The miRNA-449 family mediates doxorubicin resistance in triple-negative breast cancer by regulating cell cycle factors

scientific article published on 29 March 2019

The miRNA-449 family mediates doxorubicin resistance in triple-negative breast cancer by regulating cell cycle factors is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-019-41472-Y
P932PMC publication ID6441107
P698PubMed publication ID30926829

P50authorAna LluchQ67755317
P2093author name stringAna Rovira
Joan Albanell
Sandra Zazo
Federico Rojo
Silvia Menéndez
Octavio Burgués
Pilar Eroles
Juan Madoz-Gúrpide
Elisa Alonso
Begoña Bermejo
Eduardo Tormo
Sandra Ballester
Anna Adam-Artigues
P2860cites workmiR-449 inhibits cell proliferation and is down-regulated in gastric cancerQ21245766
Optimal strategies for the treatment of metastatic triple-negative breast cancer with currently approved agentsQ27027060
The functions of animal microRNAsQ27860621
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1Q28145116
Formation and activation of a cyclin E-cdk2 complex during the G1 phase of the human cell cycleQ28189224
The emerging role of E2F-1 in the DNA damage response and checkpoint controlQ28274309
Involvement of the CDK2-E2F1 pathway in cisplatin cytotoxicity in vitro and in vivo.Q50469558
The microRNA-449 family inhibits TGF-β-mediated liver cancer cell migration by targeting SOX4.Q50952919
Directed therapy of subtypes of triple-negative breast cancer.Q54614594
Treatment-related toxicity from a randomized trial of the sequencing of doxorubicin and radiation therapy in patients treated for early stage breast cancerQ78222751
miRpower: a web-tool to validate survival-associated miRNAs utilizing expression data from 2178 breast cancer patientsQ31136911
Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheresQ33370714
Control of the cell cycle and apoptosisQ33735440
Triple-negative breast cancer: clinical features and patterns of recurrenceQ34658655
Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin.Q34798833
E2F1-inducible microRNA 449a/b suppresses cell proliferation and promotes apoptosisQ35015916
MiR-449a suppresses the epithelial-mesenchymal transition and metastasis of hepatocellular carcinoma by multiple targetsQ35809301
DIANA-miRPath v3.0: deciphering microRNA function with experimental supportQ35810103
Mechanisms of translational control by the 3' UTR in development and differentiationQ36013975
Conserved functions of the pRB and E2F familiesQ37249375
MicroRNA microarray identifies Let-7i as a novel biomarker and therapeutic target in human epithelial ovarian cancerQ37388413
miR-449a and miR-449b are direct transcriptional targets of E2F1 and negatively regulate pRb-E2F1 activity through a feedback loop by targeting CDK6 and CDC25A.Q37393628
AMP-activated protein kinase α2 and E2F1 transcription factor mediate doxorubicin-induced cytotoxicity by forming a positive signal loop in mouse embryonic fibroblasts and non-carcinoma cellsQ37596326
Deficiency in p53 is required for doxorubicin induced transcriptional activation of NF-кB target genes in human breast cancerQ37649660
Management of triple negative breast cancerQ37728718
MiRNA-34 intrinsically links p53 tumor suppressor and Wnt signaling.Q37993984
Adjuvant treatments for triple-negative breast cancersQ38046581
Triple-negative breast cancer: epidemiological considerations and recommendationsQ38046586
miR-449a inhibits proliferation and invasion by regulating ADAM10 in hepatocellular carcinomaQ38758912
MicroRNA Profile in Response to Doxorubicin Treatment in Breast CancerQ38895915
MiR-449a exerts tumor-suppressive functions in human glioblastoma by targeting Myc-associated zinc-finger proteinQ38930784
MiR-449a functions as a tumor suppressor in endometrial cancer by targeting CDC25A.Q38978290
miR-449a Regulates proliferation and chemosensitivity to cisplatin by targeting cyclin D1 and BCL2 in SGC7901 cellsQ39061607
MicroRNAs-449a and -449b exhibit tumor suppressive effects in retinoblastomaQ39080202
Doxorubicin induces the DNA damage response in cultured human mesenchymal stem cells.Q39257323
Cyclin E2 overexpression is associated with endocrine resistance but not insensitivity to CDK2 inhibition in human breast cancer cells.Q39352451
Combining microRNA-449a/b with a HDAC inhibitor has a synergistic effect on growth arrest in lung cancer.Q39444162
MicroRNAs and their target messenger RNAs associated with ovarian cancer response to chemotherapyQ39880558
The analysis of doxorubicin resistance in human breast cancer cells using antibody microarraysQ40240269
E2F1 is crucial for E2F-dependent apoptosisQ43167748
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P921main subjectdoxorubicinQ18936
triple-negative breast cancerQ7843332
P304page(s)5316
P577publication date2019-03-29
P1433published inScientific ReportsQ2261792
P1476titleThe miRNA-449 family mediates doxorubicin resistance in triple-negative breast cancer by regulating cell cycle factors
P478volume9

Reverse relations

cites work (P2860)
Q89537417A Chemotherapy-Driven Increase in Mcl-1 Mediates the Effect of miR-375 on Cisplatin Resistance in Osteosarcoma Cells
Q92826406Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer-How We Can Rise to the Challenge
Q89989669MicroRNA‑449a regulates the progression of brain aging by targeting SCN2B in SAMP8 mice
Q92211767miR-29b-3p promotes progression of MDA-MB-231 triple-negative breast cancer cells through downregulating TRAF3
Q89720471microRNAs Orchestrate Pathophysiology of Breast Cancer Brain Metastasis: Advances in Therapy

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