Diabetes and antiplatelet therapy: from bench to bedside.

scientific article published in October 2018

Diabetes and antiplatelet therapy: from bench to bedside. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.21037/CDT.2018.05.09
P932PMC publication ID6232350
P698PubMed publication ID30498684

P50authorDominick AngiolilloQ72837721
P2093author name stringFabiana Rollini
Francesco Franchi
Jose R Rivas Rios
P2860cites workImpact of stenting and abciximab in patients with diabetes mellitus undergoing primary angioplasty in acute myocardial infarction (the CADILLAC trial).Q51562214
Influence of diabetes mellitus on clinical outcome in the thrombolytic era of acute myocardial infarction. GUSTO-I Investigators. Global Utilization of Streptokinase and Tissue Plasminogen Activator for Occluded Coronary Arteries.Q53359026
Platelet aggregation in obese and diabetic subjects: association with leptin level.Q53565307
Consistent platelet inhibition with ticagrelor 60 mg twice-daily following myocardial infarction regardless of diabetes status.Q53944880
Ticagrelor versus prasugrel in diabetic patients with an acute coronary syndrome. A pharmacodynamic randomised study.Q54704923
2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTSQ57621041
Functional profile of the platelet P2Y12 receptor signalling pathway in patients with type 2 diabetes mellitus and coronary artery diseaseQ57764459
Impact of adjunctive cilostazol therapy on platelet function profiles in patients with and without diabetes mellitus on aspirin and clopidogrel therapyQ57764478
Impact of Insulin Receptor Substrate-1 Genotypes on Platelet Reactivity and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Coronary Artery DiseaseQ57764490
Twice daily dosing of aspirin improves platelet inhibition in whole blood in patients with type 2 diabetes mellitus and micro- or macrovascular complicationsQ58329679
Increased platelet Fc receptor expression as a potential contributing cause of platelet hypersensitivity to collagen in diabetes mellitusQ60547969
Platelet function in patients with familial hypertriglyceridemia: evidence that platelet reactivity is modulated by apolipoprotein E content of very-low-density lipoprotein particles.Q60924221
Activated platelets in patients with severe hypertriglyceridemia: effects of triglyceride-lowering therapyQ62977698
Platelet insulin receptorQ67582366
Decreased platelet membrane fluidity due to glycation or acetylation of membrane proteinsQ67956034
Effects of insulin on calcium metabolism and platelet aggregationQ71258054
Platelets from diabetic subjects show diminished sensitivity to prostacyclinQ71634275
Activation of tissue factor-induced coagulation and endothelial cell dysfunction in non-insulin-dependent diabetic patients with microalbuminuriaQ71938783
ADP receptors of platelets and their inhibitionQ74314926
Insulin-induced expression of prostacyclin receptors on platelets is mediated through ADP-ribosylation of Gi alpha proteinQ77636152
Platelet and monocyte activation by hyperglycemia and hyperinsulinemia in healthy subjectsQ79383025
Randomized comparison of a high clopidogrel maintenance dose in patients with diabetes mellitus and coronary artery disease: results of the Optimizing Antiplatelet Therapy in Diabetes Mellitus (OPTIMUS) studyQ79685552
Membrane lipid fluidity of blood platelets: a common denominator that underlies the opposing actions of various agents that affect platelet activation in whole bloodQ79774080
Endothelial dysfunction, impaired endogenous platelet inhibition and platelet activation in diabetes and atherosclerosisQ80550892
Infliximab treatment shifts the balance between stimulatory and inhibitory Fcgamma receptor type II isoforms on neutrophils in patients with rheumatoid arthritisQ80607346
Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathwayQ81163093
Effects of intensive glucose control on platelet reactivity in patients with acute coronary syndromes. Results of the CHIPS Study ("Control de Hiperglucemia y Actividad Plaquetaria en Pacientes con Sindrome Coronario Agudo")Q83541230
Pharmacogenetics in cardiovascular antithrombotic therapyQ84541445
Effects of pioglitazone on platelet P2Y12-mediated signalling in clopidogrel-treated patients with type 2 diabetes mellitusQ84561624
Differential Effects of Omeprazole and Pantoprazole on the Pharmacodynamics and Pharmacokinetics of Clopidogrel in Healthy Subjects: Randomized, Placebo-Controlled, Crossover Comparison StudiesQ85036168
Impaired responsiveness to the platelet P2Y12 receptor antagonist clopidogrel in patients with type 2 diabetes and coronary artery diseaseQ85253139
Effects of Ticagrelor Versus Clopidogrel in Troponin-Negative Patients With Low-Risk ACS Undergoing Ad Hoc PCIQ87274514
2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice GuidelinesQ89104948
Diagnosis and Classification of Diabetes MellitusQ22255454
Insulin receptor substrate proteins create a link between the tyrosine phosphorylation cascade and the Ca2+-ATPases in muscle and heartQ24311811
Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patientsQ24555072
Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trialsQ24645391
Comparing the effectiveness and safety between triple antiplatelet therapy and dual antiplatelet therapy in type 2 diabetes mellitus patients after coronary stents implantation: a systematic review and meta-analysis of randomized controlled trialsQ26785723
Duration of Dual Antiplatelet Therapy After Coronary Stenting: A Review of the EvidenceQ26799079
Duration of dual antiplatelet therapy after drug-eluting stent implantation: a systematic review and meta-analysis of randomized controlled trialsQ26852886
Effects of pretreatment with clopidogrel and aspirin followed by long-term therapy in patients undergoing percutaneous coronary intervention: the PCI-CURE studyQ28165115
Percutaneous coronary intervention in diabetic patients with non-ST-segment elevation acute coronary syndromesQ28167317
Soluble CD40 ligand, soluble P-selectin, interleukin-6, and tissue factor in diabetes mellitus: relationships to cardiovascular disease and risk factor interventionQ28168588
Platelet function profiles in patients with type 2 diabetes and coronary artery disease on combined aspirin and clopidogrel treatmentQ28185431
Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevationQ28188284
Effects of P2Y(1) and P2Y(12) receptor antagonists on platelet aggregation induced by different agonists in human whole bloodQ28190630
Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomised placebo-controlled trialQ28193186
Low-dose aspirin for the prevention of atherothrombosisQ28193680
Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trialQ28194232
Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic eventsQ28195656
Insulin therapy is associated with platelet dysfunction in patients with type 2 diabetes mellitus on dual oral antiplatelet treatmentQ28199546
Platelet activation in type 2 diabetes mellitusQ28210554
Addition of clopidogrel to aspirin and fibrinolytic therapy for myocardial infarction with ST-segment elevationQ28218789
Reticulated platelets and uninhibited COX-1 and COX-2 decrease the antiplatelet effects of aspirinQ28219365
The effect of aspirin dosing on platelet function in diabetic and nondiabetic patients: an analysis from the aspirin-induced platelet effect (ASPECT) studyQ28221353
Variability in individual responsiveness to clopidogrel: clinical implications, management, and future perspectivesQ28222158
Impact of platelet reactivity on cardiovascular outcomes in patients with type 2 diabetes mellitus and coronary artery diseaseQ28222643
Regulation of platelet plasma membrane Ca2+-ATPase by cAMP-dependent and tyrosine phosphorylationQ28240515
Global estimates of the prevalence of diabetes for 2010 and 2030Q29547218
Global and societal implications of the diabetes epidemicQ29614551
Normalizing mitochondrial superoxide production blocks three pathways of hyperglycaemic damageQ29616101
Ticagrelor versus clopidogrel in patients with acute coronary syndromesQ29619002
Collaborative overview of randomised trials of antiplatelet therapy--I: Prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists' CollaborationQ29619529
A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering CommitteeQ29620666
Double-blind study of the safety of clopidogrel with and without a loading dose in combination with aspirin compared with ticlopidine in combination with aspirin after coronary stenting : the clopidogrel aspirin stent international cooperative studyQ33333456
Blockade of adenosine diphosphate receptors P2Y(12) and P2Y(1) is required to inhibit platelet aggregation in whole blood under flowQ39586331
Prasugrel versus clopidogrel for acute coronary syndromes without revascularizationQ40058838
Diabetes patients requiring glucose-lowering therapy and nondiabetics with a prior myocardial infarction carry the same cardiovascular risk: a population study of 3.3 million peopleQ40108176
Long-term use of ticagrelor in patients with prior myocardial infarctionQ40263764
Platelet Inhibition With Ticagrelor 60 mg Versus 90 mg Twice Daily in the PEGASUS-TIMI 54 TrialQ40759916
Reduction in Ischemic Events With Ticagrelor in Diabetic Patients With Prior Myocardial Infarction in PEGASUS-TIMI 54.Q40817339
Insulin, insulin resistance, and platelet signaling in diabetesQ41951212
Platelet resistance to nitrates in obesity and obese NIDDM, and normal platelet sensitivity to both insulin and nitrates in lean NIDDM.Q42453569
Alterations in platelet Ca2+ signalling in diabetic patients is due to increased formation of superoxide anions and reduced nitric oxide productionQ42468613
Dose Comparisons of Clopidogrel and Aspirin in Acute Coronary SyndromesQ42917068
Insulin/IGF-1 hybrid receptor expression on human platelets: consequences for the effect of insulin on platelet functionQ43264426
Regulation of protein kinase C by short term hyperglycaemia in human platelets in vivo and in vitro.Q43554882
Effect of weight reduction in moderately overweight patients on recorded ambulatory blood pressure and free cytosolic platelet calciumQ43566887
Platelet antioxidant enzymes in insulin-dependent diabetes mellitusQ43641231
Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in MyocarQ44056270
IRS-1 Mediates Inhibition of Ca2+ Mobilization by Insulin via the Inhibitory G-protein GiQ44645484
Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes mellitusQ44668369
Association of diabetes mellitus and glycemic control strategies with clinical outcomes after acute coronary syndromesQ44754180
Peroxisome proliferator-activated receptor-gamma agonist rosiglitazone reduces circulating platelet activity in patients without diabetes mellitus who have coronary artery diseaseQ44938343
Antiplatelet Effect Durability of a Novel, 24-Hour, Extended-Release Prescription Formulation of Acetylsalicylic Acid in Patients With Type 2 Diabetes Mellitus.Q45045640
Patients with poor responsiveness to thienopyridine treatment or with diabetes have lower levels of circulating active metabolite, but their platelets respond normally to active metabolite added ex vivoQ46214428
Role of reticulated platelets and platelet size heterogeneity on platelet activity after dual antiplatelet therapy with aspirin and clopidogrel in patients with stable coronary artery diseaseQ46418067
A randomized study assessing the impact of cilostazol on platelet function profiles in patients with diabetes mellitus and coronary artery disease on dual antiplatelet therapy: results of the OPTIMUS-2 study.Q46528728
Platelet inhibition by insulin is absent in type 2 diabetes mellitusQ46843983
Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazoneQ46856893
Prasugrel versus clopidogrel in patients with acute coronary syndromesQ46915044
Evolution of coronary stent technology and implications for duration of dual antiplatelet therapyQ47757284
The quest for safer antithrombotic treatment regimens in patients with coronary artery disease: new strategies and paradigm shiftsQ47865745
Enteric Coating and Aspirin Nonresponsiveness in Patients With Type 2 Diabetes MellitusQ47992848
Aspirin for Primary Cardiovascular Risk Prevention and Beyond in Diabetes Mellitus.Q50573978
Determinants of mean platelet volume (MPV) in an elderly population: relevance of body fat, blood glucose and ischaemic electrocardiographic changes.Q51446902
Effects of improved metabolic control on platelet reactivity in patients with type 2 diabetes mellitus following coronary angioplasty.Q51496269
Development and Validation of a Prediction Rule for Benefit and Harm of Dual Antiplatelet Therapy Beyond 1 Year After Percutaneous Coronary InterventionQ33613297
Response to ticagrelor in clopidogrel nonresponders and responders and effect of switching therapies: the RESPOND studyQ34021458
Thrombin-receptor antagonist vorapaxar in acute coronary syndromesQ34231934
Vorapaxar in the secondary prevention of atherothrombotic eventsQ34263311
Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation.Q34389439
Ticagrelor vs. clopidogrel in patients with acute coronary syndromes and diabetes: a substudy from the PLATelet inhibition and patient Outcomes (PLATO) trialQ34404150
A pharmacodynamic comparison of prasugrel vs. high-dose clopidogrel in patients with type 2 diabetes mellitus and coronary artery disease: results of the Optimizing anti-Platelet Therapy In diabetes MellitUS (OPTIMUS)-3 TrialQ34751965
Comparison of pioglitazone vs glimepiride on progression of coronary atherosclerosis in patients with type 2 diabetes: the PERISCOPE randomized controlled trialQ34766176
Atherothrombosis, inflammation, and diabetesQ35101130
Vorapaxar in patients with diabetes mellitus and previous myocardial infarction: findings from the thrombin receptor antagonist in secondary prevention of atherothrombotic ischemic events-TIMI 50 trialQ35195203
Intramural plasminogen activator inhibitor type-1 and coronary atherosclerosisQ35200308
Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part I.Q35540861
Diabetes and vascular disease: pathophysiology, clinical consequences, and medical therapy: Part II.Q35546626
Twelve or 30 months of dual antiplatelet therapy after drug-eluting stentsQ35783487
Prospective randomised study of intensive insulin treatment on long term survival after acute myocardial infarction in patients with diabetes mellitus. DIGAMI (Diabetes Mellitus, Insulin Glucose Infusion in Acute Myocardial Infarction) Study GroupQ36244558
Cilostazol: potential mechanism of action for antithrombotic effects accompanied by a low rate of bleedingQ36308327
Effects of VLDL and remnant particles on plateletsQ36551304
Randomized assessment of ticagrelor versus prasugrel antiplatelet effects in patients with diabetesQ37022618
Oxidative stress and plateletsQ37049876
Factors contributing to increased platelet reactivity in people with diabetesQ37139534
Platelet thrombin receptor antagonism and atherothrombosisQ37641556
Metabolism and disposition of the thienopyridine antiplatelet drugs ticlopidine, clopidogrel, and prasugrel in humansQ37641606
Diabetes and antiplatelet therapy in acute coronary syndrome.Q37846051
Challenges and perspectives of antiplatelet therapy in patients with diabetes mellitus and coronary artery diseaseQ38020865
The evolution of antiplatelet therapy in the treatment of acute coronary syndromes: from aspirin to the present day.Q38053481
Platelet function profiles in patients with diabetes mellitusQ38081078
Adenosine-mediated effects of ticagrelor: evidence and potential clinical relevanceQ38207389
Novel antiplatelet agents in acute coronary syndromeQ38257119
Impact of Diabetes Mellitus on the Pharmacodynamic Effects of Ticagrelor Versus Clopidogrel in Troponin-Negative Acute Coronary Syndrome Patients Undergoing Ad Hoc Percutaneous Coronary InterventionQ38378830
Pharmacodynamic Comparison of Prasugrel Versus Ticagrelor in Patients With Type 2 Diabetes Mellitus and Coronary Artery Disease: The OPTIMUS (Optimizing Antiplatelet Therapy in Diabetes Mellitus)-4 StudyQ38388438
Diabetes Mellitus and Prevention of Late Myocardial Infarction After Coronary Stenting in the Randomized Dual Antiplatelet Therapy StudyQ38394612
Role for Thrombin Receptor Antagonism With Vorapaxar in Secondary Prevention of Atherothrombotic Events: From Bench to BedsideQ38402334
Pharmacodynamic effects of different aspirin dosing regimens in type 2 diabetes mellitus patients with coronary artery diseaseQ38493656
Global burden of diabetes, 1995-2025: prevalence, numerical estimates, and projectionsQ39474763
P433issue5
P304page(s)594-609
P577publication date2018-10-01
P1433published inCardiovascular diagnosis and therapyQ26842243
P1476titleDiabetes and antiplatelet therapy: from bench to bedside.
P478volume8

Reverse relations

cites work (P2860)
Q89712805Alteration of purinergic signaling in diabetes: Focus on vascular function
Q64277113Antiplatelet therapy in very elderly and comorbid patients with acute coronary syndromes
Q92476250Aspirin, clopidogrel and prasugrel monotherapy in patients with type 2 diabetes mellitus: a double-blind randomised controlled trial of the effects on thrombotic markers and microRNA levels
Q97682139Assessment of the high risk and unmet need in patients with CAD and type 2 diabetes (ATHENA): US healthcare resource utilization, cost and burden of illness in the Diabetes Collaborative Registry
Q90666020Association of GCK gene DNA methylation with the risk of clopidogrel resistance in acute coronary syndrome patients
Q92328545Coagulatory Defects in Type-1 and Type-2 Diabetes
Q93018504Significance of circulating microRNAs in diabetes mellitus type 2 and platelet reactivity: bioinformatic analysis and review

Search more.