Oncogenic Wnt/β-catenin signalling pathways in the cancer-resistant epididymis have implications for cancer research

scientific article

Oncogenic Wnt/β-catenin signalling pathways in the cancer-resistant epididymis have implications for cancer research is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/MOLEHR/GAS051
P698PubMed publication ID23155044
P5875ResearchGate publication ID233424114

P2093author name stringH Y Wang
N Li
K Wang
T G Cooper
J Y Li
C H Yeung
P2860cites workDeletion at Dickkopf (dkk)-3 locus (11p15.2) is related with lower lymph node metastasis and better prognosis in head and neck squamous cell carcinomasQ46133868
Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre studyQ46845924
Preferential methylation of Wnt inhibitory factor-1 in acute promyelocytic leukemia: an independent poor prognostic factorQ46981618
NEMO differentially regulates TCR and TNF-α induced NF-κB pathways and has an inhibitory role in TCR-induced NF-κB activationQ48050480
Expression of epithelial cadherin in the human male reproductive tract and gametes and evidence of its participation in fertilizationQ48737872
Adherence junction proteins in angiogenesis: modulation by aspirin and salicylic acidQ48760095
Nuclear accumulation of e-cadherin correlates with loss of cytoplasmic membrane staining and invasion in pituitary adenomasQ48800573
miR-200c affects the mRNA expression of E-cadherin by regulating the mRNA level of TCF8 during post-natal epididymal development in juvenile rats.Q51902052
microRNAs as novel epigenetic biomarkers for human cancer.Q53285686
Somatic inactivation of E-cadherin and p53 in mice leads to metastatic lobular mammary carcinoma through induction of anoikis resistance and angiogenesis.Q53588886
Beta-catenin overexpression augments angiogenesis and skeletal muscle regeneration through dual mechanism of vascular endothelial growth factor-mediated endothelial cell proliferation and progenitor cell mobilization.Q53611030
Frequent accumulation of nuclear E-cadherin and alterations in the Wnt signaling pathway in esophageal squamous cell carcinomasQ57272621
A systematic screen for micro-RNAs regulating the canonical Wnt pathwayQ21134995
FoxM1 promotes β-catenin nuclear localization and controls Wnt target-gene expression and glioma tumorigenesisQ24293807
Tumour suppressor RNF43 is a stem-cell E3 ligase that induces endocytosis of Wnt receptorsQ24296595
Secreted Frizzled-related protein-2 (sFRP2) augments canonical Wnt3a-induced signalingQ24296632
SOST is a ligand for LRP5/LRP6 and a Wnt signaling inhibitorQ24303393
APCDD1 is a novel Wnt inhibitor mutated in hereditary hypotrichosis simplexQ24306673
ZNRF3 promotes Wnt receptor turnover in an R-spondin-sensitive mannerQ24320153
Wnt/β-catenin signaling regulates telomerase in stem cells and cancer cellsQ24338743
Intestinal polyposis in mice with a dominant stable mutation of the beta-catenin geneQ24529898
MicroRNA profiling identifies miR-34a and miR-21 and their target genes JAG1 and WNT1 in the coordinate regulation of dendritic cell differentiationQ24628741
Eyes wide open: a critical review of sphere-formation as an assay for stem cellsQ24631827
CEA-related cell adhesion molecule 1: a potent angiogenic factor and a major effector of vascular endothelial growth factorQ28199550
Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarraysQ28235146
Regulation of the adenomatous polyposis coli gene by the miR-135 family in colorectal cancerQ28287415
Augmented Wnt signaling in a mammalian model of accelerated agingQ28506533
Wnt9b plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital systemQ28511083
MicroRNA-29a inhibited epididymal epithelial cell proliferation by targeting nuclear autoantigenic sperm protein (NASP)Q28566117
miR-335 is involved in the rat epididymal development by targeting the mRNA of RASA1Q28568142
Neucrin is a novel neural-specific secreted antagonist to canonical Wnt signalingQ28591634
Secreted antagonists of the Wnt signalling pathwayQ29615521
Many tumors induced by the mouse mammary tumor virus contain a provirus integrated in the same region of the host genomeQ29616165
Generation of a functional mammary gland from a single stem cellQ29616496
p53 and microRNA-34 are suppressors of canonical Wnt signaling.Q30424916
De Graaf's thread: the human epididymisQ30445481
The androgen receptor can signal through Wnt/beta-Catenin in prostate cancer cells as an adaptation mechanism to castration levels of androgensQ33316388
KLF4 interacts with beta-catenin/TCF4 and blocks p300/CBP recruitment by beta-cateninQ33558845
Sphere-forming cell subpopulations with cancer stem cell properties in human hepatoma cell linesQ33931154
A positive role of cadherin in Wnt/β-catenin signalling during epithelial-mesenchymal transitionQ34016436
The Wnt/beta-catenin pathway regulates growth and maintenance of colonospheresQ34075159
Krüppel-like factor 4 is widely expressed in the mouse male and female reproductive tract and responds as an immediate early gene to activation of the protein kinase A in TM4 Sertoli cellsQ34091133
Deep sequencing analysis of small non-coding RNAs reveals the diversity of microRNAs and piRNAs in the human epididymisQ34152928
Site-dependent E-cadherin cleavage and nuclear translocation in a metastatic colorectal cancer model.Q34162522
An evolutionary review of human telomere biology: the thrifty telomere hypothesis and notes on potential adaptive paternal effectsQ34164417
MicroRNA-194 is a target of transcription factor 1 (Tcf1, HNF1α) in adult liver and controls expression of frizzled-6.Q34213102
Role of microRNAs in controlling gene expression in different segments of the human epididymisQ34236962
miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitionsQ34237504
Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotypeQ34287558
MiR-214 targets β-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma.Q34409807
Molecular action of androgen in the normal and neoplastic prostateQ34491450
Dickkopf-1 (DKK-1) stimulated prostate cancer growth and metastasis and inhibited bone formation in osteoblastic bone metastasesQ34511164
Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiationQ34696989
New class of microRNA targets containing simultaneous 5'-UTR and 3'-UTR interaction sitesQ34972173
Analysis of microRNA expression and functionQ35039269
A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition.Q35503722
MicroRNA-1826 targets VEGFC, beta-catenin (CTNNB1) and MEK1 (MAP2K1) in human bladder cancerQ35747341
Regulation of the potential marker for intestinal cells, Bmi1, by β-catenin and the zinc finger protein KLF4: implications for colon cancerQ35763252
MicroRNA-1826 directly targets beta-catenin (CTNNB1) and MEK1 (MAP2K1) in VHL-inactivated renal cancerQ35795361
Functional screening identifies miR-315 as a potent activator of Wingless signalingQ36156855
miR-218 directs a Wnt signaling circuit to promote differentiation of osteoblasts and osteomimicry of metastatic cancer cellsQ36451980
Multifaceted interaction between the androgen and Wnt signaling pathways and the implication for prostate cancerQ36495332
The Wnt signaling pathway: aging gracefully as a protectionist?Q36728844
KLF4 and SOX9 transcription factors antagonize β-catenin and inhibit TCF-activity in cancer cellsQ36787539
The microRNA miR-8 is a conserved negative regulator of Wnt signalingQ36926946
Expression of the Wnt antagonist Dickkopf-3 is associated with prognostic clinicopathologic characteristics and impairs proliferation and invasion in endometrial cancerQ36944293
Regulation of zebrafish fin regeneration by microRNAsQ36985154
Why are epididymal tumours so rare?Q37037784
New insights into epididymal biology and functionQ37090503
Nuclear E-cadherin immunoexpression: from biology to potential applications in diagnostic pathologyQ37200223
WNT signalling in the immune system: WNT is spreading its wingsQ37212748
Downregulated microRNA-200a in meningiomas promotes tumor growth by reducing E-cadherin and activating the Wnt/beta-catenin signaling pathwayQ37410761
Physiological inhibitors of Wnt signalingQ37845920
The cancer stem cell: premises, promises and challengesQ37851011
Targeting the Wnt/β-catenin signaling pathway in human cancersQ37864329
Evolution: structural and functional diversity of cadherin at the adherens junction.Q37895020
Androgen action in the epididymisQ37901988
Wise, a context-dependent activator and inhibitor of Wnt signallingQ38351852
Transcription initiation arising from E-cadherin/CDH1 intron2: a novel protein isoform that increases gastric cancer cell invasion and angiogenesisQ39321532
MicroRNA-320a suppresses human colon cancer cell proliferation by directly targeting β-cateninQ39372261
MicroRNA-122 suppresses cell proliferation and induces cell apoptosis in hepatocellular carcinoma by directly targeting Wnt/β-catenin pathwayQ39406412
Tumor suppressor microRNA-493 decreases cell motility and migration ability in human bladder cancer cells by downregulating RhoC and FZD4.Q39447197
β-Catenin/LEF1 transactivates the microRNA-371-373 cluster that modulates the Wnt/β-catenin-signaling pathwayQ39454255
IGFBP-4 activates the Wnt/beta-catenin signaling pathway and induces M-CAM expression in human renal cell carcinomaQ39612044
Alterations in the human blood-epididymis barrier in obstructive azoospermia and the development of novel epididymal cell lines from infertile men.Q39699970
Assessing the role of claudins in maintaining the integrity of epididymal tight junctions using novel human epididymal cell linesQ39738024
Role of secreted frizzled-related protein 3 in human renal cell carcinomaQ39738760
Secreted frizzled related protein (sFRP)-2 inhibits bone formation and promotes cell proliferation in ameloblastoma.Q39861708
Elevated levels of Dickkopf-related protein 3 in seminal plasma of prostate cancer patientsQ39867828
IGFBP-4 is an inhibitor of canonical Wnt signalling required for cardiogenesisQ39975112
The CEACAM1-mediated apoptosis pathway is activated by CEA and triggers dual cleavage of CEACAM1.Q40012758
The rat epididymal transcriptome: comparison of segmental gene expression in the rat and mouse epididymidesQ40260520
The mouse epididymal transcriptome: transcriptional profiling of segmental gene expression in the epididymisQ40424665
The tumour suppressor gene CEACAM1 is completely but reversibly downregulated in renal cell carcinomaQ40505620
Target disruption of the mutant beta-catenin gene in colon cancer cell line HCT116: preservation of its malignant phenotypeQ40709912
Cadherins and catenins in developmentQ41239009
Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas.Q41256855
Localization of specificity determining sites in cadherin cell adhesion moleculesQ41737531
Direct interaction of tumor suppressor CEACAM1 with beta catenin: identification of key residues in the long cytoplasmic domainQ42138941
Androgen receptor expression in human tissues: an immunohistochemical studyQ42471568
Gene expression profiling and its relevance to the blood-epididymal barrier in the human epididymisQ42508036
Alterations in beta-catenin expression and localization in prostate cancerQ42813475
OCT4 and downstream factors are expressed in human somatic urogenital epithelia and in culture of epididymal spheresQ43177745
A new nomenclature for int-1 and related genes: the Wnt gene familyQ43813245
In vitro evidence for complex modes of nuclear beta-catenin signaling during prostate growth and tumorigenesisQ43966868
MiR-200a is involved in rat epididymal development by targeting β-catenin mRNA.Q44188365
Catenins in the rat epididymis: their expression and regulation in adulthood and during postnatal developmentQ44576195
The androgen receptor can promote beta-catenin nuclear translocation independently of adenomatous polyposis coliQ45714114
Oestrogenic regulation and differential expression of WNT4 in the bonnet monkey and rodent epididymis.Q46033254
WNT signaling regulates self-renewal and differentiation of prostate cancer cells with stem cell characteristicsQ46051855
P433issue2
P304page(s)57-71
P577publication date2012-11-14
P1433published inMolecular Human ReproductionQ15761794
P1476titleOncogenic Wnt/β-catenin signalling pathways in the cancer-resistant epididymis have implications for cancer research
P478volume19

Reverse relations

cites work (P2860)
Q37391989Association between prognostic survival of human colorectal carcinoma and ZNRF3 expression
Q36748491Comparison of gene expression of the oncogenic Wnt/β-catenin signaling pathway components in the mouse and human epididymis
Q40954412Construction of interference vector targeting Ep-CAM gene and its effects on colorectal cancer cell proliferation
Q50937133Decreased expression of WNT2 in villi of unexplained recurrent spontaneous abortion patients may cause trophoblast cell dysfunction via downregulated Wnt/β-catenin signaling pathway.
Q36355895Epigenetic silencing of NKD2, a major component of Wnt signaling, promotes breast cancer growth
Q64902988Finasteride-Induced Inhibition of 5α-Reductase Type 2 Could Lead to Kidney Damage-Animal, Experimental Study.
Q35137818Gene methylation profiles as prognostic markers in ovarian clear cell and endometrioid adenocarcinomas
Q35049866Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation.
Q39586743Inhibition of disheveled-2 resensitizes cisplatin-resistant lung cancer cells through down-regulating Wnt/β-catenin signaling
Q35785987Isolated Rat Epididymal Basal Cells Share Common Properties with Adult Stem Cells
Q34466347Methylation of DACT2 promotes papillary thyroid cancer metastasis by activating Wnt signaling
Q47106409MiR-92a promotes stem cell-like properties by activating Wnt/β-catenin signaling in colorectal cancer
Q35745137Next Generation Sequencing Analysis Reveals Segmental Patterns of microRNA Expression in Mouse Epididymal Epithelial Cells.
Q92617027miR-30a inhibits breast cancer progression through the Wnt/β-catenin pathway

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