNA let-7i and its association with chemotherapeutic response in human gastric cancer
Q33688416Diffuse large B-cell lymphoma with combined TP53 mutation and MIR34A methylation: Another "double hit" lymphoma with very poor outcome?
Q21198847Down-regulated miR-9 and miR-433 in human gastric carcinoma
Q34992155Down-regulation of miR-31 expression in gastric cancer tissues and its clinical significance
Q39105165Downregulation of tumor suppressor MBP-1 by microRNA-363 in gastric carcinogenesis.
Q39204898Ectopic expression of miR-34a enhances radiosensitivity of non-small cell lung cancer cells, partly by suppressing the LyGDI signaling pathway
Q37967610Effect of microRNA-34a in cell cycle, differentiation, and apoptosis: a review
Q26752006Emerging Role of miRNAs in the Drug Resistance of Gastric Cancer
Q38058972Epigenetic alterations involved in cancer stem cell reprogramming
Q37785993Epigenetic regulation of cell life and death decisions and deregulation in cancer
Q39465400Epigenetic regulation of miR-34b and miR-129 expression in gastric cancer
Q28083951Epigenome-based personalized medicine in human cancer
Q55406904Establishment and characterization of a GES-1 human gastric epithelial cell line stably expressing miR-23a.
Q51750442Expressed microRNA associated with high rate of egg production in chicken ovarian follicles.
Q48110181Expression level of human miR-34a correlates with glioma grade and prognosis
Q90264208Expression levels of miR-34-family microRNAs are associated with TP53 mutation status in head and neck squamous cell carcinoma
Q54205015Expression of miR-34a in T-Cells Infected by Human T-Lymphotropic Virus 1.
Q64088413Friend or Foe: A Cancer Suppressor MicroRNA-34 Potentially Plays an Adverse Role in Vascular Diseases by Regulating Cell Apoptosis and Extracellular Matrix Degradation
Q42161265Genome-wide dissection of microRNA functions and cotargeting networks using gene set signatures
Q57477423Genomic Characterization of TP53-Wild-Type Esophageal Carcinoma
Q92921699High Mobility Group A (HMGA): Chromatin Nodes Controlled by a Knotty miRNA Network
Q36320924High-throughput sequencing of pituitary and hypothalamic microRNA transcriptome associated with high rate of egg production
Q33903223Implication of microRNAs in drug resistance for designing novel cancer therapy
Q28539851In-depth analysis shows synergy between erlotinib and miR-34a
Q46980193Increased expression of microRNA-21and its association with chemotherapeutic response in human colorectal cancer
Q37109858Inhibition of IRE1α-driven pro-survival pathways is a promising therapeutic application in acute myeloid leukemia
Q64112826Long Non-Coding RNA Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) Promotes Proliferation and Metastasis of Osteosarcoma Cells by Targeting c-Met and SOX4 via miR-34a/c-5p and miR-449a/b
Q38020729Macro-role of microRNA in gastric cancer
Q31148368MiR-133b is frequently decreased in gastric cancer and its overexpression reduces the metastatic potential of gastric cancer cells
Q38733014MiR-34a modulates ErbB2 in breast cancer
Q37692351MiR-34a-5p promotes multi-chemoresistance of osteosarcoma through down-regulation of the DLL1 gene
Q37317570MiR-34a-5p promotes the multi-drug resistance of osteosarcoma by targeting the CD117 gene
Q34036679MiRNA as potential biomarkers and therapeutic targets for gastric cancer.
Q37516328MiRNA-107 inhibits proliferation and migration by targeting CDK8 in breast cancer
Q36690777MiRNA-26b inhibits proliferation by targeting PTGS2 in breast cancer
Q37982054MiRNAs and LincRNAs: Could they be considered as biomarkers in colorectal cancer?
Q44139838MiRNAs and their association with locoregional staging and survival following surgery for esophageal carcinoma
Q55065193Micro-Economics of Apoptosis in Cancer: ncRNAs Modulation of BCL-2 Family Members.
Q35643732MicroRNA 34c gene down-regulation via DNA methylation promotes self-renewal and epithelial-mesenchymal transition in breast tumor-initiating cells
Q38178272MicroRNA Deregulations in Head and Neck Squamous Cell Carcinomas
Q37751868MicroRNA and drug resistance
Q38233783MicroRNA and signaling pathways in gastric cancer
Q37783909MicroRNA dysregulation in gastric cancer: a new player enters the game
Q37783459MicroRNA expression and its implication for the diagnosis and therapeutic strategies of gastric cancer
Q33497932MicroRNA miR-34 inhibits human pancreatic cancer tumor-initiating cells
Q42252202MicroRNA profiling of gastric cancer patients from formalin-fixed paraffin-embedded samples
Q35224122MicroRNA regulation of cancer stem cells
Q37618041MicroRNA regulation of cancer stem cells and therapeutic implications
Q37924177MicroRNA replacement therapy for cancer
Q45342644MicroRNA-10a-5p and microRNA-34c-5p in laryngeal epithelial premalignant lesions: differential expression and clinicopathological correlation
Q36819807MicroRNA-125a represses cell growth by targeting HuR in breast cancer
Q40499327MicroRNA-216b is Down-Regulated in Human Gastric Adenocarcinoma and Inhibits Proliferation and Cell Cycle Progression by Targeting Oncogene HDAC8.
Q39669051MicroRNA-23a promotes the growth of gastric adenocarcinoma cell line MGC803 and downregulates interleukin-6 receptor
Q39281229MicroRNA-34 dysregulation in gastric cancer and gastric cancer stem cell
Q58548157MicroRNA-34 family in breast cancer: from research to therapeutic potential
Q39333849MicroRNA-34a inhibits human brain glioma cell growth by down-regulation of Notch1.
Q38929247MicroRNA-34a inhibits the proliferation and promotes the apoptosis of non-small cell lung cancer H1299 cell line by targeting TGFβR2.
Q38828085MicroRNA-34a inhibits tumor invasion and metastasis in gastric cancer by targeting Tgif2
Q52629304MicroRNA-34a regulates proliferation and apoptosis of gastric cancer cells by targeting silent information regulator 1.
Q39351996MicroRNA-34a suppresses cell proliferation and induces apoptosis in U87 glioma stem cells
Q39124552MicroRNA-34a targets Bcl-2 and sensitizes human hepatocellular carcinoma cells to sorafenib treatment
Q47159125MicroRNA-449a maintains self-renewal in liver cancer stem-like cells by targeting Tcf3.
Q35165126MicroRNA-mediated drug resistance in breast cancer
Q38815056MicroRNA: a connecting road between apoptosis and cholesterol metabolism
Q35949461MicroRNAs and Gastroenterological Cancers
Q38184857MicroRNAs and anticancer drugs.
Q36116268MicroRNAs and cancer therapeutics
Q27022048MicroRNAs and long non-coding RNAs: prospects in diagnostics and therapy of cancer
Q57166469MicroRNAs and their role in environmental chemical carcinogenesis
Q37827156MicroRNAs as potential target gene in cancer gene therapy of gastrointestinal tumors
Q37381107MicroRNAs as therapeutic targets in chemoresistance
Q58923813MicroRNAs in Cancer Drug Resistance and Drug Sensitivity
Q38057979MicroRNAs in cancer diagnosis and therapy: from bench to bedside
Q38223219MicroRNAs in cancer stem cells: current status and future directions
Q38151490MicroRNAs in gastric cancer: from benchtop to bedside
Q38202662MicroRNAs in gastrointestinal cancer: prognostic significance and potential role in chemoresistance
Q39101272MicroRNAs in melanoma development and resistance to target therapy
Q35033659MicroRNAs in skin and wound healing.
Q38496364MicroRNAs in tumorigenesis, metastasis, diagnosis and prognosis of gastric cancer
Q34348967MicroRNAs, cancer and cancer stem cells
Q34154782MicroRNAs: key players of taxane resistance and their therapeutic potential in human cancers
Q26822633MicroRNAs: molecular features and role in cancer
Q58792269MicroRNA‑34b promotes proliferation, migration and invasion of Ewing's sarcoma cells by downregulating Notch1
Q39605990Mir-148a improves response to chemotherapy in sensitive and resistant oesophageal adenocarcinoma and squamous cell carcinoma cells.
Q47673159Molecular mechanisms and theranostic potential of miRNAs in drug resistance of gastric cancer
Q90725244NFIX Circular RNA Promotes Glioma Progression by Regulating miR-34a-5p via Notch Signaling Pathway
Q28074478NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?
Q38324456Nanocarrier-mediated drugs targeting cancer stem cells: an emerging delivery approach
Q28079367Nanomedicine strategies for sustained, controlled, and targeted treatment of cancer stem cells of the digestive system
Q34003691New promising drug targets in cancer- and metastasis-initiating cells
Q39868687No small matter: microRNAs - key regulators of cancer stem cells
Q38885498Noncoding RNAs Regulating Cancer Signaling Network
Q26864697Noncoding RNAs in DNA repair and genome integrity
Q27011225Noncoding RNAs in cancer and cancer stem cells
Q90464453Noncoding RNAs in gastric cancer: implications for drug resistance
Q34982347Notch signaling proteins: legitimate targets for cancer therapy
Q37437391Notch1 pathway-mediated microRNA-151-5p promotes gastric cancer progression.
Q24564267Novel therapeutic targets for pancreatic cancer
Q34382586Novel therapies against aggressive and recurrent epithelial cancers by molecular targeting tumor- and metastasis-initiating cells and their progenies
Q50148274Overexpression of MicroRNA-34a-5p Inhibits Proliferation and Promotes Apoptosis of Human Cervical Cancer Cells by Downregulation of Bcl-2.
Q27011547P53/microRNA-34-induced metabolic regulation: new opportunities in anticancer therapy
Q34326627Pathogenetic mechanisms in gastric cancer
Q90836137Phase 1 study of MRX34, a liposomal miR-34a mimic, in patients with advanced solid tumours
Q26744362Potential Diagnostic, Prognostic and Therapeutic Targets of MicroRNAs in Human Gastric Cancer
Q54235737Prognostic significance of miR-34a and its target proteins of FOXP1, p53, and BCL2 in gastric MALT lymphoma and DLBCL.
Q38263343Promoter methylated microRNAs: potential therapeutic targets in gastric cancer
Q41412828RASSF1A inhibits gastric cancer cell proliferation by miR-711- mediated downregulation of CDK4 expression
Q28645941Registered report: the microRNA miR-34a inhibits prostate cancer stem cells and metastasis by directly repressing CD44
Q38359738Regulation of breast cancer stem cell features
Q38068926Regulation of breast cancer tumorigenesis and metastasis by miRNAs
Q26853096Regulation of ovarian cancer stem cells or tumor-initiating cells
Q37513688Regulation of stem cell populations by microRNAs
Q39099572Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness
Q91716127Role of MicroRNAs in Pathophysiology of Non-alcoholic Fatty Liver Disease and Non-alcoholic Steatohepatitis
Q42161527Role of Notch signaling pathway in gastric cancer pathogenesis
Q33749954Role of miR-34c microRNA in the late steps of spermatogenesis
Q38237787Role of microRNA-34 family in cancer with particular reference to cancer angiogenesis.
Q28072650Roles of GSK-3 and microRNAs on epithelial mesenchymal transition and cancer stem cells
Q92840766Serum miR-34a is a potential diagnostic and prognostic marker for osteosarcoma
Q35070602Shielding the messenger (RNA): microRNA-based anticancer therapies
Q38040324Smoke-induced microRNA and related proteome alterations. Modulation by chemopreventive agents.
Q34205088Targeting Notch signaling pathway to overcome drug resistance for cancer therapy
Q26771701Targeting Notch to overcome radiation resistance
Q38309242Targeting microRNAs in epithelial-to-mesenchymal transition-induced cancer stem cells: therapeutic approaches in cancer
Q38254181The cancer stem cell hypothesis: a guide to potential molecular targets
Q34220723The clinical potential of microRNAs
Q38009641The emerging functions of the p53-miRNA network in stem cell biology
Q38156047The emerging role of miR-375 in cancer
Q35599477The emerging role of microRNAs in drug responses
Q26742058The expanding regulatory universe of p53 in gastrointestinal cancer
Q52332705The function of Notch1 intracellular domain in the differentiation of gastric cancer.
Q28245865The miR-34 family in cancer and apoptosis
Q36245752The miR-34a-5p promotes the multi-chemoresistance of osteosarcoma via repression of the AGTR1 gene
Q64105194The miRNA-449 family mediates doxorubicin resistance in triple-negative breast cancer by regulating cell cycle factors
Q26744831The miRacle in Pancreatic Cancer by miRNAs: Tiny Angels or Devils in Disease Progression
Q37765383The next thing in prognostic molecular markers: microRNA signatures of cancer
Q37625833The p53 Pathway Encounters the MicroRNA World
Q33787947The p53 Transcriptional Network Influences Microglia Behavior and Neuroinflammation
Q38210767The p53/miR-34 axis in development and disease
Q38261312The p53/microRNA connection in gastrointestinal cancer
Q36111707The predictive effect of overexpressed miR-34a on good survival of cancer patients: a systematic review and meta-analysis
Q35480938The prognostic value of miR-34a expression in completely resected gastric cancer: tumor recurrence and overall survival
Q36228497The reciprocal regulation loop of Notch2 pathway and miR-23b in controlling gastric carcinogenesis
Q39152624The role of exosomes and miRNAs in drug-resistance of cancer cells.
Q47117573The role of miRNA and lncRNA in gastric cancer
Q37934681The role of miRNA in the direct and indirect effects of ionizing radiation
Q36158807The role of microRNAs in Helicobacter pylori pathogenesis and gastric carcinogenesis
Q37601781The role of microRNAs in endometriosis and associated reproductive conditions
Q38694209The roles of microRNA-34b-5p in angiogenesis of thyroid carcinoma.
Q36887716Therapeutic strategies targeting cancer stem cells
Q36833275Therapeutic targeting of the p53 pathway in cancer stem cells.
Q35876143Therapy-, gender- and race-specific microRNA markers, target genes and networks related to glioblastoma recurrence and survival.
Q37822465Tissular and soluble miRNAs for diagnostic and therapy improvement in digestive tract cancers
Q33764768Tumor suppressive miRNA-34a suppresses cell proliferation and tumor growth of glioma stem cells by targeting Akt and Wnt signaling pathways
Q37291308Twist and miR-34a are involved in the generation of tumor-educated myeloid-derived suppressor cells
Q28236711Two new miR-16 targets: caprin-1 and HMGA1, proteins implicated in cell proliferation
Q28393225Yin Yang 1 is a target of microRNA-34 family and contributes to gastric carcinogenesis
Q34640230miR-34 - a microRNA replacement therapy is headed to the clinic
Q38784668miR-34 activity is modulated through 5'-end phosphorylation in response to DNA damage
Q26822928miR-34: from bench to bedside
Q34722558miR-34a confers chemosensitivity through modulation of MAGE-A and p53 in medulloblastoma
Q38807275miR-34a inhibits cell proliferation in prostate cancer by downregulation of SIRT1 expression
Q53007110miR-34a-5p suppresses colorectal cancer metastasis and predicts recurrence in patients with stage II/III colorectal cancer.
Q39061607miR-449a Regulates proliferation and chemosensitivity to cisplatin by targeting cyclin D1 and BCL2 in SGC7901 cells
Q35113386miRNA - Therapeutic tool in breast cancer? Where are we now?
Q35889599miRNA-34b as a tumor suppressor in estrogen-dependent growth of breast cancer cells.
Q54239648miRNA27a is a biomarker for predicting chemosensitivity and prognosis in metastatic or recurrent gastric cancer.
Q37211784miRNA: The nemesis of gastric cancer (Review).
Q39407845miRNA: the new frontier in cancer medicine
Q26747138miRNAs Signature in Head and Neck Squamous Cell Carcinoma Metastasis: A Literature Review
Q38633144miRNAs and ovarian cancer: a miRiad of mechanisms to induce cisplatin drug resistance
Q39388462miRNAs expressed differently in cancer stem cells and cancer cells of human gastric cancer cell line MKN-45.
Q39143971microRNA regulation of human pancreatic cancer stem cells
Q36225874microRNA signature for human pancreatic cancer invasion and metastasis
Q38160950microRNAs in cancer cell response to ionizing radiation.

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