Platelet function profiles in patients with diabetes mellitus

scientific article published on 13 February 2013

Platelet function profiles in patients with diabetes mellitus is …
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scholarly articleQ13442814

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P6179Dimensions Publication ID1020811248
P356DOI10.1007/S12265-013-9449-0
P698PubMed publication ID23404189

P50authorDominick AngiolilloQ72837721
P2093author name stringFabiana Rollini
Francesco Franchi
Ana Muñiz-Lozano
P2860cites work2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice GuidelinesQ22241919
Diagnosis and Classification of Diabetes MellitusQ22255454
Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patientsQ24555072
Aspirin "resistance" and risk of cardiovascular morbidity: systematic review and meta-analysisQ24645413
Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE studyQ28165115
Evaluation of anti-platelet aggregatory effects of aspirin, cilostazol and ramatroban on platelet-rich plasma and whole bloodQ28168292
Platelet aggregation according to body mass index in patients undergoing coronary stenting: should clopidogrel loading-dose be weight adjusted?Q28168661
Picotamide, a combined inhibitor of thromboxane A2 synthase and receptor, reduces 2-year mortality in diabetics with peripheral arterial disease: the DAVID studyQ28171078
P2Y12 receptors play a significant role in the development of platelet microaggregation in patients with diabetesQ28171157
Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stentsQ28174787
Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatmentQ28185431
Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevationQ28188284
Effects of P2Y(1) and P2Y(12) receptor antagonists on platelet aggregation induced by different agonists in human whole bloodQ28190630
Effect of clopidogrel pretreatment before percutaneous coronary intervention in patients with ST-elevation myocardial infarction treated with fibrinolytics: the PCI-CLARITY studyQ28190808
Cyclooxygenase-1 haplotype modulates platelet response to aspirinQ28191434
Cyclooxygenase inhibitors and the antiplatelet effects of aspirinQ28191912
Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trialQ28193186
Amplified benefit of clopidogrel versus aspirin in patients with diabetes mellitusQ28193753
Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trialQ28194232
Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic eventsQ28195656
Safety of coronary sirolimus-eluting stents in daily clinical practice: one-year follow-up of the e-Cypher registryQ28195674
Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatmentQ28199546
Platelet activation in type 2 diabetes mellitusQ28210554
Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevationQ28218789
Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirinQ28219365
Effect of enteric coating on antiplatelet activity of low-dose aspirin in healthy volunteersQ28219399
Association of laboratory-defined aspirin resistance with a higher risk of recurrent cardiovascular events: a systematic review and meta-analysisQ28219463
Prevention by NCX 4016, a nitric oxide-donating aspirin, but not by aspirin, of the acute endothelial dysfunction induced by exercise in patients with intermittent claudicationQ28219820
The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the aspirin-induced platelet effect (ASPECT) studyQ28221353
Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectivesQ28222158
Effects of pioglitazone on platelet P2Y12-mediated signalling in clopidogrel-treated patients with type 2 diabetes mellitusQ84561624
The dual thromboxane receptor antagonist and thromboxane synthase inhibitor EV-077 is a more potent inhibitor of platelet function than aspirinQ84581656
Bedside monitoring to adjust antiplatelet therapy for coronary stentingQ85345517
Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet functionQ43264426
Platelet hyperactivity and abnormal Ca(2+) homeostasis in diabetes mellitusQ43541597
Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitro.Q43554882
Effect of weight reduction in moderately overweight patients on recorded ambulatory blood pressure and free cytosolic platelet calciumQ43566887
Platelet antioxidant enzymes in insulin-dependent diabetes mellitusQ43641231
Effects of cangrelor in coronary artery disease patients with and without diabetes mellitus: an in vitro pharmacodynamic investigation.Q43744458
Platelet glycoprotein IIb/IIIa inhibitors reduce mortality in diabetic patients with non-ST-segment-elevation acute coronary syndromesQ43815690
Inhibition of platelet-collagen interaction: an in vivo action of insulin abolished by insulin resistance in obesityQ43852839
Glycated low density lipoproteins modify platelet properties: a compositional and functional studyQ43982457
Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in MyocarQ44056270
Comparison of the pharmacodynamic effects of the platelet ADP receptor antagonists clopidogrel and AR-C69931MX in patients with ischaemic heart diseaseQ44253003
Enhancing effect of advanced glycation end products on serotonin-induced platelet aggregation in patients with diabetes mellitusQ44301386
Intense metabolic control by means of insulin in patients with diabetes mellitus and acute myocardial infarction (DIGAMI 2): effects on mortality and morbidityQ44642265
Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes mellitusQ44668369
Association of diabetes mellitus and glycemic control strategies with clinical outcomes after acute coronary syndromesQ44754180
Improved metabolic control decreases platelet activation markers in patients with type-2 diabetesQ44802298
Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone reduces circulating platelet activity in patients without diabetes mellitus who have coronary artery diseaseQ44938343
Thromboxane biosynthesis and platelet function in type II diabetes mellitusQ45056796
Randomized comparison of adjunctive cilostazol versus high maintenance dose clopidogrel in patients with high post-treatment platelet reactivity: results of the ACCEL-RESISTANCE (Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in PatiQ46073177
Intensive versus conventional glucose control in critically ill patientsQ46076336
Prasugrel compared with clopidogrel in patients undergoing percutaneous coronary intervention for ST-elevation myocardial infarction (TRITON-TIMI 38): double-blind, randomised controlled trialQ46105774
Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivoQ46214428
Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery diseaseQ46418067
A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study.Q46528728
Hydrogen peroxide and peroxynitrite enhance Ca2+ mobilization and aggregation in platelets from type 2 diabetic patients.Q46553183
Safety and efficacy of bivalirudin monotherapy in patients with diabetes mellitus and acute coronary syndromes: a report from the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) trialQ46627427
Cigarette smoking is associated with a dose-response effect in clopidogrel-treated patients with diabetes mellitus and coronary artery disease: results of a pharmacodynamic study.Q46678626
Drug-eluting stenting followed by cilostazol treatment reduces late restenosis in patients with diabetes mellitus the DECLARE-DIABETES Trial (A Randomized Comparison of Triple Antiplatelet Therapy with Dual Antiplatelet Therapy After Drug-Eluting StQ46690785
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazoneQ46856893
Prasugrel versus clopidogrel in patients with acute coronary syndromesQ46915044
Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery diseaseQ28222643
Effects of intensive glucose lowering in type 2 diabetesQ29547736
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damageQ29616101
Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarctionQ29618673
Ticagrelor versus clopidogrel in patients with acute coronary syndromesQ29619002
A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering CommitteeQ29620666
Activation of receptor for advanced glycation end products: a mechanism for chronic vascular dysfunction in diabetic vasculopathy and atherosclerosisQ33542625
Low-dose aspirin for primary prevention of atherosclerotic events in patients with type 2 diabetes: a randomized controlled trialQ34014586
Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study.Q34020220
2011 ACCF/AHA/SCAI Guideline for Percutaneous Coronary Intervention. A report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines and the Society for Cardiovascular Angiography and InterventiQ34231154
Rivaroxaban in patients with a recent acute coronary syndromeQ34231902
Thrombin-receptor antagonist vorapaxar in acute coronary syndromesQ34231934
Vorapaxar in the secondary prevention of atherothrombotic eventsQ34263311
New oral anticoagulants in atrial fibrillation and acute coronary syndromes: ESC Working Group on Thrombosis-Task Force on Anticoagulants in Heart Disease position paperQ34267825
2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice GuidelinesQ34318814
Platelet dysfunction in type 2 diabetesQ34319534
Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibition and patient Outcomes (PLATO) trialQ34404150
A pharmacodynamic comparison of prasugrel vs. high-dose clopidogrel in patients with type 2 diabetes mellitus and coronary artery disease: results of the Optimizing anti-Platelet Therapy In diabetes MellitUS (OPTIMUS)-3 TrialQ34751965
Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trialQ34766176
Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I.Q35540861
Advanced glycation endproducts--role in pathology of diabetic complicationsQ35994161
Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study GroupQ36244558
Atherothrombosis and high-risk plaque: part I: evolving conceptsQ36259704
Pathobiology and cell interactions of platelets in diabetesQ36320564
Effects of VLDL and remnant particles on plateletsQ36551304
Effects of hyperglycemia and hyperinsulinemia on the tissue factor pathway of blood coagulationQ36839933
Platelet activation and atherothrombosisQ37031278
Oxidative stress and plateletsQ37049876
The prevention of progression of arterial disease and diabetes (POPADAD) trial: factorial randomised placebo controlled trial of aspirin and antioxidants in patients with diabetes and asymptomatic peripheral arterial disease.Q37135995
Factors contributing to increased platelet reactivity in people with diabetesQ37139534
Pharmacology of emerging novel platelet inhibitorsQ37227747
Diabetes, vascular complications and antiplatelet therapy: open problems.Q37338975
Variability in responsiveness to oral antiplatelet therapyQ37376462
Antiplatelet therapy in diabetes: efficacy and limitations of current treatment strategies and future directionsQ37428365
Platelet dysfunction in central obesityQ37433187
Inhibition of platelet aggregation by AZD6140, a reversible oral P2Y12 receptor antagonist, compared with clopidogrel in patients with acute coronary syndromesQ46916589
Correlates and long-term outcomes of angiographically proven stent thrombosis with sirolimus- and paclitaxel-eluting stentsQ46954392
A comparison of platelet function tests and thromboxane metabolites to evaluate aspirin response in healthy individuals and patients with coronary artery diseaseQ50199243
Clopidogrel response variability: current status and future directionsQ50329075
Platelet response to clopidogrel is attenuated in diabetic patients undergoing coronary stent implantation.Q51079603
Determinants of mean platelet volume (MPV) in an elderly population: relevance of body fat, blood glucose and ischaemic electrocardiographic changes.Q51446902
Large Platelets Circulate in an Activated State in Diabetes MellitusQ51609166
Pharmacodynamic effects of adjunctive cilostazol therapy in patients with coronary artery disease on dual antiplatelet therapy: impact of high on-treatment platelet reactivity and diabetes mellitus status.Q53178855
Platelet aggregation in obese and diabetic subjects: association with leptin level.Q53565307
Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary: The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD)Q57245141
Impacto del tratamiento adyuvante con cilostazol comparado con dosis altas de mantenimiento de clopidogrel en pacientes con diabetes mellitus y respuesta subóptimaQ57764391
Functional profile of the platelet P2Y12 receptor signalling pathway in patients with type 2 diabetes mellitus and coronary artery diseaseQ57764459
Impact of adjunctive cilostazol therapy on platelet function profiles in patients with and without diabetes mellitus on aspirin and clopidogrel therapyQ57764478
Impact of Insulin Receptor Substrate-1 Genotypes on Platelet Reactivity and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Coronary Artery DiseaseQ57764490
Impact of Diabetes on Long-Term Prognosis in Patients With Unstable Angina and Non–Q-Wave Myocardial InfarctionQ58040699
2011 ACCF/AHA Focused Update Incorporated Into the ACC/AHA 2007 Guidelines for the Management of Patients With Unstable Angina/Non–ST-Elevation Myocardial InfarctionQ59355957
Platelet function in patients with familial hypertriglyceridemia: evidence that platelet reactivity is modulated by apolipoprotein E content of very-low-density lipoprotein particles.Q60924221
Platelet insulin receptorQ67582366
Effects of high-density lipoprotein on acetylcholine-induced coronary vasoreactivityQ67769877
Decreased platelet membrane fluidity due to glycation or acetylation of membrane proteinsQ67956034
Aspirin effects on mortality and morbidity in patients with diabetes mellitus. Early Treatment Diabetic Retinopathy Study report 14. ETDRS InvestigatorsQ68021310
Effects of aspirin on coronary reocclusion and recurrent ischemia after thrombolysis: a meta-analysisQ68053164
Altered cellular Ca2+ and Na+ transport in diabetes mellitusQ68463918
Trial of repeated low-dose aspirin in diabetic angiopathyQ70304992
Effects of insulin on calcium metabolism and platelet aggregationQ71258054
Platelets from diabetic subjects show diminished sensitivity to prostacyclinQ71634275
Activation of tissue factor-induced coagulation and endothelial cell dysfunction in non-insulin-dependent diabetic patients with microalbuminuriaQ71938783
Characterization of the mechanism for the chronic activation of diacylglycerol-protein kinase C pathway in diabetes and hypergalactosemiaQ72150727
Changes in fibrinolytic parameters in male patients with type 2 (non-insulin-dependent) diabetes mellitusQ72595397
Randomized trial of ridogrel, a combined thromboxane A2 synthase inhibitor and thromboxane A2/prostaglandin endoperoxide receptor antagonist, versus aspirin as adjunct to thrombolysis in patients with acute myocardial infarction. The Ridogrel VersusQ72786073
ADP receptors of platelets and their inhibitionQ74314926
Acute hyperglycemia attenuates endothelium-dependent vasodilation in humans in vivoQ74561887
Von Willebrand factor in diabetic angiopathyQ77523254
Insulin-induced expression of prostacyclin receptors on platelets is mediated through ADP-ribosylation of Gi alpha proteinQ77636152
Alterations of adenine nucleotide metabolism and function of blood platelets in patients with diabetesQ79678239
Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) studyQ79685552
Membrane lipid fluidity of blood platelets: a common denominator that underlies the opposing actions of various agents that affect platelet activation in whole bloodQ79774080
Endogenously generated reactive oxygen species reduce PMCA activity in platelets from patients with non-insulin-dependent diabetes mellitusQ80158723
Endothelial dysfunction, impaired endogenous platelet inhibition and platelet activation in diabetes and atherosclerosisQ80550892
Impact of body mass index on platelet aggregation after administration of a high loading dose of 600 mg of clopidogrel before percutaneous coronary interventionQ80611170
Baseline platelet activity and response after clopidogrel in 257 diabetics among 822 patients with coronary artery diseaseQ81607383
Effects of intensive glucose control on platelet reactivity in patients with acute coronary syndromes. Results of the CHIPS Study ("Control de Hiperglucemia y Actividad Plaquetaria en Pacientes con Sindrome Coronario Agudo")Q83541230
The recovery of platelet cyclooxygenase activity explains interindividual variability in responsiveness to low-dose aspirin in patients with and without diabetesQ83797596
Optimizing platelet inhibition in clopidogrel poor metabolizers: therapeutic options and practical considerationsQ83927336
Cangrelor: a review on its mechanism of action and clinical development.Q37611039
Platelet thrombin receptor antagonism and atherothrombosisQ37641556
Platelet adenosine diphosphate P2Y12 receptor antagonism: benefits and limitations of current treatment strategies and future directionsQ37678656
Mechanism of action and clinical development of ticagrelor, a novel platelet ADP P2Y12 receptor antagonistQ37688144
Diabetes and the platelet: toward new therapeutic paradigms for diabetic atherothrombosisQ37731651
Hyperglycemia: a prothrombotic factor?Q37759238
Aspirin for primary prevention of cardiovascular events in people with diabetesQ37767786
Diabetes and antiplatelet therapy in acute coronary syndrome.Q37846051
Challenges and perspectives of antiplatelet therapy in patients with diabetes mellitus and coronary artery diseaseQ38020865
Clinical practice. Diagnosis of diabetesQ38032903
Effect of rosiglitazone on progression of coronary atherosclerosis in patients with type 2 diabetes mellitus and coronary artery disease: the assessment on the prevention of progression by rosiglitazone on atherosclerosis in diabetes patients with cQ38375360
Reconstituted high-density lipoprotein attenuates platelet function in individuals with type 2 diabetes mellitus by promoting cholesterol effluxQ38377760
A randomized, double-blind, active-controlled phase 2 trial to evaluate a novel selective and reversible intravenous and oral P2Y12 inhibitor elinogrel versus clopidogrel in patients undergoing nonurgent percutaneous coronary intervention: the INNOVQ38470620
Pharmacokinetic and pharmacodynamic effects of elinogrel: results of the platelet function substudy from the intravenous and oral administration of elinogrel to evaluate tolerability and efficacy in nonurgent percutaneous coronary intervention patieQ38471086
Standard- vs high-dose clopidogrel based on platelet function testing after percutaneous coronary intervention: the GRAVITAS randomized trialQ38493350
Pharmacodynamic effects of different aspirin dosing regimens in type 2 diabetes mellitus patients with coronary artery diseaseQ38493656
Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under flowQ39586331
Advanced glycation end products, oxidant stress and vascular lesionsQ41375234
What cardiologists need to know about diabetes.Q41556867
Insulin, insulin resistance, and platelet signaling in diabetesQ41951212
Platelet resistance to nitrates in obesity and obese NIDDM, and normal platelet sensitivity to both insulin and nitrates in lean NIDDM.Q42453569
Alterations in platelet Ca2+ signalling in diabetic patients is due to increased formation of superoxide anions and reduced nitric oxide productionQ42468613
Increased intracellular calcium mobilization in platelets from patients with type 2 (non-insulin-dependent) diabetes mellitusQ42472895
Safety and feasibility of adjunctive antiplatelet therapy with intravenous elinogrel, a direct-acting and reversible P2Y12 ADP-receptor antagonist, before primary percutaneous intervention in patients with ST-elevation myocardial infarction: the EarQ42641710
Dose Comparisons of Clopidogrel and Aspirin in Acute Coronary SyndromesQ42917068
Double-dose versus standard-dose clopidogrel and high-dose versus low-dose aspirin in individuals undergoing percutaneous coronary intervention for acute coronary syndromes (CURRENT-OASIS 7): a randomised factorial trialQ42917584
Elinogrel: pharmacological principles, preclinical and early phase clinical testingQ42978644
Impact of cytochrome P450 2C19 loss-of-function polymorphism and of major demographic characteristics on residual platelet function after loading and maintenance treatment with clopidogrel in patients undergoing elective coronary stent placementQ43051165
Reduced platelet response to aspirin in patients with coronary artery disease and type 2 diabetes mellitus.Q43069429
Impact of chronic kidney disease on platelet function profiles in diabetes mellitus patients with coronary artery disease taking dual antiplatelet therapyQ43133050
Intravenous platelet blockade with cangrelor during PCI.Q43241907
Platelet inhibition with cangrelor in patients undergoing PCI.Q43241909
In central obesity, weight loss restores platelet sensitivity to nitric oxide and prostacyclinQ43260380
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)329-345
P577publication date2013-02-13
P1433published inJournal of Cardiovascular Translational ResearchQ6294906
P1476titlePlatelet function profiles in patients with diabetes mellitus
P478volume6

Reverse relations

cites work (P2860)
Q64935943Diabetes and antiplatelet therapy: from bench to bedside.
Q89452333Flavin monooxygenase 3, the host hepatic enzyme in the metaorganismal trimethylamine N-oxide-generating pathway, modulates platelet responsiveness and thrombosis risk
Q38596700Glucose Homeostasis and Cardiovascular Alterations in Diabetes
Q35736714High-risk type-2 diabetes mellitus patients, without prior ischemic events, have normal blood platelet functionality profiles: a cross-sectional study
Q37692590Hypofibrinolysis in diabetes: a therapeutic target for the reduction of cardiovascular risk
Q38378830Impact of Diabetes Mellitus on the Pharmacodynamic Effects of Ticagrelor Versus Clopidogrel in Troponin-Negative Acute Coronary Syndrome Patients Undergoing Ad Hoc Percutaneous Coronary Intervention
Q34389439Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation.
Q35766245Loss of the insulin receptor in murine megakaryocytes/platelets causes thrombocytosis and alterations in IGF signalling.
Q64241217Mean Platelet Volume (MPV): New Perspectives for an Old Marker in the Course and Prognosis of Inflammatory Conditions
Q46921727Pharmacodynamic effects of EV-077 in patients with diabetes mellitus and coronary artery disease on aspirin or clopidogrel monotherapy: results of an in vitro pilot investigation
Q93018504Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review
Q38846534Targeting Select Cellular Stress Pathways to Prevent Hyperglycemia-Related Complications: Shifting the Paradigm
Q48512017Thrombosis and Vascular Inflammation in Diabetes: Mechanisms and Potential Therapeutic Targets

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