MicroRNAs: molecular features and role in cancer

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MicroRNAs: molecular features and role in cancer is …
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scholarly articleQ13442814

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P356DOI10.2741/4068
P932PMC publication ID3815439
P698PubMed publication ID22652795

P2093author name stringBerger F
Guttin A
Ipas H
Issartel JP
Lages E
Nesr H
P2860cites workDistinct passenger strand and mRNA cleavage activities of human Argonaute proteinsQ84962168
MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxiaQ21092263
Characterization and identification of microRNA core promoters in four model speciesQ21092578
Let-7 microRNA family is selectively secreted into the extracellular environment via exosomes in a metastatic gastric cancer cell lineQ21136096
The tumor suppressors p53, p63, and p73 are regulators of microRNA processing complexQ21136376
Detection of microRNA expression in human peripheral blood microvesiclesQ21144210
Translation repression in human cells by microRNA-induced gene silencing requires RCK/p54Q21146051
Principles of microRNA-target recognitionQ21146368
MiR-221 and miR-222 target PUMA to induce cell survival in glioblastomaQ21245708
Human MicroRNA targetsQ21563637
Exportin-5, a novel karyopherin, mediates nuclear export of double-stranded RNA binding proteinsQ24292097
Asymmetry in the assembly of the RNAi enzyme complexQ27860763
Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targetsQ27860792
A cellular function for the RNA-interference enzyme Dicer in the maturation of the let-7 small temporal RNAQ27860813
Role for a bidentate ribonuclease in the initiation step of RNA interferenceQ27860832
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14Q27860849
Identification of tissue-specific microRNAs from mouseQ27860892
Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?Q27860893
Identification of novel genes coding for small expressed RNAsQ27860917
Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsQ27860960
Biogenesis of small RNAs in animalsQ27861013
Functional siRNAs and miRNAs Exhibit Strand BiasQ27861038
c-Myc-regulated microRNAs modulate E2F1 expressionQ27861046
MicroRNAs: genomics, biogenesis, mechanism, and functionQ27861070
Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNAQ27861092
The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegansQ27861103
Decapping and Decay of Messenger RNA Occur in Cytoplasmic Processing BodiesQ27931286
MicroRNA expression profiles classify human cancersQ28032481
Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibitionQ28115131
Passenger-strand cleavage facilitates assembly of siRNA into Ago2-containing RNAi enzyme complexesQ28115751
Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteinsQ28117928
MicroRNA silencing through RISC recruitment of eIF6Q28118262
Dicer functions in RNA interference and in synthesis of small RNA involved in developmental timing in C. elegansQ28131807
bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in DrosophilaQ28131827
The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translationQ28143010
Vertebrate microRNA genesQ28181605
Loss of PDCD4 expression in human lung cancer correlates with tumour progression and prognosisQ28191748
Exportin-5 mediates nuclear export of minihelix-containing RNAsQ28201293
The small RNA profile during Drosophila melanogaster developmentQ28201894
Embryonic stem cell-specific MicroRNAsQ28201906
Stress granules: sites of mRNA triage that regulate mRNA stability and translatabilityQ28215404
Death and anti-death: tumour resistance to apoptosisQ28217065
Prediction of plant microRNA targetsQ28219387
let-7 microRNA functions as a potential growth suppressor in human colon cancer cellsQ28237683
The nuclear RNase III Drosha initiates microRNA processingQ24295234
Regulation of angiogenesis through a microRNA (miR-130a) that down-regulates antiangiogenic homeobox genes GAX and HOXA5Q24298525
A human, ATP-independent, RISC assembly machine fueled by pre-miRNAQ24298937
Human Argonaute2 mediates RNA cleavage targeted by miRNAs and siRNAsQ24299641
Identification and proteomic profiling of exosomes in human urineQ24301829
Exosomal-like vesicles are present in human blood plasmaQ24303407
A genetic defect in exportin-5 traps precursor microRNAs in the nucleus of cancer cellsQ24303520
In vitro reconstitution of the human RISC-loading complexQ24305536
TRBP recruits the Dicer complex to Ago2 for microRNA processing and gene silencingQ24306121
An mRNA m7G cap binding-like motif within human Ago2 represses translationQ24306727
FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosisQ24307362
Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascadeQ24311006
The Microprocessor complex mediates the genesis of microRNAsQ24312976
Large-scale proteomics and phosphoproteomics of urinary exosomesQ24321631
Overexpression of exportin 5 enhances RNA interference mediated by short hairpin RNAs and microRNAsQ24324793
ATP-dependent human RISC assembly pathwaysQ24336545
A phosphorylated cytoplasmic autoantigen, GW182, associates with a unique population of human mRNAs within novel cytoplasmic specklesQ24515264
Micro-RNA regulation of the mammalian lin-28 gene during neuronal differentiation of embryonal carcinoma cellsQ24534931
The role of microRNA genes in papillary thyroid carcinomaQ24535848
miR-15 and miR-16 induce apoptosis by targeting BCL2Q24536069
Human microRNAs are processed from capped, polyadenylated transcripts that can also function as mRNAsQ24537328
TarBase: A comprehensive database of experimentally supported animal microRNA targetsQ24537513
MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail functionQ24538996
Human Dicer preferentially cleaves dsRNAs at their termini without a requirement for ATPQ24539076
Frequent deletions and down-regulation of micro- RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemiaQ24539231
The human LSm1-7 proteins colocalize with the mRNA-degrading enzymes Dcp1/2 and Xrnl in distinct cytoplasmic fociQ24540163
New microRNAs from mouse and humanQ24540176
Numerous microRNPs in neuronal cells containing novel microRNAsQ24540181
A microRNA expression signature of human solid tumors defines cancer gene targetsQ24541455
Cleavage of the siRNA passenger strand during RISC assembly in human cellsQ24545975
Accumulation of miR-155 and BIC RNA in human B cell lymphomasQ24556523
Identification of mammalian microRNA host genes and transcription unitsQ24562298
MicroRNA genes are transcribed by RNA polymerase IIQ24562649
Double-stranded-RNA-dependent protein kinase and TAR RNA-binding protein form homo- and heterodimers in vivoQ24563365
Distinct roles for Argonaute proteins in small RNA-directed RNA cleavage pathwaysQ24564402
miR-126 regulates angiogenic signaling and vascular integrityQ24569770
MicroRNA-221 and microRNA-222 regulate gastric carcinoma cell proliferation and radioresistance by targeting PTENQ24597730
The microRNA RegistryQ24600787
MicroRNA targeting specificity in mammals: determinants beyond seed pairingQ24607724
MicroRNA-210 modulates endothelial cell response to hypoxia and inhibits the receptor tyrosine kinase ligand Ephrin-A3Q24607952
MicroRNAs: target recognition and regulatory functionsQ24609584
Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkersQ24614672
Exosomes from human saliva as a source of microRNA biomarkersQ24614806
Regression of murine lung tumors by the let-7 microRNAQ24621218
Human microRNA genes are frequently located at fragile sites and genomic regions involved in cancersQ24625794
Targeted deletion reveals essential and overlapping functions of the miR-17 through 92 family of miRNA clustersQ24645192
AngiomiRs--key regulators of angiogenesisQ24645570
Widespread microRNA repression by Myc contributes to tumorigenesisQ24647067
MiR-15a and miR-16-1 cluster functions in human leukemiaQ24647555
Genetic variants of miRNA sequences and non-small cell lung cancer survivalQ24648054
miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cellsQ24649056
miRBase: tools for microRNA genomicsQ24649872
The microRNA.org resource: targets and expressionQ24650094
Mesenchymal stem cell secretes microparticles enriched in pre-microRNAsQ24651962
Mammalian mirtron genesQ24652239
MicroRNA-373 induces expression of genes with complementary promoter sequencesQ24652547
miR-34a repression of SIRT1 regulates apoptosisQ24652720
Most mammalian mRNAs are conserved targets of microRNAsQ24655061
Truncation in CCND1 mRNA alters miR-16-1 regulation in mantle cell lymphomaQ24655119
Down-regulation of micro-RNA-1 (miR-1) in lung cancer. Suppression of tumorigenic property of lung cancer cells and their sensitization to doxorubicin-induced apoptosis by miR-1Q24655144
miR2Disease: a manually curated database for microRNA deregulation in human diseaseQ24655615
A SNP in a let-7 microRNA complementary site in the KRAS 3' untranslated region increases non-small cell lung cancer riskQ24655762
Intronic microRNA precursors that bypass Drosha processingQ24656618
The endothelial-specific microRNA miR-126 governs vascular integrity and angiogenesisQ24656947
Disrupting the pairing between let-7 and Hmga2 enhances oncogenic transformationQ24658400
A role for the P-body component GW182 in microRNA functionQ24669847
miRNPs: a novel class of ribonucleoproteins containing numerous microRNAsQ24672368
MicroRNAs in plantsQ24674274
Cytoplasmic foci are sites of mRNA decay in human cellsQ24677437
Stress granules and processing bodies are dynamically linked sites of mRNP remodelingQ24678779
Regulation of the p27(Kip1) tumor suppressor by miR-221 and miR-222 promotes cancer cell proliferationQ24679746
The tumor suppressor microRNA let-7 represses the HMGA2 oncogeneQ24681392
A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear exportQ24682010
MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu and Fus-1 expressionQ24683830
The crystal structure of the Argonaute2 PAZ domain reveals an RNA binding motif in RNAi effector complexesQ27642580
Crystal structure and ligand binding of the MID domain of a eukaryotic Argonaute proteinQ27662170
Prediction of mammalian microRNA targetsQ27860498
Combinatorial microRNA target predictionsQ27860510
RAS is regulated by the let-7 microRNA familyQ27860522
Mammalian microRNAs predominantly act to decrease target mRNA levelsQ27860535
Argonaute2 is the catalytic engine of mammalian RNAiQ27860545
Posttranscriptional regulation of the heterochronic gene lin-14 by lin-4 mediates temporal pattern formation in C. elegansQ27860584
Unique microRNA molecular profiles in lung cancer diagnosis and prognosisQ27860631
MicroRNAs modulate hematopoietic lineage differentiationQ27860661
Nuclear export of microRNA precursorsQ27860686
MicroRNA gene expression deregulation in human breast cancerQ27860690
A microRNA polycistron as a potential human oncogeneQ27860720
MicroRNAS and their regulatory roles in plantsQ28237934
The muscle-specific microRNAs miR-1 and miR-133 produce opposing effects on apoptosis by targeting HSP60, HSP70 and caspase-9 in cardiomyocytesQ28241840
Molecular basis for the recognition of primary microRNAs by the Drosha-DGCR8 complexQ28243956
A germline-specific class of small RNAs binds mammalian Piwi proteinsQ28244097
Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cellsQ28245307
MicroRNA-21 is an antiapoptotic factor in human glioblastoma cellsQ28262214
Structural basis for overhang-specific small interfering RNA recognition by the PAZ domainQ28262499
Inhibition of translational initiation by Let-7 MicroRNA in human cellsQ28265842
Regulation by let-7 and lin-4 miRNAs results in target mRNA degradationQ28268899
Exosomes: from biogenesis and secretion to biological functionQ28270550
Movement of eukaryotic mRNAs between polysomes and cytoplasmic processing bodiesQ28270553
E2F1-regulated microRNAs impair TGFbeta-dependent cell-cycle arrest and apoptosis in gastric cancerQ28271985
RNASEN regulates cell proliferation and affects survival in esophageal cancer patientsQ28275189
A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemiaQ28279141
P bodies: at the crossroads of post-transcriptional pathwaysQ28280058
A polycistronic microRNA cluster, miR-17-92, is overexpressed in human lung cancers and enhances cell proliferationQ28280072
Human RISC couples microRNA biogenesis and posttranscriptional gene silencingQ28280424
Genetic unmasking of an epigenetically silenced microRNA in human cancer cellsQ28288806
Mechanistic principles of chromatin remodeling guided by siRNAs and miRNAsQ28291487
Inactivation of miR-34a by aberrant CpG methylation in multiple types of cancerQ28291502
MicroRNA-7, a homeobox D10 target, inhibits p21-activated kinase 1 and regulates its functionsQ28297593
Role of Dicer and Drosha for endothelial microRNA expression and angiogenesisQ28304607
Functional anatomy of siRNAs for mediating efficient RNAi in Drosophila melanogaster embryo lysateQ28365532
A novel class of small RNAs bind to MILI protein in mouse testesQ28505738
MicroRNA-21 is a downstream effector of AKT that mediates its antiapoptotic effects via suppression of Fas ligandQ28509297
Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytesQ28584881
DEAD-box RNA helicase subunits of the Drosha complex are required for processing of rRNA and a subset of microRNAsQ28589022
A novel class of small RNAs in mouse spermatogenic cellsQ28593537
Cleavage of the star strand facilitates assembly of some microRNAs into Ago2-containing silencing complexes in mammalsQ28609635
Bid induces the oligomerization and insertion of Bax into the outer mitochondrial membraneQ28647586
Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAsQ28750201
Specificity of microRNA target selection in translational repressionQ28776123
Collapse of Germline piRNAs in the Absence of Argonaute3 Reveals Somatic piRNAs in FliesQ29028136
The role of site accessibility in microRNA target recognitionQ29547436
Molecular mechanism of chemoresistance by miR-215 in osteosarcoma and colon cancer cellsQ33895297
Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovaryQ33901565
MicroRNA and target protein patterns reveal physiopathological features of glioma subtypesQ33926927
Genomic analysis of human microRNA transcriptsQ34007864
Transcriptional control of gene expression by microRNAsQ34093632
The code within the code: microRNAs target coding regionsQ34108802
Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosisQ34125617
OncomiR addiction in an in vivo model of microRNA-21-induced pre-B-cell lymphoma.Q34130311
Functional microRNA is transferred between glioma cellsQ34137987
Indirect activation of naïve CD4+ T cells by dendritic cell-derived exosomesQ34158527
Patterns of flanking sequence conservation and a characteristic upstream motif for microRNA gene identificationQ34365956
Short RNAs repress translation after initiation in mammalian cells.Q34495292
Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinomaQ34577463
HMGA2 overexpression in non-small cell lung cancer.Q34625219
Common SNP in pre-miR-146a decreases mature miR expression and predisposes to papillary thyroid carcinomaQ34778280
Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancerQ34803786
MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cellsQ34842477
HMGA2 participates in transformation in human lung cancerQ34911792
A novel mutation in the miR-128b gene reduces miRNA processing and leads to glucocorticoid resistance of MLL-AF4 acute lymphocytic leukemia cellsQ34987995
Avian bic, a gene isolated from a common retroviral site in avian leukosis virus-induced lymphomas that encodes a noncoding RNA, cooperates with c-myc in lymphomagenesis and erythroleukemogenesisQ34998323
The role of the Bcl-2 protein family in cancerQ35091123
Widespread expression of piRNA-like molecules in somatic tissuesQ35174748
New molecular pathways in angiogenesisQ35179088
The role of mRNA 5'-noncoding and 3'-end sequences on 40S ribosomal subunit recruitment, and how RNA viruses successfully compete with cellular mRNAs to ensure their own protein synthesisQ35179474
Human polymorphism at microRNAs and microRNA target sitesQ35652513
Role of mitochondrial membrane permeabilization in apoptosis and cancerQ35743123
Point mutations and genomic deletions in CCND1 create stable truncated cyclin D1 mRNAs that are associated with increased proliferation rate and shorter survivalQ35828800
RETRACTED: A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 functionQ35871679
MicroRNAs: a developing storyQ36083275
MicroRNAs in vertebrate developmentQ36175229
MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemiaQ36288982
Expression profiling of difficult-to-diagnose thyroid histologic subtypes shows distinct expression profiles and identify candidate diagnostic microRNAsQ36326608
A 3'-untranslated region KRAS variant and triple-negative breast cancer: a case-control and genetic analysisQ36369415
Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavageQ36399157
Principles and therapeutic implications of angiogenesis, vasculogenesis and arteriogenesisQ36603046
Epigenetic activation of tumor suppressor microRNAs in human cancer cellsQ36609070
MicroRNAs: a new insight into cancer genomeQ36609075
Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line.Q36846027
MicroRNA-directed transcriptional gene silencing in mammalian cellsQ36945167
Myeloid cell differentiation arrest by miR-125b-1 in myelodysplastic syndrome and acute myeloid leukemia with the t(2;11)(p21;q23) translocationQ36946531
Chromatin structure analyses identify miRNA promotersQ36995384
p53-Repressed miRNAs are involved with E2F in a feed-forward loop promoting proliferation.Q37010494
Inhibition of microRNA with antisense oligonucleotidesQ37044780
The database of experimentally supported targets: a functional update of TarBaseQ37202497
The regulatory activity of microRNA* species has substantial influence on microRNA and 3' UTR evolutionQ37233219
Dicer, Drosha, and outcomes in patients with ovarian cancerQ37262584
MicroRNA and cancer--focus on apoptosisQ37295059
Senescence-associated exosome release from human prostate cancer cells.Q37352797
Patient-derived tumor-reactive antibodies as diagnostic markers for ovarian cancerQ37383509
Separation of Specific Initiation Factors Involved in the Translation of Myosin and Myoglobin Messenger RNAs and the Isolation of a New RNA Involved in TranslationQ37448926
Developing therapeutic microRNAs for cancerQ37543146
Apoptomirs: small molecules have gained the license to killQ37611309
EGFL7 meets miRNA-126: an angiogenesis allianceQ37763307
Resistance may not be futile: microRNA biomarkers for chemoresistance and potential therapeuticsQ37799682
Polymorphisms within micro-RNA-binding sites and risk of sporadic colorectal cancerQ38294581
An increased high-mobility group A2 expression level is associated with malignant phenotype in pancreatic exocrine tissueQ38303658
MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1).Q38303663
Differentially regulated micro-RNAs and actively translated messenger RNA transcripts by tumor suppressor p53 in colon cancerQ38314320
Nucleic acid 3'-end recognition by the Argonaute2 PAZ domainQ38340880
Allosteric regulation of Argonaute proteins by miRNAs.Q39475198
MicroRNA-17-92 significantly enhances radioresistance in human mantle cell lymphoma cellsQ39637411
MicroRNA 92a-2*: a biomarker predictive for chemoresistance and prognostic for survival in patients with small cell lung cancerQ39863822
Role of microRNAs in drug-resistant ovarian cancer cellsQ39934697
A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor geneQ39978280
Single nucleotide polymorphism associated with mature miR-125a alters the processing of pri-miRNA.Q40151267
AU-rich-element-mediated upregulation of translation by FXR1 and Argonaute 2.Q40154871
Overexpression of Dicer in precursor lesions of lung adenocarcinomaQ40164453
The human let-7a-3 locus contains an epigenetically regulated microRNA gene with oncogenic function.Q40169748
Human let-7a miRNA blocks protein production on actively translating polyribosomesQ40204130
Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosisQ29547575
Exosomal microRNA: a diagnostic marker for lung cancerQ29614235
MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancerQ29614237
A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumorsQ29614399
MicroRNAs direct rapid deadenylation of mRNAQ29614566
Molecular mechanisms of translational controlQ29614568
Crystal structure of Argonaute and its implications for RISC slicer activityQ29614980
Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cellsQ29615089
The mirtron pathway generates microRNA-class regulatory RNAs in DrosophilaQ29615827
Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infectionQ29615959
MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancerQ29616316
The enzymes and control of eukaryotic mRNA turnoverQ29616563
Single processing center models for human Dicer and bacterial RNase IIIQ29618466
A combined computational-experimental approach predicts human microRNA targetsQ29619021
Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E(mu)-miR155 transgenic miceQ29619279
Transcriptional activation of miR-34a contributes to p53-mediated apoptosisQ29619556
Target mRNAs are repressed as efficiently by microRNA-binding sites in the 5' UTR as in the 3' UTRQ29619777
Molecular mechanisms of translation initiation in eukaryotesQ29619902
Augmentation of tumor angiogenesis by a Myc-activated microRNA clusterQ29620726
BIC and miR-155 are highly expressed in Hodgkin, primary mediastinal and diffuse large B cell lymphomasQ29622911
Chromosomal deletions and tumor suppressor genes in prostate cancer.Q30309572
The elephant in the room: do microRNA-based therapies have a realistic chance of succeeding for brain tumors such as glioblastoma?Q30426792
microRNA-34a is tumor suppressive in brain tumors and glioma stem cellsQ30428366
Structural requirements for pre-microRNA binding and nuclear export by Exportin 5.Q30448922
miR-328 functions as an RNA decoy to modulate hnRNP E2 regulation of mRNA translation in leukemic blastsQ30496174
Identification and characterization of two novel classes of small RNAs in the mouse germline: retrotransposon-derived siRNAs in oocytes and germline small RNAs in testesQ33246418
Inference of miRNA targets using evolutionary conservation and pathway analysisQ33276269
Aberrant allele frequencies of the SNPs located in microRNA target sites are potentially associated with human cancersQ33288464
Genome-scale microRNA and small interfering RNA screens identify small RNA modulators of TRAIL-induced apoptosis pathwayQ33305776
Restoration of tumor suppressor miR-34 inhibits human p53-mutant gastric cancer tumorspheresQ33370714
Nanostructural and transcriptomic analyses of human saliva derived exosomesQ33522242
A microRNA screen to identify modulators of sensitivity to BCL2 inhibitor ABT-263 (navitoclax).Q33688796
Multiple E2F-induced microRNAs prevent replicative stress in response to mitogenic signaling.Q33877588
Argonaute2 cleaves the anti-guide strand of siRNA during RISC activationQ40354595
Effects of DNA methylation on DNA-binding proteins and gene expression.Q40912883
Mechanism of chemoresistance mediated by miR-140 in human osteosarcoma and colon cancer cellsQ42009448
Pro-photoreceptor activity of chick neurogenin1.Q42106919
MicroRNA promoter element discovery in ArabidopsisQ42135770
Expression levels of the microRNA processing enzymes Drosha and dicer in epithelial skin cancerQ42468331
Structural determinants of miRNAs for RISC loading and slicer-independent unwindingQ43291103
Reduced expression of Dicer associated with poor prognosis in lung cancer patients.Q43573248
Two genetic circuits repress the Caenorhabditis elegans heterochronic gene lin-28 after translation initiationQ43909170
Accurate molecular classification of kidney cancer subtypes using microRNA signatureQ44252068
Evidence that microRNAs are associated with translating messenger RNAs in human cellsQ45345564
Polymorphisms in predicted microRNA-binding sites in integrin genes and breast cancer: ITGB4 as prognostic markerQ46542867
The role of Bcl-2 family members in the progression of cutaneous melanomaQ47404782
Differential regulation of microRNAs by p53 revealed by massively parallel sequencing: miR-34a is a p53 target that induces apoptosis and G1-arrestQ48078984
MicroRNA let-7a down-regulates MYC and reverts MYC-induced growth in Burkitt lymphoma cells.Q52582850
PPM1D is a potential target for 17q gain in neuroblastomaQ52828743
An insertion/deletion polymorphism at miRNA-122-binding site in the interleukin-1alpha 3' untranslated region confers risk for hepatocellular carcinoma.Q53304696
Dual role for argonautes in microRNA processing and posttranscriptional regulation of microRNA expression.Q53510675
Increased expression of high mobility group A proteins in lung cancer.Q53633597
Bcl-2 family proteins and mitochondria.Q53947366
Annotation of mammalian primary microRNAsQ57008990
Germline mutation of microRNA-125a is associated with breast cancerQ57828433
Microvesicles Released from Human Renal Cancer Stem Cells Stimulate Angiogenesis and Formation of Lung Premetastatic NicheQ58831489
A guide through present computational approaches for the identification of mammalian microRNA targetsQ61161512
MicroRNAs modulate the angiogenic properties of HUVECsQ62083234
The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18aQ64462273
Dicer dependent microRNAs regulate gene expression and functions in human endothelial cellsQ80019578
CD24 is a marker of exosomes secreted into urine and amniotic fluidQ80799629
siRNA-mediated knockdown of Pdcd4 expression causes upregulation of p21(Waf1/Cip1) expressionQ81127317
Loss of programmed cell death 4 expression marks adenoma-carcinoma transition, correlates inversely with phosphorylated protein kinase B, and is an independent prognostic factor in resected colorectal cancerQ81236490
A functional polymorphism in Pre-miR-146a gene is associated with prostate cancer risk and mature miR-146a expression in vivoQ84875379
P407language of work or nameEnglishQ1860
P921main subjectmicroRNAQ310899
P304page(s)2508-40
P577publication date2012-06-01
P1433published inFrontiers in BioscienceQ5506062
P1476titleMicroRNAs: molecular features and role in cancer
P478volume17

Reverse relations

cites work (P2860)
Q37317341A double-negative feedback loop between E2F3b and miR- 200b regulates docetaxel chemosensitivity of human lung adenocarcinoma cells
Q38935921A three-microRNA signature identifies two subtypes of glioblastoma patients with different clinical outcomes
Q34227615Acquisition of radioresistance in docetaxel-resistant human lung adenocarcinoma cells is linked with dysregulation of miR-451/c-Myc-survivin/rad-51 signaling
Q90338547Amygdala-Based Altered miRNome and Epigenetic Contribution of miR-128-3p in Conferring Susceptibility to Depression-Like Behavior via Wnt Signaling
Q47119323Angiogenesis in adenosquamous cancer of pancreas
Q57825996Angiogenesis: Managing the Culprits behind Tumorigenesis and Metastasis
Q36782590Angiomirs expression profiling in diffuse large B-Cell lymphoma
Q33635653Animal models to improve our understanding and treatment of suicidal behavior
Q64107195Blood Circulating miRNAs as Cancer Biomarkers for Diagnosis and Surgical Treatment Response
Q41653568Bone Marrow Microenvironment Niche Regulates miR-221/222 in Acute Lymphoblastic Leukemia
Q48096598CD133 positive U87 glioblastoma cells-derived exosomal microRNAs in hypoxia- versus normoxia-microenviroment.
Q90193810Circulating miRNA Profiling in Plasma Samples of Ovarian Cancer Patients
Q97523674Clinical significance of miR-1180-3p in hepatocellular carcinoma: a study based on bioinformatics analysis and RT-qPCR validation
Q33720978Colorectal Cancer: From the Genetic Model to Posttranscriptional Regulation by Noncoding RNAs
Q35108084Computational systems biology approaches to anti-angiogenic cancer therapeutics.
Q34987355Decreased expression of microRNA-126 is associated with poor prognosis in patients with cervical cancer
Q36998610Diagnostic Value of Cell-free Circulating MicroRNAs for Obesity and Type 2 Diabetes: A Meta-analysis.
Q47365566Diagnostic significance and potential function of miR-338-5p in hepatocellular carcinoma: A bioinformatics study with microarray and RNA sequencing data
Q41831196Different normalization strategies might cause inconsistent variation in circulating microRNAs in patients with hepatocellular carcinoma
Q36764042Differential miRNA expression profiles between the first and third trimester human placentas
Q58761772Effect of dietary components on miRNA and colorectal carcinogenesis
Q28262162Epigenetic reduction of DNA repair in progression to gastrointestinal cancer
Q61809321Exosomal transfer of obesity adipose tissue for decreased miR-141-3p mediate insulin resistance of hepatocytes
Q60957149Expression of miR‑542‑3p in osteosarcoma with miRNA microarray data, and its potential signaling pathways
Q35233770Ganoderma lucidum polysaccharide extract inhibits hepatocellular carcinoma growth by downregulating regulatory T cells accumulation and function by inducing microRNA-125b
Q35552790High microRNA-23a expression in laryngeal squamous cell carcinoma is associated with poor patient prognosis
Q35448741Human Staufen1 associates to miRNAs involved in neuronal cell differentiation and is required for correct dendritic formation
Q38761203Hypoxia-induced microRNA-301b regulates apoptosis by targeting Bim in lung cancer.
Q33727542Identification of microRNA profiles in salivary adenoid cystic carcinoma cells during metastatic progression
Q41665045Identification of potential therapeutic target genes and miRNAs for primary myelofibrosis with microarray analysis
Q34925849Inhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21.
Q57069810Knockdown of miR-194-5p inhibits cell proliferation, migration and invasion in breast cancer by regulating the Wnt/β-catenin signaling pathway
Q92528503Long non-coding RNA FGD5-AS1 promotes non-small cell lung cancer cell proliferation through sponging hsa-miR-107 to up-regulate FGFRL1
Q36538354MiR-218 impairs tumor growth and increases chemo-sensitivity to cisplatin in cervical cancer
Q35238499MiR-578 and miR-573 as potential players in BRCA-related breast cancer angiogenesis
Q41025694MicroRNA Expression in Malignant Pleural Mesothelioma and Asbestosis: A Pilot Study.
Q26768416MicroRNA aberrations: An emerging field for gallbladder cancer management
Q35190405MicroRNA profiling in Muc2 knockout mice of colitis-associated cancer model reveals epigenetic alterations during chronic colitis malignant transformation
Q38887150MicroRNA-15a induces cell apoptosis and inhibits metastasis by targeting BCL2L2 in non-small cell lung cancer
Q91972631MicroRNA-191 targets CCAAT/enhanced binding protein β and functions as an oncogenic molecule in human non-small cell lung carcinoma cells
Q35032496MicroRNA-26a inhibits angiogenesis by down-regulating VEGFA through the PIK3C2α/Akt/HIF-1α pathway in hepatocellular carcinoma
Q38721661MicroRNA-377 Downregulates Bcl-xL and Increases Apoptosis in Hepatocellular Carcinoma Cells
Q38795589MicroRNA-497 inhibits cell proliferation, migration, and invasion by targeting AMOT in human osteosarcoma cells
Q40023363MicroRNA-96 Regulates Apoptosis by Targeting PDCD4 in Human Glioma Cells
Q50062795MicroRNA-Directed Cancer Therapies: Implications in Melanoma Intervention.
Q38064320MicroRNAs as active players in the pathogenesis of multiple sclerosis
Q38396353MicroRNAs as novel biomarkers in the diagnosis of non-small cell lung cancer: a meta-analysis based on 20 studies
Q38201677MicroRNAs expression and function in cerebral ischemia reperfusion injury
Q27015778MicroRNAs, hepatitis C virus, and HCV/HIV-1 co-infection: new insights in pathogenesis and therapy
Q36443626MicroRNAs: a novel promising therapeutic target for cerebral ischemia/reperfusion injury?
Q90654564MicroRNA‑200a suppresses migration and invasion and enhances the radiosensitivity of NSCLC cells by inhibiting the HGF/c‑Met signaling pathway
Q38761907Mir-150 Up-Regulates Glut1 and Increases Glycolysis in Osteosarcoma Cells
Q37587033Myotube-derived exosomal miRNAs downregulate Sirtuin1 in myoblasts during muscle cell differentiation
Q54980098Negative Regulation of PTEN by MicroRNA-221 and Its Association with Drug Resistance and Cellular Senescence in Lung Cancer Cells.
Q35956471Pathogenetic and therapeutic applications of microRNAs in major depressive disorder
Q44140172Prognostic significance of serum miR-17-5p in lung cancer
Q47130047Radiation-Induced Changes of microRNA Expression Profiles in Radiosensitive and Radioresistant Leukemia Cell Lines with Different Levels of Chromosome Abnormalities
Q38823959SPARC overexpression alters microRNA expression profiles involved in tumor progression
Q64972245Serum starvation induces cell death in NSCLC via miR-224.
Q64234672Systematic review and meta-analysis of prognostic microRNA biomarkers for survival outcome in nasopharyngeal carcinoma
Q41048323TGF-â1-induced miR-503 controls cell growth and apoptosis by targeting PDCD4 in glioblastoma cells
Q64064521The Role of MicroRNAs in Recurrence and Metastasis of Head and Neck Squamous Cell Carcinoma
Q35060824The association between two microRNA variants (miR-499, miR-149) and gastrointestinal cancer risk: a meta-analysis
Q37115691The identification of novel targets of miR-16 and characterization of their biological functions in cancer cells
Q90631783The utility of combined mutation analysis and microRNA classification in reclassifying cancer risk of cytologically indeterminate thyroid nodules
Q98612741Thyroid Tumor: Investigating MicroRNA-21 Gene Suppression in FTC and FTA
Q34105277Tumor suppressor microRNA-27a in colorectal carcinogenesis and progression by targeting SGPP1 and Smad2
Q36153397Up-regulation of microRNA-491-5p suppresses cell proliferation and promotes apoptosis by targeting FOXP4 in human osteosarcoma.
Q35908647Use of miRNAs in biofluids as biomarkers in dietary and lifestyle intervention studies
Q24658453miR-106b promotes cancer progression in hepatitis B virus-associated hepatocellular carcinoma
Q36291106miR-491-5p-induced apoptosis in ovarian carcinoma depends on the direct inhibition of both BCL-XL and EGFR leading to BIM activation
Q38721636miR-940 Upregulation Suppresses Cell Proliferation and Induces Apoptosis by Targeting PKC-δ in Ovarian Cancer OVCAR3 Cells
Q36312098miRNA-218 contributes to the regulation of D-glucuronyl C5-epimerase expression in normal and tumor breast tissues.
Q33980238miRNAs affect the development of hepatocellular carcinoma via dysregulation of their biogenesis and expression
Q53417690miR‑29a suppresses IL‑13‑induced cell invasion by inhibiting YY1 in the AKT pathway in lung adenocarcinoma A549 cells.
Q50055592microRNA-mediated regulation of splicing factors SRSF1, SRSF2 and hnRNP A1 in context of their alternatively spliced 3'UTRs.
Q36584886microRNAs as Biomarker in Depression Pathogenesis

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